A method for studying expectorant action in the mouse by measurement of tracheobronchial phenol red secretion.
Identifieur interne : 000784 ( PubMed/Corpus ); précédent : 000783; suivant : 000785A method for studying expectorant action in the mouse by measurement of tracheobronchial phenol red secretion.
Auteurs : G. Coppi ; M T GattiSource :
- Farmaco (Società chimica italiana : 1989) [ 0014-827X ] ; 1989.
English descriptors
- KwdEn :
- MESH :
- chemical , pharmacology : Expectorants.
- drug effects : Bronchi, Mucus, Trachea.
- metabolism : Bronchi, Trachea.
- secretion : Mucus.
- Animals, Female, Mice, Phenolphthaleins, Phenolsulfonphthalein, Time Factors.
Abstract
The paper reports a method for studying mucosecretolytic drugs in the mouse. After i.p. application of phenol red, part of the dye is secreted in the tracheobronchial tract and collected by lung washings with saline. The concentration of secreted phenol red is measured photometrically at 546 nm. All the most important expectorant drugs increase the tracheobronchial secretion of phenol red in the mouse. The ED50 values, calculated as mg/kg, show practically the same activity for N-acetylcysteine, Tiopronine, SF-1284 and S-carboxymethylcysteine, and a lower activity for Ambroxol and Sobrerol. The method was validated for reproducibility utilizing Tiopronine in many experiments performed over twelve months.
PubMed: 2789630
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pubmed:2789630Le document en format XML
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Coppi</name><affiliation><nlm:affiliation>Proter Research Laboratories, Opera, Milano, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Gatti, M T" sort="Gatti, M T" uniqKey="Gatti M" first="M T" last="Gatti">M T Gatti</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1989">1989</date><idno type="RBID">pubmed:2789630</idno><idno type="pmid">2789630</idno><idno type="wicri:Area/PubMed/Corpus">000784</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A method for studying expectorant action in the mouse by measurement of tracheobronchial phenol red secretion.</title><author><name sortKey="Coppi, G" sort="Coppi, G" uniqKey="Coppi G" first="G" last="Coppi">G. Coppi</name><affiliation><nlm:affiliation>Proter Research Laboratories, Opera, Milano, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Gatti, M T" sort="Gatti, M T" uniqKey="Gatti M" first="M T" last="Gatti">M T Gatti</name></author></analytic><series><title level="j">Farmaco (Società chimica italiana : 1989)</title><idno type="ISSN">0014-827X</idno><imprint><date when="1989" type="published">1989</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Bronchi (drug effects)</term><term>Bronchi (metabolism)</term><term>Expectorants (pharmacology)</term><term>Female</term><term>Mice</term><term>Mucus (drug effects)</term><term>Mucus (secretion)</term><term>Phenolphthaleins</term><term>Phenolsulfonphthalein</term><term>Time Factors</term><term>Trachea (drug effects)</term><term>Trachea (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Expectorants</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Bronchi</term><term>Mucus</term><term>Trachea</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Bronchi</term><term>Trachea</term></keywords><keywords scheme="MESH" qualifier="secretion" xml:lang="en"><term>Mucus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Female</term><term>Mice</term><term>Phenolphthaleins</term><term>Phenolsulfonphthalein</term><term>Time Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The paper reports a method for studying mucosecretolytic drugs in the mouse. After i.p. application of phenol red, part of the dye is secreted in the tracheobronchial tract and collected by lung washings with saline. The concentration of secreted phenol red is measured photometrically at 546 nm. All the most important expectorant drugs increase the tracheobronchial secretion of phenol red in the mouse. The ED50 values, calculated as mg/kg, show practically the same activity for N-acetylcysteine, Tiopronine, SF-1284 and S-carboxymethylcysteine, and a lower activity for Ambroxol and Sobrerol. The method was validated for reproducibility utilizing Tiopronine in many experiments performed over twelve months.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">2789630</PMID><DateCreated><Year>1989</Year><Month>11</Month><Day>22</Day></DateCreated><DateCompleted><Year>1989</Year><Month>11</Month><Day>22</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0014-827X</ISSN><JournalIssue CitedMedium="Print"><Volume>44</Volume><Issue>5</Issue><PubDate><Year>1989</Year><Month>May</Month></PubDate></JournalIssue><Title>Farmaco (Società chimica italiana : 1989)</Title><ISOAbbreviation>Farmaco</ISOAbbreviation></Journal><ArticleTitle>A method for studying expectorant action in the mouse by measurement of tracheobronchial phenol red secretion.</ArticleTitle><Pagination><MedlinePgn>541-5</MedlinePgn></Pagination><Abstract><AbstractText>The paper reports a method for studying mucosecretolytic drugs in the mouse. After i.p. application of phenol red, part of the dye is secreted in the tracheobronchial tract and collected by lung washings with saline. The concentration of secreted phenol red is measured photometrically at 546 nm. All the most important expectorant drugs increase the tracheobronchial secretion of phenol red in the mouse. The ED50 values, calculated as mg/kg, show practically the same activity for N-acetylcysteine, Tiopronine, SF-1284 and S-carboxymethylcysteine, and a lower activity for Ambroxol and Sobrerol. The method was validated for reproducibility utilizing Tiopronine in many experiments performed over twelve months.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Coppi</LastName><ForeName>G</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Proter Research Laboratories, Opera, Milano, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gatti</LastName><ForeName>M T</ForeName><Initials>MT</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>ITALY</Country><MedlineTA>Farmaco</MedlineTA><NlmUniqueID>8912641</NlmUniqueID><ISSNLinking>0014-827X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005100">Expectorants</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010635">Phenolphthaleins</NameOfSubstance></Chemical><Chemical><RegistryNumber>I6G9Y0J1OJ</RegistryNumber><NameOfSubstance UI="D010637">Phenolsulfonphthalein</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000818">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001980">Bronchi</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000187">drug effects</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005100">Expectorants</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000494">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D051379">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009093">Mucus</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000187">drug effects</QualifierName><QualifierName MajorTopicYN="N" UI="Q000557">secretion</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010635">Phenolphthaleins</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D010637">Phenolsulfonphthalein</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013997">Time Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D014132">Trachea</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000187">drug effects</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000378">metabolism</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1989</Year><Month>5</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1989</Year><Month>5</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1989</Year><Month>5</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">2789630</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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