Interaction of electrically evoked responses in networks of dissociated cortical neurons.
Identifieur interne : 000374 ( PubMed/Corpus ); précédent : 000373; suivant : 000375Interaction of electrically evoked responses in networks of dissociated cortical neurons.
Auteurs : Pieter Laurens Baljon ; Michela Chiappalone ; Sergio MartinoiaSource :
- Physical review. E, Statistical, nonlinear, and soft matter physics ; 2009.
English descriptors
- KwdEn :
- MESH :
- cytology : Cerebral Cortex, Nerve Net, Neurons.
- metabolism : Neurons.
- physiology : Nerve Net.
- Animals, Electric Stimulation, Electrodes, Evoked Potentials, Female, Pregnancy, Rats, Rats, Sprague-Dawley, Time Factors.
Abstract
In this work we describe the interaction of the responses of neuronal networks to pairs of electrical stimuli. For this we use networks of dissociated cortical neurons cultured on planar microelectrode arrays. We compare the response to pairs of stimuli with the response to a stimulus in isolation. To evaluate the influence of both stimuli we introduce a normalization of the root-mean square of the response. Furthermore we consider the response to a pair of stimuli as the linear superposition of the two constituents. The two methods combined show that the neuronal network strongly suppresses the second stimulus. At the same time we find a possible window of integration in which two stimuli from separate locations in the network can interact to form a new response.
DOI: 10.1103/PhysRevE.80.031906
PubMed: 19905145
Links to Exploration step
pubmed:19905145Le document en format XML
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For this we use networks of dissociated cortical neurons cultured on planar microelectrode arrays. We compare the response to pairs of stimuli with the response to a stimulus in isolation. To evaluate the influence of both stimuli we introduce a normalization of the root-mean square of the response. Furthermore we consider the response to a pair of stimuli as the linear superposition of the two constituents. The two methods combined show that the neuronal network strongly suppresses the second stimulus. At the same time we find a possible window of integration in which two stimuli from separate locations in the network can interact to form a new response.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">19905145</PMID><DateCreated><Year>2009</Year><Month>11</Month><Day>12</Day></DateCreated><DateCompleted><Year>2010</Year><Month>01</Month><Day>13</Day></DateCompleted><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1550-2376</ISSN><JournalIssue CitedMedium="Internet"><Volume>80</Volume><Issue>3 Pt 1</Issue><PubDate><Year>2009</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Physical review. E, Statistical, nonlinear, and soft matter physics</Title><ISOAbbreviation>Phys Rev E Stat Nonlin Soft Matter Phys</ISOAbbreviation></Journal><ArticleTitle>Interaction of electrically evoked responses in networks of dissociated cortical neurons.</ArticleTitle><Pagination><MedlinePgn>031906</MedlinePgn></Pagination><Abstract><AbstractText>In this work we describe the interaction of the responses of neuronal networks to pairs of electrical stimuli. For this we use networks of dissociated cortical neurons cultured on planar microelectrode arrays. We compare the response to pairs of stimuli with the response to a stimulus in isolation. To evaluate the influence of both stimuli we introduce a normalization of the root-mean square of the response. Furthermore we consider the response to a pair of stimuli as the linear superposition of the two constituents. The two methods combined show that the neuronal network strongly suppresses the second stimulus. At the same time we find a possible window of integration in which two stimuli from separate locations in the network can interact to form a new response.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Baljon</LastName><ForeName>Pieter Laurens</ForeName><Initials>PL</Initials><AffiliationInfo><Affiliation>Department of Biophysical and Electronic Engineering, Neuroengineering and Bio-Nano Technology Group, University of Genova, Via Opera Pia 11a, 16145 Genova, Italy. pieter.laurens@unige.it</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chiappalone</LastName><ForeName>Michela</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Martinoia</LastName><ForeName>Sergio</ForeName><Initials>S</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2009</Year><Month>09</Month><Day>18</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Phys Rev E Stat Nonlin Soft Matter Phys</MedlineTA><NlmUniqueID>101136452</NlmUniqueID><ISSNLinking>1539-3755</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000818">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D002540">Cerebral Cortex</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000166">cytology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004558">Electric Stimulation</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004566">Electrodes</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D005071">Evoked Potentials</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009415">Nerve Net</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000166">cytology</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009474">Neurons</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000166">cytology</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011247">Pregnancy</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D051381">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D017207">Rats, Sprague-Dawley</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013997">Time Factors</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2009</Year><Month>5</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2009</Year><Month>7</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="aheadofprint"><Year>2009</Year><Month>9</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2009</Year><Month>11</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2009</Year><Month>11</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2010</Year><Month>1</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">19905145</ArticleId><ArticleId IdType="doi">10.1103/PhysRevE.80.031906</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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