CRP genotype and haplotype associations with serum C-reactive protein level and DAS28 in untreated early rheumatoid arthritis patients.
Identifieur interne : 000135 ( PubMed/Corpus ); précédent : 000134; suivant : 000136CRP genotype and haplotype associations with serum C-reactive protein level and DAS28 in untreated early rheumatoid arthritis patients.
Auteurs : Christian Gytz Ammitzb Ll ; Rudi Steffensen ; Martin B Gsted ; Kim H Rslev-Petersen ; Merete L. Hetland ; Peter Junker ; Julia S. Johansen ; Jan P Denphant ; Mikkel Stergaard ; Torkell Ellingsen ; Kristian Stengaard-PedersenSource :
- Arthritis research & therapy ; 2014.
English descriptors
- KwdEn :
- Adult, Aged, Antirheumatic Agents (therapeutic use), Arthritis, Rheumatoid (blood), Arthritis, Rheumatoid (drug therapy), Arthritis, Rheumatoid (genetics), C-Reactive Protein (genetics), C-Reactive Protein (metabolism), Cohort Studies, Female, Gene Frequency, Genotype, Haplotypes, Humans, Linear Models, Male, Middle Aged, Polymorphism, Single Nucleotide, Randomized Controlled Trials as Topic, Severity of Illness Index, Treatment Outcome.
- MESH :
- chemical , genetics : C-Reactive Protein.
- chemical , metabolism : C-Reactive Protein.
- chemical , therapeutic use : Antirheumatic Agents.
- blood : Arthritis, Rheumatoid.
- drug therapy : Arthritis, Rheumatoid.
- genetics : Arthritis, Rheumatoid.
- Adult, Aged, Cohort Studies, Female, Gene Frequency, Genotype, Haplotypes, Humans, Linear Models, Male, Middle Aged, Polymorphism, Single Nucleotide, Randomized Controlled Trials as Topic, Severity of Illness Index, Treatment Outcome.
Abstract
Single-nucleotide polymorphisms (SNPs) in the CRP gene are implicated in the regulation of the constitutional C-reactive protein (CRP) expression and its response to proinflammatory stimuli. Previous reports suggest that these effects may have an impact on clinical decision-making tools based on CRP, such as the Disease Activity Score in 28 joints (DAS28). We aimed to investigate the possible association between seven CRP SNPs, their haplotypes and the serum levels of CRP, as well as DAS28 scores, in two cohorts of untreated active early rheumatoid arthritis (RA) patients followed during their initial treatment.
DOI: 10.1186/s13075-014-0475-3
PubMed: 25359432
Links to Exploration step
pubmed:25359432Le document en format XML
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Hetland</name></author><author><name sortKey="Junker, Peter" sort="Junker, Peter" uniqKey="Junker P" first="Peter" last="Junker">Peter Junker</name></author><author><name sortKey="Johansen, Julia S" sort="Johansen, Julia S" uniqKey="Johansen J" first="Julia S" last="Johansen">Julia S. Johansen</name></author><author><name sortKey="P Denphant, Jan" sort="P Denphant, Jan" uniqKey="P Denphant J" first="Jan" last="P Denphant">Jan P Denphant</name></author><author><name sortKey=" Stergaard, Mikkel" sort=" Stergaard, Mikkel" uniqKey=" Stergaard M" first="Mikkel" last=" Stergaard">Mikkel Stergaard</name></author><author><name sortKey="Ellingsen, Torkell" sort="Ellingsen, Torkell" uniqKey="Ellingsen T" first="Torkell" last="Ellingsen">Torkell Ellingsen</name></author><author><name sortKey="Stengaard Pedersen, Kristian" sort="Stengaard Pedersen, Kristian" uniqKey="Stengaard Pedersen K" first="Kristian" last="Stengaard-Pedersen">Kristian Stengaard-Pedersen</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="doi">10.1186/s13075-014-0475-3</idno><idno type="RBID">pubmed:25359432</idno><idno type="pmid">25359432</idno><idno type="wicri:Area/PubMed/Corpus">000135</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">CRP genotype and haplotype associations with serum C-reactive protein level and DAS28 in untreated early rheumatoid arthritis patients.</title><author><name sortKey="Ammitzb Ll, Christian Gytz" sort="Ammitzb Ll, Christian Gytz" uniqKey="Ammitzb Ll C" first="Christian Gytz" last="Ammitzb Ll">Christian Gytz Ammitzb Ll</name></author><author><name sortKey="Steffensen, Rudi" sort="Steffensen, Rudi" uniqKey="Steffensen R" first="Rudi" last="Steffensen">Rudi Steffensen</name></author><author><name sortKey="B Gsted, Martin" sort="B Gsted, Martin" uniqKey="B Gsted M" first="Martin" last="B Gsted">Martin B Gsted</name></author><author><name sortKey="H Rslev Petersen, Kim" sort="H Rslev Petersen, Kim" uniqKey="H Rslev Petersen K" first="Kim" last="H Rslev-Petersen">Kim H Rslev-Petersen</name></author><author><name sortKey="Hetland, Merete L" sort="Hetland, Merete L" uniqKey="Hetland M" first="Merete L" last="Hetland">Merete L. Hetland</name></author><author><name sortKey="Junker, Peter" sort="Junker, Peter" uniqKey="Junker P" first="Peter" last="Junker">Peter Junker</name></author><author><name sortKey="Johansen, Julia S" sort="Johansen, Julia S" uniqKey="Johansen J" first="Julia S" last="Johansen">Julia S. Johansen</name></author><author><name sortKey="P Denphant, Jan" sort="P Denphant, Jan" uniqKey="P Denphant J" first="Jan" last="P Denphant">Jan P Denphant</name></author><author><name sortKey=" Stergaard, Mikkel" sort=" Stergaard, Mikkel" uniqKey=" Stergaard M" first="Mikkel" last=" Stergaard">Mikkel Stergaard</name></author><author><name sortKey="Ellingsen, Torkell" sort="Ellingsen, Torkell" uniqKey="Ellingsen T" first="Torkell" last="Ellingsen">Torkell Ellingsen</name></author><author><name sortKey="Stengaard Pedersen, Kristian" sort="Stengaard Pedersen, Kristian" uniqKey="Stengaard Pedersen K" first="Kristian" last="Stengaard-Pedersen">Kristian Stengaard-Pedersen</name></author></analytic><series><title level="j">Arthritis research & therapy</title><idno type="e-ISSN">1478-6362</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Antirheumatic Agents (therapeutic use)</term><term>Arthritis, Rheumatoid (blood)</term><term>Arthritis, Rheumatoid (drug therapy)</term><term>Arthritis, Rheumatoid (genetics)</term><term>C-Reactive Protein (genetics)</term><term>C-Reactive Protein (metabolism)</term><term>Cohort Studies</term><term>Female</term><term>Gene Frequency</term><term>Genotype</term><term>Haplotypes</term><term>Humans</term><term>Linear Models</term><term>Male</term><term>Middle Aged</term><term>Polymorphism, Single Nucleotide</term><term>Randomized Controlled Trials as Topic</term><term>Severity of Illness Index</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>C-Reactive Protein</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>C-Reactive Protein</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antirheumatic Agents</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Arthritis, Rheumatoid</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Arthritis, Rheumatoid</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Arthritis, Rheumatoid</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Cohort Studies</term><term>Female</term><term>Gene Frequency</term><term>Genotype</term><term>Haplotypes</term><term>Humans</term><term>Linear Models</term><term>Male</term><term>Middle Aged</term><term>Polymorphism, Single Nucleotide</term><term>Randomized Controlled Trials as Topic</term><term>Severity of Illness Index</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Single-nucleotide polymorphisms (SNPs) in the CRP gene are implicated in the regulation of the constitutional C-reactive protein (CRP) expression and its response to proinflammatory stimuli. Previous reports suggest that these effects may have an impact on clinical decision-making tools based on CRP, such as the Disease Activity Score in 28 joints (DAS28). We aimed to investigate the possible association between seven CRP SNPs, their haplotypes and the serum levels of CRP, as well as DAS28 scores, in two cohorts of untreated active early rheumatoid arthritis (RA) patients followed during their initial treatment.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">25359432</PMID><DateCreated><Year>2015</Year><Month>01</Month><Day>10</Day></DateCreated><DateCompleted><Year>2015</Year><Month>08</Month><Day>11</Day></DateCompleted><DateRevised><Year>2015</Year><Month>10</Month><Day>29</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1478-6362</ISSN><JournalIssue CitedMedium="Internet"><Volume>16</Volume><Issue>5</Issue><PubDate><Year>2014</Year></PubDate></JournalIssue><Title>Arthritis research & therapy</Title><ISOAbbreviation>Arthritis Res. Ther.</ISOAbbreviation></Journal><ArticleTitle>CRP genotype and haplotype associations with serum C-reactive protein level and DAS28 in untreated early rheumatoid arthritis patients.</ArticleTitle><Pagination><MedlinePgn>475</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1186/s13075-014-0475-3</ELocationID><Abstract><AbstractText Label="INTRODUCTION" NlmCategory="BACKGROUND">Single-nucleotide polymorphisms (SNPs) in the CRP gene are implicated in the regulation of the constitutional C-reactive protein (CRP) expression and its response to proinflammatory stimuli. Previous reports suggest that these effects may have an impact on clinical decision-making tools based on CRP, such as the Disease Activity Score in 28 joints (DAS28). We aimed to investigate the possible association between seven CRP SNPs, their haplotypes and the serum levels of CRP, as well as DAS28 scores, in two cohorts of untreated active early rheumatoid arthritis (RA) patients followed during their initial treatment.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Overall, 315 patients with RA from two randomized controlled trials (the CIMESTRA and OPERA trials) who were naïve to disease-modifying antirheumatic drugs and steroids with disease durations less than 6 months were included. Seven CRP SNPs were investigated: rs11265257, rs1130864, rs1205, rs1800947, rs2808632, rs3093077 and rs876538. The genotype and haplotype associations with CRP and DAS28 levels were evaluated using linear regression analysis adjusted for age, sex and treatment.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The minor allele of rs1205 C > T was associated with decreased CRP levels at baseline (P = 0.03), with the TT genotype having a 50% reduction in CRP from 16.7 to 8.4 mg/L (P = 0.005) compared to homozygosity of the major allele, but no association was observed at year 1 (P = 0.38). The common H2 haplotype, characterized by the T allele of rs1205, was associated with a 26% reduction in CRP at baseline (P = 0.043), although no effect was observed at year 1 (P = 0.466). No other SNP or haplotype was associated with CRP at baseline or at year 1 (P ≥ 0.09). We observed no associations between SNPs or haplotypes and DAS28 scores at baseline or at year 1 (P ≥ 0.10).</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">CRP genotype and haplotype were only marginally associated with serum CRP levels and had no association with the DAS28 score. This study shows that DAS28, the core parameter for inflammatory activity in RA, can be used for clinical decision-making without adjustment for CRP gene variants.</AbstractText><AbstractText Label="TRIAL REGISTRATION" NlmCategory="BACKGROUND">The OPERA study is registered at Clinicaltrials.gov (NCT00660647). The CIMESTRA study is not listed in a clinical trials registry, because patients were included between October 1999 and October 2002.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ammitzbøll</LastName><ForeName>Christian Gytz</ForeName><Initials>CG</Initials></Author><Author ValidYN="Y"><LastName>Steffensen</LastName><ForeName>Rudi</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Bøgsted</LastName><ForeName>Martin</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Hørslev-Petersen</LastName><ForeName>Kim</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Hetland</LastName><ForeName>Merete L</ForeName><Initials>ML</Initials></Author><Author ValidYN="Y"><LastName>Junker</LastName><ForeName>Peter</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Johansen</LastName><ForeName>Julia S</ForeName><Initials>JS</Initials></Author><Author ValidYN="Y"><LastName>Pødenphant</LastName><ForeName>Jan</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Østergaard</LastName><ForeName>Mikkel</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Ellingsen</LastName><ForeName>Torkell</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Stengaard-Pedersen</LastName><ForeName>Kristian</ForeName><Initials>K</Initials></Author></AuthorList><Language>eng</Language><DataBankList CompleteYN="Y"><DataBank><DataBankName>ClinicalTrials.gov</DataBankName><AccessionNumberList><AccessionNumber>NCT00660647</AccessionNumber></AccessionNumberList></DataBank></DataBankList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>10</Month><Day>31</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Arthritis Res Ther</MedlineTA><NlmUniqueID>101154438</NlmUniqueID><ISSNLinking>1478-6354</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018501">Antirheumatic Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>9007-41-4</RegistryNumber><NameOfSubstance UI="D002097">C-Reactive Protein</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Atherosclerosis. 2001 Feb 15;154(3):681-9</RefSource><PMID Version="1">11257270</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann Intern Med. 2003 Jun 3;138(11):891-7</RefSource><PMID Version="1">12779299</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Clin Invest. 2003 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UI="D002097">C-Reactive Protein</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000235">genetics</QualifierName><QualifierName MajorTopicYN="N" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D015331">Cohort Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005787">Gene Frequency</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005838">Genotype</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D006239">Haplotypes</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D016014">Linear Models</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D020641">Polymorphism, Single Nucleotide</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D016032">Randomized Controlled Trials as Topic</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012720">Severity of Illness Index</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D016896">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC4247621</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>3</Month><Day>21</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>10</Month><Day>17</Day></PubMedPubDate><PubMedPubDate 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