Association between individual and combined SNPs in genes related to innate immunity and incidence of CMV infection in seropositive kidney transplant recipients.
Identifieur interne : 000100 ( PubMed/Corpus ); précédent : 000099; suivant : 000101Association between individual and combined SNPs in genes related to innate immunity and incidence of CMV infection in seropositive kidney transplant recipients.
Auteurs : M. Fernández-Ruiz ; I. Corrales ; M. Arias ; J M Campistol ; E. Giménez ; J. Crespo ; M O L Pez-Oliva ; I. Beneyto ; P L Martín-Moreno ; F. Llamas-Fuente ; A. Gutiérrez ; T. García-Álvarez ; R. Guerra-Rodríguez ; N. Calvo ; A. Fernández-Rodríguez ; J M Tabernero-Romo ; M D Navarro ; A. Ramos-Verde ; J M Aguado ; D. NavarroSource :
- American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons ; 2015.
English descriptors
- KwdEn :
- Adult, Aged, Alleles, Cell Adhesion Molecules (genetics), Cytomegalovirus Infections (blood), Cytomegalovirus Infections (genetics), Female, Genotype, Humans, Immunity, Innate (genetics), Incidence, Interleukins (genetics), Kidney Failure, Chronic (blood), Kidney Failure, Chronic (genetics), Kidney Failure, Chronic (surgery), Kidney Transplantation, Lectins, C-Type (genetics), Male, Middle Aged, Odds Ratio, Polymorphism, Single Nucleotide, Proportional Hazards Models, Prospective Studies, Receptors, Cell Surface (genetics), Transplant Recipients.
- MESH :
- chemical , genetics : Cell Adhesion Molecules, Interleukins, Lectins, C-Type, Receptors, Cell Surface.
- blood : Cytomegalovirus Infections, Kidney Failure, Chronic.
- genetics : Cytomegalovirus Infections, Immunity, Innate, Kidney Failure, Chronic.
- surgery : Kidney Failure, Chronic.
- Adult, Aged, Alleles, Female, Genotype, Humans, Incidence, Kidney Transplantation, Male, Middle Aged, Odds Ratio, Polymorphism, Single Nucleotide, Proportional Hazards Models, Prospective Studies, Transplant Recipients.
Abstract
In this study, we assessed the association between single-nucleotide polymorphisms (SNPs) in seven candidate genes involved in orchestrating the immune response against cytomegalovirus (CMV) and the 12-month incidence of CMV infection in 315 CMV-seropositive kidney transplant (KT) recipients. Patients were managed either by antiviral prophylaxis or preemptive therapy. CMV infection occurred in 140 patients (44.4%), including 13 episodes of disease. After adjusting for various clinical covariates, patients harboring T-allele genotypes of interleukin-28B (IL28B) (rs12979860) SNP had lower incidence of CMV infection (adjusted hazard ratio [aHR]: 0.66; 95% confidence interval [CI]: 0.46-0.96; p-value = 0.029). In the analysis restricted to patients not receiving prophylaxis, carriers of the TT genotype of toll-like receptor 9 (TLR9) (rs5743836) SNP had lower incidence of infection (aHR: 0.61; 95% CI: 0.38-0.96; p-value = 0.035), whereas the GG genotype of dendritic cell-specific ICAM 3-grabbing nonintegrin (DC-SIGN) (rs735240) SNP exerted the opposite effect (aHR: 1.86; 95% CI: 1.18-2.94; p-value = 0.008). An independent association was found between the number of unfavorable SNP genotypes carried by the patient and the incidence of CMV infection. In conclusion, specific SNPs in IL28B, TLR9 and DC-SIGN genes may play a role in modulating the susceptibility to CMV infection in CMV-seropositive KT recipients.
DOI: 10.1111/ajt.13107
PubMed: 25777542
Links to Exploration step
pubmed:25777542Le document en format XML
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Arias</name></author><author><name sortKey="Campistol, J M" sort="Campistol, J M" uniqKey="Campistol J" first="J M" last="Campistol">J M Campistol</name></author><author><name sortKey="Gimenez, E" sort="Gimenez, E" uniqKey="Gimenez E" first="E" last="Giménez">E. Giménez</name></author><author><name sortKey="Crespo, J" sort="Crespo, J" uniqKey="Crespo J" first="J" last="Crespo">J. Crespo</name></author><author><name sortKey="L Pez Oliva, M O" sort="L Pez Oliva, M O" uniqKey="L Pez Oliva M" first="M O" last="L Pez-Oliva">M O L Pez-Oliva</name></author><author><name sortKey="Beneyto, I" sort="Beneyto, I" uniqKey="Beneyto I" first="I" last="Beneyto">I. Beneyto</name></author><author><name sortKey="Martin Moreno, P L" sort="Martin Moreno, P L" uniqKey="Martin Moreno P" first="P L" last="Martín-Moreno">P L Martín-Moreno</name></author><author><name sortKey="Llamas Fuente, F" sort="Llamas Fuente, F" uniqKey="Llamas Fuente F" first="F" last="Llamas-Fuente">F. 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Corrales</name></author><author><name sortKey="Arias, M" sort="Arias, M" uniqKey="Arias M" first="M" last="Arias">M. Arias</name></author><author><name sortKey="Campistol, J M" sort="Campistol, J M" uniqKey="Campistol J" first="J M" last="Campistol">J M Campistol</name></author><author><name sortKey="Gimenez, E" sort="Gimenez, E" uniqKey="Gimenez E" first="E" last="Giménez">E. Giménez</name></author><author><name sortKey="Crespo, J" sort="Crespo, J" uniqKey="Crespo J" first="J" last="Crespo">J. Crespo</name></author><author><name sortKey="L Pez Oliva, M O" sort="L Pez Oliva, M O" uniqKey="L Pez Oliva M" first="M O" last="L Pez-Oliva">M O L Pez-Oliva</name></author><author><name sortKey="Beneyto, I" sort="Beneyto, I" uniqKey="Beneyto I" first="I" last="Beneyto">I. Beneyto</name></author><author><name sortKey="Martin Moreno, P L" sort="Martin Moreno, P L" uniqKey="Martin Moreno P" first="P L" last="Martín-Moreno">P L Martín-Moreno</name></author><author><name sortKey="Llamas Fuente, F" sort="Llamas Fuente, F" uniqKey="Llamas Fuente F" first="F" last="Llamas-Fuente">F. Llamas-Fuente</name></author><author><name sortKey="Gutierrez, A" sort="Gutierrez, A" uniqKey="Gutierrez A" first="A" last="Gutiérrez">A. Gutiérrez</name></author><author><name sortKey="Garcia Lvarez, T" sort="Garcia Lvarez, T" uniqKey="Garcia Lvarez T" first="T" last="García-Álvarez">T. García-Álvarez</name></author><author><name sortKey="Guerra Rodriguez, R" sort="Guerra Rodriguez, R" uniqKey="Guerra Rodriguez R" first="R" last="Guerra-Rodríguez">R. Guerra-Rodríguez</name></author><author><name sortKey="Calvo, N" sort="Calvo, N" uniqKey="Calvo N" first="N" last="Calvo">N. Calvo</name></author><author><name sortKey="Fernandez Rodriguez, A" sort="Fernandez Rodriguez, A" uniqKey="Fernandez Rodriguez A" first="A" last="Fernández-Rodríguez">A. Fernández-Rodríguez</name></author><author><name sortKey="Tabernero Romo, J M" sort="Tabernero Romo, J M" uniqKey="Tabernero Romo J" first="J M" last="Tabernero-Romo">J M Tabernero-Romo</name></author><author><name sortKey="Navarro, M D" sort="Navarro, M D" uniqKey="Navarro M" first="M D" last="Navarro">M D Navarro</name></author><author><name sortKey="Ramos Verde, A" sort="Ramos Verde, A" uniqKey="Ramos Verde A" first="A" last="Ramos-Verde">A. Ramos-Verde</name></author><author><name sortKey="Aguado, J M" sort="Aguado, J M" uniqKey="Aguado J" first="J M" last="Aguado">J M Aguado</name></author><author><name sortKey="Navarro, D" sort="Navarro, D" uniqKey="Navarro D" first="D" last="Navarro">D. Navarro</name></author></analytic><series><title level="j">American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons</title><idno type="e-ISSN">1600-6143</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Alleles</term><term>Cell Adhesion Molecules (genetics)</term><term>Cytomegalovirus Infections (blood)</term><term>Cytomegalovirus Infections (genetics)</term><term>Female</term><term>Genotype</term><term>Humans</term><term>Immunity, Innate (genetics)</term><term>Incidence</term><term>Interleukins (genetics)</term><term>Kidney Failure, Chronic (blood)</term><term>Kidney Failure, Chronic (genetics)</term><term>Kidney Failure, Chronic (surgery)</term><term>Kidney Transplantation</term><term>Lectins, C-Type (genetics)</term><term>Male</term><term>Middle Aged</term><term>Odds Ratio</term><term>Polymorphism, Single Nucleotide</term><term>Proportional Hazards Models</term><term>Prospective Studies</term><term>Receptors, Cell Surface (genetics)</term><term>Transplant Recipients</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Cell Adhesion Molecules</term><term>Interleukins</term><term>Lectins, C-Type</term><term>Receptors, Cell Surface</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Cytomegalovirus Infections</term><term>Kidney Failure, Chronic</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Cytomegalovirus Infections</term><term>Immunity, Innate</term><term>Kidney Failure, Chronic</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Kidney Failure, Chronic</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Alleles</term><term>Female</term><term>Genotype</term><term>Humans</term><term>Incidence</term><term>Kidney Transplantation</term><term>Male</term><term>Middle Aged</term><term>Odds Ratio</term><term>Polymorphism, Single Nucleotide</term><term>Proportional Hazards Models</term><term>Prospective Studies</term><term>Transplant Recipients</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In this study, we assessed the association between single-nucleotide polymorphisms (SNPs) in seven candidate genes involved in orchestrating the immune response against cytomegalovirus (CMV) and the 12-month incidence of CMV infection in 315 CMV-seropositive kidney transplant (KT) recipients. Patients were managed either by antiviral prophylaxis or preemptive therapy. CMV infection occurred in 140 patients (44.4%), including 13 episodes of disease. After adjusting for various clinical covariates, patients harboring T-allele genotypes of interleukin-28B (IL28B) (rs12979860) SNP had lower incidence of CMV infection (adjusted hazard ratio [aHR]: 0.66; 95% confidence interval [CI]: 0.46-0.96; p-value = 0.029). In the analysis restricted to patients not receiving prophylaxis, carriers of the TT genotype of toll-like receptor 9 (TLR9) (rs5743836) SNP had lower incidence of infection (aHR: 0.61; 95% CI: 0.38-0.96; p-value = 0.035), whereas the GG genotype of dendritic cell-specific ICAM 3-grabbing nonintegrin (DC-SIGN) (rs735240) SNP exerted the opposite effect (aHR: 1.86; 95% CI: 1.18-2.94; p-value = 0.008). An independent association was found between the number of unfavorable SNP genotypes carried by the patient and the incidence of CMV infection. In conclusion, specific SNPs in IL28B, TLR9 and DC-SIGN genes may play a role in modulating the susceptibility to CMV infection in CMV-seropositive KT recipients.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">25777542</PMID><DateCreated><Year>2015</Year><Month>04</Month><Day>21</Day></DateCreated><DateCompleted><Year>2016</Year><Month>01</Month><Day>12</Day></DateCompleted><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1600-6143</ISSN><JournalIssue CitedMedium="Internet"><Volume>15</Volume><Issue>5</Issue><PubDate><Year>2015</Year><Month>May</Month></PubDate></JournalIssue><Title>American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons</Title><ISOAbbreviation>Am. J. Transplant.</ISOAbbreviation></Journal><ArticleTitle>Association between individual and combined SNPs in genes related to innate immunity and incidence of CMV infection in seropositive kidney transplant recipients.</ArticleTitle><Pagination><MedlinePgn>1323-35</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/ajt.13107</ELocationID><Abstract><AbstractText>In this study, we assessed the association between single-nucleotide polymorphisms (SNPs) in seven candidate genes involved in orchestrating the immune response against cytomegalovirus (CMV) and the 12-month incidence of CMV infection in 315 CMV-seropositive kidney transplant (KT) recipients. Patients were managed either by antiviral prophylaxis or preemptive therapy. CMV infection occurred in 140 patients (44.4%), including 13 episodes of disease. After adjusting for various clinical covariates, patients harboring T-allele genotypes of interleukin-28B (IL28B) (rs12979860) SNP had lower incidence of CMV infection (adjusted hazard ratio [aHR]: 0.66; 95% confidence interval [CI]: 0.46-0.96; p-value = 0.029). In the analysis restricted to patients not receiving prophylaxis, carriers of the TT genotype of toll-like receptor 9 (TLR9) (rs5743836) SNP had lower incidence of infection (aHR: 0.61; 95% CI: 0.38-0.96; p-value = 0.035), whereas the GG genotype of dendritic cell-specific ICAM 3-grabbing nonintegrin (DC-SIGN) (rs735240) SNP exerted the opposite effect (aHR: 1.86; 95% CI: 1.18-2.94; p-value = 0.008). An independent association was found between the number of unfavorable SNP genotypes carried by the patient and the incidence of CMV infection. In conclusion, specific SNPs in IL28B, TLR9 and DC-SIGN genes may play a role in modulating the susceptibility to CMV infection in CMV-seropositive KT recipients.</AbstractText><CopyrightInformation>© Copyright 2015 The American Society of Transplantation and the American Society of Transplant Surgeons.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Fernández-Ruiz</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Unit of Infectious Diseases, Hospital Universitario 12 de Octubre, Instituto de Investigación Hospital 12 de Octubre, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Corrales</LastName><ForeName>I</ForeName><Initials>I</Initials></Author><Author ValidYN="Y"><LastName>Arias</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Campistol</LastName><ForeName>J M</ForeName><Initials>JM</Initials></Author><Author ValidYN="Y"><LastName>Giménez</LastName><ForeName>E</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Crespo</LastName><ForeName>J</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>López-Oliva</LastName><ForeName>M O</ForeName><Initials>MO</Initials></Author><Author ValidYN="Y"><LastName>Beneyto</LastName><ForeName>I</ForeName><Initials>I</Initials></Author><Author ValidYN="Y"><LastName>Martín-Moreno</LastName><ForeName>P L</ForeName><Initials>PL</Initials></Author><Author ValidYN="Y"><LastName>Llamas-Fuente</LastName><ForeName>F</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Gutiérrez</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>García-Álvarez</LastName><ForeName>T</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Guerra-Rodríguez</LastName><ForeName>R</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Calvo</LastName><ForeName>N</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Fernández-Rodríguez</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Tabernero-Romo</LastName><ForeName>J M</ForeName><Initials>JM</Initials></Author><Author ValidYN="Y"><LastName>Navarro</LastName><ForeName>M D</ForeName><Initials>MD</Initials></Author><Author ValidYN="Y"><LastName>Ramos-Verde</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Aguado</LastName><ForeName>J M</ForeName><Initials>JM</Initials></Author><Author ValidYN="Y"><LastName>Navarro</LastName><ForeName>D</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><CollectiveName>OPERA Study Group</CollectiveName></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D064888">Observational Study</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>03</Month><Day>16</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Am J Transplant</MedlineTA><NlmUniqueID>100968638</NlmUniqueID><ISSNLinking>1600-6135</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015815">Cell Adhesion Molecules</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C405948">DC-specific ICAM-3 grabbing nonintegrin</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C471044">IL28B protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007378">Interleukins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D037181">Lectins, C-Type</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011956">Receptors, Cell Surface</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000328">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000483">Alleles</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D015815">Cell Adhesion Molecules</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000235">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D003586">Cytomegalovirus Infections</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000097">blood</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000235">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005838">Genotype</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007113">Immunity, Innate</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000235">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D015994">Incidence</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007378">Interleukins</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000235">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007676">Kidney Failure, Chronic</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000097">blood</QualifierName><QualifierName MajorTopicYN="N" UI="Q000235">genetics</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000601">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D016030">Kidney Transplantation</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D037181">Lectins, C-Type</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000235">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D016017">Odds Ratio</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D020641">Polymorphism, Single Nucleotide</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D016016">Proportional Hazards Models</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011446">Prospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011956">Receptors, Cell Surface</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000235">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D066027">Transplant Recipients</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">clinical research / practice</Keyword><Keyword MajorTopicYN="N">immune regulation</Keyword><Keyword MajorTopicYN="N">infection and infectious agents</Keyword><Keyword MajorTopicYN="N">infectious disease</Keyword><Keyword MajorTopicYN="N">kidney disease: infectious</Keyword><Keyword MajorTopicYN="N">kidney transplantation / nephrology</Keyword><Keyword MajorTopicYN="N">molecular biology: single polynucleotide polymorphism</Keyword><Keyword MajorTopicYN="N">translational research / science</Keyword><Keyword MajorTopicYN="N">viral: Cytomegalovirus (CMV)</Keyword></KeywordList><InvestigatorList><Investigator ValidYN="Y"><LastName>Arias</LastName><ForeName>Manuel</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Gómez Alamillo</LastName><ForeName>Carlos</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Campistol</LastName><ForeName>Josep Maria</ForeName><Initials>JM</Initials></Investigator><Investigator ValidYN="Y"><LastName>Cofán</LastName><ForeName>Federico</ForeName><Initials>F</Initials></Investigator><Investigator ValidYN="Y"><LastName>Aguado</LastName><ForeName>José María</ForeName><Initials>JM</Initials></Investigator><Investigator ValidYN="Y"><LastName>González</LastName><ForeName>Esther</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Fernández Ruiz</LastName><ForeName>Mario</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Navarro</LastName><ForeName>David</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Gómez Huertas</LastName><ForeName>Ernesto</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Gómez Márquez</LastName><ForeName>Gonzalo</ForeName><Initials>G</Initials></Investigator><Investigator ValidYN="Y"><LastName>Díaz</LastName><ForeName>Juan Manuel</ForeName><Initials>JM</Initials></Investigator><Investigator ValidYN="Y"><LastName>Hernández</LastName><ForeName>Domingo</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Sola</LastName><ForeName>Eugenia</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Bernal Blanco</LastName><ForeName>Gabriel</ForeName><Initials>G</Initials></Investigator><Investigator ValidYN="Y"><LastName>Jimeno</LastName><ForeName>Luisa</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Franco Esteve</LastName><ForeName>Antonio</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Moreso</LastName><ForeName>Francisco</ForeName><Initials>F</Initials></Investigator><Investigator ValidYN="Y"><LastName>Mendiluce</LastName><ForeName>Alicia</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Luna Huerta</LastName><ForeName>Enrique</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>López Oliva</LastName><ForeName>María Ovidia</ForeName><Initials>MO</Initials></Investigator><Investigator ValidYN="Y"><LastName>Beneyto</LastName><ForeName>Isabel</ForeName><Initials>I</Initials></Investigator><Investigator ValidYN="Y"><LastName>Martín-Moreno</LastName><ForeName>Paloma L</ForeName><Initials>PL</Initials></Investigator><Investigator ValidYN="Y"><LastName>Llamas Fuente</LastName><ForeName>Francisco</ForeName><Initials>F</Initials></Investigator><Investigator ValidYN="Y"><LastName>Gutiérrez</LastName><ForeName>Alex</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>García Álvarez</LastName><ForeName>Teresa</ForeName><Initials>T</Initials></Investigator><Investigator ValidYN="Y"><LastName>Guerra Rodríguez</LastName><ForeName>Rita</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Calvo</LastName><ForeName>Natividad</ForeName><Initials>N</Initials></Investigator><Investigator ValidYN="Y"><LastName>Fernández Rodríguez</LastName><ForeName>Ana</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Tabernero Romo</LastName><ForeName>José Matías</ForeName><Initials>JM</Initials></Investigator><Investigator ValidYN="Y"><LastName>Navarro</LastName><ForeName>María Dolores</ForeName><Initials>MD</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ramos Verde</LastName><ForeName>Ana</ForeName><Initials>A</Initials></Investigator></InvestigatorList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>9</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2014</Year><Month>11</Month><Day>4</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>11</Month><Day>8</Day></PubMedPubDate><PubMedPubDate PubStatus="aheadofprint"><Year>2015</Year><Month>3</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>3</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>3</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>1</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25777542</ArticleId><ArticleId IdType="doi">10.1111/ajt.13107</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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