An efficient liposome based method for antioxidants encapsulation.
Identifieur interne : 000032 ( PubMed/Corpus ); précédent : 000031; suivant : 000033An efficient liposome based method for antioxidants encapsulation.
Auteurs : Marco Paini ; Sean Ryan Daly ; Bahar Aliakbarian ; Ali Fathi ; Elmira Arab Tehrany ; Patrizia Perego ; Fariba Dehghani ; Peter ValtchevSource :
- Colloids and surfaces. B, Biointerfaces ; 2015.
Abstract
Apigenin is an antioxidant that has shown a preventive activity against different cancer and cardiovascular disorders. In this study, we encapsulate apigenin with liposome to tackle the issue of its poor bioavailability and low stability. Apigenin loaded liposomes are fabricated with food-grade rapeseed lecithin in an aqueous medium in absence of any organic solvent. The liposome particle characteristics, such as particle size and polydispersity are optimised by tuning ultrasonic processing parameters. In addition, to measure the liposome encapsulation efficiency accurately, we establish a unique high-performance liquid chromatography technique in which an alkaline buffer mobile phase is used to prevent apigenin precipitation in the column;. salt is added to separate lipid particles from the aqeuous phase. Our results demonstrate that apigenin encapsulation efficiency is nearly 98% that is remarkably higher than any other reported value for encapsulation of this compound. In addition, the average particle size of these liposomes is 158.9±6.1nm that is suitable for the formulation of many food products, such as fortified fruit juice. The encapsulation method developed in this study, therefore have a high potential for the production of innovative, functional foods or nutraceutical products.
DOI: 10.1016/j.colsurfb.2015.10.038
PubMed: 26590900
Links to Exploration step
pubmed:26590900Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">An efficient liposome based method for antioxidants encapsulation.</title><author><name sortKey="Paini, Marco" sort="Paini, Marco" uniqKey="Paini M" first="Marco" last="Paini">Marco Paini</name><affiliation><nlm:affiliation>Department of Civil, Chemical and Environmental Engineering, University of Genoa, Via Opera Pia 15, 16145 Genoa, Italy; Research Center for Biologically Inspired Engineering in Vascular Medicine and Longevity (BELONG), Via Montallegro 1, 16145 Genoa, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Daly, Sean Ryan" sort="Daly, Sean Ryan" uniqKey="Daly S" first="Sean Ryan" last="Daly">Sean Ryan Daly</name><affiliation><nlm:affiliation>School of Chemical and Biomolecular Engineering, University of Sydney, Sydney, NSW 2006, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Aliakbarian, Bahar" sort="Aliakbarian, Bahar" uniqKey="Aliakbarian B" first="Bahar" last="Aliakbarian">Bahar Aliakbarian</name><affiliation><nlm:affiliation>Department of Civil, Chemical and Environmental Engineering, University of Genoa, Via Opera Pia 15, 16145 Genoa, Italy; Research Center for Biologically Inspired Engineering in Vascular Medicine and Longevity (BELONG), Via Montallegro 1, 16145 Genoa, Italy. Electronic address: bahar.aliakbarian@unige.it.</nlm:affiliation></affiliation></author><author><name sortKey="Fathi, Ali" sort="Fathi, Ali" uniqKey="Fathi A" first="Ali" last="Fathi">Ali Fathi</name><affiliation><nlm:affiliation>School of Chemical and Biomolecular Engineering, University of Sydney, Sydney, NSW 2006, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Tehrany, Elmira Arab" sort="Tehrany, Elmira Arab" uniqKey="Tehrany E" first="Elmira Arab" last="Tehrany">Elmira Arab Tehrany</name><affiliation><nlm:affiliation>Laboratoire d'Ingénierie des Biomolécules, Nancy-Université, 2 avenue de la Forêt de Haye, 54505 Vandoeuvre-Lès-Nancy, France.</nlm:affiliation></affiliation></author><author><name sortKey="Perego, Patrizia" sort="Perego, Patrizia" uniqKey="Perego P" first="Patrizia" last="Perego">Patrizia Perego</name><affiliation><nlm:affiliation>Department of Civil, Chemical and Environmental Engineering, University of Genoa, Via Opera Pia 15, 16145 Genoa, Italy; Research Center for Biologically Inspired Engineering in Vascular Medicine and Longevity (BELONG), Via Montallegro 1, 16145 Genoa, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Dehghani, Fariba" sort="Dehghani, Fariba" uniqKey="Dehghani F" first="Fariba" last="Dehghani">Fariba Dehghani</name><affiliation><nlm:affiliation>School of Chemical and Biomolecular Engineering, University of Sydney, Sydney, NSW 2006, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Valtchev, Peter" sort="Valtchev, Peter" uniqKey="Valtchev P" first="Peter" last="Valtchev">Peter Valtchev</name><affiliation><nlm:affiliation>School of Chemical and Biomolecular Engineering, University of Sydney, Sydney, NSW 2006, Australia.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:26590900</idno><idno type="pmid">26590900</idno><idno type="doi">10.1016/j.colsurfb.2015.10.038</idno><idno type="wicri:Area/PubMed/Corpus">000032</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">An efficient liposome based method for antioxidants encapsulation.</title><author><name sortKey="Paini, Marco" sort="Paini, Marco" uniqKey="Paini M" first="Marco" last="Paini">Marco Paini</name><affiliation><nlm:affiliation>Department of Civil, Chemical and Environmental Engineering, University of Genoa, Via Opera Pia 15, 16145 Genoa, Italy; Research Center for Biologically Inspired Engineering in Vascular Medicine and Longevity (BELONG), Via Montallegro 1, 16145 Genoa, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Daly, Sean Ryan" sort="Daly, Sean Ryan" uniqKey="Daly S" first="Sean Ryan" last="Daly">Sean Ryan Daly</name><affiliation><nlm:affiliation>School of Chemical and Biomolecular Engineering, University of Sydney, Sydney, NSW 2006, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Aliakbarian, Bahar" sort="Aliakbarian, Bahar" uniqKey="Aliakbarian B" first="Bahar" last="Aliakbarian">Bahar Aliakbarian</name><affiliation><nlm:affiliation>Department of Civil, Chemical and Environmental Engineering, University of Genoa, Via Opera Pia 15, 16145 Genoa, Italy; Research Center for Biologically Inspired Engineering in Vascular Medicine and Longevity (BELONG), Via Montallegro 1, 16145 Genoa, Italy. Electronic address: bahar.aliakbarian@unige.it.</nlm:affiliation></affiliation></author><author><name sortKey="Fathi, Ali" sort="Fathi, Ali" uniqKey="Fathi A" first="Ali" last="Fathi">Ali Fathi</name><affiliation><nlm:affiliation>School of Chemical and Biomolecular Engineering, University of Sydney, Sydney, NSW 2006, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Tehrany, Elmira Arab" sort="Tehrany, Elmira Arab" uniqKey="Tehrany E" first="Elmira Arab" last="Tehrany">Elmira Arab Tehrany</name><affiliation><nlm:affiliation>Laboratoire d'Ingénierie des Biomolécules, Nancy-Université, 2 avenue de la Forêt de Haye, 54505 Vandoeuvre-Lès-Nancy, France.</nlm:affiliation></affiliation></author><author><name sortKey="Perego, Patrizia" sort="Perego, Patrizia" uniqKey="Perego P" first="Patrizia" last="Perego">Patrizia Perego</name><affiliation><nlm:affiliation>Department of Civil, Chemical and Environmental Engineering, University of Genoa, Via Opera Pia 15, 16145 Genoa, Italy; Research Center for Biologically Inspired Engineering in Vascular Medicine and Longevity (BELONG), Via Montallegro 1, 16145 Genoa, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Dehghani, Fariba" sort="Dehghani, Fariba" uniqKey="Dehghani F" first="Fariba" last="Dehghani">Fariba Dehghani</name><affiliation><nlm:affiliation>School of Chemical and Biomolecular Engineering, University of Sydney, Sydney, NSW 2006, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Valtchev, Peter" sort="Valtchev, Peter" uniqKey="Valtchev P" first="Peter" last="Valtchev">Peter Valtchev</name><affiliation><nlm:affiliation>School of Chemical and Biomolecular Engineering, University of Sydney, Sydney, NSW 2006, Australia.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Colloids and surfaces. B, Biointerfaces</title><idno type="e-ISSN">1873-4367</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Apigenin is an antioxidant that has shown a preventive activity against different cancer and cardiovascular disorders. In this study, we encapsulate apigenin with liposome to tackle the issue of its poor bioavailability and low stability. Apigenin loaded liposomes are fabricated with food-grade rapeseed lecithin in an aqueous medium in absence of any organic solvent. The liposome particle characteristics, such as particle size and polydispersity are optimised by tuning ultrasonic processing parameters. In addition, to measure the liposome encapsulation efficiency accurately, we establish a unique high-performance liquid chromatography technique in which an alkaline buffer mobile phase is used to prevent apigenin precipitation in the column;. salt is added to separate lipid particles from the aqeuous phase. Our results demonstrate that apigenin encapsulation efficiency is nearly 98% that is remarkably higher than any other reported value for encapsulation of this compound. In addition, the average particle size of these liposomes is 158.9±6.1nm that is suitable for the formulation of many food products, such as fortified fruit juice. The encapsulation method developed in this study, therefore have a high potential for the production of innovative, functional foods or nutraceutical products.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="In-Data-Review"><PMID Version="1">26590900</PMID><DateCreated><Year>2015</Year><Month>12</Month><Day>29</Day></DateCreated><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-4367</ISSN><JournalIssue CitedMedium="Internet"><Volume>136</Volume><PubDate><Year>2015</Year><Month>Dec</Month><Day>1</Day></PubDate></JournalIssue><Title>Colloids and surfaces. B, Biointerfaces</Title><ISOAbbreviation>Colloids Surf B Biointerfaces</ISOAbbreviation></Journal><ArticleTitle>An efficient liposome based method for antioxidants encapsulation.</ArticleTitle><Pagination><MedlinePgn>1067-72</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.colsurfb.2015.10.038</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0927-7765(15)30269-1</ELocationID><Abstract><AbstractText>Apigenin is an antioxidant that has shown a preventive activity against different cancer and cardiovascular disorders. In this study, we encapsulate apigenin with liposome to tackle the issue of its poor bioavailability and low stability. Apigenin loaded liposomes are fabricated with food-grade rapeseed lecithin in an aqueous medium in absence of any organic solvent. The liposome particle characteristics, such as particle size and polydispersity are optimised by tuning ultrasonic processing parameters. In addition, to measure the liposome encapsulation efficiency accurately, we establish a unique high-performance liquid chromatography technique in which an alkaline buffer mobile phase is used to prevent apigenin precipitation in the column;. salt is added to separate lipid particles from the aqeuous phase. Our results demonstrate that apigenin encapsulation efficiency is nearly 98% that is remarkably higher than any other reported value for encapsulation of this compound. In addition, the average particle size of these liposomes is 158.9±6.1nm that is suitable for the formulation of many food products, such as fortified fruit juice. The encapsulation method developed in this study, therefore have a high potential for the production of innovative, functional foods or nutraceutical products.</AbstractText><CopyrightInformation>Copyright © 2015 Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Paini</LastName><ForeName>Marco</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Civil, Chemical and Environmental Engineering, University of Genoa, Via Opera Pia 15, 16145 Genoa, Italy; Research Center for Biologically Inspired Engineering in Vascular Medicine and Longevity (BELONG), Via Montallegro 1, 16145 Genoa, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Daly</LastName><ForeName>Sean Ryan</ForeName><Initials>SR</Initials><AffiliationInfo><Affiliation>School of Chemical and Biomolecular Engineering, University of Sydney, Sydney, NSW 2006, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aliakbarian</LastName><ForeName>Bahar</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Civil, Chemical and Environmental Engineering, University of Genoa, Via Opera Pia 15, 16145 Genoa, Italy; Research Center for Biologically Inspired Engineering in Vascular Medicine and Longevity (BELONG), Via Montallegro 1, 16145 Genoa, Italy. Electronic address: bahar.aliakbarian@unige.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fathi</LastName><ForeName>Ali</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>School of Chemical and Biomolecular Engineering, University of Sydney, Sydney, NSW 2006, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tehrany</LastName><ForeName>Elmira Arab</ForeName><Initials>EA</Initials><AffiliationInfo><Affiliation>Laboratoire d'Ingénierie des Biomolécules, Nancy-Université, 2 avenue de la Forêt de Haye, 54505 Vandoeuvre-Lès-Nancy, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Perego</LastName><ForeName>Patrizia</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Civil, Chemical and Environmental Engineering, University of Genoa, Via Opera Pia 15, 16145 Genoa, Italy; Research Center for Biologically Inspired Engineering in Vascular Medicine and Longevity (BELONG), Via Montallegro 1, 16145 Genoa, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dehghani</LastName><ForeName>Fariba</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>School of Chemical and Biomolecular Engineering, University of Sydney, Sydney, NSW 2006, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Valtchev</LastName><ForeName>Peter</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>School of Chemical and Biomolecular Engineering, University of Sydney, Sydney, NSW 2006, Australia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>10</Month><Day>31</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Colloids Surf B Biointerfaces</MedlineTA><NlmUniqueID>9315133</NlmUniqueID><ISSNLinking>0927-7765</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Antioxidant</Keyword><Keyword MajorTopicYN="N">Apigenin</Keyword><Keyword MajorTopicYN="N">Encapsulation efficiency</Keyword><Keyword MajorTopicYN="N">Flavone</Keyword><Keyword MajorTopicYN="N">Liposomes</Keyword><Keyword MajorTopicYN="N">Polyphenol</Keyword><Keyword MajorTopicYN="N">Rapeseed lecithin</Keyword><Keyword MajorTopicYN="N">Sonication</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>6</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2015</Year><Month>10</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>10</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="aheadofprint"><Year>2015</Year><Month>10</Month><Day>31</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>11</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>11</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>11</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26590900</ArticleId><ArticleId IdType="pii">S0927-7765(15)30269-1</ArticleId><ArticleId IdType="doi">10.1016/j.colsurfb.2015.10.038</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Musique/explor/OperaV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000032 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 000032 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Musique
|area= OperaV1
|flux= PubMed
|étape= Corpus
|type= RBID
|clé= pubmed:26590900
|texte= An efficient liposome based method for antioxidants encapsulation.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:26590900" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a OperaV1
| This area was generated with Dilib version V0.6.21. |  |