Changes in Soluble CD18 in Murine Autoimmune Arthritis and Rheumatoid Arthritis Reflect Disease Establishment and Treatment Response.
Identifieur interne : 000017 ( PubMed/Corpus ); précédent : 000016; suivant : 000018Changes in Soluble CD18 in Murine Autoimmune Arthritis and Rheumatoid Arthritis Reflect Disease Establishment and Treatment Response.
Auteurs : Tue Wenzel Kragstrup ; Babak Jalilian ; Kresten Krarup Keller ; Xianwei Zhang ; Julie Kristine Laustsen ; Kristian Stengaard-Pedersen ; Merete Lund Hetland ; Kim H Rslev-Petersen ; Peter Junker ; Mikkel Stergaard ; Ellen-Margrethe Hauge ; Malene Hvid ; Thomas Vorup-Jensen ; Bent DeleuranSource :
- PloS one ; 2016.
Abstract
In rheumatoid arthritis (RA) immune activation and presence of autoantibodies may precede clinical onset of disease, and joint destruction can progress despite remission. However, the underlying temporal changes of such immune system abnormalities in the inflammatory response during treat-to-target strategies remain poorly understood. We have previously reported low levels of the soluble form of CD18 (sCD18) in plasma from patients with chronic RA and spondyloarthritis. Here, we study the changes of sCD18 before and during treatment of early RA and following arthritis induction in murine models of rheumatoid arthritis.
DOI: 10.1371/journal.pone.0148486
PubMed: 26849368
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Changes in Soluble CD18 in Murine Autoimmune Arthritis and Rheumatoid Arthritis Reflect Disease Establishment and Treatment Response.</title><author><name sortKey="Kragstrup, Tue Wenzel" sort="Kragstrup, Tue Wenzel" uniqKey="Kragstrup T" first="Tue Wenzel" last="Kragstrup">Tue Wenzel Kragstrup</name><affiliation><nlm:affiliation>Department of Biomedicine, Aarhus University, Aarhus, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Jalilian, Babak" sort="Jalilian, Babak" uniqKey="Jalilian B" first="Babak" last="Jalilian">Babak Jalilian</name><affiliation><nlm:affiliation>Department of Biomedicine, Aarhus University, Aarhus, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Keller, Kresten Krarup" sort="Keller, Kresten Krarup" uniqKey="Keller K" first="Kresten Krarup" last="Keller">Kresten Krarup Keller</name><affiliation><nlm:affiliation>Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Xianwei" sort="Zhang, Xianwei" uniqKey="Zhang X" first="Xianwei" last="Zhang">Xianwei Zhang</name><affiliation><nlm:affiliation>Department of Biomedicine, Aarhus University, Aarhus, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Laustsen, Julie Kristine" sort="Laustsen, Julie Kristine" uniqKey="Laustsen J" first="Julie Kristine" last="Laustsen">Julie Kristine Laustsen</name><affiliation><nlm:affiliation>Department of Biomedicine, Aarhus University, Aarhus, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Stengaard Pedersen, Kristian" sort="Stengaard Pedersen, Kristian" uniqKey="Stengaard Pedersen K" first="Kristian" last="Stengaard-Pedersen">Kristian Stengaard-Pedersen</name><affiliation><nlm:affiliation>Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Hetland, Merete Lund" sort="Hetland, Merete Lund" uniqKey="Hetland M" first="Merete Lund" last="Hetland">Merete Lund Hetland</name><affiliation><nlm:affiliation>Copenhagen Center for Arthritis Research, Rigshospitalet, Glostrup, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="H Rslev Petersen, Kim" sort="H Rslev Petersen, Kim" uniqKey="H Rslev Petersen K" first="Kim" last="H Rslev-Petersen">Kim H Rslev-Petersen</name><affiliation><nlm:affiliation>University of Southern Denmark, Odense, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Junker, Peter" sort="Junker, Peter" uniqKey="Junker P" first="Peter" last="Junker">Peter Junker</name><affiliation><nlm:affiliation>Odense University Hospital, Odense, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey=" Stergaard, Mikkel" sort=" Stergaard, Mikkel" uniqKey=" Stergaard M" first="Mikkel" last=" Stergaard">Mikkel Stergaard</name><affiliation><nlm:affiliation>Copenhagen Center for Arthritis Research, Rigshospitalet, Glostrup, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Hauge, Ellen Margrethe" sort="Hauge, Ellen Margrethe" uniqKey="Hauge E" first="Ellen-Margrethe" last="Hauge">Ellen-Margrethe Hauge</name><affiliation><nlm:affiliation>Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Hvid, Malene" sort="Hvid, Malene" uniqKey="Hvid M" first="Malene" last="Hvid">Malene Hvid</name><affiliation><nlm:affiliation>Department of Biomedicine, Aarhus University, Aarhus, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Vorup Jensen, Thomas" sort="Vorup Jensen, Thomas" uniqKey="Vorup Jensen T" first="Thomas" last="Vorup-Jensen">Thomas Vorup-Jensen</name><affiliation><nlm:affiliation>Department of Biomedicine, Aarhus University, Aarhus, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Deleuran, Bent" sort="Deleuran, Bent" uniqKey="Deleuran B" first="Bent" last="Deleuran">Bent Deleuran</name><affiliation><nlm:affiliation>Department of Biomedicine, Aarhus University, Aarhus, Denmark.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="doi">10.1371/journal.pone.0148486</idno><idno type="RBID">pubmed:26849368</idno><idno type="pmid">26849368</idno><idno type="wicri:Area/PubMed/Corpus">000017</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Changes in Soluble CD18 in Murine Autoimmune Arthritis and Rheumatoid Arthritis Reflect Disease Establishment and Treatment Response.</title><author><name sortKey="Kragstrup, Tue Wenzel" sort="Kragstrup, Tue Wenzel" uniqKey="Kragstrup T" first="Tue Wenzel" last="Kragstrup">Tue Wenzel Kragstrup</name><affiliation><nlm:affiliation>Department of Biomedicine, Aarhus University, Aarhus, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Jalilian, Babak" sort="Jalilian, Babak" uniqKey="Jalilian B" first="Babak" last="Jalilian">Babak Jalilian</name><affiliation><nlm:affiliation>Department of Biomedicine, Aarhus University, Aarhus, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Keller, Kresten Krarup" sort="Keller, Kresten Krarup" uniqKey="Keller K" first="Kresten Krarup" last="Keller">Kresten Krarup Keller</name><affiliation><nlm:affiliation>Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Xianwei" sort="Zhang, Xianwei" uniqKey="Zhang X" first="Xianwei" last="Zhang">Xianwei Zhang</name><affiliation><nlm:affiliation>Department of Biomedicine, Aarhus University, Aarhus, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Laustsen, Julie Kristine" sort="Laustsen, Julie Kristine" uniqKey="Laustsen J" first="Julie Kristine" last="Laustsen">Julie Kristine Laustsen</name><affiliation><nlm:affiliation>Department of Biomedicine, Aarhus University, Aarhus, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Stengaard Pedersen, Kristian" sort="Stengaard Pedersen, Kristian" uniqKey="Stengaard Pedersen K" first="Kristian" last="Stengaard-Pedersen">Kristian Stengaard-Pedersen</name><affiliation><nlm:affiliation>Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Hetland, Merete Lund" sort="Hetland, Merete Lund" uniqKey="Hetland M" first="Merete Lund" last="Hetland">Merete Lund Hetland</name><affiliation><nlm:affiliation>Copenhagen Center for Arthritis Research, Rigshospitalet, Glostrup, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="H Rslev Petersen, Kim" sort="H Rslev Petersen, Kim" uniqKey="H Rslev Petersen K" first="Kim" last="H Rslev-Petersen">Kim H Rslev-Petersen</name><affiliation><nlm:affiliation>University of Southern Denmark, Odense, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Junker, Peter" sort="Junker, Peter" uniqKey="Junker P" first="Peter" last="Junker">Peter Junker</name><affiliation><nlm:affiliation>Odense University Hospital, Odense, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey=" Stergaard, Mikkel" sort=" Stergaard, Mikkel" uniqKey=" Stergaard M" first="Mikkel" last=" Stergaard">Mikkel Stergaard</name><affiliation><nlm:affiliation>Copenhagen Center for Arthritis Research, Rigshospitalet, Glostrup, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Hauge, Ellen Margrethe" sort="Hauge, Ellen Margrethe" uniqKey="Hauge E" first="Ellen-Margrethe" last="Hauge">Ellen-Margrethe Hauge</name><affiliation><nlm:affiliation>Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Hvid, Malene" sort="Hvid, Malene" uniqKey="Hvid M" first="Malene" last="Hvid">Malene Hvid</name><affiliation><nlm:affiliation>Department of Biomedicine, Aarhus University, Aarhus, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Vorup Jensen, Thomas" sort="Vorup Jensen, Thomas" uniqKey="Vorup Jensen T" first="Thomas" last="Vorup-Jensen">Thomas Vorup-Jensen</name><affiliation><nlm:affiliation>Department of Biomedicine, Aarhus University, Aarhus, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Deleuran, Bent" sort="Deleuran, Bent" uniqKey="Deleuran B" first="Bent" last="Deleuran">Bent Deleuran</name><affiliation><nlm:affiliation>Department of Biomedicine, Aarhus University, Aarhus, Denmark.</nlm:affiliation></affiliation></author></analytic><series><title level="j">PloS one</title><idno type="e-ISSN">1932-6203</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In rheumatoid arthritis (RA) immune activation and presence of autoantibodies may precede clinical onset of disease, and joint destruction can progress despite remission. However, the underlying temporal changes of such immune system abnormalities in the inflammatory response during treat-to-target strategies remain poorly understood. We have previously reported low levels of the soluble form of CD18 (sCD18) in plasma from patients with chronic RA and spondyloarthritis. Here, we study the changes of sCD18 before and during treatment of early RA and following arthritis induction in murine models of rheumatoid arthritis.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="In-Data-Review"><PMID Version="1">26849368</PMID><DateCreated><Year>2016</Year><Month>02</Month><Day>06</Day></DateCreated><DateRevised><Year>2016</Year><Month>02</Month><Day>12</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN><JournalIssue CitedMedium="Internet"><Volume>11</Volume><Issue>2</Issue><PubDate><Year>2016</Year></PubDate></JournalIssue><Title>PloS one</Title><ISOAbbreviation>PLoS ONE</ISOAbbreviation></Journal><ArticleTitle>Changes in Soluble CD18 in Murine Autoimmune Arthritis and Rheumatoid Arthritis Reflect Disease Establishment and Treatment Response.</ArticleTitle><Pagination><MedlinePgn>e0148486</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0148486</ELocationID><Abstract><AbstractText Label="INTRODUCTION" NlmCategory="BACKGROUND">In rheumatoid arthritis (RA) immune activation and presence of autoantibodies may precede clinical onset of disease, and joint destruction can progress despite remission. However, the underlying temporal changes of such immune system abnormalities in the inflammatory response during treat-to-target strategies remain poorly understood. We have previously reported low levels of the soluble form of CD18 (sCD18) in plasma from patients with chronic RA and spondyloarthritis. Here, we study the changes of sCD18 before and during treatment of early RA and following arthritis induction in murine models of rheumatoid arthritis.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">The level of sCD18 was analyzed with a time-resolved immunoflourometric assay in 1) plasma from early treatment naïve RA patients during a treat-to-target strategy (the OPERA cohort), 2) plasma from chronic RA patients, 3) serum from SKG and CIA mice following arthritis induction, and 4) supernatants from synovial fluid mononuclear cells (SFMCs) and peripheral blood mononuclear cells (PBMCs) from 6 RA patients cultured with TNFα or adalimumab.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Plasma levels of sCD18 were decreased in chronic RA patients compared with early RA patients and in early RA patients compared with healthy controls. After 12 months of treatment the levels in early RA patients were similar to healthy controls. This normalization of plasma sCD18 levels was more pronounced in patients with very early disease who achieved an early ACR response. Plasma sCD18 levels were associated with radiographic progression. Correspondingly, the serum level of sCD18 was decreased in SKG mice 6 weeks after arthritis induction compared with healthy littermates. The sCD18 levels in both SKG and CIA mice exhibited a biphasic course after arthritis induction with an initial increase above baseline followed by a decline. Shedding of CD18 from RA SFMC and RA PBMC cultures was increased by TNFα and decreased by adalimumab.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The plasma sCD18 levels were altered in patients with RA, in mice with autoimmune arthritis and in cell cultures treated with TNFα and adalimumab. Decreased levels of plasma sCD18 could reflect autoimmunity in transition from early to chronic disease and normalization in response to treatment could reflect autoimmunity in remission.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kragstrup</LastName><ForeName>Tue Wenzel</ForeName><Initials>TW</Initials><AffiliationInfo><Affiliation>Department of Biomedicine, Aarhus University, Aarhus, Denmark.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jalilian</LastName><ForeName>Babak</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Biomedicine, Aarhus University, Aarhus, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Keller</LastName><ForeName>Kresten Krarup</ForeName><Initials>KK</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Xianwei</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Department of Biomedicine, Aarhus University, Aarhus, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Laustsen</LastName><ForeName>Julie Kristine</ForeName><Initials>JK</Initials><AffiliationInfo><Affiliation>Department of Biomedicine, Aarhus University, Aarhus, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stengaard-Pedersen</LastName><ForeName>Kristian</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hetland</LastName><ForeName>Merete Lund</ForeName><Initials>ML</Initials><AffiliationInfo><Affiliation>Copenhagen Center for Arthritis Research, Rigshospitalet, Glostrup, Denmark.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hørslev-Petersen</LastName><ForeName>Kim</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>University of Southern Denmark, Odense, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Junker</LastName><ForeName>Peter</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Odense University Hospital, Odense, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Østergaard</LastName><ForeName>Mikkel</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Copenhagen Center for Arthritis Research, Rigshospitalet, Glostrup, Denmark.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hauge</LastName><ForeName>Ellen-Margrethe</ForeName><Initials>EM</Initials><AffiliationInfo><Affiliation>Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hvid</LastName><ForeName>Malene</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Biomedicine, Aarhus University, Aarhus, Denmark.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vorup-Jensen</LastName><ForeName>Thomas</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Biomedicine, Aarhus University, Aarhus, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Deleuran</LastName><ForeName>Bent</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Biomedicine, Aarhus University, Aarhus, Denmark.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>02</Month><Day>05</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>PLoS 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