Morphofunctional and signaling molecules overlap of the pineal gland and thymus: role and significance in aging.
Identifieur interne : 000008 ( PubMed/Corpus ); précédent : 000007; suivant : 000009Morphofunctional and signaling molecules overlap of the pineal gland and thymus: role and significance in aging.
Auteurs : Michael A. Paltsev ; Victoria O. Polyakova ; Igor M. Kvetnoy ; George Anderson ; Tatiana V. Kvetnaia ; Natalia S. Linkova ; Ekaterina M. Paltseva ; Rosa Rubino ; Salvatore De Cosmo ; Angelo De Cata ; Gianluigi MazzoccoliSource :
- Oncotarget ; 2016.
Abstract
Deficits in neuroendocrine-immune system functioning, including alterations in pineal and thymic glands, contribute to aging-associated diseases. This study looks at ageing-associated alterations in pineal and thymic gland functioning evaluating common signaling molecules present in both human and animal pinealocytes and thymocytes: endocrine cell markers (melatonin, serotonin, pCREB, AANAT, CGRP, VIP, chromogranin А); cell renovation markers (p53, AIF, Ki67), matrix metalloproteinases (MMP2, MMP9) and lymphocytes markers (CD4, CD5, CD8, CD20). Pineal melatonin is decreased, as is one of the melatonin pathway synthesis enzymes in the thymic gland. A further similarity is the increased MMPs levels evident over age in both glands. Significant differences are evident in cell renovation processes, which deteriorate more quickly in the aged thymus versus the pineal gland. Decreases in the number of pineal B-cells and thymic T-cells were also observed over aging. Collected data indicate that cellular involution of the pineal gland and thymus show many commonalities, but also significant changes in aging-associated proteins. It is proposed that such ageing-associated alterations in these two glands provide novel pharmaceutical targets for the wide array of medical conditions that are more likely to emerge over the course of ageing.
DOI: 10.18632/oncotarget.7863
PubMed: 26943046
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Paltsev</name><affiliation><nlm:affiliation>Russian Academy of Science, Moscow, Russian Federation, Russia.</nlm:affiliation></affiliation></author><author><name sortKey="Polyakova, Victoria O" sort="Polyakova, Victoria O" uniqKey="Polyakova V" first="Victoria O" last="Polyakova">Victoria O. Polyakova</name><affiliation><nlm:affiliation>Department of Pathology, Ott Institute of Obstetrics, Gynecology and Reproductology, St. Petersburg, Russian Federation, Russia.</nlm:affiliation></affiliation></author><author><name sortKey="Kvetnoy, Igor M" sort="Kvetnoy, Igor M" uniqKey="Kvetnoy I" first="Igor M" last="Kvetnoy">Igor M. Kvetnoy</name><affiliation><nlm:affiliation>Department of Pathology, Ott Institute of Obstetrics, Gynecology and Reproductology, St. Petersburg, Russian Federation, Russia.</nlm:affiliation></affiliation></author><author><name sortKey="Anderson, George" sort="Anderson, George" uniqKey="Anderson G" first="George" last="Anderson">George Anderson</name><affiliation><nlm:affiliation>CRC Scotland and London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Kvetnaia, Tatiana V" sort="Kvetnaia, Tatiana V" uniqKey="Kvetnaia T" first="Tatiana V" last="Kvetnaia">Tatiana V. Kvetnaia</name><affiliation><nlm:affiliation>Department of Pathology, Ott Institute of Obstetrics, Gynecology and Reproductology, St. Petersburg, Russian Federation, Russia.</nlm:affiliation></affiliation></author><author><name sortKey="Linkova, Natalia S" sort="Linkova, Natalia S" uniqKey="Linkova N" first="Natalia S" last="Linkova">Natalia S. Linkova</name><affiliation><nlm:affiliation>Department of Pathology, Ott Institute of Obstetrics, Gynecology and Reproductology, St. Petersburg, Russian Federation, Russia.</nlm:affiliation></affiliation></author><author><name sortKey="Paltseva, Ekaterina M" sort="Paltseva, Ekaterina M" uniqKey="Paltseva E" first="Ekaterina M" last="Paltseva">Ekaterina M. Paltseva</name><affiliation><nlm:affiliation>Division of Immuhistochemistry, B.V. Petrovsky Russian Surgery Research Center, Moscow, Russian Federation, Russia.</nlm:affiliation></affiliation></author><author><name sortKey="Rubino, Rosa" sort="Rubino, Rosa" uniqKey="Rubino R" first="Rosa" last="Rubino">Rosa Rubino</name><affiliation><nlm:affiliation>Department of Medical Sciences, Division of Internal Medicine and Chronobiology Unit, IRCCS Scientific Institute and Regional General Hospital "Casa Sollievo della Sofferenza", Opera di Padre Pio da Pietrelcina, San Giovanni Rotondo (FG), Italy.</nlm:affiliation></affiliation></author><author><name sortKey="De Cosmo, Salvatore" sort="De Cosmo, Salvatore" uniqKey="De Cosmo S" first="Salvatore" last="De Cosmo">Salvatore De Cosmo</name><affiliation><nlm:affiliation>Department of Medical Sciences, Division of Internal Medicine and Chronobiology Unit, IRCCS Scientific Institute and Regional General Hospital "Casa Sollievo della Sofferenza", Opera di Padre Pio da Pietrelcina, San Giovanni Rotondo (FG), Italy.</nlm:affiliation></affiliation></author><author><name sortKey="De Cata, Angelo" sort="De Cata, Angelo" uniqKey="De Cata A" first="Angelo" last="De Cata">Angelo De Cata</name><affiliation><nlm:affiliation>Department of Medical Sciences, Division of Internal Medicine and Chronobiology Unit, IRCCS Scientific Institute and Regional General Hospital "Casa Sollievo della Sofferenza", Opera di Padre Pio da Pietrelcina, San Giovanni Rotondo (FG), Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Mazzoccoli, Gianluigi" sort="Mazzoccoli, Gianluigi" uniqKey="Mazzoccoli G" first="Gianluigi" last="Mazzoccoli">Gianluigi Mazzoccoli</name><affiliation><nlm:affiliation>Department of Medical Sciences, Division of Internal Medicine and Chronobiology Unit, IRCCS Scientific Institute and Regional General Hospital "Casa Sollievo della Sofferenza", Opera di Padre Pio da Pietrelcina, San Giovanni Rotondo (FG), Italy.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Oncotarget</title><idno type="e-ISSN">1949-2553</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Deficits in neuroendocrine-immune system functioning, including alterations in pineal and thymic glands, contribute to aging-associated diseases. This study looks at ageing-associated alterations in pineal and thymic gland functioning evaluating common signaling molecules present in both human and animal pinealocytes and thymocytes: endocrine cell markers (melatonin, serotonin, pCREB, AANAT, CGRP, VIP, chromogranin А); cell renovation markers (p53, AIF, Ki67), matrix metalloproteinases (MMP2, MMP9) and lymphocytes markers (CD4, CD5, CD8, CD20). Pineal melatonin is decreased, as is one of the melatonin pathway synthesis enzymes in the thymic gland. A further similarity is the increased MMPs levels evident over age in both glands. Significant differences are evident in cell renovation processes, which deteriorate more quickly in the aged thymus versus the pineal gland. Decreases in the number of pineal B-cells and thymic T-cells were also observed over aging. Collected data indicate that cellular involution of the pineal gland and thymus show many commonalities, but also significant changes in aging-associated proteins. It is proposed that such ageing-associated alterations in these two glands provide novel pharmaceutical targets for the wide array of medical conditions that are more likely to emerge over the course of ageing.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">26943046</PMID><DateCreated><Year>2016</Year><Month>3</Month><Day>4</Day></DateCreated><DateRevised><Year>2016</Year><Month>3</Month><Day>5</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1949-2553</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2016</Year><Month>Mar</Month><Day>2</Day></PubDate></JournalIssue><Title>Oncotarget</Title><ISOAbbreviation>Oncotarget</ISOAbbreviation></Journal><ArticleTitle>Morphofunctional and signaling molecules overlap of the pineal gland and thymus: role and significance in aging.</ArticleTitle><Pagination><MedlinePgn></MedlinePgn></Pagination><ELocationID EIdType="doi">10.18632/oncotarget.7863</ELocationID><Abstract><AbstractText NlmCategory="UNASSIGNED">Deficits in neuroendocrine-immune system functioning, including alterations in pineal and thymic glands, contribute to aging-associated diseases. This study looks at ageing-associated alterations in pineal and thymic gland functioning evaluating common signaling molecules present in both human and animal pinealocytes and thymocytes: endocrine cell markers (melatonin, serotonin, pCREB, AANAT, CGRP, VIP, chromogranin А); cell renovation markers (p53, AIF, Ki67), matrix metalloproteinases (MMP2, MMP9) and lymphocytes markers (CD4, CD5, CD8, CD20). Pineal melatonin is decreased, as is one of the melatonin pathway synthesis enzymes in the thymic gland. A further similarity is the increased MMPs levels evident over age in both glands. Significant differences are evident in cell renovation processes, which deteriorate more quickly in the aged thymus versus the pineal gland. Decreases in the number of pineal B-cells and thymic T-cells were also observed over aging. Collected data indicate that cellular involution of the pineal gland and thymus show many commonalities, but also significant changes in aging-associated proteins. It is proposed that such ageing-associated alterations in these two glands provide novel pharmaceutical targets for the wide array of medical conditions that are more likely to emerge over the course of ageing.</AbstractText></Abstract><AuthorList><Author><LastName>Paltsev</LastName><ForeName>Michael A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Russian Academy of Science, Moscow, Russian Federation, Russia.</Affiliation></AffiliationInfo></Author><Author><LastName>Polyakova</LastName><ForeName>Victoria O</ForeName><Initials>VO</Initials><AffiliationInfo><Affiliation>Department of Pathology, Ott Institute of Obstetrics, Gynecology and Reproductology, St. Petersburg, Russian Federation, Russia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Laboratory of Cell Biology and Pathology, Institute of Bioregulation and Gerontology, St. Petersburg, Russian Federation, Russia.</Affiliation></AffiliationInfo></Author><Author><LastName>Kvetnoy</LastName><ForeName>Igor M</ForeName><Initials>IM</Initials><AffiliationInfo><Affiliation>Department of Pathology, Ott Institute of Obstetrics, Gynecology and Reproductology, St. Petersburg, Russian Federation, Russia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Laboratory of Cell Biology and Pathology, Institute of Bioregulation and Gerontology, St. Petersburg, Russian Federation, Russia.</Affiliation></AffiliationInfo></Author><Author><LastName>Anderson</LastName><ForeName>George</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>CRC Scotland and London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author><LastName>Kvetnaia</LastName><ForeName>Tatiana V</ForeName><Initials>TV</Initials><AffiliationInfo><Affiliation>Department of Pathology, Ott Institute of Obstetrics, Gynecology and Reproductology, St. Petersburg, Russian Federation, Russia.</Affiliation></AffiliationInfo></Author><Author><LastName>Linkova</LastName><ForeName>Natalia S</ForeName><Initials>NS</Initials><AffiliationInfo><Affiliation>Department of Pathology, Ott Institute of Obstetrics, Gynecology and Reproductology, St. Petersburg, Russian Federation, Russia.</Affiliation></AffiliationInfo></Author><Author><LastName>Paltseva</LastName><ForeName>Ekaterina M</ForeName><Initials>EM</Initials><AffiliationInfo><Affiliation>Division of Immuhistochemistry, B.V. Petrovsky Russian Surgery Research Center, Moscow, Russian Federation, Russia.</Affiliation></AffiliationInfo></Author><Author><LastName>Rubino</LastName><ForeName>Rosa</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Medical Sciences, Division of Internal Medicine and Chronobiology Unit, IRCCS Scientific Institute and Regional General Hospital "Casa Sollievo della Sofferenza", Opera di Padre Pio da Pietrelcina, San Giovanni Rotondo (FG), Italy.</Affiliation></AffiliationInfo></Author><Author><LastName>De Cosmo</LastName><ForeName>Salvatore</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Medical Sciences, Division of Internal Medicine and Chronobiology Unit, IRCCS Scientific Institute and Regional General Hospital "Casa Sollievo della Sofferenza", Opera di Padre Pio da Pietrelcina, San Giovanni Rotondo (FG), Italy.</Affiliation></AffiliationInfo></Author><Author><LastName>De Cata</LastName><ForeName>Angelo</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Medical Sciences, Division of Internal Medicine and Chronobiology Unit, IRCCS Scientific Institute and Regional General Hospital "Casa Sollievo della Sofferenza", Opera di Padre Pio da Pietrelcina, San Giovanni Rotondo (FG), Italy.</Affiliation></AffiliationInfo></Author><Author><LastName>Mazzoccoli</LastName><ForeName>Gianluigi</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Medical Sciences, Division of Internal Medicine and Chronobiology Unit, IRCCS Scientific Institute and Regional General Hospital "Casa Sollievo della Sofferenza", Opera di Padre Pio da Pietrelcina, San Giovanni Rotondo (FG), Italy.</Affiliation></AffiliationInfo></Author></AuthorList><Language>ENG</Language><PublicationTypeList><PublicationType UI="">JOURNAL ARTICLE</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>3</Month><Day>2</Day></ArticleDate></Article><MedlineJournalInfo><MedlineTA>Oncotarget</MedlineTA><NlmUniqueID>101532965</NlmUniqueID><ISSNLinking>1949-2553</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Gerotarget</Keyword><Keyword MajorTopicYN="N">aging</Keyword><Keyword MajorTopicYN="N">melatonin</Keyword><Keyword MajorTopicYN="N">neuroendocrine-immune</Keyword><Keyword MajorTopicYN="N">pineal</Keyword><Keyword MajorTopicYN="N">thymus</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>2</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>2</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>3</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>3</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>3</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pii">7863</ArticleId><ArticleId IdType="doi">10.18632/oncotarget.7863</ArticleId><ArticleId IdType="pubmed">26943046</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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