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Fine-tuning of eTRPM8 expression and activity conditions keratinocyte fate.

Identifieur interne : 000005 ( PubMed/Corpus ); précédent : 000004; suivant : 000006

Fine-tuning of eTRPM8 expression and activity conditions keratinocyte fate.

Auteurs : Gabriel Bidaux ; Anne-Sophie Borowiec ; Natalia Prevarskaya ; Dmitri Gordienko

Source :

Channels (Austin, Tex.) ; 2016.

RBID : pubmed:27014839

Abstract

Recently, we reported the cloning and characterization of short isoform of the icilin-activated cold receptor TRPM8 channel in keratinocytes, dubbed eTRPM8. We demonstrated that eTRPM8 via fine tuning of the endoplasmic reticulum (ER) - mitochondria Ca(2+) shuttling regulates mitochondrial ATP and superoxide (O2(•-)) production and, thereby, mediates control of epidermal homeostasis by mild cold. Here, we provide additional information explaining why eTRPM8 suppression and TRPM8 stimulation both inhibit keratinocyte growth. We also demonstrate that stimulation of eTRPM8 with icilin may give rise to sustained oscillatory responses. Furthermore, we show that ATP-induced cytosolic and mitochondrial Ca(2+) responses are attenuated by eTRPM8 suppression. This suggests positive interplay between eTRPM8 and purinergic signaling pathways, what may serve to facilitate the ER-mitochondria Ca(2+) shuttling. Finally, we demonstrate that cold (25°C) induces eTRPM8-dependent superoxide-mediated necrosis of keratinocytes. Altogether, these results are in line with our model of eTRPM8-mediated cold-dependent balance between keratinocyte proliferation and differentiation.

DOI: 10.1080/19336950.2016.1168551
PubMed: 27014839

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pubmed:27014839

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<author><name sortKey="Bidaux, Gabriel" sort="Bidaux, Gabriel" uniqKey="Bidaux G" first="Gabriel" last="Bidaux">Gabriel Bidaux</name>
<affiliation><nlm:affiliation>a Inserm, U-1003, Equipe labellisée par la Ligue Nationale contre le cancer, Villeneuve d'Ascq, F-59655 France; Université des Sciences et Technologies de Lille (USTL) , Villeneuve d'Ascq , F-59655 France .</nlm:affiliation>
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<author><name sortKey="Borowiec, Anne Sophie" sort="Borowiec, Anne Sophie" uniqKey="Borowiec A" first="Anne-Sophie" last="Borowiec">Anne-Sophie Borowiec</name>
<affiliation><nlm:affiliation>a Inserm, U-1003, Equipe labellisée par la Ligue Nationale contre le cancer, Villeneuve d'Ascq, F-59655 France; Université des Sciences et Technologies de Lille (USTL) , Villeneuve d'Ascq , F-59655 France .</nlm:affiliation>
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<author><name sortKey="Prevarskaya, Natalia" sort="Prevarskaya, Natalia" uniqKey="Prevarskaya N" first="Natalia" last="Prevarskaya">Natalia Prevarskaya</name>
<affiliation><nlm:affiliation>a Inserm, U-1003, Equipe labellisée par la Ligue Nationale contre le cancer, Villeneuve d'Ascq, F-59655 France; Université des Sciences et Technologies de Lille (USTL) , Villeneuve d'Ascq , F-59655 France .</nlm:affiliation>
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<author><name sortKey="Gordienko, Dmitri" sort="Gordienko, Dmitri" uniqKey="Gordienko D" first="Dmitri" last="Gordienko">Dmitri Gordienko</name>
<affiliation><nlm:affiliation>a Inserm, U-1003, Equipe labellisée par la Ligue Nationale contre le cancer, Villeneuve d'Ascq, F-59655 France; Université des Sciences et Technologies de Lille (USTL) , Villeneuve d'Ascq , F-59655 France .</nlm:affiliation>
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<author><name sortKey="Borowiec, Anne Sophie" sort="Borowiec, Anne Sophie" uniqKey="Borowiec A" first="Anne-Sophie" last="Borowiec">Anne-Sophie Borowiec</name>
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<author><name sortKey="Prevarskaya, Natalia" sort="Prevarskaya, Natalia" uniqKey="Prevarskaya N" first="Natalia" last="Prevarskaya">Natalia Prevarskaya</name>
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<series><title level="j">Channels (Austin, Tex.)</title>
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<front><div type="abstract" xml:lang="en">Recently, we reported the cloning and characterization of short isoform of the icilin-activated cold receptor TRPM8 channel in keratinocytes, dubbed eTRPM8. We demonstrated that eTRPM8 via fine tuning of the endoplasmic reticulum (ER) - mitochondria Ca(2+) shuttling regulates mitochondrial ATP and superoxide (O2(•-)) production and, thereby, mediates control of epidermal homeostasis by mild cold. Here, we provide additional information explaining why eTRPM8 suppression and TRPM8 stimulation both inhibit keratinocyte growth. We also demonstrate that stimulation of eTRPM8 with icilin may give rise to sustained oscillatory responses. Furthermore, we show that ATP-induced cytosolic and mitochondrial Ca(2+) responses are attenuated by eTRPM8 suppression. This suggests positive interplay between eTRPM8 and purinergic signaling pathways, what may serve to facilitate the ER-mitochondria Ca(2+) shuttling. Finally, we demonstrate that cold (25°C) induces eTRPM8-dependent superoxide-mediated necrosis of keratinocytes. Altogether, these results are in line with our model of eTRPM8-mediated cold-dependent balance between keratinocyte proliferation and differentiation.</div>
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<Title>Channels (Austin, Tex.)</Title>
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<Abstract><AbstractText NlmCategory="UNASSIGNED">Recently, we reported the cloning and characterization of short isoform of the icilin-activated cold receptor TRPM8 channel in keratinocytes, dubbed eTRPM8. We demonstrated that eTRPM8 via fine tuning of the endoplasmic reticulum (ER) - mitochondria Ca(2+) shuttling regulates mitochondrial ATP and superoxide (O2(•-)) production and, thereby, mediates control of epidermal homeostasis by mild cold. Here, we provide additional information explaining why eTRPM8 suppression and TRPM8 stimulation both inhibit keratinocyte growth. We also demonstrate that stimulation of eTRPM8 with icilin may give rise to sustained oscillatory responses. Furthermore, we show that ATP-induced cytosolic and mitochondrial Ca(2+) responses are attenuated by eTRPM8 suppression. This suggests positive interplay between eTRPM8 and purinergic signaling pathways, what may serve to facilitate the ER-mitochondria Ca(2+) shuttling. Finally, we demonstrate that cold (25°C) induces eTRPM8-dependent superoxide-mediated necrosis of keratinocytes. Altogether, these results are in line with our model of eTRPM8-mediated cold-dependent balance between keratinocyte proliferation and differentiation.</AbstractText>
</Abstract>
<AuthorList><Author><LastName>Bidaux</LastName>
<ForeName>Gabriel</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>a Inserm, U-1003, Equipe labellisée par la Ligue Nationale contre le cancer, Villeneuve d'Ascq, F-59655 France; Université des Sciences et Technologies de Lille (USTL) , Villeneuve d'Ascq , F-59655 France .</Affiliation>
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<AffiliationInfo><Affiliation>b Univ Lyon, CarMeN laboratory, INSERM UMR1060, INRA UMR1397, Univ Lyon1, Insa-Lyon , F-69500 , BRON , France.</Affiliation>
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<AffiliationInfo><Affiliation>c IHU OPERA, Hospices Civils de Lyon, Groupement Hospitalier EST , F-69500 , BRON , France.</Affiliation>
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</Author>
<Author><LastName>Borowiec</LastName>
<ForeName>Anne-Sophie</ForeName>
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<AffiliationInfo><Affiliation>a Inserm, U-1003, Equipe labellisée par la Ligue Nationale contre le cancer, Villeneuve d'Ascq, F-59655 France; Université des Sciences et Technologies de Lille (USTL) , Villeneuve d'Ascq , F-59655 France .</Affiliation>
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<Author><LastName>Prevarskaya</LastName>
<ForeName>Natalia</ForeName>
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<Author><LastName>Gordienko</LastName>
<ForeName>Dmitri</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>a Inserm, U-1003, Equipe labellisée par la Ligue Nationale contre le cancer, Villeneuve d'Ascq, F-59655 France; Université des Sciences et Technologies de Lille (USTL) , Villeneuve d'Ascq , F-59655 France .</Affiliation>
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<AffiliationInfo><Affiliation>d Laboratory of Molecular Pharmacology and Biophysics of Cell Signalling, Bogomoletz Institute of Physiology , Kiev , Ukraine.</Affiliation>
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<Language>ENG</Language>
<PublicationTypeList><PublicationType UI="">JOURNAL ARTICLE</PublicationType>
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<Month>3</Month>
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<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">ATP</Keyword>
<Keyword MajorTopicYN="N">cell death</Keyword>
<Keyword MajorTopicYN="N">differentiation</Keyword>
<Keyword MajorTopicYN="N">eTRPM8</Keyword>
<Keyword MajorTopicYN="N">epidermal homeostasis</Keyword>
<Keyword MajorTopicYN="N">mild cold</Keyword>
<Keyword MajorTopicYN="N">proliferation</Keyword>
<Keyword MajorTopicYN="N">superoxide</Keyword>
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Fine-tuning of eTRPM8 expression and activity conditions keratinocyte fate.

Fine-tuning of eTRPM8 expression and activity conditions keratinocyte fate.

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Abstract

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