A confirmatory report for the close interaction of Helicobacter pylori with gastric epithelial MUC5AC expression.
Identifieur interne : 000530 ( PubMed/Checkpoint ); précédent : 000529; suivant : 000531A confirmatory report for the close interaction of Helicobacter pylori with gastric epithelial MUC5AC expression.
Auteurs : Belma Kocer [Turquie] ; Murat Ulas ; Yucel Ustundag ; Sibel Erdogan ; Melih Karabeyoglu ; Osman Yldrm ; Bülent Unal ; Omer Cengiz ; Atilla SoranSource :
- Journal of clinical gastroenterology [ 0192-0790 ] ; 2004.
English descriptors
- KwdEn :
- Adult, Aged, Biopsy, Needle, Case-Control Studies, Culture Techniques, Female, Gastric Mucosa (immunology), Gastric Mucosa (pathology), Gastritis (immunology), Gastritis (microbiology), Gastritis (pathology), Gene Expression Regulation, Genetic Markers, Helicobacter Infections (immunology), Helicobacter Infections (pathology), Helicobacter pylori (immunology), Helicobacter pylori (isolation & purification), Humans, Immunohistochemistry, Male, Middle Aged, Mucin 5AC, Mucins (genetics), Mucins (metabolism), Probability, Prognosis, Reference Values, Sensitivity and Specificity.
- MESH :
- chemical , genetics : Mucins.
- chemical , metabolism : Mucins.
- chemical : Genetic Markers, Mucin 5AC.
- immunology : Gastric Mucosa, Gastritis, Helicobacter Infections, Helicobacter pylori.
- isolation & purification : Helicobacter pylori.
- microbiology : Gastritis.
- pathology : Gastric Mucosa, Gastritis, Helicobacter Infections.
- Adult, Aged, Biopsy, Needle, Case-Control Studies, Culture Techniques, Female, Gene Expression Regulation, Humans, Immunohistochemistry, Male, Middle Aged, Probability, Prognosis, Reference Values, Sensitivity and Specificity.
Abstract
Helicobacter pylori (H. pylori) infection is associated with the development of gastritis and peptic ulcer and is presumed to be a risk factor for low-grade B-cell lymphoma and gastric cancer. H. pylori also causes critical alterations in gastric mucin structure. Our aim was to determine the effect of H. pylori on MUC1, MUC2, and MUC5AC expression.
PubMed: 15220684
Affiliations:
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pubmed:15220684Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A confirmatory report for the close interaction of Helicobacter pylori with gastric epithelial MUC5AC expression.</title><author><name sortKey="Kocer, Belma" sort="Kocer, Belma" uniqKey="Kocer B" first="Belma" last="Kocer">Belma Kocer</name><affiliation wicri:level="1"><nlm:affiliation>Surgery Department, Ankara Numune Research and Teaching Hospital, Opera, Ankara, Turkey. belmak@mailcity.com</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>Surgery Department, Ankara Numune Research and Teaching Hospital, Opera, Ankara</wicri:regionArea><wicri:noRegion>Ankara</wicri:noRegion></affiliation></author><author><name sortKey="Ulas, Murat" sort="Ulas, Murat" uniqKey="Ulas M" first="Murat" last="Ulas">Murat Ulas</name></author><author><name sortKey="Ustundag, Yucel" sort="Ustundag, Yucel" uniqKey="Ustundag Y" first="Yucel" last="Ustundag">Yucel Ustundag</name></author><author><name sortKey="Erdogan, Sibel" sort="Erdogan, Sibel" uniqKey="Erdogan S" first="Sibel" last="Erdogan">Sibel Erdogan</name></author><author><name sortKey="Karabeyoglu, Melih" sort="Karabeyoglu, Melih" uniqKey="Karabeyoglu M" first="Melih" last="Karabeyoglu">Melih Karabeyoglu</name></author><author><name sortKey="Yldrm, Osman" sort="Yldrm, Osman" uniqKey="Yldrm O" first="Osman" last="Yldrm">Osman Yldrm</name></author><author><name sortKey="Unal, Bulent" sort="Unal, Bulent" uniqKey="Unal B" first="Bülent" last="Unal">Bülent Unal</name></author><author><name sortKey="Cengiz, Omer" sort="Cengiz, Omer" uniqKey="Cengiz O" first="Omer" last="Cengiz">Omer Cengiz</name></author><author><name sortKey="Soran, Atilla" sort="Soran, Atilla" uniqKey="Soran A" first="Atilla" last="Soran">Atilla Soran</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2004">2004</date><idno type="RBID">pubmed:15220684</idno><idno type="pmid">15220684</idno><idno type="wicri:Area/PubMed/Corpus">000553</idno><idno type="wicri:Area/PubMed/Curation">000553</idno><idno type="wicri:Area/PubMed/Checkpoint">000530</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A confirmatory report for the close interaction of Helicobacter pylori with gastric epithelial MUC5AC expression.</title><author><name sortKey="Kocer, Belma" sort="Kocer, Belma" uniqKey="Kocer B" first="Belma" last="Kocer">Belma Kocer</name><affiliation wicri:level="1"><nlm:affiliation>Surgery Department, Ankara Numune Research and Teaching Hospital, Opera, Ankara, Turkey. belmak@mailcity.com</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>Surgery Department, Ankara Numune Research and Teaching Hospital, Opera, Ankara</wicri:regionArea><wicri:noRegion>Ankara</wicri:noRegion></affiliation></author><author><name sortKey="Ulas, Murat" sort="Ulas, Murat" uniqKey="Ulas M" first="Murat" last="Ulas">Murat Ulas</name></author><author><name sortKey="Ustundag, Yucel" sort="Ustundag, Yucel" uniqKey="Ustundag Y" first="Yucel" last="Ustundag">Yucel Ustundag</name></author><author><name sortKey="Erdogan, Sibel" sort="Erdogan, Sibel" uniqKey="Erdogan S" first="Sibel" last="Erdogan">Sibel Erdogan</name></author><author><name sortKey="Karabeyoglu, Melih" sort="Karabeyoglu, Melih" uniqKey="Karabeyoglu M" first="Melih" last="Karabeyoglu">Melih Karabeyoglu</name></author><author><name sortKey="Yldrm, Osman" sort="Yldrm, Osman" uniqKey="Yldrm O" first="Osman" last="Yldrm">Osman Yldrm</name></author><author><name sortKey="Unal, Bulent" sort="Unal, Bulent" uniqKey="Unal B" first="Bülent" last="Unal">Bülent Unal</name></author><author><name sortKey="Cengiz, Omer" sort="Cengiz, Omer" uniqKey="Cengiz O" first="Omer" last="Cengiz">Omer Cengiz</name></author><author><name sortKey="Soran, Atilla" sort="Soran, Atilla" uniqKey="Soran A" first="Atilla" last="Soran">Atilla Soran</name></author></analytic><series><title level="j">Journal of clinical gastroenterology</title><idno type="ISSN">0192-0790</idno><imprint><date when="2004" type="published">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Biopsy, Needle</term><term>Case-Control Studies</term><term>Culture Techniques</term><term>Female</term><term>Gastric Mucosa (immunology)</term><term>Gastric Mucosa (pathology)</term><term>Gastritis (immunology)</term><term>Gastritis (microbiology)</term><term>Gastritis (pathology)</term><term>Gene Expression Regulation</term><term>Genetic Markers</term><term>Helicobacter Infections (immunology)</term><term>Helicobacter Infections (pathology)</term><term>Helicobacter pylori (immunology)</term><term>Helicobacter pylori (isolation & purification)</term><term>Humans</term><term>Immunohistochemistry</term><term>Male</term><term>Middle Aged</term><term>Mucin 5AC</term><term>Mucins (genetics)</term><term>Mucins (metabolism)</term><term>Probability</term><term>Prognosis</term><term>Reference Values</term><term>Sensitivity and Specificity</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Mucins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Mucins</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Genetic Markers</term><term>Mucin 5AC</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Gastric Mucosa</term><term>Gastritis</term><term>Helicobacter Infections</term><term>Helicobacter pylori</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Helicobacter pylori</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Gastritis</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Gastric Mucosa</term><term>Gastritis</term><term>Helicobacter Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Biopsy, Needle</term><term>Case-Control Studies</term><term>Culture Techniques</term><term>Female</term><term>Gene Expression Regulation</term><term>Humans</term><term>Immunohistochemistry</term><term>Male</term><term>Middle Aged</term><term>Probability</term><term>Prognosis</term><term>Reference Values</term><term>Sensitivity and Specificity</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Helicobacter pylori (H. pylori) infection is associated with the development of gastritis and peptic ulcer and is presumed to be a risk factor for low-grade B-cell lymphoma and gastric cancer. H. pylori also causes critical alterations in gastric mucin structure. Our aim was to determine the effect of H. pylori on MUC1, MUC2, and MUC5AC expression.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">15220684</PMID><DateCreated><Year>2004</Year><Month>06</Month><Day>28</Day></DateCreated><DateCompleted><Year>2004</Year><Month>09</Month><Day>23</Day></DateCompleted><DateRevised><Year>2008</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0192-0790</ISSN><JournalIssue CitedMedium="Print"><Volume>38</Volume><Issue>6</Issue><PubDate><Year>2004</Year><Month>Jul</Month></PubDate></JournalIssue><Title>Journal of clinical gastroenterology</Title><ISOAbbreviation>J. Clin. Gastroenterol.</ISOAbbreviation></Journal><ArticleTitle>A confirmatory report for the close interaction of Helicobacter pylori with gastric epithelial MUC5AC expression.</ArticleTitle><Pagination><MedlinePgn>496-502</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Helicobacter pylori (H. pylori) infection is associated with the development of gastritis and peptic ulcer and is presumed to be a risk factor for low-grade B-cell lymphoma and gastric cancer. H. pylori also causes critical alterations in gastric mucin structure. Our aim was to determine the effect of H. pylori on MUC1, MUC2, and MUC5AC expression.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Thirty H. pylori-positive and 15 H. pylori-negative antral gastric endoscopic biopsy specimens were evaluated for MUC1, MUC2, and MUC5AC expression with immunohistochemical staining. From the same specimens, we scrutinized the presence of H. pylori infection by hematoxylin and eosin and immunohistochemical staining.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">In H. pylori infected patients, the expression of MUC5AC was found to be localized to the cells in the superficial epithelium and upper parts of the gastric glands. The number of MUC5AC-expressing cells and the staining intensity of MUC5AC were shown to decrease in patients with H. pylori infection. Histopathology and immunostaining patterns of gastric mucins implied that H. pylori was physically associated with extracellular MUC5AC and MUC5AC-producing cells. H. pylori infection does not significantly affect staining intensity and patterns of MUC1 and MUC2 expressions. MUC1 was not found in dysplastic tissues or intestinal metaplasia areas. MUC5AC was expressed in dysplastic areas, but not in intestinal metaplasia. MUC2 was expressed in both dysplastic and intestinal metaplasia areas.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">H. pylori decreases the amount of MUC5AC expression. With reducing MUC5AC-producing cells and MUC5AC mucin, H. pylori may potentially cause significant alterations of the structure and function of gastric mucins. H. pylori-dependent inhibition of mucin synthesis deserves more investigations to clarify the role of H. pylori and gastric MUC5AC interaction.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kocer</LastName><ForeName>Belma</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Surgery Department, Ankara Numune Research and Teaching Hospital, Opera, Ankara, Turkey. belmak@mailcity.com</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ulas</LastName><ForeName>Murat</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Ustundag</LastName><ForeName>Yucel</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Erdogan</LastName><ForeName>Sibel</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Karabeyoglu</LastName><ForeName>Melih</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Yldrm</LastName><ForeName>Osman</ForeName><Initials>O</Initials></Author><Author ValidYN="Y"><LastName>Unal</LastName><ForeName>Bülent</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Cengiz</LastName><ForeName>Omer</ForeName><Initials>O</Initials></Author><Author ValidYN="Y"><LastName>Soran</LastName><ForeName>Atilla</ForeName><Initials>A</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Clin Gastroenterol</MedlineTA><NlmUniqueID>7910017</NlmUniqueID><ISSNLinking>0192-0790</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005819">Genetic Markers</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C524678">MUC5AC protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D055271">Mucin 5AC</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D009077">Mucins</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000328">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001707">Biopsy, Needle</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D016022">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D046508">Culture Techniques</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005753">Gastric Mucosa</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000276">immunology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000473">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005756">Gastritis</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000276">immunology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000382">microbiology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000473">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005786">Gene Expression Regulation</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005819">Genetic Markers</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D016481">Helicobacter Infections</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000276">immunology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000473">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D016480">Helicobacter pylori</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000276">immunology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000302">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007150">Immunohistochemistry</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D055271">Mucin 5AC</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009077">Mucins</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000235">genetics</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011336">Probability</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011379">Prognosis</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012016">Reference Values</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012680">Sensitivity and Specificity</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2004</Year><Month>6</Month><Day>29</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2004</Year><Month>9</Month><Day>24</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2004</Year><Month>6</Month><Day>29</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">15220684</ArticleId><ArticleId IdType="pii">00004836-200407000-00006</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Turquie</li></country></list><tree><noCountry><name sortKey="Cengiz, Omer" sort="Cengiz, Omer" uniqKey="Cengiz O" first="Omer" last="Cengiz">Omer Cengiz</name><name sortKey="Erdogan, Sibel" sort="Erdogan, Sibel" uniqKey="Erdogan S" first="Sibel" last="Erdogan">Sibel Erdogan</name><name sortKey="Karabeyoglu, Melih" sort="Karabeyoglu, Melih" uniqKey="Karabeyoglu M" first="Melih" last="Karabeyoglu">Melih Karabeyoglu</name><name sortKey="Soran, Atilla" sort="Soran, Atilla" uniqKey="Soran A" first="Atilla" last="Soran">Atilla Soran</name><name sortKey="Ulas, Murat" sort="Ulas, Murat" uniqKey="Ulas M" first="Murat" last="Ulas">Murat Ulas</name><name sortKey="Unal, Bulent" sort="Unal, Bulent" uniqKey="Unal B" first="Bülent" last="Unal">Bülent Unal</name><name sortKey="Ustundag, Yucel" sort="Ustundag, Yucel" uniqKey="Ustundag Y" first="Yucel" last="Ustundag">Yucel Ustundag</name><name sortKey="Yldrm, Osman" sort="Yldrm, Osman" uniqKey="Yldrm O" first="Osman" last="Yldrm">Osman Yldrm</name></noCountry><country name="Turquie"><noRegion><name sortKey="Kocer, Belma" sort="Kocer, Belma" uniqKey="Kocer B" first="Belma" last="Kocer">Belma Kocer</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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