Prevalence and features of peripheral neuropathy in Parkinson's disease patients under different therapeutic regimens.
Identifieur interne : 000145 ( PubMed/Checkpoint ); précédent : 000144; suivant : 000146Prevalence and features of peripheral neuropathy in Parkinson's disease patients under different therapeutic regimens.
Auteurs : F. Mancini [Italie] ; C. Comi [Italie] ; G D Oggioni [Italie] ; C. Pacchetti [Italie] ; D. Calandrella [Italie] ; M. Coletti Moja [Italie] ; G. Riboldazzi [Italie] ; S. Tunesi [Italie] ; M. Dal Fante [Italie] ; L. Manfredi [Italie] ; M. Lacerenza [Italie] ; R. Cantello [Italie] ; A. Antonini [Italie]Source :
- Parkinsonism & related disorders ; 2014.
English descriptors
- KwdEn :
- Aged, Antiparkinson Agents (adverse effects), Cross-Sectional Studies, Electromyography, Female, Folic Acid (blood), Homocysteine (blood), Humans, Levodopa (adverse effects), Male, Middle Aged, Parkinson Disease (blood), Parkinson Disease (complications), Parkinson Disease (drug therapy), Peripheral Nervous System Diseases (blood), Peripheral Nervous System Diseases (epidemiology), Peripheral Nervous System Diseases (etiology), Prevalence, Vitamin B 12 (blood).
- MESH :
- chemical , adverse effects : Antiparkinson Agents, Levodopa.
- chemical , blood : Folic Acid, Homocysteine, Vitamin B 12.
- blood : Parkinson Disease, Peripheral Nervous System Diseases.
- complications : Parkinson Disease.
- drug therapy : Parkinson Disease.
- epidemiology : Peripheral Nervous System Diseases.
- etiology : Peripheral Nervous System Diseases.
- Aged, Cross-Sectional Studies, Electromyography, Female, Humans, Male, Middle Aged, Prevalence.
Abstract
Recent reports suggest increased frequency of peripheral neuropathy (PN) in Parkinson's disease (PD) patients on levodopa compared with age-matched controls particularly during continuous levodopa delivery by intestinal infusion (CLDII). The aim of this study is to compare frequency, clinical features, and outcome of PN in PD patients undergoing different therapeutic regimens.
DOI: 10.1016/j.parkreldis.2013.09.007
PubMed: 24099722
Affiliations:
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Comi</name><affiliation wicri:level="1"><nlm:affiliation>Parkinson's Disease and Movement Disorders Centre, Department of Neurology, University of Eastern Piedmont "Amedeo Avogadro", Novara, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Parkinson's Disease and Movement Disorders Centre, Department of Neurology, University of Eastern Piedmont "Amedeo Avogadro", Novara</wicri:regionArea><wicri:noRegion>Novara</wicri:noRegion></affiliation></author><author><name sortKey="Oggioni, G D" sort="Oggioni, G D" uniqKey="Oggioni G" first="G D" last="Oggioni">G D Oggioni</name><affiliation wicri:level="1"><nlm:affiliation>Parkinson's Disease and Movement Disorders Centre, Department of Neurology, University of Eastern Piedmont "Amedeo Avogadro", Novara, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Parkinson's Disease and Movement Disorders Centre, Department of Neurology, University of Eastern Piedmont "Amedeo Avogadro", Novara</wicri:regionArea><wicri:noRegion>Novara</wicri:noRegion></affiliation></author><author><name sortKey="Pacchetti, C" sort="Pacchetti, C" uniqKey="Pacchetti C" first="C" last="Pacchetti">C. 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Coletti Moja</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Mauriziano Umberto I Hospital, Turin, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurology, Mauriziano Umberto I Hospital, Turin</wicri:regionArea><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Riboldazzi, G" sort="Riboldazzi, G" uniqKey="Riboldazzi G" first="G" last="Riboldazzi">G. Riboldazzi</name><affiliation wicri:level="1"><nlm:affiliation>Parkinson's Disease and Movement Disorders Centre, University of Insubria, Varese, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Parkinson's Disease and Movement Disorders Centre, University of Insubria, Varese</wicri:regionArea><wicri:noRegion>Varese</wicri:noRegion></affiliation></author><author><name sortKey="Tunesi, S" sort="Tunesi, S" uniqKey="Tunesi S" first="S" last="Tunesi">S. Tunesi</name><affiliation wicri:level="1"><nlm:affiliation>Unit of Medical Statistics and Epidemiology, Department Translational Medicine, University of Eastern Piedmont "Amedeo Avogadro", Novara, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Unit of Medical Statistics and Epidemiology, Department Translational Medicine, University of Eastern Piedmont "Amedeo Avogadro", Novara</wicri:regionArea><wicri:noRegion>Novara</wicri:noRegion></affiliation></author><author><name sortKey="Dal Fante, M" sort="Dal Fante, M" uniqKey="Dal Fante M" first="M" last="Dal Fante">M. Dal Fante</name><affiliation wicri:level="1"><nlm:affiliation>Endoscopy Unit San Pio X Clinic, Fondazione Opera San Camillo, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Endoscopy Unit San Pio X Clinic, Fondazione Opera San Camillo, Milan</wicri:regionArea><wicri:noRegion>Milan</wicri:noRegion></affiliation></author><author><name sortKey="Manfredi, L" sort="Manfredi, L" uniqKey="Manfredi L" first="L" last="Manfredi">L. Manfredi</name><affiliation wicri:level="1"><nlm:affiliation>Parkinson's Disease and Movement Disorders Centre, Neurology Unit, San Pio X Clinic, Fondazione Opera San Camillo, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Parkinson's Disease and Movement Disorders Centre, Neurology Unit, San Pio X Clinic, Fondazione Opera San Camillo, Milan</wicri:regionArea><wicri:noRegion>Milan</wicri:noRegion></affiliation></author><author><name sortKey="Lacerenza, M" sort="Lacerenza, M" uniqKey="Lacerenza M" first="M" last="Lacerenza">M. Lacerenza</name><affiliation wicri:level="1"><nlm:affiliation>Parkinson's Disease and Movement Disorders Centre, Neurology Unit, San Pio X Clinic, Fondazione Opera San Camillo, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Parkinson's Disease and Movement Disorders Centre, Neurology Unit, San Pio X Clinic, Fondazione Opera San Camillo, Milan</wicri:regionArea><wicri:noRegion>Milan</wicri:noRegion></affiliation></author><author><name sortKey="Cantello, R" sort="Cantello, R" uniqKey="Cantello R" first="R" last="Cantello">R. Cantello</name><affiliation wicri:level="1"><nlm:affiliation>Parkinson's Disease and Movement Disorders Centre, Department of Neurology, University of Eastern Piedmont "Amedeo Avogadro", Novara, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Parkinson's Disease and Movement Disorders Centre, Department of Neurology, University of Eastern Piedmont "Amedeo Avogadro", Novara</wicri:regionArea><wicri:noRegion>Novara</wicri:noRegion></affiliation></author><author><name sortKey="Antonini, A" sort="Antonini, A" uniqKey="Antonini A" first="A" last="Antonini">A. Antonini</name><affiliation wicri:level="1"><nlm:affiliation>Department for Parkinson Disease, IRCCS San Camillo, Venice, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department for Parkinson Disease, IRCCS San Camillo, Venice</wicri:regionArea><wicri:noRegion>Venice</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24099722</idno><idno type="pmid">24099722</idno><idno type="doi">10.1016/j.parkreldis.2013.09.007</idno><idno type="wicri:Area/PubMed/Corpus">000205</idno><idno type="wicri:Area/PubMed/Curation">000205</idno><idno type="wicri:Area/PubMed/Checkpoint">000145</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Prevalence and features of peripheral neuropathy in Parkinson's disease patients under different therapeutic regimens.</title><author><name sortKey="Mancini, F" sort="Mancini, F" uniqKey="Mancini F" first="F" last="Mancini">F. Mancini</name><affiliation wicri:level="1"><nlm:affiliation>Parkinson's Disease and Movement Disorders Centre, Neurology Unit, San Pio X Clinic, Fondazione Opera San Camillo, Milan, Italy. Electronic address: francesca.mancini@tin.it.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Parkinson's Disease and Movement Disorders Centre, Neurology Unit, San Pio X Clinic, Fondazione Opera San Camillo, Milan</wicri:regionArea><wicri:noRegion>Milan</wicri:noRegion></affiliation></author><author><name sortKey="Comi, C" sort="Comi, C" uniqKey="Comi C" first="C" last="Comi">C. Comi</name><affiliation wicri:level="1"><nlm:affiliation>Parkinson's Disease and Movement Disorders Centre, Department of Neurology, University of Eastern Piedmont "Amedeo Avogadro", Novara, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Parkinson's Disease and Movement Disorders Centre, Department of Neurology, University of Eastern Piedmont "Amedeo Avogadro", Novara</wicri:regionArea><wicri:noRegion>Novara</wicri:noRegion></affiliation></author><author><name sortKey="Oggioni, G D" sort="Oggioni, G D" uniqKey="Oggioni G" first="G D" last="Oggioni">G D Oggioni</name><affiliation wicri:level="1"><nlm:affiliation>Parkinson's Disease and Movement Disorders Centre, Department of Neurology, University of Eastern Piedmont "Amedeo Avogadro", Novara, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Parkinson's Disease and Movement Disorders Centre, Department of Neurology, University of Eastern Piedmont "Amedeo Avogadro", Novara</wicri:regionArea><wicri:noRegion>Novara</wicri:noRegion></affiliation></author><author><name sortKey="Pacchetti, C" sort="Pacchetti, C" uniqKey="Pacchetti C" first="C" last="Pacchetti">C. Pacchetti</name><affiliation wicri:level="1"><nlm:affiliation>Parkinson's Disease and Movement Disorders Centre, Neurological Institute IRCCS "C. Mondino", Pavia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Parkinson's Disease and Movement Disorders Centre, Neurological Institute IRCCS "C. Mondino", Pavia</wicri:regionArea><wicri:noRegion>Pavia</wicri:noRegion></affiliation></author><author><name sortKey="Calandrella, D" sort="Calandrella, D" uniqKey="Calandrella D" first="D" last="Calandrella">D. Calandrella</name><affiliation wicri:level="1"><nlm:affiliation>Parkinson's Disease and Movement Disorders Centre, Neurology Unit, San Pio X Clinic, Fondazione Opera San Camillo, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Parkinson's Disease and Movement Disorders Centre, Neurology Unit, San Pio X Clinic, Fondazione Opera San Camillo, Milan</wicri:regionArea><wicri:noRegion>Milan</wicri:noRegion></affiliation></author><author><name sortKey="Coletti Moja, M" sort="Coletti Moja, M" uniqKey="Coletti Moja M" first="M" last="Coletti Moja">M. Coletti Moja</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Mauriziano Umberto I Hospital, Turin, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurology, Mauriziano Umberto I Hospital, Turin</wicri:regionArea><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Riboldazzi, G" sort="Riboldazzi, G" uniqKey="Riboldazzi G" first="G" last="Riboldazzi">G. Riboldazzi</name><affiliation wicri:level="1"><nlm:affiliation>Parkinson's Disease and Movement Disorders Centre, University of Insubria, Varese, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Parkinson's Disease and Movement Disorders Centre, University of Insubria, Varese</wicri:regionArea><wicri:noRegion>Varese</wicri:noRegion></affiliation></author><author><name sortKey="Tunesi, S" sort="Tunesi, S" uniqKey="Tunesi S" first="S" last="Tunesi">S. Tunesi</name><affiliation wicri:level="1"><nlm:affiliation>Unit of Medical Statistics and Epidemiology, Department Translational Medicine, University of Eastern Piedmont "Amedeo Avogadro", Novara, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Unit of Medical Statistics and Epidemiology, Department Translational Medicine, University of Eastern Piedmont "Amedeo Avogadro", Novara</wicri:regionArea><wicri:noRegion>Novara</wicri:noRegion></affiliation></author><author><name sortKey="Dal Fante, M" sort="Dal Fante, M" uniqKey="Dal Fante M" first="M" last="Dal Fante">M. Dal Fante</name><affiliation wicri:level="1"><nlm:affiliation>Endoscopy Unit San Pio X Clinic, Fondazione Opera San Camillo, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Endoscopy Unit San Pio X Clinic, Fondazione Opera San Camillo, Milan</wicri:regionArea><wicri:noRegion>Milan</wicri:noRegion></affiliation></author><author><name sortKey="Manfredi, L" sort="Manfredi, L" uniqKey="Manfredi L" first="L" last="Manfredi">L. Manfredi</name><affiliation wicri:level="1"><nlm:affiliation>Parkinson's Disease and Movement Disorders Centre, Neurology Unit, San Pio X Clinic, Fondazione Opera San Camillo, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Parkinson's Disease and Movement Disorders Centre, Neurology Unit, San Pio X Clinic, Fondazione Opera San Camillo, Milan</wicri:regionArea><wicri:noRegion>Milan</wicri:noRegion></affiliation></author><author><name sortKey="Lacerenza, M" sort="Lacerenza, M" uniqKey="Lacerenza M" first="M" last="Lacerenza">M. Lacerenza</name><affiliation wicri:level="1"><nlm:affiliation>Parkinson's Disease and Movement Disorders Centre, Neurology Unit, San Pio X Clinic, Fondazione Opera San Camillo, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Parkinson's Disease and Movement Disorders Centre, Neurology Unit, San Pio X Clinic, Fondazione Opera San Camillo, Milan</wicri:regionArea><wicri:noRegion>Milan</wicri:noRegion></affiliation></author><author><name sortKey="Cantello, R" sort="Cantello, R" uniqKey="Cantello R" first="R" last="Cantello">R. Cantello</name><affiliation wicri:level="1"><nlm:affiliation>Parkinson's Disease and Movement Disorders Centre, Department of Neurology, University of Eastern Piedmont "Amedeo Avogadro", Novara, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Parkinson's Disease and Movement Disorders Centre, Department of Neurology, University of Eastern Piedmont "Amedeo Avogadro", Novara</wicri:regionArea><wicri:noRegion>Novara</wicri:noRegion></affiliation></author><author><name sortKey="Antonini, A" sort="Antonini, A" uniqKey="Antonini A" first="A" last="Antonini">A. Antonini</name><affiliation wicri:level="1"><nlm:affiliation>Department for Parkinson Disease, IRCCS San Camillo, Venice, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department for Parkinson Disease, IRCCS San Camillo, Venice</wicri:regionArea><wicri:noRegion>Venice</wicri:noRegion></affiliation></author></analytic><series><title level="j">Parkinsonism & related disorders</title><idno type="e-ISSN">1873-5126</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Antiparkinson Agents (adverse effects)</term><term>Cross-Sectional Studies</term><term>Electromyography</term><term>Female</term><term>Folic Acid (blood)</term><term>Homocysteine (blood)</term><term>Humans</term><term>Levodopa (adverse effects)</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (blood)</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (drug therapy)</term><term>Peripheral Nervous System Diseases (blood)</term><term>Peripheral Nervous System Diseases (epidemiology)</term><term>Peripheral Nervous System Diseases (etiology)</term><term>Prevalence</term><term>Vitamin B 12 (blood)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antiparkinson Agents</term><term>Levodopa</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Folic Acid</term><term>Homocysteine</term><term>Vitamin B 12</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Parkinson Disease</term><term>Peripheral Nervous System Diseases</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Peripheral Nervous System Diseases</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Peripheral Nervous System Diseases</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Cross-Sectional Studies</term><term>Electromyography</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Prevalence</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Recent reports suggest increased frequency of peripheral neuropathy (PN) in Parkinson's disease (PD) patients on levodopa compared with age-matched controls particularly during continuous levodopa delivery by intestinal infusion (CLDII). The aim of this study is to compare frequency, clinical features, and outcome of PN in PD patients undergoing different therapeutic regimens.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">24099722</PMID><DateCreated><Year>2014</Year><Month>01</Month><Day>27</Day></DateCreated><DateCompleted><Year>2014</Year><Month>09</Month><Day>12</Day></DateCompleted><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-5126</ISSN><JournalIssue CitedMedium="Internet"><Volume>20</Volume><Issue>1</Issue><PubDate><Year>2014</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Parkinsonism & related disorders</Title><ISOAbbreviation>Parkinsonism Relat. Disord.</ISOAbbreviation></Journal><ArticleTitle>Prevalence and features of peripheral neuropathy in Parkinson's disease patients under different therapeutic regimens.</ArticleTitle><Pagination><MedlinePgn>27-31</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.parkreldis.2013.09.007</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S1353-8020(13)00337-4</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Recent reports suggest increased frequency of peripheral neuropathy (PN) in Parkinson's disease (PD) patients on levodopa compared with age-matched controls particularly during continuous levodopa delivery by intestinal infusion (CLDII). The aim of this study is to compare frequency, clinical features, and outcome of PN in PD patients undergoing different therapeutic regimens.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Three groups of consecutive PD patients, 50 on intestinal levodopa (CLDII), 50 on oral levodopa (O-LD) and 50 on other dopaminergic treatment (ODT), were enrolled in this study to assess frequency of PN using clinical and neurophysiological parameters. A biochemical study of all PN patients was performed.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Frequency of PN of no evident cause was 28% in CLDII, 20% in O-LD, and 6% in ODT patients. Clinically, 71% of CLDII patients and all O-LD and ODT PN patients displayed a subacute sensory PN. In contrast, 29% of CLDII patients presented acute motor PN. Levodopa daily dose, vitamin B12 (VB12) and homocysteine (hcy) levels differed significantly in patients with PN compared to patients without PN.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Our findings support the relationship between levodopa and PN and confirm that an imbalance in VB12/hcy may be a key pathogenic factor. We suggest two different, possibly overlapping mechanisms of PN in patients on CDLII: axonal degeneration due to vitamin deficiency and inflammatory damage. Whether inflammatory damage is triggered by vitamin deficiency and/or by modifications in the intestinal micro-environment should be further explored. Proper vitamin supplementation may prevent peripheral damage in most cases.</AbstractText><CopyrightInformation>Copyright © 2013 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Mancini</LastName><ForeName>F</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Parkinson's Disease and Movement Disorders Centre, Neurology Unit, San Pio X Clinic, Fondazione Opera San Camillo, Milan, Italy. Electronic address: francesca.mancini@tin.it.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Comi</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Parkinson's Disease and Movement Disorders Centre, Department of Neurology, University of Eastern Piedmont "Amedeo Avogadro", Novara, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Oggioni</LastName><ForeName>G D</ForeName><Initials>GD</Initials><AffiliationInfo><Affiliation>Parkinson's Disease and Movement Disorders Centre, Department of Neurology, University of Eastern Piedmont "Amedeo Avogadro", Novara, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pacchetti</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Parkinson's Disease and Movement Disorders Centre, Neurological Institute IRCCS "C. Mondino", Pavia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Calandrella</LastName><ForeName>D</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Parkinson's Disease and Movement Disorders Centre, Neurology Unit, San Pio X Clinic, Fondazione Opera San Camillo, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Coletti Moja</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Neurology, Mauriziano Umberto I Hospital, Turin, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Riboldazzi</LastName><ForeName>G</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Parkinson's Disease and Movement Disorders Centre, University of Insubria, Varese, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tunesi</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Unit of Medical Statistics and Epidemiology, Department Translational Medicine, University of Eastern Piedmont "Amedeo Avogadro", Novara, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dal Fante</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Endoscopy Unit San Pio X Clinic, Fondazione Opera San Camillo, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Manfredi</LastName><ForeName>L</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Parkinson's Disease and Movement Disorders Centre, Neurology Unit, San Pio X Clinic, Fondazione Opera San Camillo, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lacerenza</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Parkinson's Disease and Movement Disorders Centre, Neurology Unit, San Pio X Clinic, Fondazione Opera San Camillo, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cantello</LastName><ForeName>R</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Parkinson's Disease and Movement Disorders Centre, Department of Neurology, University of Eastern Piedmont "Amedeo Avogadro", Novara, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Antonini</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department for Parkinson Disease, IRCCS San Camillo, Venice, Italy.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>09</Month><Day>25</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Parkinsonism Relat Disord</MedlineTA><NlmUniqueID>9513583</NlmUniqueID><ISSNLinking>1353-8020</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000978">Antiparkinson Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0LVT1QZ0BA</RegistryNumber><NameOfSubstance UI="D006710">Homocysteine</NameOfSubstance></Chemical><Chemical><RegistryNumber>46627O600J</RegistryNumber><NameOfSubstance UI="D007980">Levodopa</NameOfSubstance></Chemical><Chemical><RegistryNumber>935E97BOY8</RegistryNumber><NameOfSubstance UI="D005492">Folic Acid</NameOfSubstance></Chemical><Chemical><RegistryNumber>P6YC3EG204</RegistryNumber><NameOfSubstance UI="D014805">Vitamin B 12</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000978">Antiparkinson Agents</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000009">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D003430">Cross-Sectional Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004576">Electromyography</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005492">Folic Acid</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000097">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006710">Homocysteine</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000097">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007980">Levodopa</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000009">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000097">blood</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000150">complications</QualifierName><QualifierName MajorTopicYN="N" UI="Q000188">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010523">Peripheral Nervous System Diseases</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000097">blood</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000453">epidemiology</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000209">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D015995">Prevalence</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D014805">Vitamin B 12</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000097">blood</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Levodopa intestinal infusion</Keyword><Keyword MajorTopicYN="N">Neuropathy</Keyword><Keyword MajorTopicYN="N">Parkinson's disease</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2013</Year><Month>1</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2013</Year><Month>9</Month><Day>5</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2013</Year><Month>9</Month><Day>5</Day></PubMedPubDate><PubMedPubDate PubStatus="aheadofprint"><Year>2013</Year><Month>9</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>10</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2013</Year><Month>10</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>9</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24099722</ArticleId><ArticleId IdType="pii">S1353-8020(13)00337-4</ArticleId><ArticleId IdType="doi">10.1016/j.parkreldis.2013.09.007</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Italie</li></country><region><li>Piémont</li></region><settlement><li>Turin</li></settlement></list><tree><country name="Italie"><noRegion><name sortKey="Mancini, F" sort="Mancini, F" uniqKey="Mancini F" first="F" last="Mancini">F. Mancini</name></noRegion><name sortKey="Antonini, A" sort="Antonini, A" uniqKey="Antonini A" first="A" last="Antonini">A. Antonini</name><name sortKey="Calandrella, D" sort="Calandrella, D" uniqKey="Calandrella D" first="D" last="Calandrella">D. Calandrella</name><name sortKey="Cantello, R" sort="Cantello, R" uniqKey="Cantello R" first="R" last="Cantello">R. Cantello</name><name sortKey="Coletti Moja, M" sort="Coletti Moja, M" uniqKey="Coletti Moja M" first="M" last="Coletti Moja">M. Coletti Moja</name><name sortKey="Comi, C" sort="Comi, C" uniqKey="Comi C" first="C" last="Comi">C. Comi</name><name sortKey="Dal Fante, M" sort="Dal Fante, M" uniqKey="Dal Fante M" first="M" last="Dal Fante">M. Dal Fante</name><name sortKey="Lacerenza, M" sort="Lacerenza, M" uniqKey="Lacerenza M" first="M" last="Lacerenza">M. Lacerenza</name><name sortKey="Manfredi, L" sort="Manfredi, L" uniqKey="Manfredi L" first="L" last="Manfredi">L. Manfredi</name><name sortKey="Oggioni, G D" sort="Oggioni, G D" uniqKey="Oggioni G" first="G D" last="Oggioni">G D Oggioni</name><name sortKey="Pacchetti, C" sort="Pacchetti, C" uniqKey="Pacchetti C" first="C" last="Pacchetti">C. Pacchetti</name><name sortKey="Riboldazzi, G" sort="Riboldazzi, G" uniqKey="Riboldazzi G" first="G" last="Riboldazzi">G. Riboldazzi</name><name sortKey="Tunesi, S" sort="Tunesi, S" uniqKey="Tunesi S" first="S" last="Tunesi">S. Tunesi</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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