OperaV1, PascalFrancis, Corpus, bibRecord, 000326

Organ preservation surgery for advanced unilateral glottic and subglottic cancer

Identifieur interne : 000326 ( PascalFrancis/Corpus ); précédent : 000325; suivant : 000327

Organ preservation surgery for advanced unilateral glottic and subglottic cancer

Auteurs : Pierre Delaere ; Ann Goeleven ; Vincent Vander Poorten ; Robert Hermans ; Robert Hierner ; Jan Vranckx

Source :

The Laryngoscope [ 0023-852X ] ; 2007.

RBID : Pascal:07-0475045

Descripteurs français

Pascal (Inist)
- Cancer glotte, Tumeur maligne, Chondrosarcome, Chirurgie, Autotransplantation, Conservation organe, Stade avancé, Unilatéral, Sousglotte, Cartilage cricoïde, Trachée, Revascularisation, Traitement, Sarcome.

English descriptors

KwdEn :
- Advanced stage, Autotransplantation, Chondrosarcoma, Cricoid cartilage, Glottis cancer, Malignant tumor, Organ preservation, Revascularization, Sarcoma, Subglottis, Surgery, Trachea, Treatment, Unilateral.

Abstract

Objectives: Functional surgery of unilateral T_2b to T3 glottic cancer and cricoid chondrosarcoma is possible using the technique of tracheal autotransplantation. The objective of this paper is to report the functional and oncologic outcome of 24 consecutive patients treated with this technique between 2001 and 2007. Methods: Seventeen patients, of whom nine were previously irradiated, had unilateral glottic cancer with impaired mobility of the vocal fold. Clinical staging was T_2b to₃N₀. Seven patients had a chondrosarcoma of the cricoid cartilage. In a first operation, an extended hemilaryngectomy was performed, and a radial forearm flap, comprising a distal fascial and a proximal skin component, was transferred to the neck. The fascial paddle was wrapped around the upper 4-cm segment of cervical trachea, and the skin paddle was used for temporary closure of the extended hemilaryngectomy defect. The definitive reconstruction was performed after 2 to 3 months and consisted of removal of the skin paddle from the laryngeal defect and a transplantation of a patch of revascularized cervical trachea to reconstruct the laryngeal defect. Results: Swallowing and speech were restored after the first operation. The glottic and subglottic airway lumen was restored during the second opera; tion. The tracheostomy could be closed in 20 patients. After a median follow-up period of 33 (range, 1-66) months or almost 3 years, 23 patients remained free of tumor recurrence. Conclusions: Tracheal autotransplantation can be recommended as a functional treatment for selected T_2b to T₃ glottic cancers and for unilateral chondrosarcomas of the cricoid cartilage. The technique is oncologically robust while resulting in good postoperative function.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A08	`01`	`1`	`ENG`	`@1 Organ preservation surgery for advanced unilateral glottic and subglottic cancer`
A11	`01`	`1`		`@1 DELAERE (Pierre)`
A11	`02`	`1`		`@1 GOELEVEN (Ann)`
A11	`03`	`1`		`@1 VANDER POORTEN (Vincent)`
A11	`04`	`1`		`@1 HERMANS (Robert)`
A11	`05`	`1`		`@1 HIERNER (Robert)`
A11	`06`	`1`		`@1 VRANCKX (Jan)`
A14	`01`			`@1 Department of Otorhinolaryngology-Head and Neck Surgery, University Hospital K.U. Leuven @2 Leuven @3 BEL @Z 1 aut. @Z 2 aut. @Z 3 aut.`
A14	`02`			`@1 Department of Radiology, University Hospital K.U. Leuven @2 Leuven @3 BEL @Z 4 aut.`
A14	`03`			`@1 Department of Plastic and Reconstructive Surgery, University Hospital K.U. Leuven @2 Leuven @3 BEL @Z 5 aut. @Z 6 aut.`
A20				`@1 1764-1769`
A21				`@1 2007`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 3102 @5 354000143487920100`
A44				`@0 0000 @1 © 2007 INIST-CNRS. All rights reserved.`
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A64	`01`	`1`		`@0 The Laryngoscope`
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C01	`01`		`ENG`	@0 Objectives: Functional surgery of unilateral T_2b to T3 glottic cancer and cricoid chondrosarcoma is possible using the technique of tracheal autotransplantation. The objective of this paper is to report the functional and oncologic outcome of 24 consecutive patients treated with this technique between 2001 and 2007. Methods: Seventeen patients, of whom nine were previously irradiated, had unilateral glottic cancer with impaired mobility of the vocal fold. Clinical staging was T_2b to₃N₀. Seven patients had a chondrosarcoma of the cricoid cartilage. In a first operation, an extended hemilaryngectomy was performed, and a radial forearm flap, comprising a distal fascial and a proximal skin component, was transferred to the neck. The fascial paddle was wrapped around the upper 4-cm segment of cervical trachea, and the skin paddle was used for temporary closure of the extended hemilaryngectomy defect. The definitive reconstruction was performed after 2 to 3 months and consisted of removal of the skin paddle from the laryngeal defect and a transplantation of a patch of revascularized cervical trachea to reconstruct the laryngeal defect. Results: Swallowing and speech were restored after the first operation. The glottic and subglottic airway lumen was restored during the second opera; tion. The tracheostomy could be closed in 20 patients. After a median follow-up period of 33 (range, 1-66) months or almost 3 years, 23 patients remained free of tumor recurrence. Conclusions: Tracheal autotransplantation can be recommended as a functional treatment for selected T_2b to T₃ glottic cancers and for unilateral chondrosarcomas of the cricoid cartilage. The technique is oncologically robust while resulting in good postoperative function.
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C02	`02`	`X`		`@0 002B15C`
C03	`01`	`X`	`FRE`	`@0 Cancer glotte @2 NM @5 01`
C03	`01`	`X`	`ENG`	`@0 Glottis cancer @2 NM @5 01`
C03	`01`	`X`	`SPA`	`@0 Cáncer glotis @2 NM @5 01`
C03	`02`	`X`	`FRE`	`@0 Tumeur maligne @5 02`
C03	`02`	`X`	`ENG`	`@0 Malignant tumor @5 02`
C03	`02`	`X`	`SPA`	`@0 Tumor maligno @5 02`
C03	`03`	`X`	`FRE`	`@0 Chondrosarcome @5 03`
C03	`03`	`X`	`ENG`	`@0 Chondrosarcoma @5 03`
C03	`03`	`X`	`SPA`	`@0 Condrosarcoma @5 03`
C03	`04`	`X`	`FRE`	`@0 Chirurgie @5 04`
C03	`04`	`X`	`ENG`	`@0 Surgery @5 04`
C03	`04`	`X`	`SPA`	`@0 Cirugía @5 04`
C03	`05`	`X`	`FRE`	`@0 Autotransplantation @5 05`
C03	`05`	`X`	`ENG`	`@0 Autotransplantation @5 05`
C03	`05`	`X`	`SPA`	`@0 Autotrasplante @5 05`
C03	`06`	`X`	`FRE`	`@0 Conservation organe @5 07`
C03	`06`	`X`	`ENG`	`@0 Organ preservation @5 07`
C03	`06`	`X`	`SPA`	`@0 Conservación organo @5 07`
C03	`07`	`X`	`FRE`	`@0 Stade avancé @5 08`
C03	`07`	`X`	`ENG`	`@0 Advanced stage @5 08`
C03	`07`	`X`	`SPA`	`@0 Estadio avanzado @5 08`
C03	`08`	`X`	`FRE`	`@0 Unilatéral @5 09`
C03	`08`	`X`	`ENG`	`@0 Unilateral @5 09`
C03	`08`	`X`	`SPA`	`@0 Unilateral @5 09`
C03	`09`	`X`	`FRE`	`@0 Sousglotte @5 13`
C03	`09`	`X`	`ENG`	`@0 Subglottis @5 13`
C03	`09`	`X`	`SPA`	`@0 Subglotis @5 13`
C03	`10`	`X`	`FRE`	`@0 Cartilage cricoïde @5 14`
C03	`10`	`X`	`ENG`	`@0 Cricoid cartilage @5 14`
C03	`10`	`X`	`SPA`	`@0 Cartílago cricoides @5 14`
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C03	`13`	`X`	`FRE`	`@0 Traitement @5 30`
C03	`13`	`X`	`ENG`	`@0 Treatment @5 30`
C03	`13`	`X`	`SPA`	`@0 Tratamiento @5 30`
C03	`14`	`X`	`FRE`	`@0 Sarcome @5 31`
C03	`14`	`X`	`ENG`	`@0 Sarcoma @5 31`
C03	`14`	`X`	`SPA`	`@0 Sarcoma @5 31`
C07	`01`	`X`	`FRE`	`@0 ORL pathologie @5 37`
C07	`01`	`X`	`ENG`	`@0 ENT disease @5 37`
C07	`01`	`X`	`SPA`	`@0 ORL patología @5 37`
C07	`02`	`X`	`FRE`	`@0 Larynx pathologie @5 38`
C07	`02`	`X`	`ENG`	`@0 Larynx disease @5 38`
C07	`02`	`X`	`SPA`	`@0 Laringe patología @5 38`
C07	`03`	`X`	`FRE`	`@0 Système ostéoarticulaire pathologie @5 39`
C07	`03`	`X`	`ENG`	`@0 Diseases of the osteoarticular system @5 39`
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C07	`05`	`X`	`FRE`	`@0 Greffe @5 41`
C07	`05`	`X`	`ENG`	`@0 Graft @5 41`
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N21				`@1 309`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 07-0475045 INIST
ET :	Organ preservation surgery for advanced unilateral glottic and subglottic cancer
AU :	DELAERE (Pierre); GOELEVEN (Ann); VANDER POORTEN (Vincent); HERMANS (Robert); HIERNER (Robert); VRANCKX (Jan)
AF :	Department of Otorhinolaryngology-Head and Neck Surgery, University Hospital K.U. Leuven/Leuven/Belgique (1 aut., 2 aut., 3 aut.); Department of Radiology, University Hospital K.U. Leuven/Leuven/Belgique (4 aut.); Department of Plastic and Reconstructive Surgery, University Hospital K.U. Leuven/Leuven/Belgique (5 aut., 6 aut.)
DT :	Publication en série; Niveau analytique
SO :	The Laryngoscope; ISSN 0023-852X; Coden LARYA8; Etats-Unis; Da. 2007; Vol. 117; No. 10; Pp. 1764-1769; Bibl. 9 ref.
LA :	Anglais
EA :	Objectives: Functional surgery of unilateral T_2b to T3 glottic cancer and cricoid chondrosarcoma is possible using the technique of tracheal autotransplantation. The objective of this paper is to report the functional and oncologic outcome of 24 consecutive patients treated with this technique between 2001 and 2007. Methods: Seventeen patients, of whom nine were previously irradiated, had unilateral glottic cancer with impaired mobility of the vocal fold. Clinical staging was T_2b to₃N₀. Seven patients had a chondrosarcoma of the cricoid cartilage. In a first operation, an extended hemilaryngectomy was performed, and a radial forearm flap, comprising a distal fascial and a proximal skin component, was transferred to the neck. The fascial paddle was wrapped around the upper 4-cm segment of cervical trachea, and the skin paddle was used for temporary closure of the extended hemilaryngectomy defect. The definitive reconstruction was performed after 2 to 3 months and consisted of removal of the skin paddle from the laryngeal defect and a transplantation of a patch of revascularized cervical trachea to reconstruct the laryngeal defect. Results: Swallowing and speech were restored after the first operation. The glottic and subglottic airway lumen was restored during the second opera; tion. The tracheostomy could be closed in 20 patients. After a median follow-up period of 33 (range, 1-66) months or almost 3 years, 23 patients remained free of tumor recurrence. Conclusions: Tracheal autotransplantation can be recommended as a functional treatment for selected T_2b to T₃ glottic cancers and for unilateral chondrosarcomas of the cricoid cartilage. The technique is oncologically robust while resulting in good postoperative function.
CC :	002B10B01; 002B15C
FD :	Cancer glotte; Tumeur maligne; Chondrosarcome; Chirurgie; Autotransplantation; Conservation organe; Stade avancé; Unilatéral; Sousglotte; Cartilage cricoïde; Trachée; Revascularisation; Traitement; Sarcome
FG :	ORL pathologie; Larynx pathologie; Système ostéoarticulaire pathologie; Transplantation; Greffe
ED :	Glottis cancer; Malignant tumor; Chondrosarcoma; Surgery; Autotransplantation; Organ preservation; Advanced stage; Unilateral; Subglottis; Cricoid cartilage; Trachea; Revascularization; Treatment; Sarcoma
EG :	ENT disease; Larynx disease; Diseases of the osteoarticular system; Transplantation; Graft
SD :	Cáncer glotis; Tumor maligno; Condrosarcoma; Cirugía; Autotrasplante; Conservación organo; Estadio avanzado; Unilateral; Subglotis; Cartílago cricoides; Tráquea; Revascularización; Tratamiento; Sarcoma
LO :	INIST-3102.354000143487920100
ID :	07-0475045

Links to Exploration step

Pascal:07-0475045

Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Advanced stage</term>
<term>Autotransplantation</term>
<term>Chondrosarcoma</term>
<term>Cricoid cartilage</term>
<term>Glottis cancer</term>
<term>Malignant tumor</term>
<term>Organ preservation</term>
<term>Revascularization</term>
<term>Sarcoma</term>
<term>Subglottis</term>
<term>Surgery</term>
<term>Trachea</term>
<term>Treatment</term>
<term>Unilateral</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Cancer glotte</term>
<term>Tumeur maligne</term>
<term>Chondrosarcome</term>
<term>Chirurgie</term>
<term>Autotransplantation</term>
<term>Conservation organe</term>
<term>Stade avancé</term>
<term>Unilatéral</term>
<term>Sousglotte</term>
<term>Cartilage cricoïde</term>
<term>Trachée</term>
<term>Revascularisation</term>
<term>Traitement</term>
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<front><div type="abstract" xml:lang="en">Objectives: Functional surgery of unilateral T<sub>2b</sub>
 to T3 glottic cancer and cricoid chondrosarcoma is possible using the technique of tracheal autotransplantation. The objective of this paper is to report the functional and oncologic outcome of 24 consecutive patients treated with this technique between 2001 and 2007. Methods: Seventeen patients, of whom nine were previously irradiated, had unilateral glottic cancer with impaired mobility of the vocal fold. Clinical staging was T<sub>2b</sub>
 to<sub> 3</sub>
N<sub>0</sub>
. Seven patients had a chondrosarcoma of the cricoid cartilage. In a first operation, an extended hemilaryngectomy was performed, and a radial forearm flap, comprising a distal fascial and a proximal skin component, was transferred to the neck. The fascial paddle was wrapped around the upper 4-cm segment of cervical trachea, and the skin paddle was used for temporary closure of the extended hemilaryngectomy defect. The definitive reconstruction was performed after 2 to 3 months and consisted of removal of the skin paddle from the laryngeal defect and a transplantation of a patch of revascularized cervical trachea to reconstruct the laryngeal defect. Results: Swallowing and speech were restored after the first operation. The glottic and subglottic airway lumen was restored during the second opera; tion. The tracheostomy could be closed in 20 patients. After a median follow-up period of 33 (range, 1-66) months or almost 3 years, 23 patients remained free of tumor recurrence. Conclusions: Tracheal autotransplantation can be recommended as a functional treatment for selected T<sub>2b</sub>
 to T<sub>3</sub>
 glottic cancers and for unilateral chondrosarcomas of the cricoid cartilage. The technique is oncologically robust while resulting in good postoperative function.</div>
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<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Department of Radiology, University Hospital K.U. Leuven</s1>
<s2>Leuven</s2>
<s3>BEL</s3>
<sZ>4 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Department of Plastic and Reconstructive Surgery, University Hospital K.U. Leuven</s1>
<s2>Leuven</s2>
<s3>BEL</s3>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</fA14>
<fA20><s1>1764-1769</s1>
</fA20>
<fA21><s1>2007</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>3102</s2>
<s5>354000143487920100</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2007 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>9 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>07-0475045</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>The Laryngoscope</s0>
</fA64>
<fA66 i1="01"><s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Objectives: Functional surgery of unilateral T<sub>2b</sub>
 to T3 glottic cancer and cricoid chondrosarcoma is possible using the technique of tracheal autotransplantation. The objective of this paper is to report the functional and oncologic outcome of 24 consecutive patients treated with this technique between 2001 and 2007. Methods: Seventeen patients, of whom nine were previously irradiated, had unilateral glottic cancer with impaired mobility of the vocal fold. Clinical staging was T<sub>2b</sub>
 to<sub> 3</sub>
N<sub>0</sub>
. Seven patients had a chondrosarcoma of the cricoid cartilage. In a first operation, an extended hemilaryngectomy was performed, and a radial forearm flap, comprising a distal fascial and a proximal skin component, was transferred to the neck. The fascial paddle was wrapped around the upper 4-cm segment of cervical trachea, and the skin paddle was used for temporary closure of the extended hemilaryngectomy defect. The definitive reconstruction was performed after 2 to 3 months and consisted of removal of the skin paddle from the laryngeal defect and a transplantation of a patch of revascularized cervical trachea to reconstruct the laryngeal defect. Results: Swallowing and speech were restored after the first operation. The glottic and subglottic airway lumen was restored during the second opera; tion. The tracheostomy could be closed in 20 patients. After a median follow-up period of 33 (range, 1-66) months or almost 3 years, 23 patients remained free of tumor recurrence. Conclusions: Tracheal autotransplantation can be recommended as a functional treatment for selected T<sub>2b</sub>
 to T<sub>3</sub>
 glottic cancers and for unilateral chondrosarcomas of the cricoid cartilage. The technique is oncologically robust while resulting in good postoperative function.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B10B01</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B15C</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Cancer glotte</s0>
<s2>NM</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Glottis cancer</s0>
<s2>NM</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Cáncer glotis</s0>
<s2>NM</s2>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Tumeur maligne</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Malignant tumor</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Tumor maligno</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Chondrosarcome</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Chondrosarcoma</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Condrosarcoma</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Chirurgie</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Surgery</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Cirugía</s0>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Autotransplantation</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Autotransplantation</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Autotrasplante</s0>
<s5>05</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Conservation organe</s0>
<s5>07</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Organ preservation</s0>
<s5>07</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Conservación organo</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Stade avancé</s0>
<s5>08</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Advanced stage</s0>
<s5>08</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Estadio avanzado</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Unilatéral</s0>
<s5>09</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Unilateral</s0>
<s5>09</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Unilateral</s0>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Sousglotte</s0>
<s5>13</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Subglottis</s0>
<s5>13</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Subglotis</s0>
<s5>13</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Cartilage cricoïde</s0>
<s5>14</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Cricoid cartilage</s0>
<s5>14</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Cartílago cricoides</s0>
<s5>14</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE"><s0>Trachée</s0>
<s5>15</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG"><s0>Trachea</s0>
<s5>15</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA"><s0>Tráquea</s0>
<s5>15</s5>
</fC03>
<fC03 i1="12" i2="X" l="FRE"><s0>Revascularisation</s0>
<s5>16</s5>
</fC03>
<fC03 i1="12" i2="X" l="ENG"><s0>Revascularization</s0>
<s5>16</s5>
</fC03>
<fC03 i1="12" i2="X" l="SPA"><s0>Revascularización</s0>
<s5>16</s5>
</fC03>
<fC03 i1="13" i2="X" l="FRE"><s0>Traitement</s0>
<s5>30</s5>
</fC03>
<fC03 i1="13" i2="X" l="ENG"><s0>Treatment</s0>
<s5>30</s5>
</fC03>
<fC03 i1="13" i2="X" l="SPA"><s0>Tratamiento</s0>
<s5>30</s5>
</fC03>
<fC03 i1="14" i2="X" l="FRE"><s0>Sarcome</s0>
<s5>31</s5>
</fC03>
<fC03 i1="14" i2="X" l="ENG"><s0>Sarcoma</s0>
<s5>31</s5>
</fC03>
<fC03 i1="14" i2="X" l="SPA"><s0>Sarcoma</s0>
<s5>31</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>ORL pathologie</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>ENT disease</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>ORL patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Larynx pathologie</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Larynx disease</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Laringe patología</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Système ostéoarticulaire pathologie</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Diseases of the osteoarticular system</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Sistema osteoarticular patología</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Transplantation</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Transplantation</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Trasplantación</s0>
<s5>40</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Greffe</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Graft</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Injerto</s0>
<s5>41</s5>
</fC07>
<fN21><s1>309</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
<server><NO>PASCAL 07-0475045 INIST</NO>
<ET>Organ preservation surgery for advanced unilateral glottic and subglottic cancer</ET>
<AU>DELAERE (Pierre); GOELEVEN (Ann); VANDER POORTEN (Vincent); HERMANS (Robert); HIERNER (Robert); VRANCKX (Jan)</AU>
<AF>Department of Otorhinolaryngology-Head and Neck Surgery, University Hospital K.U. Leuven/Leuven/Belgique (1 aut., 2 aut., 3 aut.); Department of Radiology, University Hospital K.U. Leuven/Leuven/Belgique (4 aut.); Department of Plastic and Reconstructive Surgery, University Hospital K.U. Leuven/Leuven/Belgique (5 aut., 6 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>The Laryngoscope; ISSN 0023-852X; Coden LARYA8; Etats-Unis; Da. 2007; Vol. 117; No. 10; Pp. 1764-1769; Bibl. 9 ref.</SO>
<LA>Anglais</LA>
<EA>Objectives: Functional surgery of unilateral T<sub>2b</sub>
 to T3 glottic cancer and cricoid chondrosarcoma is possible using the technique of tracheal autotransplantation. The objective of this paper is to report the functional and oncologic outcome of 24 consecutive patients treated with this technique between 2001 and 2007. Methods: Seventeen patients, of whom nine were previously irradiated, had unilateral glottic cancer with impaired mobility of the vocal fold. Clinical staging was T<sub>2b</sub>
 to<sub> 3</sub>
N<sub>0</sub>
. Seven patients had a chondrosarcoma of the cricoid cartilage. In a first operation, an extended hemilaryngectomy was performed, and a radial forearm flap, comprising a distal fascial and a proximal skin component, was transferred to the neck. The fascial paddle was wrapped around the upper 4-cm segment of cervical trachea, and the skin paddle was used for temporary closure of the extended hemilaryngectomy defect. The definitive reconstruction was performed after 2 to 3 months and consisted of removal of the skin paddle from the laryngeal defect and a transplantation of a patch of revascularized cervical trachea to reconstruct the laryngeal defect. Results: Swallowing and speech were restored after the first operation. The glottic and subglottic airway lumen was restored during the second opera; tion. The tracheostomy could be closed in 20 patients. After a median follow-up period of 33 (range, 1-66) months or almost 3 years, 23 patients remained free of tumor recurrence. Conclusions: Tracheal autotransplantation can be recommended as a functional treatment for selected T<sub>2b</sub>
 to T<sub>3</sub>
 glottic cancers and for unilateral chondrosarcomas of the cricoid cartilage. The technique is oncologically robust while resulting in good postoperative function.</EA>
<CC>002B10B01; 002B15C</CC>
<FD>Cancer glotte; Tumeur maligne; Chondrosarcome; Chirurgie; Autotransplantation; Conservation organe; Stade avancé; Unilatéral; Sousglotte; Cartilage cricoïde; Trachée; Revascularisation; Traitement; Sarcome</FD>
<FG>ORL pathologie; Larynx pathologie; Système ostéoarticulaire pathologie; Transplantation; Greffe</FG>
<ED>Glottis cancer; Malignant tumor; Chondrosarcoma; Surgery; Autotransplantation; Organ preservation; Advanced stage; Unilateral; Subglottis; Cricoid cartilage; Trachea; Revascularization; Treatment; Sarcoma</ED>
<EG>ENT disease; Larynx disease; Diseases of the osteoarticular system; Transplantation; Graft</EG>
<SD>Cáncer glotis; Tumor maligno; Condrosarcoma; Cirugía; Autotrasplante; Conservación organo; Estadio avanzado; Unilateral; Subglotis; Cartílago cricoides; Tráquea; Revascularización; Tratamiento; Sarcoma</SD>
<LO>INIST-3102.354000143487920100</LO>
<ID>07-0475045</ID>
</server>
</inist>
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Organ preservation surgery for advanced unilateral glottic and subglottic cancer

Organ preservation surgery for advanced unilateral glottic and subglottic cancer

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