Serum levels of C-terminal agrin fragment (CAF) are associated with sarcopenia in older multimorbid community-dwellers: Results from the ilSIRENTE study.
Identifieur interne : 000F05 ( Ncbi/Merge ); précédent : 000F04; suivant : 000F06Serum levels of C-terminal agrin fragment (CAF) are associated with sarcopenia in older multimorbid community-dwellers: Results from the ilSIRENTE study.
Auteurs : Francesco Landi [Italie] ; Riccardo Calvani [Italie] ; Maria Lorenzi [Italie] ; Anna Maria Martone [Italie] ; Matteo Tosato [Italie] ; Michael Drey [Allemagne] ; Emanuela D'Angelo [Italie] ; Ettore Capoluongo [Italie] ; Andrea Russo [Italie] ; Roberto Bernabei [Italie] ; Graziano Onder [Italie] ; Emanuele Marzetti [Italie]Source :
- Experimental gerontology ; 2016.
Abstract
The C-terminal agrin fragment (CAF), a circulating byproduct of neuromuscular junction disassembly, has been proposed as a possible biomarker for sarcopenia. However, its validity in "real-world", multimorbid older persons is currently unknown. The present study was undertaken to verify if serum CAF levels were associated with sarcopenia in a population of old and very old persons living in the community.
DOI: 10.1016/j.exger.2016.03.012
PubMed: 27015736
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L'Aquila, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Teaching Nursing Home "Opera Santa Maria della Pace", Fontecchio-Celano, L'Aquila</wicri:regionArea><wicri:noRegion>L'Aquila</wicri:noRegion></affiliation></author><author><name sortKey="Bernabei, Roberto" sort="Bernabei, Roberto" uniqKey="Bernabei R" first="Roberto" last="Bernabei">Roberto Bernabei</name><affiliation wicri:level="3"><nlm:affiliation>Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Onder, Graziano" sort="Onder, Graziano" uniqKey="Onder G" first="Graziano" last="Onder">Graziano 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Electronic address: emarzetti@live.com.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27015736</idno><idno type="pmid">27015736</idno><idno type="doi">10.1016/j.exger.2016.03.012</idno><idno type="wicri:Area/PubMed/Corpus">000004</idno><idno type="wicri:Area/PubMed/Curation">000004</idno><idno type="wicri:Area/PubMed/Checkpoint">000010</idno><idno type="wicri:Area/Ncbi/Merge">000F05</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Serum levels of C-terminal agrin fragment (CAF) are associated with sarcopenia in older multimorbid community-dwellers: Results from the ilSIRENTE study.</title><author><name sortKey="Landi, Francesco" sort="Landi, Francesco" uniqKey="Landi F" first="Francesco" last="Landi">Francesco Landi</name><affiliation wicri:level="3"><nlm:affiliation>Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, Rome, Italy. Electronic address: francesco.landi@rm.unicatt.it.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Calvani, Riccardo" sort="Calvani, Riccardo" uniqKey="Calvani R" first="Riccardo" last="Calvani">Riccardo Calvani</name><affiliation wicri:level="3"><nlm:affiliation>Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Lorenzi, Maria" sort="Lorenzi, Maria" uniqKey="Lorenzi M" first="Maria" last="Lorenzi">Maria Lorenzi</name><affiliation wicri:level="3"><nlm:affiliation>Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Martone, Anna Maria" sort="Martone, Anna Maria" uniqKey="Martone A" first="Anna Maria" last="Martone">Anna Maria Martone</name><affiliation wicri:level="3"><nlm:affiliation>Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Tosato, Matteo" sort="Tosato, Matteo" uniqKey="Tosato M" first="Matteo" last="Tosato">Matteo Tosato</name><affiliation wicri:level="3"><nlm:affiliation>Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Drey, Michael" sort="Drey, Michael" uniqKey="Drey M" first="Michael" last="Drey">Michael Drey</name><affiliation wicri:level="3"><nlm:affiliation>Medizinische Klinik und Poliklinik IV, Schwerpunkt Akutgeriatrie, Klinikum der Universitat Munchen, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Medizinische Klinik und Poliklinik IV, Schwerpunkt Akutgeriatrie, Klinikum der Universitat Munchen, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="D Angelo, Emanuela" sort="D Angelo, Emanuela" uniqKey="D Angelo E" first="Emanuela" last="D'Angelo">Emanuela D'Angelo</name><affiliation wicri:level="3"><nlm:affiliation>Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Capoluongo, Ettore" sort="Capoluongo, Ettore" uniqKey="Capoluongo E" first="Ettore" last="Capoluongo">Ettore Capoluongo</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Biochemistry and Clinical Biochemistry, Catholic University of the Sacred Heart, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Biochemistry and Clinical Biochemistry, Catholic University of the Sacred Heart, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Russo, Andrea" sort="Russo, Andrea" uniqKey="Russo A" first="Andrea" last="Russo">Andrea Russo</name><affiliation wicri:level="1"><nlm:affiliation>Teaching Nursing Home "Opera Santa Maria della Pace", Fontecchio-Celano, L'Aquila, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Teaching Nursing Home "Opera Santa Maria della Pace", Fontecchio-Celano, L'Aquila</wicri:regionArea><wicri:noRegion>L'Aquila</wicri:noRegion></affiliation></author><author><name sortKey="Bernabei, Roberto" sort="Bernabei, Roberto" uniqKey="Bernabei R" first="Roberto" last="Bernabei">Roberto Bernabei</name><affiliation wicri:level="3"><nlm:affiliation>Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Onder, Graziano" sort="Onder, Graziano" uniqKey="Onder G" first="Graziano" last="Onder">Graziano Onder</name><affiliation wicri:level="3"><nlm:affiliation>Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Marzetti, Emanuele" sort="Marzetti, Emanuele" uniqKey="Marzetti E" first="Emanuele" last="Marzetti">Emanuele Marzetti</name><affiliation wicri:level="3"><nlm:affiliation>Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, Rome, Italy. Electronic address: emarzetti@live.com.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author></analytic><series><title level="j">Experimental gerontology</title><idno type="e-ISSN">1873-6815</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The C-terminal agrin fragment (CAF), a circulating byproduct of neuromuscular junction disassembly, has been proposed as a possible biomarker for sarcopenia. However, its validity in "real-world", multimorbid older persons is currently unknown. The present study was undertaken to verify if serum CAF levels were associated with sarcopenia in a population of old and very old persons living in the community.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">27015736</PMID><DateCreated><Year>2016</Year><Month>4</Month><Day>12</Day></DateCreated><DateRevised><Year>2016</Year><Month>4</Month><Day>12</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-6815</ISSN><JournalIssue CitedMedium="Internet"><Volume>79</Volume><PubDate><Year>2016</Year><Month>Mar</Month><Day>23</Day></PubDate></JournalIssue><Title>Experimental gerontology</Title><ISOAbbreviation>Exp. Gerontol.</ISOAbbreviation></Journal><ArticleTitle>Serum levels of C-terminal agrin fragment (CAF) are associated with sarcopenia in older multimorbid community-dwellers: Results from the ilSIRENTE study.</ArticleTitle><Pagination><MedlinePgn>31-36</MedlinePgn></Pagination><ELocationID EIdType="pii">S0531-5565(16)30080-8</ELocationID><ELocationID EIdType="doi">10.1016/j.exger.2016.03.012</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The C-terminal agrin fragment (CAF), a circulating byproduct of neuromuscular junction disassembly, has been proposed as a possible biomarker for sarcopenia. However, its validity in "real-world", multimorbid older persons is currently unknown. The present study was undertaken to verify if serum CAF levels were associated with sarcopenia in a population of old and very old persons living in the community.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Data were from the ilSIRENTE Aging and Longevity Study, a prospective cohort study conducted in all persons aged 80years and older residing in the Sirente geographic area (Italy; n=332). The identification of sarcopenia was based on the criteria elaborated by the European Working Group on Sarcopenia in Older People (EWGSOP). Serum levels of CAF were determined using a commercial ELISA kit.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Sarcopenia was identified in 101 participants (30.8%). Serum levels of CAF were significantly higher in older adults with sarcopenia compared with non-sarcopenic participants (96.99±5.40pmol/L vs. 76.54±2.15pmol/L; p<0.001). The association remained significant in both genders after adjustment for several possible confounding factors, including age, cognition, disability status, body mass index, congestive heart failure, lung diseases, diabetes, renal failure, and plasma levels of C-reactive protein and interleukin 6.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Our results obtained from a fairly large sample of old and very old, multimorbid community-dwellers show that elevated serum CAF levels are associated with sarcopenia, independent of age, gender and several clinical, functional, anthropometric, and biochemical variables. The determination of serum CAF concentration may therefore be proposed as a simple screening test for sarcopenia in the community.</AbstractText><CopyrightInformation>Copyright © 2016 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList><Author><LastName>Landi</LastName><ForeName>Francesco</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, Rome, Italy. Electronic address: francesco.landi@rm.unicatt.it.</Affiliation></AffiliationInfo></Author><Author><LastName>Calvani</LastName><ForeName>Riccardo</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, Rome, Italy.</Affiliation></AffiliationInfo></Author><Author><LastName>Lorenzi</LastName><ForeName>Maria</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, Rome, Italy.</Affiliation></AffiliationInfo></Author><Author><LastName>Martone</LastName><ForeName>Anna Maria</ForeName><Initials>AM</Initials><AffiliationInfo><Affiliation>Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, Rome, Italy.</Affiliation></AffiliationInfo></Author><Author><LastName>Tosato</LastName><ForeName>Matteo</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, Rome, Italy.</Affiliation></AffiliationInfo></Author><Author><LastName>Drey</LastName><ForeName>Michael</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Medizinische Klinik und Poliklinik IV, Schwerpunkt Akutgeriatrie, Klinikum der Universitat Munchen, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author><LastName>D'Angelo</LastName><ForeName>Emanuela</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, Rome, Italy.</Affiliation></AffiliationInfo></Author><Author><LastName>Capoluongo</LastName><ForeName>Ettore</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Institute of Biochemistry and Clinical Biochemistry, Catholic University of the Sacred Heart, Rome, Italy.</Affiliation></AffiliationInfo></Author><Author><LastName>Russo</LastName><ForeName>Andrea</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Teaching Nursing Home "Opera Santa Maria della Pace", Fontecchio-Celano, L'Aquila, Italy.</Affiliation></AffiliationInfo></Author><Author><LastName>Bernabei</LastName><ForeName>Roberto</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, Rome, Italy.</Affiliation></AffiliationInfo></Author><Author><LastName>Onder</LastName><ForeName>Graziano</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, Rome, Italy.</Affiliation></AffiliationInfo></Author><Author><LastName>Marzetti</LastName><ForeName>Emanuele</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, Rome, Italy. Electronic address: emarzetti@live.com.</Affiliation></AffiliationInfo></Author></AuthorList><Language>ENG</Language><PublicationTypeList><PublicationType UI="">JOURNAL ARTICLE</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>3</Month><Day>23</Day></ArticleDate></Article><MedlineJournalInfo><MedlineTA>Exp Gerontol</MedlineTA><NlmUniqueID>0047061</NlmUniqueID><ISSNLinking>0531-5565</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Aging</Keyword><Keyword MajorTopicYN="N">Anthropometry</Keyword><Keyword MajorTopicYN="N">Biomarkers</Keyword><Keyword MajorTopicYN="N">Co-morbidity</Keyword><Keyword MajorTopicYN="N">Frailty</Keyword><Keyword MajorTopicYN="N">Functional impairment</Keyword><Keyword MajorTopicYN="N">Gait speed</Keyword><Keyword MajorTopicYN="N">Handgrip</Keyword><Keyword MajorTopicYN="N">Mid-arm muscle circumference</Keyword><Keyword MajorTopicYN="N">Muscle wasting</Keyword><Keyword MajorTopicYN="N">Neuromuscular junction</Keyword><Keyword MajorTopicYN="N">Physical performance</Keyword><Keyword MajorTopicYN="N">Renal failure</Keyword><Keyword MajorTopicYN="N">Skeletal muscle</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>2</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2016</Year><Month>3</Month><Day>3</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>3</Month><Day>21</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>3</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>3</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>3</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27015736</ArticleId><ArticleId IdType="pii">S0531-5565(16)30080-8</ArticleId><ArticleId IdType="doi">10.1016/j.exger.2016.03.012</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li><li>Italie</li></country><region><li>Bavière</li><li>District de Haute-Bavière</li><li>Latium</li></region><settlement><li>Munich</li><li>Rome</li></settlement></list><tree><country name="Italie"><region name="Latium"><name sortKey="Landi, Francesco" sort="Landi, Francesco" uniqKey="Landi F" first="Francesco" last="Landi">Francesco Landi</name></region><name sortKey="Bernabei, Roberto" sort="Bernabei, Roberto" uniqKey="Bernabei R" first="Roberto" last="Bernabei">Roberto Bernabei</name><name sortKey="Calvani, Riccardo" sort="Calvani, Riccardo" uniqKey="Calvani R" first="Riccardo" last="Calvani">Riccardo Calvani</name><name sortKey="Capoluongo, Ettore" sort="Capoluongo, Ettore" uniqKey="Capoluongo E" first="Ettore" last="Capoluongo">Ettore Capoluongo</name><name sortKey="D Angelo, Emanuela" sort="D Angelo, Emanuela" uniqKey="D Angelo E" first="Emanuela" last="D'Angelo">Emanuela D'Angelo</name><name sortKey="Lorenzi, Maria" sort="Lorenzi, Maria" uniqKey="Lorenzi M" first="Maria" last="Lorenzi">Maria Lorenzi</name><name sortKey="Martone, Anna Maria" sort="Martone, Anna Maria" uniqKey="Martone A" first="Anna Maria" last="Martone">Anna Maria Martone</name><name sortKey="Marzetti, Emanuele" sort="Marzetti, Emanuele" uniqKey="Marzetti E" first="Emanuele" last="Marzetti">Emanuele Marzetti</name><name sortKey="Onder, Graziano" sort="Onder, Graziano" uniqKey="Onder G" first="Graziano" last="Onder">Graziano Onder</name><name sortKey="Russo, Andrea" sort="Russo, Andrea" uniqKey="Russo A" first="Andrea" last="Russo">Andrea Russo</name><name sortKey="Tosato, Matteo" sort="Tosato, Matteo" uniqKey="Tosato M" first="Matteo" last="Tosato">Matteo Tosato</name></country><country name="Allemagne"><region name="Bavière"><name sortKey="Drey, Michael" sort="Drey, Michael" uniqKey="Drey M" first="Michael" last="Drey">Michael Drey</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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