Insulin levels in insulin resistance: phantom of the metabolic opera?
Identifieur interne : 000406 ( Ncbi/Merge ); précédent : 000405; suivant : 000407Insulin levels in insulin resistance: phantom of the metabolic opera?
Auteurs : Katherine Samaras [Australie] ; Aidan Mcelduff ; Stephen M. Twigg ; Joseph Proietto ; John B. Prins ; Timothy A. Welborn ; Paul Zimmet ; Donald J. Chisholm ; Lesley V. CampbellSource :
- The Medical journal of Australia [ 0025-729X ] ; 2006.
English descriptors
- KwdEn :
- MESH :
- chemical , blood : Insulin.
- blood : Metabolic Syndrome X.
- diagnosis : Metabolic Syndrome X.
- etiology : Cardiovascular Diseases.
- physiology : Insulin Resistance.
- physiopathology : Metabolic Syndrome X.
- Humans, Risk Factors.
Abstract
Insulin resistance is considered a core component in the pathophysiology of the metabolic syndrome. Some clinicians measure serum insulin concentrations in the mistaken belief that they can be used to diagnose insulin resistance. Serum insulin levels are poor measures of insulin resistance. Furthermore, there is no clinical benefit in measuring insulin resistance in clinical practice. Measurements of fasting serum insulin levels should be reserved for large population-based epidemiological studies, where they can provide valuable data on the relationship of insulin sensitivity to risk factors for diabetes and cardiovascular disease. Clinicians should shift from identifying "insulin resistance" to identifying risk factors, such as fasting glucose and lipid levels, hypertension and central obesity. These proven risk factors converge within the metabolic syndrome. Individuals "at risk" of diabetes and atherosclerotic cardiac disease can be identified simply and inexpensively, using classic clinical techniques, such as history-taking, physical examination, and very basic investigations.
PubMed: 16893359
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Insulin levels in insulin resistance: phantom of the metabolic opera?</title><author><name sortKey="Samaras, Katherine" sort="Samaras, Katherine" uniqKey="Samaras K" first="Katherine" last="Samaras">Katherine Samaras</name><affiliation wicri:level="1"><nlm:affiliation>Diabetes and Obesity Program, Garvan Institute of Medical Research, Sydney, New South Wales. k.samaras@arvan.org.au</nlm:affiliation><country wicri:rule="url">Australie</country></affiliation></author><author><name sortKey="Mcelduff, Aidan" sort="Mcelduff, Aidan" uniqKey="Mcelduff A" first="Aidan" last="Mcelduff">Aidan Mcelduff</name></author><author><name sortKey="Twigg, Stephen M" sort="Twigg, Stephen M" uniqKey="Twigg S" first="Stephen M" last="Twigg">Stephen M. Twigg</name></author><author><name sortKey="Proietto, Joseph" sort="Proietto, Joseph" uniqKey="Proietto J" first="Joseph" last="Proietto">Joseph Proietto</name></author><author><name sortKey="Prins, John B" sort="Prins, John B" uniqKey="Prins J" first="John B" last="Prins">John B. Prins</name></author><author><name sortKey="Welborn, Timothy A" sort="Welborn, Timothy A" uniqKey="Welborn T" first="Timothy A" last="Welborn">Timothy A. Welborn</name></author><author><name sortKey="Zimmet, Paul" sort="Zimmet, Paul" uniqKey="Zimmet P" first="Paul" last="Zimmet">Paul Zimmet</name></author><author><name sortKey="Chisholm, Donald J" sort="Chisholm, Donald J" uniqKey="Chisholm D" first="Donald J" last="Chisholm">Donald J. Chisholm</name></author><author><name sortKey="Campbell, Lesley V" sort="Campbell, Lesley V" uniqKey="Campbell L" first="Lesley V" last="Campbell">Lesley V. Campbell</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2006">2006</date><idno type="RBID">pubmed:16893359</idno><idno type="pmid">16893359</idno><idno type="wicri:Area/PubMed/Corpus">000482</idno><idno type="wicri:Area/PubMed/Curation">000482</idno><idno type="wicri:Area/PubMed/Checkpoint">000465</idno><idno type="wicri:Area/Ncbi/Merge">000406</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Insulin levels in insulin resistance: phantom of the metabolic opera?</title><author><name sortKey="Samaras, Katherine" sort="Samaras, Katherine" uniqKey="Samaras K" first="Katherine" last="Samaras">Katherine Samaras</name><affiliation wicri:level="1"><nlm:affiliation>Diabetes and Obesity Program, Garvan Institute of Medical Research, Sydney, New South Wales. k.samaras@arvan.org.au</nlm:affiliation><country wicri:rule="url">Australie</country></affiliation></author><author><name sortKey="Mcelduff, Aidan" sort="Mcelduff, Aidan" uniqKey="Mcelduff A" first="Aidan" last="Mcelduff">Aidan Mcelduff</name></author><author><name sortKey="Twigg, Stephen M" sort="Twigg, Stephen M" uniqKey="Twigg S" first="Stephen M" last="Twigg">Stephen M. Twigg</name></author><author><name sortKey="Proietto, Joseph" sort="Proietto, Joseph" uniqKey="Proietto J" first="Joseph" last="Proietto">Joseph Proietto</name></author><author><name sortKey="Prins, John B" sort="Prins, John B" uniqKey="Prins J" first="John B" last="Prins">John B. Prins</name></author><author><name sortKey="Welborn, Timothy A" sort="Welborn, Timothy A" uniqKey="Welborn T" first="Timothy A" last="Welborn">Timothy A. Welborn</name></author><author><name sortKey="Zimmet, Paul" sort="Zimmet, Paul" uniqKey="Zimmet P" first="Paul" last="Zimmet">Paul Zimmet</name></author><author><name sortKey="Chisholm, Donald J" sort="Chisholm, Donald J" uniqKey="Chisholm D" first="Donald J" last="Chisholm">Donald J. Chisholm</name></author><author><name sortKey="Campbell, Lesley V" sort="Campbell, Lesley V" uniqKey="Campbell L" first="Lesley V" last="Campbell">Lesley V. Campbell</name></author></analytic><series><title level="j">The Medical journal of Australia</title><idno type="ISSN">0025-729X</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cardiovascular Diseases (etiology)</term><term>Humans</term><term>Insulin (blood)</term><term>Insulin Resistance (physiology)</term><term>Metabolic Syndrome X (blood)</term><term>Metabolic Syndrome X (diagnosis)</term><term>Metabolic Syndrome X (physiopathology)</term><term>Risk Factors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Insulin</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Metabolic Syndrome X</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Metabolic Syndrome X</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cardiovascular Diseases</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Insulin Resistance</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Metabolic Syndrome X</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Risk Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Insulin resistance is considered a core component in the pathophysiology of the metabolic syndrome. Some clinicians measure serum insulin concentrations in the mistaken belief that they can be used to diagnose insulin resistance. Serum insulin levels are poor measures of insulin resistance. Furthermore, there is no clinical benefit in measuring insulin resistance in clinical practice. Measurements of fasting serum insulin levels should be reserved for large population-based epidemiological studies, where they can provide valuable data on the relationship of insulin sensitivity to risk factors for diabetes and cardiovascular disease. Clinicians should shift from identifying "insulin resistance" to identifying risk factors, such as fasting glucose and lipid levels, hypertension and central obesity. These proven risk factors converge within the metabolic syndrome. Individuals "at risk" of diabetes and atherosclerotic cardiac disease can be identified simply and inexpensively, using classic clinical techniques, such as history-taking, physical examination, and very basic investigations.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">16893359</PMID><DateCreated><Year>2006</Year><Month>08</Month><Day>08</Day></DateCreated><DateCompleted><Year>2006</Year><Month>09</Month><Day>12</Day></DateCompleted><DateRevised><Year>2011</Year><Month>11</Month><Day>17</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0025-729X</ISSN><JournalIssue CitedMedium="Print"><Volume>185</Volume><Issue>3</Issue><PubDate><Year>2006</Year><Month>Aug</Month><Day>7</Day></PubDate></JournalIssue><Title>The Medical journal of Australia</Title><ISOAbbreviation>Med. J. Aust.</ISOAbbreviation></Journal><ArticleTitle>Insulin levels in insulin resistance: phantom of the metabolic opera?</ArticleTitle><Pagination><MedlinePgn>159-61</MedlinePgn></Pagination><Abstract><AbstractText>Insulin resistance is considered a core component in the pathophysiology of the metabolic syndrome. Some clinicians measure serum insulin concentrations in the mistaken belief that they can be used to diagnose insulin resistance. Serum insulin levels are poor measures of insulin resistance. Furthermore, there is no clinical benefit in measuring insulin resistance in clinical practice. Measurements of fasting serum insulin levels should be reserved for large population-based epidemiological studies, where they can provide valuable data on the relationship of insulin sensitivity to risk factors for diabetes and cardiovascular disease. Clinicians should shift from identifying "insulin resistance" to identifying risk factors, such as fasting glucose and lipid levels, hypertension and central obesity. These proven risk factors converge within the metabolic syndrome. Individuals "at risk" of diabetes and atherosclerotic cardiac disease can be identified simply and inexpensively, using classic clinical techniques, such as history-taking, physical examination, and very basic investigations.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Samaras</LastName><ForeName>Katherine</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Diabetes and Obesity Program, Garvan Institute of Medical Research, Sydney, New South Wales. k.samaras@arvan.org.au</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McElduff</LastName><ForeName>Aidan</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Twigg</LastName><ForeName>Stephen M</ForeName><Initials>SM</Initials></Author><Author ValidYN="Y"><LastName>Proietto</LastName><ForeName>Joseph</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Prins</LastName><ForeName>John B</ForeName><Initials>JB</Initials></Author><Author ValidYN="Y"><LastName>Welborn</LastName><ForeName>Timothy A</ForeName><Initials>TA</Initials></Author><Author ValidYN="Y"><LastName>Zimmet</LastName><ForeName>Paul</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Chisholm</LastName><ForeName>Donald J</ForeName><Initials>DJ</Initials></Author><Author ValidYN="Y"><LastName>Campbell</LastName><ForeName>Lesley V</ForeName><Initials>LV</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Australia</Country><MedlineTA>Med J Aust</MedlineTA><NlmUniqueID>0400714</NlmUniqueID><ISSNLinking>0025-729X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007328">Insulin</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Med J Aust. 2007 Mar 5;186(5):268-9; author reply 271-2</RefSource><PMID Version="1">17391092</PMID></CommentsCorrections><CommentsCorrections RefType="CommentIn"><RefSource>Med J Aust. 2007 Mar 5;186(5):268; author reply 271-2</RefSource><PMID Version="1">17391093</PMID></CommentsCorrections><CommentsCorrections RefType="CommentIn"><RefSource>Med J Aust. 2007 Mar 5;186(5):269; author reply 271-2</RefSource><PMID Version="1">17391095</PMID></CommentsCorrections><CommentsCorrections RefType="CommentIn"><RefSource>Med J Aust. 2007 Mar 5;186(5):271; author reply 271-2</RefSource><PMID Version="1">17391099</PMID></CommentsCorrections><CommentsCorrections RefType="CommentIn"><RefSource>Med J Aust. 2007 Mar 5;186(5):270-1; author reply 271-2</RefSource><PMID Version="1">17391096</PMID></CommentsCorrections><CommentsCorrections RefType="CommentIn"><RefSource>Med J Aust. 2007 Mar 5;186(5):270; author reply 271-2</RefSource><PMID Version="1">17391097</PMID></CommentsCorrections><CommentsCorrections RefType="CommentIn"><RefSource>Med J Aust. 2007 Mar 5;186(5):269-70; author reply 271-2</RefSource><PMID Version="1">17391094</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D002318">Cardiovascular Diseases</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000209">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007328">Insulin</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000097">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007333">Insulin Resistance</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D024821">Metabolic Syndrome X</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000097">blood</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000175">diagnosis</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012307">Risk Factors</DescriptorName></MeshHeading></MeshHeadingList><NumberOfReferences>14</NumberOfReferences></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2006</Year><Month>3</Month><Day>5</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2006</Year><Month>5</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2006</Year><Month>8</Month><Day>9</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2006</Year><Month>9</Month><Day>13</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2006</Year><Month>8</Month><Day>9</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pii">sam10224_fm</ArticleId><ArticleId IdType="pubmed">16893359</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Australie</li></country></list><tree><noCountry><name sortKey="Campbell, Lesley V" sort="Campbell, Lesley V" uniqKey="Campbell L" first="Lesley V" last="Campbell">Lesley V. Campbell</name><name sortKey="Chisholm, Donald J" sort="Chisholm, Donald J" uniqKey="Chisholm D" first="Donald J" last="Chisholm">Donald J. Chisholm</name><name sortKey="Mcelduff, Aidan" sort="Mcelduff, Aidan" uniqKey="Mcelduff A" first="Aidan" last="Mcelduff">Aidan Mcelduff</name><name sortKey="Prins, John B" sort="Prins, John B" uniqKey="Prins J" first="John B" last="Prins">John B. Prins</name><name sortKey="Proietto, Joseph" sort="Proietto, Joseph" uniqKey="Proietto J" first="Joseph" last="Proietto">Joseph Proietto</name><name sortKey="Twigg, Stephen M" sort="Twigg, Stephen M" uniqKey="Twigg S" first="Stephen M" last="Twigg">Stephen M. Twigg</name><name sortKey="Welborn, Timothy A" sort="Welborn, Timothy A" uniqKey="Welborn T" first="Timothy A" last="Welborn">Timothy A. Welborn</name><name sortKey="Zimmet, Paul" sort="Zimmet, Paul" uniqKey="Zimmet P" first="Paul" last="Zimmet">Paul Zimmet</name></noCountry><country name="Australie"><noRegion><name sortKey="Samaras, Katherine" sort="Samaras, Katherine" uniqKey="Samaras K" first="Katherine" last="Samaras">Katherine Samaras</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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