Chitosan/dextran multilayer microcapsules for polyphenol co-delivery.
Identifieur interne : 000C79 ( Ncbi/Curation ); précédent : 000C78; suivant : 000C80Chitosan/dextran multilayer microcapsules for polyphenol co-delivery.
Auteurs : Marco Paini [Italie] ; Bahar Aliakbarian [Italie] ; Alessandro A. Casazza [Italie] ; Patrizia Perego [Italie] ; Carmelina Ruggiero [Italie] ; Laura Pastorino [Italie]Source :
- Materials science & engineering. C, Materials for biological applications ; 2015.
English descriptors
- KwdEn :
- MESH :
- chemical , administration & dosage : Polyphenols.
- chemical , chemistry : Chitosan, Dextrans.
- Chromatography, High Pressure Liquid, Microscopy, Electron, Scanning, Spectrophotometry, Ultraviolet.
Abstract
Polysaccharide-based nanostructured polymeric microcapsules were fabricated by the electrostatic layer-by-layer self-assembly technique and used to encapsulate mixtures of four different polyphenols in order to achieve their controlled release. The real-time fabrication of the dextran/chitosan multilayer was monitored by quartz crystal microbalance with dissipation monitoring, and the morphology of the nanostructured polymeric capsules was characterized by scanning electron microscopy. The polyphenol encapsulation was obtained by reversible permeability variation of the capsule shell in ethanol:water mixtures. The loading efficiency in different water:ethanol mixtures and the release rate in acidic conditions were characterized by UV spectroscopy and HPLC. The higher loading efficiency was obtained with an ethanol:water 35:65 phenolic solution, equal to 42.0±0.6%, with a total release of 11.5±0.7 mg of total polyphenols per 11.3 μL of microcapsules after 240 min of incubation in acidic environment. The results suggest that polysaccharide-based capsules can be successfully used to encapsulate and release low water-soluble molecules, such as polyphenols.
DOI: 10.1016/j.msec.2014.10.047
PubMed: 25492000
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pubmed:25492000Le document en format XML
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<affiliation wicri:level="1"><nlm:affiliation>Department of Civil, Chemical and Environmental Engineering, University of Genoa, via Opera Pia 15, 16145 Genoa, Italy; Research Center for Biologically Inspired Engineering in Vascular Medicine and Longevity (BELONG), Via Montallegro 1, 16145 Genoa, Italy. Electronic address: marco.paini@unige.it.</nlm:affiliation>
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<wicri:regionArea>Department of Civil, Chemical and Environmental Engineering, University of Genoa, via Opera Pia 15, 16145 Genoa, Italy; Research Center for Biologically Inspired Engineering in Vascular Medicine and Longevity (BELONG), Via Montallegro 1, 16145 Genoa</wicri:regionArea>
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<front><div type="abstract" xml:lang="en">Polysaccharide-based nanostructured polymeric microcapsules were fabricated by the electrostatic layer-by-layer self-assembly technique and used to encapsulate mixtures of four different polyphenols in order to achieve their controlled release. The real-time fabrication of the dextran/chitosan multilayer was monitored by quartz crystal microbalance with dissipation monitoring, and the morphology of the nanostructured polymeric capsules was characterized by scanning electron microscopy. The polyphenol encapsulation was obtained by reversible permeability variation of the capsule shell in ethanol:water mixtures. The loading efficiency in different water:ethanol mixtures and the release rate in acidic conditions were characterized by UV spectroscopy and HPLC. The higher loading efficiency was obtained with an ethanol:water 35:65 phenolic solution, equal to 42.0±0.6%, with a total release of 11.5±0.7 mg of total polyphenols per 11.3 μL of microcapsules after 240 min of incubation in acidic environment. The results suggest that polysaccharide-based capsules can be successfully used to encapsulate and release low water-soluble molecules, such as polyphenols.</div>
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