An organic transistor-based system for reference-less electrophysiological monitoring of excitable cells.
Identifieur interne : 000D21 ( Ncbi/Checkpoint ); précédent : 000D20; suivant : 000D22An organic transistor-based system for reference-less electrophysiological monitoring of excitable cells.
Auteurs : A. Spanu [Italie] ; S. Lai [Italie] ; P. Cosseddu [Italie] ; M. Tedesco [Italie] ; S. Martinoia [Italie] ; A. Bonfiglio [Italie]Source :
- Scientific reports ; 2015.
English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : Organic Chemicals.
- instrumentation : Electrochemical Techniques.
- methods : Electrochemical Techniques.
- physiology : Myocytes, Cardiac, Neurons.
- Electrophysiological Phenomena.
Abstract
In the last four decades, substantial advances have been done in the understanding of the electrical behavior of excitable cells. From the introduction in the early 70's of the Ion Sensitive Field Effect Transistor (ISFET), a lot of effort has been put in the development of more and more performing transistor-based devices to reliably interface electrogenic cells such as, for example, cardiac myocytes and neurons. However, depending on the type of application, the electronic devices used to this aim face several problems like the intrinsic rigidity of the materials (associated with foreign body rejection reactions), lack of transparency and the presence of a reference electrode. Here, an innovative system based on a novel kind of organic thin film transistor (OTFT), called organic charge modulated FET (OCMFET), is proposed as a flexible, transparent, reference-less transducer of the electrical activity of electrogenic cells. The exploitation of organic electronics in interfacing the living matters will open up new perspectives in the electrophysiological field allowing us to head toward a modern era of flexible, reference-less, and low cost probes with high-spatial and high-temporal resolution for a new generation of in-vitro and in-vivo monitoring platforms.
DOI: 10.1038/srep08807
PubMed: 25744085
Affiliations:
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Spanu</name><affiliation wicri:level="1"><nlm:affiliation>1] University of Cagliari - Dept. of Electrical and Electronic Engineering, Piazza d'Armi, 09123 Cagliari, Italy [2] University of Genova - Dept. of Informatics, Bioengineering, Robotics and System Engineering, Via Opera Pia 13, 16145 Genova, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>1] University of Cagliari - Dept. of Electrical and Electronic Engineering, Piazza d'Armi, 09123 Cagliari, Italy [2] University of Genova - Dept. of Informatics, Bioengineering, Robotics and System Engineering, Via Opera Pia 13, 16145 Genova</wicri:regionArea><wicri:noRegion>16145 Genova</wicri:noRegion></affiliation></author><author><name sortKey="Lai, S" sort="Lai, S" uniqKey="Lai S" first="S" last="Lai">S. 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Spanu</name><affiliation wicri:level="1"><nlm:affiliation>1] University of Cagliari - Dept. of Electrical and Electronic Engineering, Piazza d'Armi, 09123 Cagliari, Italy [2] University of Genova - Dept. of Informatics, Bioengineering, Robotics and System Engineering, Via Opera Pia 13, 16145 Genova, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>1] University of Cagliari - Dept. of Electrical and Electronic Engineering, Piazza d'Armi, 09123 Cagliari, Italy [2] University of Genova - Dept. of Informatics, Bioengineering, Robotics and System Engineering, Via Opera Pia 13, 16145 Genova</wicri:regionArea><wicri:noRegion>16145 Genova</wicri:noRegion></affiliation></author><author><name sortKey="Lai, S" sort="Lai, S" uniqKey="Lai S" first="S" last="Lai">S. Lai</name><affiliation wicri:level="1"><nlm:affiliation>University of Cagliari - Dept. of Electrical and Electronic Engineering, Piazza d'Armi, 09123 Cagliari, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>University of Cagliari - Dept. of Electrical and Electronic Engineering, Piazza d'Armi, 09123 Cagliari</wicri:regionArea><wicri:noRegion>09123 Cagliari</wicri:noRegion></affiliation></author><author><name sortKey="Cosseddu, P" sort="Cosseddu, P" uniqKey="Cosseddu P" first="P" last="Cosseddu">P. Cosseddu</name><affiliation wicri:level="1"><nlm:affiliation>University of Cagliari - Dept. of Electrical and Electronic Engineering, Piazza d'Armi, 09123 Cagliari, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>University of Cagliari - Dept. of Electrical and Electronic Engineering, Piazza d'Armi, 09123 Cagliari</wicri:regionArea><wicri:noRegion>09123 Cagliari</wicri:noRegion></affiliation></author><author><name sortKey="Tedesco, M" sort="Tedesco, M" uniqKey="Tedesco M" first="M" last="Tedesco">M. Tedesco</name><affiliation wicri:level="1"><nlm:affiliation>University of Genova - Dept. of Informatics, Bioengineering, Robotics and System Engineering, Via Opera Pia 13, 16145 Genova, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>University of Genova - Dept. of Informatics, Bioengineering, Robotics and System Engineering, Via Opera Pia 13, 16145 Genova</wicri:regionArea><wicri:noRegion>16145 Genova</wicri:noRegion></affiliation></author><author><name sortKey="Martinoia, S" sort="Martinoia, S" uniqKey="Martinoia S" first="S" last="Martinoia">S. Martinoia</name><affiliation wicri:level="1"><nlm:affiliation>University of Genova - Dept. of Informatics, Bioengineering, Robotics and System Engineering, Via Opera Pia 13, 16145 Genova, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>University of Genova - Dept. of Informatics, Bioengineering, Robotics and System Engineering, Via Opera Pia 13, 16145 Genova</wicri:regionArea><wicri:noRegion>16145 Genova</wicri:noRegion></affiliation></author><author><name sortKey="Bonfiglio, A" sort="Bonfiglio, A" uniqKey="Bonfiglio A" first="A" last="Bonfiglio">A. Bonfiglio</name><affiliation wicri:level="1"><nlm:affiliation>1] University of Cagliari - Dept. of Electrical and Electronic Engineering, Piazza d'Armi, 09123 Cagliari, Italy [2] CNR - Institute of Nanoscience, Via Campi 213/A, 41125 Modena, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>1] University of Cagliari - Dept. of Electrical and Electronic Engineering, Piazza d'Armi, 09123 Cagliari, Italy [2] CNR - Institute of Nanoscience, Via Campi 213/A, 41125 Modena</wicri:regionArea><wicri:noRegion>41125 Modena</wicri:noRegion></affiliation></author></analytic><series><title level="j">Scientific reports</title><idno type="e-ISSN">2045-2322</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Electrochemical Techniques (instrumentation)</term><term>Electrochemical Techniques (methods)</term><term>Electrophysiological Phenomena</term><term>Myocytes, Cardiac (physiology)</term><term>Neurons (physiology)</term><term>Organic Chemicals (chemistry)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Organic Chemicals</term></keywords><keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Electrochemical Techniques</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Electrochemical Techniques</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Myocytes, Cardiac</term><term>Neurons</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Electrophysiological Phenomena</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In the last four decades, substantial advances have been done in the understanding of the electrical behavior of excitable cells. From the introduction in the early 70's of the Ion Sensitive Field Effect Transistor (ISFET), a lot of effort has been put in the development of more and more performing transistor-based devices to reliably interface electrogenic cells such as, for example, cardiac myocytes and neurons. However, depending on the type of application, the electronic devices used to this aim face several problems like the intrinsic rigidity of the materials (associated with foreign body rejection reactions), lack of transparency and the presence of a reference electrode. Here, an innovative system based on a novel kind of organic thin film transistor (OTFT), called organic charge modulated FET (OCMFET), is proposed as a flexible, transparent, reference-less transducer of the electrical activity of electrogenic cells. The exploitation of organic electronics in interfacing the living matters will open up new perspectives in the electrophysiological field allowing us to head toward a modern era of flexible, reference-less, and low cost probes with high-spatial and high-temporal resolution for a new generation of in-vitro and in-vivo monitoring platforms.</div></front></TEI><affiliations><list><country><li>Italie</li></country></list><tree><country name="Italie"><noRegion><name sortKey="Spanu, A" sort="Spanu, A" uniqKey="Spanu A" first="A" last="Spanu">A. Spanu</name></noRegion><name sortKey="Bonfiglio, A" sort="Bonfiglio, A" uniqKey="Bonfiglio A" first="A" last="Bonfiglio">A. Bonfiglio</name><name sortKey="Cosseddu, P" sort="Cosseddu, P" uniqKey="Cosseddu P" first="P" last="Cosseddu">P. Cosseddu</name><name sortKey="Lai, S" sort="Lai, S" uniqKey="Lai S" first="S" last="Lai">S. Lai</name><name sortKey="Martinoia, S" sort="Martinoia, S" uniqKey="Martinoia S" first="S" last="Martinoia">S. Martinoia</name><name sortKey="Tedesco, M" sort="Tedesco, M" uniqKey="Tedesco M" first="M" last="Tedesco">M. Tedesco</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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