Music Exposure Induced Prolongation of Cardiac Allograft Survival and Generated Regulatory CD4+ Cells in Mice
Identifieur interne : 000909 ( Main/Merge ); précédent : 000908; suivant : 000910Music Exposure Induced Prolongation of Cardiac Allograft Survival and Generated Regulatory CD4+ Cells in Mice
Auteurs : M. Uchiyama [Japon] ; X. Jin [Japon, République populaire de Chine] ; Q. Zhang [Japon] ; A. Amano [Japon] ; T. Watanabe [Japon] ; M. Niimi [Japon]Source :
- Transplantation proceedings [ 0041-1345 ] ; 2012.
Descripteurs français
- Pascal (Inist)
- Wicri :
English descriptors
- KwdEn :
Abstract
In clinical practice, music has been used to decrease stress, heart rate, and blood pressure and to provide a distraction from disease symptoms. We investigated sound effects on alloimmune responses in murine heart transplantation. Naive and eardrum-ruptured CBA/N (CBA, H2K) underwent transplantation of a C57BL/6 (B6, H2b) heart and were exposed to 1 of 3 types of music-opera (La Traviata), classical (Mozart), and New Age (Enya)-or 1 of 6 different single sound frequencies for 7 days. An adoptive transfer study was performed to determine whether regulatory cells were generated in allograft recipients. Cell-proliferation, cytokine, and flow cytometry assessments were also performed. CBA recipients of a B6 graft exposed to opera and classical music had significantly prolonged allograft survival (median survival times [MSTs], 26.5 and 20 days, respectively), whereas those exposed to 6 single sound frequencies and New Age did not (MSTs, 7, 8, 9, 8, 8, 8, and 11 days, respectively). Untreated and eardrum-ruptured CBA rejected B6 grafts acutely (MSTs, 7 and 8.5 days, respectively). Adoptive transfer of whole splenocytes, CD4+ cells, and CD4+CD25+ cells from opera-exposed primary recipients resulted in significantly prolonged allograft survival in naive secondary recipients (MSTs, 36, 68, and >50 days, respectively). Cell-proliferation, interleukin (IL)-2 and interferon-y were suppressed in opera-exposed mice, whereas IL-4 and IL-10 from opera-exposed recipients were up-regulated. Flow cytometry studies showed an increased CD4+CD25+Foxp3+ cell population in splenocytes from opera-exposed mice. In conclusion, exposure to some types of music may induce prolonged survival of fully allogeneic cardiac allografts and generate CD4+CD25+Foxp3+ regulatory cells.
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Music Exposure Induced Prolongation of Cardiac Allograft Survival and Generated Regulatory CD4<sup>+</sup>
Cells in Mice</title>
<author><name sortKey="Uchiyama, M" sort="Uchiyama, M" uniqKey="Uchiyama M" first="M." last="Uchiyama">M. Uchiyama</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Cardiovascular Surgery , Juntendo University Hospital</s1>
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<placeName><settlement type="city">Tokyo</settlement>
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<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Surgery , Teikyo University</s1>
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<author><name sortKey="Jin, X" sort="Jin, X" uniqKey="Jin X" first="X." last="Jin">X. Jin</name>
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<placeName><settlement type="city">Tokyo</settlement>
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<s2>Harbin</s2>
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</inist:fA14>
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<wicri:noRegion>Harbin</wicri:noRegion>
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<author><name sortKey="Zhang, Q" sort="Zhang, Q" uniqKey="Zhang Q" first="Q." last="Zhang">Q. Zhang</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Surgery , Teikyo University</s1>
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<author><name sortKey="Watanabe, T" sort="Watanabe, T" uniqKey="Watanabe T" first="T." last="Watanabe">T. Watanabe</name>
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<s2>Tokyo</s2>
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<placeName><settlement type="city">Tokyo</settlement>
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<author><name sortKey="Niimi, M" sort="Niimi, M" uniqKey="Niimi M" first="M." last="Niimi">M. Niimi</name>
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<series><title level="j" type="main">Transplantation proceedings</title>
<title level="j" type="abbreviated">Transplant. proc.</title>
<idno type="ISSN">0041-1345</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
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</sourceDesc>
<seriesStmt><title level="j" type="main">Transplantation proceedings</title>
<title level="j" type="abbreviated">Transplant. proc.</title>
<idno type="ISSN">0041-1345</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal</term>
<term>Exposure</term>
<term>Graft</term>
<term>Heart</term>
<term>Homotransplantation</term>
<term>Medicine</term>
<term>Mouse</term>
<term>Music</term>
<term>Prognosis</term>
<term>Regulatory cell</term>
<term>Survival</term>
<term>T-Lymphocyte</term>
<term>Transplantation</term>
<term>Treatment</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Homotransplantation</term>
<term>Musique</term>
<term>Exposition</term>
<term>Coeur</term>
<term>Survie</term>
<term>Pronostic</term>
<term>Lymphocyte T</term>
<term>Animal</term>
<term>Souris</term>
<term>Médecine</term>
<term>Transplantation</term>
<term>Greffe</term>
<term>Traitement</term>
<term>Antigène CD4</term>
<term>Cellule régulatrice</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Musique</term>
<term>Médecine</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">In clinical practice, music has been used to decrease stress, heart rate, and blood pressure and to provide a distraction from disease symptoms. We investigated sound effects on alloimmune responses in murine heart transplantation. Naive and eardrum-ruptured CBA/N (CBA, H2<sup>K</sup>
) underwent transplantation of a C57BL/6 (B6, H2<sup>b</sup>
) heart and were exposed to 1 of 3 types of music-opera (La Traviata), classical (Mozart), and New Age (Enya)-or 1 of 6 different single sound frequencies for 7 days. An adoptive transfer study was performed to determine whether regulatory cells were generated in allograft recipients. Cell-proliferation, cytokine, and flow cytometry assessments were also performed. CBA recipients of a B6 graft exposed to opera and classical music had significantly prolonged allograft survival (median survival times [MSTs], 26.5 and 20 days, respectively), whereas those exposed to 6 single sound frequencies and New Age did not (MSTs, 7, 8, 9, 8, 8, 8, and 11 days, respectively). Untreated and eardrum-ruptured CBA rejected B6 grafts acutely (MSTs, 7 and 8.5 days, respectively). Adoptive transfer of whole splenocytes, CD4<sup>+</sup>
cells, and CD4<sup>+</sup>
CD25<sup>+</sup>
cells from opera-exposed primary recipients resulted in significantly prolonged allograft survival in naive secondary recipients (MSTs, 36, 68, and >50 days, respectively). Cell-proliferation, interleukin (IL)-2 and interferon-y were suppressed in opera-exposed mice, whereas IL-4 and IL-10 from opera-exposed recipients were up-regulated. Flow cytometry studies showed an increased CD4<sup>+</sup>
CD25<sup>+</sup>
Foxp3<sup>+</sup>
cell population in splenocytes from opera-exposed mice. In conclusion, exposure to some types of music may induce prolonged survival of fully allogeneic cardiac allografts and generate CD4<sup>+</sup>
CD25<sup>+</sup>
Foxp3<sup>+</sup>
regulatory cells.</div>
</front>
</TEI>
<affiliations><list><country><li>Japon</li>
<li>République populaire de Chine</li>
</country>
<settlement><li>Tokyo</li>
</settlement>
</list>
<tree><country name="Japon"><noRegion><name sortKey="Uchiyama, M" sort="Uchiyama, M" uniqKey="Uchiyama M" first="M." last="Uchiyama">M. Uchiyama</name>
</noRegion>
<name sortKey="Amano, A" sort="Amano, A" uniqKey="Amano A" first="A." last="Amano">A. Amano</name>
<name sortKey="Jin, X" sort="Jin, X" uniqKey="Jin X" first="X." last="Jin">X. Jin</name>
<name sortKey="Niimi, M" sort="Niimi, M" uniqKey="Niimi M" first="M." last="Niimi">M. Niimi</name>
<name sortKey="Uchiyama, M" sort="Uchiyama, M" uniqKey="Uchiyama M" first="M." last="Uchiyama">M. Uchiyama</name>
<name sortKey="Watanabe, T" sort="Watanabe, T" uniqKey="Watanabe T" first="T." last="Watanabe">T. Watanabe</name>
<name sortKey="Zhang, Q" sort="Zhang, Q" uniqKey="Zhang Q" first="Q." last="Zhang">Q. Zhang</name>
</country>
<country name="République populaire de Chine"><noRegion><name sortKey="Jin, X" sort="Jin, X" uniqKey="Jin X" first="X." last="Jin">X. Jin</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
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