Do codeine and caffeine enhance the analgesic effect of aspirin?—A systematic overview
Identifieur interne : 002979 ( Main/Exploration ); précédent : 002978; suivant : 002980Do codeine and caffeine enhance the analgesic effect of aspirin?—A systematic overview
Auteurs : W. Y. Zhang [Royaume-Uni] ; A. Li Wan Po [Royaume-Uni]Source :
- Journal of Clinical Pharmacy and Therapeutics [ 0269-4727 ] ; 1997-04.
Abstract
Objective: To assess whether codeine and caffeine enhance the analgesic effect of aspirin in postoperative pain. Method: Systematic overview of the literature and meta‐analysis of published randomized controlled trials (RCTs). Results: Codeine 60 mg leads to a small increase in the analgesic effect of 650 mg of aspirin when total pain relief score (TOTPAE.%) is used as an efficacy end‐point. This increased effect was not seen when sum of pain intensity (SPID%) and proportion of patients responding with moderate to excellent pain relief were used as outcome measures. Caffeine did not enhance the analgesic effect of aspirin. Conclusion: Codeine 60 mg may produce a small increase in the analgesic effect of aspirin 650 mg. However, this effect is not clinically meaningful. Caffeine has no adjuvant analgesic effect. At over‐the‐counter (OTC) doses, caffeine and codeine are not useful in aspirin formulations.
Url:
DOI: 10.1111/j.1365-2710.1997.tb00002.x
Affiliations:
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Y." last="Zhang">W. Y. Zhang</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Evidence‐Based Pharmacotherapy, Department of Pharmaceutical Sciences, The University of Nottingham, University Park, Nottingham NG7 2RD</wicri:regionArea><orgName type="university">Université de Nottingham</orgName><placeName><settlement type="city">Nottingham</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Nottinghamshire</region></placeName></affiliation></author><author><name sortKey="Po, A Li Wan" sort="Po, A Li Wan" uniqKey="Po A" first="A. Li Wan" last="Po">A. Li Wan Po</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Evidence‐Based Pharmacotherapy, Department of Pharmaceutical Sciences, The University of Nottingham, University Park, Nottingham NG7 2RD</wicri:regionArea><orgName type="university">Université de Nottingham</orgName><placeName><settlement type="city">Nottingham</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Nottinghamshire</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Clinical Pharmacy and Therapeutics</title><idno type="ISSN">0269-4727</idno><idno type="eISSN">1365-2710</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1997-04">1997-04</date><biblScope unit="volume">22</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="79">79</biblScope><biblScope unit="page" to="97">97</biblScope></imprint><idno type="ISSN">0269-4727</idno></series><idno type="istex">0AE01455D293D3A9A6FE19D5F95CA46E353DE72C</idno><idno type="DOI">10.1111/j.1365-2710.1997.tb00002.x</idno><idno type="ArticleID">JCPT79</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0269-4727</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective: To assess whether codeine and caffeine enhance the analgesic effect of aspirin in postoperative pain. Method: Systematic overview of the literature and meta‐analysis of published randomized controlled trials (RCTs). Results: Codeine 60 mg leads to a small increase in the analgesic effect of 650 mg of aspirin when total pain relief score (TOTPAE.%) is used as an efficacy end‐point. This increased effect was not seen when sum of pain intensity (SPID%) and proportion of patients responding with moderate to excellent pain relief were used as outcome measures. Caffeine did not enhance the analgesic effect of aspirin. Conclusion: Codeine 60 mg may produce a small increase in the analgesic effect of aspirin 650 mg. However, this effect is not clinically meaningful. Caffeine has no adjuvant analgesic effect. At over‐the‐counter (OTC) doses, caffeine and codeine are not useful in aspirin formulations.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Nottinghamshire</li></region><settlement><li>Nottingham</li></settlement><orgName><li>Université de Nottingham</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Zhang, W Y" sort="Zhang, W Y" uniqKey="Zhang W" first="W. Y." last="Zhang">W. Y. Zhang</name></region><name sortKey="Po, A Li Wan" sort="Po, A Li Wan" uniqKey="Po A" first="A. Li Wan" last="Po">A. Li Wan Po</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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