OperaV1, Main, Exploration, bibRecord, 000450

Effect of Paricalcitol on Left Ventricular Mass and Function in CKD-The OPERA Trial

Identifieur interne : 000450 ( Main/Exploration ); précédent : 000449; suivant : 000451

Effect of Paricalcitol on Left Ventricular Mass and Function in CKD-The OPERA Trial

Auteurs : Angela Yee-Moon Wang [Hong Kong] ; FANG FANG [Hong Kong] ; John Chan [Hong Kong] ; Yue-Yi Wen [Hong Kong] ; SHANG QING [Hong Kong] ; Iris Hiu-Shuen Chan [Hong Kong] ; Gladys Lo [Hong Kong] ; Kar-Neng Lai [Hong Kong] ; Wai-Kei Lo [Hong Kong] ; Christopher Wai-Kei Lam [République populaire de Chine] ; Cheuk-Man Yu [Hong Kong]

Source :

Journal of the American Society of Nephrology [ 1046-6673 ] ; 2014.

RBID : Pascal:14-0078136

Descripteurs français

Pascal (Inist)
- Paricalcitol, Fonction ventriculaire gauche, Masse, Néphropathie chronique, Essai clinique, Néphrologie, Urologie.

English descriptors

KwdEn :
- Chronic kidney disease, Clinical trial, Left ventricle performance, Mass, Nephrology, Paricalcitol, Urology.

Abstract

Vitamin D seems to protect against cardiovascular disease, but the reported effects of vitamin D on patient outcomes in CKD are controversial. We conducted a prospective, double blind, randomized, placebo-controlled trial to determine whether oral activated vitamin D reduces left ventricular (LV) mass in patients with stages 3-5 CKD with LV hypertrophy. Subjects with echocardiographic criteria of LV hypertrophy were randomly assigned to receive either oral paricalcitol (1 μg) one time daily (n=30) or matching placebo (n=30) for 52 weeks. The primary end point was change in LV mass index over 52 weeks, which was measured by cardiac magnetic resonance imaging. Secondary end points included changes in LV volume, echocardiographic measures of systolic and diastolic function, biochemical parameters of mineral bone disease, and measures of renal function. Change in LV mass index did not differ significantly between groups (median [interquartile range], -2.59 [-6.13 to 0.32] g/m²with paricalcitol versus -4.85 [-9.89 to 1.10] g/m² with placebo). Changes in LV volume, ejection fraction, tissue Doppler-derived measures of early diastolic and systolic mitral annular velocities, and ratio of early mitral inflow velocity to early diastolic mitral annular velocity did not differ between the groups. However, paricalcitol treatment significantly reduced intact parathyroid hormone (P<0.001) and alkaline phosphatase (P=0.001) levels as well as the number of cardiovascular-related hospitalizations compared with placebo. In conclusion, 52 weeks of treatment with oral paricalcitol (1 μg one time daily) significantly improved secondary hyperparathyroidism but did not alter measures of LV structure and function in patients with severe CKD.

Affiliations:

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Le document en format XML

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<author><name sortKey="Chan, Iris Hiu Shuen" sort="Chan, Iris Hiu Shuen" uniqKey="Chan I" first="Iris Hiu-Shuen" last="Chan">Iris Hiu-Shuen Chan</name>
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<author><name sortKey="Lo, Gladys" sort="Lo, Gladys" uniqKey="Lo G" first="Gladys" last="Lo">Gladys Lo</name>
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<author><name sortKey="Lai, Kar Neng" sort="Lai, Kar Neng" uniqKey="Lai K" first="Kar-Neng" last="Lai">Kar-Neng Lai</name>
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<author><name sortKey="Lo, Wai Kei" sort="Lo, Wai Kei" uniqKey="Lo W" first="Wai-Kei" last="Lo">Wai-Kei Lo</name>
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<sZ>9 aut.</sZ>
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<country>Hong Kong</country>
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<author><name sortKey="Lam, Christopher Wai Kei" sort="Lam, Christopher Wai Kei" uniqKey="Lam C" first="Christopher Wai-Kei" last="Lam">Christopher Wai-Kei Lam</name>
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<wicri:noRegion>Macau</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yu, Cheuk Man" sort="Yu, Cheuk Man" uniqKey="Yu C" first="Cheuk-Man" last="Yu">Cheuk-Man Yu</name>
<affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Division of Cardiology, Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong</s1>
<s3>HKG</s3>
<sZ>2 aut.</sZ>
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<country>Hong Kong</country>
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</placeName>
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</affiliation>
</author>
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<series><title level="j" type="main">Journal of the American Society of Nephrology</title>
<title level="j" type="abbreviated">J. Am. Soc. Nephrol.</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Chronic kidney disease</term>
<term>Clinical trial</term>
<term>Left ventricle performance</term>
<term>Mass</term>
<term>Nephrology</term>
<term>Paricalcitol</term>
<term>Urology</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Paricalcitol</term>
<term>Fonction ventriculaire gauche</term>
<term>Masse</term>
<term>Néphropathie chronique</term>
<term>Essai clinique</term>
<term>Néphrologie</term>
<term>Urologie</term>
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<front><div type="abstract" xml:lang="en">Vitamin D seems to protect against cardiovascular disease, but the reported effects of vitamin D on patient outcomes in CKD are controversial. We conducted a prospective, double blind, randomized, placebo-controlled trial to determine whether oral activated vitamin D reduces left ventricular (LV) mass in patients with stages 3-5 CKD with LV hypertrophy. Subjects with echocardiographic criteria of LV hypertrophy were randomly assigned to receive either oral paricalcitol (1 μg) one time daily (n=30) or matching placebo (n=30) for 52 weeks. The primary end point was change in LV mass index over 52 weeks, which was measured by cardiac magnetic resonance imaging. Secondary end points included changes in LV volume, echocardiographic measures of systolic and diastolic function, biochemical parameters of mineral bone disease, and measures of renal function. Change in LV mass index did not differ significantly between groups (median [interquartile range], -2.59 [-6.13 to 0.32] g/m<sup>2 </sup>
with paricalcitol versus -4.85 [-9.89 to 1.10] g/m<sup>2</sup>
 with placebo). Changes in LV volume, ejection fraction, tissue Doppler-derived measures of early diastolic and systolic mitral annular velocities, and ratio of early mitral inflow velocity to early diastolic mitral annular velocity did not differ between the groups. However, paricalcitol treatment significantly reduced intact parathyroid hormone (P<0.001) and alkaline phosphatase (P=0.001) levels as well as the number of cardiovascular-related hospitalizations compared with placebo. In conclusion, 52 weeks of treatment with oral paricalcitol (1 μg one time daily) significantly improved secondary hyperparathyroidism but did not alter measures of LV structure and function in patients with severe CKD.</div>
</front>
</TEI>
<affiliations><list><country><li>Hong Kong</li>
<li>République populaire de Chine</li>
</country>
<settlement><li>Sha Tin</li>
</settlement>
<orgName><li>Université chinoise de Hong Kong</li>
</orgName>
</list>
<tree><country name="Hong Kong"><noRegion><name sortKey="Wang, Angela Yee Moon" sort="Wang, Angela Yee Moon" uniqKey="Wang A" first="Angela Yee-Moon" last="Wang">Angela Yee-Moon Wang</name>
</noRegion>
<name sortKey="Chan, Iris Hiu Shuen" sort="Chan, Iris Hiu Shuen" uniqKey="Chan I" first="Iris Hiu-Shuen" last="Chan">Iris Hiu-Shuen Chan</name>
<name sortKey="Chan, John" sort="Chan, John" uniqKey="Chan J" first="John" last="Chan">John Chan</name>
<name sortKey="Fang Fang" sort="Fang Fang" uniqKey="Fang Fang" last="Fang Fang">FANG FANG</name>
<name sortKey="Lai, Kar Neng" sort="Lai, Kar Neng" uniqKey="Lai K" first="Kar-Neng" last="Lai">Kar-Neng Lai</name>
<name sortKey="Lo, Gladys" sort="Lo, Gladys" uniqKey="Lo G" first="Gladys" last="Lo">Gladys Lo</name>
<name sortKey="Lo, Wai Kei" sort="Lo, Wai Kei" uniqKey="Lo W" first="Wai-Kei" last="Lo">Wai-Kei Lo</name>
<name sortKey="Shang Qing" sort="Shang Qing" uniqKey="Shang Qing" last="Shang Qing">SHANG QING</name>
<name sortKey="Wen, Yue Yi" sort="Wen, Yue Yi" uniqKey="Wen Y" first="Yue-Yi" last="Wen">Yue-Yi Wen</name>
<name sortKey="Yu, Cheuk Man" sort="Yu, Cheuk Man" uniqKey="Yu C" first="Cheuk-Man" last="Yu">Cheuk-Man Yu</name>
</country>
<country name="République populaire de Chine"><noRegion><name sortKey="Lam, Christopher Wai Kei" sort="Lam, Christopher Wai Kei" uniqKey="Lam C" first="Christopher Wai-Kei" last="Lam">Christopher Wai-Kei Lam</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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Effect of Paricalcitol on Left Ventricular Mass and Function in CKD-The OPERA Trial

Effect of Paricalcitol on Left Ventricular Mass and Function in CKD-The OPERA Trial

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Abstract

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