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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Early environmental exposures influence schizophrenia expression even in the presence of strong genetic predisposition</title><author><name sortKey="Husted, Janice A" sort="Husted, Janice A" uniqKey="Husted J" first="Janice A." last="Husted">Janice A. Husted</name><affiliation><nlm:aff id="A1">School of Public Health and Health Systems, University of Waterloo, Waterloo, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Ahmed, Rashid" sort="Ahmed, Rashid" uniqKey="Ahmed R" first="Rashid" last="Ahmed">Rashid Ahmed</name><affiliation><nlm:aff id="A2">Department of Statistics, University of Waterloo, Waterloo, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Chow, Eva W C" sort="Chow, Eva W C" uniqKey="Chow E" first="Eva W. C." last="Chow">Eva W. C. Chow</name><affiliation><nlm:aff id="A3">Clinical Genetics Research Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Brzustowicz, Linda M" sort="Brzustowicz, Linda M" uniqKey="Brzustowicz L" first="Linda M." last="Brzustowicz">Linda M. Brzustowicz</name><affiliation><nlm:aff id="A5">Department of Genetics, Rutgers University, Piscataway, NJ, United States</nlm:aff></affiliation></author><author><name sortKey="Bassett, Anne S" sort="Bassett, Anne S" uniqKey="Bassett A" first="Anne S." last="Bassett">Anne S. Bassett</name><affiliation><nlm:aff id="A3">Clinical Genetics Research Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22381191</idno><idno type="pmc">3436901</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3436901</idno><idno type="RBID">PMC:3436901</idno><idno type="doi">10.1016/j.schres.2012.02.009</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">000E09</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000E09</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Early environmental exposures influence schizophrenia expression even in the presence of strong genetic predisposition</title><author><name sortKey="Husted, Janice A" sort="Husted, Janice A" uniqKey="Husted J" first="Janice A." last="Husted">Janice A. Husted</name><affiliation><nlm:aff id="A1">School of Public Health and Health Systems, University of Waterloo, Waterloo, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Ahmed, Rashid" sort="Ahmed, Rashid" uniqKey="Ahmed R" first="Rashid" last="Ahmed">Rashid Ahmed</name><affiliation><nlm:aff id="A2">Department of Statistics, University of Waterloo, Waterloo, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Chow, Eva W C" sort="Chow, Eva W C" uniqKey="Chow E" first="Eva W. C." last="Chow">Eva W. C. Chow</name><affiliation><nlm:aff id="A3">Clinical Genetics Research Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Brzustowicz, Linda M" sort="Brzustowicz, Linda M" uniqKey="Brzustowicz L" first="Linda M." last="Brzustowicz">Linda M. Brzustowicz</name><affiliation><nlm:aff id="A5">Department of Genetics, Rutgers University, Piscataway, NJ, United States</nlm:aff></affiliation></author><author><name sortKey="Bassett, Anne S" sort="Bassett, Anne S" uniqKey="Bassett A" first="Anne S." last="Bassett">Anne S. Bassett</name><affiliation><nlm:aff id="A3">Clinical Genetics Research Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada</nlm:aff></affiliation></author></analytic><series><title level="j">Schizophrenia research</title><idno type="ISSN">0920-9964</idno><idno type="eISSN">1573-2509</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">There are few studies of environmental factors in familial forms of schizophrenia. We investigated whether childhood adversity or environmental factors were associated with schizophrenia in a familial sample where schizophrenia is associated with the <italic>NOSA1P</italic> gene. We found that a cumulative adversity index including childhood illness, family instability and cannabis use was significantly associated with narrow schizophrenia, independent of <italic>NOSA1P</italic> risk genotype, previously measured childhood trauma, covariates and familial clustering (adjusted odds ratio (95% confidence interval)=1.55 (1.01, 2.38)). The results provide further support that early environmental exposures influence schizophrenia expression even in the presence of strong genetic predisposition.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8804207</journal-id><journal-id journal-id-type="pubmed-jr-id">1862</journal-id><journal-id journal-id-type="nlm-ta">Schizophr Res</journal-id><journal-id journal-id-type="iso-abbrev">Schizophr. Res.</journal-id><journal-title-group><journal-title>Schizophrenia research</journal-title></journal-title-group><issn pub-type="ppub">0920-9964</issn><issn pub-type="epub">1573-2509</issn></journal-meta><article-meta><article-id pub-id-type="pmid">22381191</article-id><article-id pub-id-type="pmc">3436901</article-id><article-id pub-id-type="doi">10.1016/j.schres.2012.02.009</article-id><article-id pub-id-type="manuscript">CAMS2328</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Early environmental exposures influence schizophrenia expression even in the presence of strong genetic predisposition</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Husted</surname><given-names>Janice A.</given-names></name><xref ref-type="aff" rid="A1">a</xref><xref rid="FN1" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Ahmed</surname><given-names>Rashid</given-names></name><xref ref-type="aff" rid="A2">b</xref></contrib><contrib contrib-type="author"><name><surname>Chow</surname><given-names>Eva W.C.</given-names></name><xref ref-type="aff" rid="A3">c</xref><xref ref-type="aff" rid="A4">d</xref></contrib><contrib contrib-type="author"><name><surname>Brzustowicz</surname><given-names>Linda M.</given-names></name><xref ref-type="aff" rid="A5">e</xref></contrib><contrib contrib-type="author"><name><surname>Bassett</surname><given-names>Anne S.</given-names></name><xref ref-type="aff" rid="A3">c</xref><xref ref-type="aff" rid="A4">d</xref></contrib></contrib-group><aff id="A1"><label>a</label>School of Public Health and Health Systems, University of Waterloo, Waterloo, Ontario, Canada</aff><aff id="A2"><label>b</label>Department of Statistics, University of Waterloo, Waterloo, Ontario, Canada</aff><aff id="A3"><label>c</label>Clinical Genetics Research Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada</aff><aff id="A4"><label>d</label>Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada</aff><aff id="A5"><label>e</label>Department of Genetics, Rutgers University, Piscataway, NJ, United States</aff><author-notes><corresp id="FN1"><label>*</label>Corresponding author at: University of Waterloo, School of Public Health and Health Systems, 200 University Avenue West, Waterloo, Ontario, Canada, N2L 3G1. Tel.: +1 519 888 4567; fax: +1 519 746 2510. <email>jhusted@uwaterloo.ca</email> (J.A. Husted)</corresp></author-notes><pub-date pub-type="nihms-submitted"><day>27</day><month>8</month><year>2012</year></pub-date><pub-date pub-type="epub"><day>03</day><month>3</month><year>2012</year></pub-date><pub-date pub-type="ppub"><month>5</month><year>2012</year></pub-date><pub-date pub-type="pmc-release"><day>07</day><month>9</month><year>2012</year></pub-date><volume>137</volume><issue>1-3</issue><fpage>166</fpage><lpage>168</lpage><pmc-comment>elocation-id from pubmed: 10.1016/j.schres.2012.02.009</pmc-comment>
<abstract><p id="P1">There are few studies of environmental factors in familial forms of schizophrenia. We investigated whether childhood adversity or environmental factors were associated with schizophrenia in a familial sample where schizophrenia is associated with the <italic>NOSA1P</italic> gene. We found that a cumulative adversity index including childhood illness, family instability and cannabis use was significantly associated with narrow schizophrenia, independent of <italic>NOSA1P</italic> risk genotype, previously measured childhood trauma, covariates and familial clustering (adjusted odds ratio (95% confidence interval)=1.55 (1.01, 2.38)). The results provide further support that early environmental exposures influence schizophrenia expression even in the presence of strong genetic predisposition.</p></abstract><kwd-group><kwd>Familial schizophrenia</kwd><kwd>Childhood adversity</kwd><kwd>Early trauma</kwd><kwd>Risk factor</kwd><kwd>Genetic predisposition</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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