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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Childhood trauma and genetic factors in familial schizophrenia associated with the <italic>NOS1AP</italic> gene</title><author><name sortKey="Husted, Janice A" sort="Husted, Janice A" uniqKey="Husted J" first="Janice A." last="Husted">Janice A. Husted</name><affiliation><nlm:aff id="A1"> Department of Health Studies and Gerontology, University of Waterloo, Waterloo, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Ahmed, Rashid" sort="Ahmed, Rashid" uniqKey="Ahmed R" first="Rashid" last="Ahmed">Rashid Ahmed</name><affiliation><nlm:aff id="A2"> Department of Statistics, University of Waterloo, Waterloo, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Chow, Eva W C" sort="Chow, Eva W C" uniqKey="Chow E" first="Eva W. C." last="Chow">Eva W. C. Chow</name><affiliation><nlm:aff id="A3"> Clinical Genetics Research Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A4"> Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Brzustowicz, Linda M" sort="Brzustowicz, Linda M" uniqKey="Brzustowicz L" first="Linda M." last="Brzustowicz">Linda M. Brzustowicz</name><affiliation><nlm:aff id="A5"> Department of Genetics, Rutgers University, Piscataway, NJ, USA</nlm:aff></affiliation></author><author><name sortKey="Bassett, Anne S" sort="Bassett, Anne S" uniqKey="Bassett A" first="Anne S." last="Bassett">Anne S. Bassett</name><affiliation><nlm:aff id="A3"> Clinical Genetics Research Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A4"> Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20541371</idno><idno type="pmc">3127865</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3127865</idno><idno type="RBID">PMC:3127865</idno><idno type="doi">10.1016/j.schres.2010.05.021</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">000E08</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000E08</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Childhood trauma and genetic factors in familial schizophrenia associated with the <italic>NOS1AP</italic> gene</title><author><name sortKey="Husted, Janice A" sort="Husted, Janice A" uniqKey="Husted J" first="Janice A." last="Husted">Janice A. Husted</name><affiliation><nlm:aff id="A1"> Department of Health Studies and Gerontology, University of Waterloo, Waterloo, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Ahmed, Rashid" sort="Ahmed, Rashid" uniqKey="Ahmed R" first="Rashid" last="Ahmed">Rashid Ahmed</name><affiliation><nlm:aff id="A2"> Department of Statistics, University of Waterloo, Waterloo, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Chow, Eva W C" sort="Chow, Eva W C" uniqKey="Chow E" first="Eva W. C." last="Chow">Eva W. C. Chow</name><affiliation><nlm:aff id="A3"> Clinical Genetics Research Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A4"> Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada</nlm:aff></affiliation></author><author><name sortKey="Brzustowicz, Linda M" sort="Brzustowicz, Linda M" uniqKey="Brzustowicz L" first="Linda M." last="Brzustowicz">Linda M. Brzustowicz</name><affiliation><nlm:aff id="A5"> Department of Genetics, Rutgers University, Piscataway, NJ, USA</nlm:aff></affiliation></author><author><name sortKey="Bassett, Anne S" sort="Bassett, Anne S" uniqKey="Bassett A" first="Anne S." last="Bassett">Anne S. Bassett</name><affiliation><nlm:aff id="A3"> Clinical Genetics Research Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A4"> Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada</nlm:aff></affiliation></author></analytic><series><title level="j">Schizophrenia research</title><idno type="ISSN">0920-9964</idno><idno type="eISSN">1573-2509</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">There is some evidence that childhood adversity may be associated with the expression of schizophrenia but whether genetic risk affects this finding is unknown. We investigated the history of early trauma in 194 subjects from 24 multiply affected families where schizophrenia was previously shown to be associated with a functional allele in the <italic>NOS1AP</italic> gene. In subjects with schizophrenia (n=79), only events prior to the onset of psychosis were considered. Generalized estimating equation models that adjusted for familial clustering were used to estimate odds ratios (ORs) and 95% confidence intervals (CI). Subjects with narrowly defined schizophrenia were more likely than their unaffected family members to have a history of early trauma (adjusted OR=4.17, 95% CI=1.52, 11.44). The results were similar after adjusting for the <italic>NOS1AP</italic> risk genotype (adjusted OR=3.57, 95% CI=1.32, 9.65) and for maternal or paternal history of schizophrenia (adjusted ORs=3.27, 95% CI=1.45, 7.38; 4.38, 95% CI=1.61, 11.91, respectively). The results suggest that childhood trauma is associated with expression of schizophrenia independent of measured genetic susceptibility and may be a candidate for gene-environment research using genetic variants.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8804207</journal-id><journal-id journal-id-type="pubmed-jr-id">1862</journal-id><journal-id journal-id-type="nlm-ta">Schizophr Res</journal-id><journal-id journal-id-type="iso-abbrev">Schizophr. Res.</journal-id><journal-title-group><journal-title>Schizophrenia research</journal-title></journal-title-group><issn pub-type="ppub">0920-9964</issn><issn pub-type="epub">1573-2509</issn></journal-meta><article-meta><article-id pub-id-type="pmid">20541371</article-id><article-id pub-id-type="pmc">3127865</article-id><article-id pub-id-type="doi">10.1016/j.schres.2010.05.021</article-id><article-id pub-id-type="manuscript">CAMS1808</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Childhood trauma and genetic factors in familial schizophrenia associated with the <italic>NOS1AP</italic> gene</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Husted</surname><given-names>Janice A.</given-names></name><xref ref-type="aff" rid="A1">a</xref><xref rid="FN1" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Ahmed</surname><given-names>Rashid</given-names></name><xref ref-type="aff" rid="A2">b</xref></contrib><contrib contrib-type="author"><name><surname>Chow</surname><given-names>Eva W.C.</given-names></name><xref ref-type="aff" rid="A3">c</xref><xref ref-type="aff" rid="A4">d</xref></contrib><contrib contrib-type="author"><name><surname>Brzustowicz</surname><given-names>Linda M.</given-names></name><xref ref-type="aff" rid="A5">e</xref></contrib><contrib contrib-type="author"><name><surname>Bassett</surname><given-names>Anne S.</given-names></name><xref ref-type="aff" rid="A3">c</xref><xref ref-type="aff" rid="A4">d</xref></contrib></contrib-group><aff id="A1"><label>a</label> Department of Health Studies and Gerontology, University of Waterloo, Waterloo, Ontario, Canada</aff><aff id="A2"><label>b</label> Department of Statistics, University of Waterloo, Waterloo, Ontario, Canada</aff><aff id="A3"><label>c</label> Clinical Genetics Research Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada</aff><aff id="A4"><label>d</label> Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada</aff><aff id="A5"><label>e</label> Department of Genetics, Rutgers University, Piscataway, NJ, USA</aff><author-notes><corresp id="FN1"><label>*</label>Corresponding author. University of Waterloo, Health Studies & Gerontology, 200 University Avenue West, Waterloo, Ontario, Canada N2L 3G1. Tel.: +1 519 885 1211; fax: +1 519 746 2510. <email>jhusted@uwaterloo.ca</email> (J.A. Husted)</corresp></author-notes><pub-date pub-type="nihms-submitted"><day>9</day><month>6</month><year>2011</year></pub-date><pub-date pub-type="epub"><day>11</day><month>6</month><year>2010</year></pub-date><pub-date pub-type="ppub"><month>8</month><year>2010</year></pub-date><pub-date pub-type="pmc-release"><day>30</day><month>6</month><year>2011</year></pub-date><volume>121</volume><issue>1-3</issue><fpage>187</fpage><lpage>192</lpage><pmc-comment>elocation-id from pubmed: 10.1016/j.schres.2010.05.021</pmc-comment>
<abstract><p id="P1">There is some evidence that childhood adversity may be associated with the expression of schizophrenia but whether genetic risk affects this finding is unknown. We investigated the history of early trauma in 194 subjects from 24 multiply affected families where schizophrenia was previously shown to be associated with a functional allele in the <italic>NOS1AP</italic> gene. In subjects with schizophrenia (n=79), only events prior to the onset of psychosis were considered. Generalized estimating equation models that adjusted for familial clustering were used to estimate odds ratios (ORs) and 95% confidence intervals (CI). Subjects with narrowly defined schizophrenia were more likely than their unaffected family members to have a history of early trauma (adjusted OR=4.17, 95% CI=1.52, 11.44). The results were similar after adjusting for the <italic>NOS1AP</italic> risk genotype (adjusted OR=3.57, 95% CI=1.32, 9.65) and for maternal or paternal history of schizophrenia (adjusted ORs=3.27, 95% CI=1.45, 7.38; 4.38, 95% CI=1.61, 11.91, respectively). The results suggest that childhood trauma is associated with expression of schizophrenia independent of measured genetic susceptibility and may be a candidate for gene-environment research using genetic variants.</p></abstract><kwd-group><kwd>Familial schizophrenia</kwd><kwd>Childhood adversity</kwd><kwd>Early trauma</kwd><kwd>Risk factor</kwd><kwd>Genetic predisposition</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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