Calcium/calmodulin-sensitive adenylyl cyclase as an example of a molecular associative integrator
Identifieur interne : 000D29 ( Main/Exploration ); précédent : 000D28; suivant : 000D30Calcium/calmodulin-sensitive adenylyl cyclase as an example of a molecular associative integrator
Auteurs : Thomas W. Abrams [États-Unis]Source :
- Behavioral and Brain Sciences [ 0140-525X ] ; 1995-09.
Abstract
Evidence suggests that the Ca2+/calmodulin-sensitive adenylyl cyclase may play a key role in neural plasticity and learning in Aplysia, Drosophila, and mammals. This dually-regulated enzyme has been proposed as a possible site of stimulus convergence during associative learning. This commentary discusses the evidence that is required to demonstrate that a protein in a second messenger cascade actually functions as a molecular site of associative integration. It also addresses the issue of how a dually-regulated protein could contribute to the temporal pairing requirements of classical conditioning: that relationship between stimuli display both temporal contiguity and predictability.
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DOI: 10.1017/S0140525X00039224
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