Influence of the Diketonato Ligand on the Cytotoxicities of [Ru(η6‐p‐cymene)(R2acac)(PTA)]+ Complexes (PTA = 1,3,5‐triaza‐7‐phosphaadamantane)
Identifieur interne : 000113 ( Istex/Corpus ); précédent : 000112; suivant : 000114Influence of the Diketonato Ligand on the Cytotoxicities of [Ru(η6‐p‐cymene)(R2acac)(PTA)]+ Complexes (PTA = 1,3,5‐triaza‐7‐phosphaadamantane)
Auteurs : Carsten A. Vock ; Anna K. Renfrew ; Rosario Scopelliti ; Lucienne Juillerat-Jeanneret ; Paul J. DysonSource :
- European Journal of Inorganic Chemistry [ 1434-1948 ] ; 2008-04.
English descriptors
- KwdEn :
- Teeft :
- Aqueous nacl, Aqueous nacl solution, Bph4, Calcd, Cancer cells, Cdcl3, Cell line, Ch3cn, Chcl3 solution, Chem, Cochco, Cytotoxic, Cytotoxicity, Derivative, Diketonato ligand, Dyson, Equiv, Et2o, Ether, Full paper, General formula, Gmbh, High cytotoxicities, Hydrolysis behaviour, Inorg, Kgaa, Ligand, Me2acac, Mmol, More times, Nacl, Nacl solution, Nch2n, Nchahbn, Neutral complexes, Pch2n, Petroleum, Petroleum ether, Ph2acac, Reflux temperature, Relative collision energy, Room temperature, Sadler, Scopelliti, Sept, Tbu2acac, Temperature cycle, Total reaction time, Vacuo, Verlag, Verlag gmbh, Vock, Weinheim.
Abstract
A series of compounds of general formula [Ru(η6‐p‐cymene)(R2acac)(PTA)][X] (R2acac = Me2acac, tBu2acac, Ph2acac, Me2acac‐Cl; PTA = 1,3,5‐triaza‐7‐phosphaadamantane; X = BPh4, BF4), and the precursor to the Me2acac‐Cl derivative [Ru(η6‐p‐cymene)(Me2acac‐Cl)Cl], have been prepared and characterised spectroscopically. Five of the compounds have also been characterised in the solid state by X‐ray crystallography. The tetrafluoroborate salts are water‐soluble, quite resistant to hydrolysis, and have been evaluated for cytotoxicity against A549 lung carcinoma and A2780 human ovarian cancer cells. The compounds are cytotoxic towards the latter cell line, and relative activities are discussed in terms of hydrolysis (less important) and lipophilicity, which appears to exert the dominating influence. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Some hydrolysis‐resistant organometallic complexes have been prepared and characterised and their cytotoxicity studied in twocancer cell lines. The results indicate that hydrolysis may not be a prerequisite (or the first step) in their mode of action.
Url:
DOI: 10.1002/ejic.200701291
Links to Exploration step
ISTEX:0AAFB6BFA1498BF6AB0F73AB800226B58253AD30Le document en format XML
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Five of the compounds have also been characterised in the solid state by X‐ray crystallography. The tetrafluoroborate salts are water‐soluble, quite resistant to hydrolysis, and have been evaluated for cytotoxicity against A549 lung carcinoma and A2780 human ovarian cancer cells. The compounds are cytotoxic towards the latter cell line, and relative activities are discussed in terms of hydrolysis (less important) and lipophilicity, which appears to exert the dominating influence. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)</div><div type="abstract" xml:lang="en">Some hydrolysis‐resistant organometallic complexes have been prepared and characterised and their cytotoxicity studied in twocancer cell lines. 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Vock</name><affiliations><json:string>Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland, Fax: +41‐21‐693 98 85</json:string><json:string>Current address: Laboratory of Pharmaceutical and Medicinal Chemistry, Department of Pharmacy, Saarland University, P. O. Box 151150, 66041 Saarbrücken, Germany</json:string><json:string>E-mail: c.vock@mx.uni‐saarland.de</json:string></affiliations></json:item><json:item><name>Anna K. Renfrew</name><affiliations><json:string>Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland, Fax: +41‐21‐693 98 85</json:string></affiliations></json:item><json:item><name>Rosario Scopelliti</name><affiliations><json:string>Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland, Fax: +41‐21‐693 98 85</json:string></affiliations></json:item><json:item><name>Lucienne Juillerat‐Jeanneret</name><affiliations><json:string>University Institute of Pathology, Centre Hospitalier Universitaire Vaudois (CHUV), 1011 Lausanne, Switzerland</json:string></affiliations></json:item><json:item><name>Paul J. Dyson</name><affiliations><json:string>Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland, Fax: +41‐21‐693 98 85</json:string><json:string>E-mail: paul.dyson@epfl.ch</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Bioorganometallics</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Anticancer drugs</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Metal‐based drugs</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Ruthenium</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>X‐ray structure</value></json:item></subject><articleId><json:string>EJIC200701291</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>bookReview</json:string></originalGenre><abstract>A series of compounds of general formula [Ru(η6‐p‐cymene)(R2acac)(PTA)][X] (R2acac = Me2acac, tBu2acac, Ph2acac, Me2acac‐Cl; PTA = 1,3,5‐triaza‐7‐phosphaadamantane; X = BPh4, BF4), and the precursor to the Me2acac‐Cl derivative [Ru(η6‐p‐cymene)(Me2acac‐Cl)Cl], have been prepared and characterised spectroscopically. Five of the compounds have also been characterised in the solid state by X‐ray crystallography. The tetrafluoroborate salts are water‐soluble, quite resistant to hydrolysis, and have been evaluated for cytotoxicity against A549 lung carcinoma and A2780 human ovarian cancer cells. The compounds are cytotoxic towards the latter cell line, and relative activities are discussed in terms of hydrolysis (less important) and lipophilicity, which appears to exert the dominating influence. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)</abstract><qualityIndicators><score>6.38</score><pdfVersion>1.3</pdfVersion><pdfPageSize>593 x 794 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>869</abstractCharCount><pdfWordCount>7932</pdfWordCount><pdfCharCount>45986</pdfCharCount><pdfPageCount>11</pdfPageCount><abstractWordCount>115</abstractWordCount></qualityIndicators><title>Influence of the Diketonato Ligand on the Cytotoxicities of [Ru(η6‐p‐cymene)(R2acac)(PTA)]+ Complexes (PTA = 1,3,5‐triaza‐7‐phosphaadamantane)</title><genre><json:string>book-reviews</json:string></genre><host><title>European Journal of Inorganic Chemistry</title><language><json:string>unknown</json:string></language><doi><json:string>10.1002/(ISSN)1099-0682c</json:string></doi><issn><json:string>1434-1948</json:string></issn><eissn><json:string>1099-0682</json:string></eissn><publisherId><json:string>EJIC</json:string></publisherId><volume>2008</volume><issue>10</issue><pages><first>1661</first><last>1671</last><total>11</total></pages><genre><json:string>journal</json:string></genre><subject><json:item><value>Full Paper</value></json:item></subject></host><categories><wos><json:string>science</json:string><json:string>chemistry, inorganic & nuclear</json:string></wos><scienceMetrix><json:string>natural sciences</json:string><json:string>chemistry</json:string><json:string>inorganic & nuclear chemistry</json:string></scienceMetrix><inist><json:string>sciences appliquees, technologies et medecines</json:string><json:string>sciences biologiques et medicales</json:string><json:string>sciences biologiques fondamentales et appliquees. psychologie</json:string><json:string>biophysique des tissus, organes et organismes</json:string></inist></categories><publicationDate>2008</publicationDate><copyrightDate>2008</copyrightDate><doi><json:string>10.1002/ejic.200701291</json:string></doi><id>0AAFB6BFA1498BF6AB0F73AB800226B58253AD30</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/0AAFB6BFA1498BF6AB0F73AB800226B58253AD30/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/0AAFB6BFA1498BF6AB0F73AB800226B58253AD30/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/0AAFB6BFA1498BF6AB0F73AB800226B58253AD30/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Influence of the Diketonato Ligand on the Cytotoxicities of [Ru(η6‐p‐cymene)(R2acac)(PTA)]+ Complexes (PTA = 1,3,5‐triaza‐7‐phosphaadamantane)</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>WILEY‐VCH Verlag</publisher><pubPlace>Weinheim</pubPlace><availability><p>Copyright © 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</p></availability><date>2008</date></publicationStmt><notesStmt><note>Swiss Cancer League</note><note>EPFL</note><note>COST (Switzerland)</note><note>Swiss National Science Foundation (SNF)</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Influence of the Diketonato Ligand on the Cytotoxicities of [Ru(η6‐p‐cymene)(R2acac)(PTA)]+ Complexes (PTA = 1,3,5‐triaza‐7‐phosphaadamantane)</title><author xml:id="author-1"><persName><forename type="first">Carsten A.</forename><surname>Vock</surname></persName><email>c.vock@mx.uni‐saarland.de</email><affiliation>Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland, Fax: +41‐21‐693 98 85</affiliation><affiliation>Current address: Laboratory of Pharmaceutical and Medicinal Chemistry, Department of Pharmacy, Saarland University, P. O. Box 151150, 66041 Saarbrücken, Germany</affiliation></author><author xml:id="author-2"><persName><forename type="first">Anna K.</forename><surname>Renfrew</surname></persName><affiliation>Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland, Fax: +41‐21‐693 98 85</affiliation></author><author xml:id="author-3"><persName><forename type="first">Rosario</forename><surname>Scopelliti</surname></persName><affiliation>Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland, Fax: +41‐21‐693 98 85</affiliation></author><author xml:id="author-4"><persName><forename type="first">Lucienne</forename><surname>Juillerat‐Jeanneret</surname></persName><affiliation>University Institute of Pathology, Centre Hospitalier Universitaire Vaudois (CHUV), 1011 Lausanne, Switzerland</affiliation></author><author xml:id="author-5"><persName><forename type="first">Paul J.</forename><surname>Dyson</surname></persName><email>paul.dyson@epfl.ch</email><affiliation>Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland, Fax: +41‐21‐693 98 85</affiliation></author></analytic><monogr><title level="j">European Journal of Inorganic Chemistry</title><title level="j" type="abbrev">Eur. J. Inorg. Chem.</title><idno type="pISSN">1434-1948</idno><idno type="eISSN">1099-0682</idno><idno type="DOI">10.1002/(ISSN)1099-0682c</idno><imprint><publisher>WILEY‐VCH Verlag</publisher><pubPlace>Weinheim</pubPlace><date type="published" when="2008-04"></date><biblScope unit="volume">2008</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1661">1661</biblScope><biblScope unit="page" to="1671">1671</biblScope></imprint></monogr><idno type="istex">0AAFB6BFA1498BF6AB0F73AB800226B58253AD30</idno><idno type="DOI">10.1002/ejic.200701291</idno><idno type="ArticleID">EJIC200701291</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2008</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>A series of compounds of general formula [Ru(η6‐p‐cymene)(R2acac)(PTA)][X] (R2acac = Me2acac, tBu2acac, Ph2acac, Me2acac‐Cl; PTA = 1,3,5‐triaza‐7‐phosphaadamantane; X = BPh4, BF4), and the precursor to the Me2acac‐Cl derivative [Ru(η6‐p‐cymene)(Me2acac‐Cl)Cl], have been prepared and characterised spectroscopically. Five of the compounds have also been characterised in the solid state by X‐ray crystallography. The tetrafluoroborate salts are water‐soluble, quite resistant to hydrolysis, and have been evaluated for cytotoxicity against A549 lung carcinoma and A2780 human ovarian cancer cells. The compounds are cytotoxic towards the latter cell line, and relative activities are discussed in terms of hydrolysis (less important) and lipophilicity, which appears to exert the dominating influence. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)</p></abstract><abstract xml:lang="en" style="graphical"><p>Some hydrolysis‐resistant organometallic complexes have been prepared and characterised and their cytotoxicity studied in twocancer cell lines. The results indicate that hydrolysis may not be a prerequisite (or the first step) in their mode of action.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>keywords</head><item><term>Bioorganometallics</term></item><item><term>Anticancer drugs</term></item><item><term>Metal‐based drugs</term></item><item><term>Ruthenium</term></item><item><term>X‐ray structure</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article-category</head><item><term>Full Paper</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2007-11-30">Received</change><change when="2008-04">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/0AAFB6BFA1498BF6AB0F73AB800226B58253AD30/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>WILEY‐VCH Verlag</publisherName><publisherLoc>Weinheim</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1099-0682c</doi><issn type="print">1434-1948</issn><issn type="electronic">1099-0682</issn><idGroup><id type="product" value="EJIC"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="EUROPEAN JOURNAL OF INORGANIC CHEMISTRY">European Journal of Inorganic Chemistry</title><title type="short">Eur. J. Inorg. Chem.</title></titleGroup></publicationMeta><publicationMeta level="part" position="100"><doi origin="wiley" registered="yes">10.1002/ejic.v2008:10</doi><numberingGroup><numbering type="journalVolume" number="2008">2008</numbering><numbering type="journalIssue">10</numbering></numberingGroup><coverDate startDate="2008-04">April 2008</coverDate></publicationMeta><publicationMeta level="unit" type="bookReview" position="17" status="forIssue"><doi origin="wiley" registered="yes">10.1002/ejic.200701291</doi><idGroup><id type="unit" value="EJIC200701291"></id></idGroup><countGroup><count type="pageTotal" number="11"></count></countGroup><titleGroup><title type="articleCategory">Full Paper</title><title type="tocHeading1">Full Papers</title></titleGroup><copyright ownership="publisher">Copyright © 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</copyright><eventGroup><event type="manuscriptReceived" date="2007-11-30"></event><event type="firstOnline" date="2008-02-06"></event><event type="publishedOnlineFinalForm" date="2008-03-18"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.3.12 mode:FullText source:FullText result:FullText mathml2tex" date="2010-07-09"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-24"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-16"></event></eventGroup><numberingGroup><numbering type="pageFirst">1661</numbering><numbering type="pageLast">1671</numbering></numberingGroup><linkGroup><link type="toTypesetVersion" href="file:EJIC.EJIC200701291.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="5"></count><count type="tableTotal" number="5"></count><count type="referenceTotal" number="25"></count></countGroup><titleGroup><title type="main" xml:lang="en">Influence of the Diketonato Ligand on the Cytotoxicities of [Ru(η<sup>6</sup>‐<i>p</i>‐cymene)(R<sub>2</sub>acac)(PTA)]<sup>+</sup> Complexes (PTA = 1,3,5‐triaza‐7‐phosphaadamantane)</title><title type="short" xml:lang="en">Cytotoxicities of [Ru(η<sup>6</sup>‐<i>p</i>‐cymene)(R<sub>2</sub>acac)(PTA)]<sup>+</sup> Complexes</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1 #af3"><personName><givenNames>Carsten A.</givenNames><familyName>Vock</familyName></personName><contactDetails><email normalForm="c.vock@mx.uni-saarland.de">c.vock@mx.uni‐saarland.de</email></contactDetails></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Anna K.</givenNames><familyName>Renfrew</familyName></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Rosario</givenNames><familyName>Scopelliti</familyName></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Lucienne</givenNames><familyName>Juillerat‐Jeanneret</familyName></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Paul J.</givenNames><familyName>Dyson</familyName></personName><contactDetails><email>paul.dyson@epfl.ch</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="CH" type="organization"><unparsedAffiliation>Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland, Fax: +41‐21‐693 98 85</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="CH" type="organization"><unparsedAffiliation>University Institute of Pathology, Centre Hospitalier Universitaire Vaudois (CHUV), 1011 Lausanne, Switzerland</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="DE" type="organization"><unparsedAffiliation>Current address: Laboratory of Pharmaceutical and Medicinal Chemistry, Department of Pharmacy, Saarland University, P. O. Box 151150, 66041 Saarbrücken, Germany</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Bioorganometallics</keyword><keyword xml:id="kwd2">Anticancer drugs</keyword><keyword xml:id="kwd3">Metal‐based drugs</keyword><keyword xml:id="kwd4">Ruthenium</keyword><keyword xml:id="kwd5">X‐ray structure</keyword></keywordGroup><fundingInfo><fundingAgency>Swiss Cancer League</fundingAgency></fundingInfo><fundingInfo><fundingAgency>EPFL</fundingAgency></fundingInfo><fundingInfo><fundingAgency>COST (Switzerland)</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Swiss National Science Foundation (SNF)</fundingAgency></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>A series of compounds of general formula [Ru(η<sup>6</sup>‐<i>p</i>‐cymene)(R<sub>2</sub>acac)(PTA)][X] (R<sub>2</sub>acac = Me<sub>2</sub>acac, <i>t</i>Bu<sub>2</sub>acac, Ph<sub>2</sub>acac, Me<sub>2</sub>acac‐Cl; PTA = 1,3,5‐triaza‐7‐phosphaadamantane; X = BPh<sub>4</sub>, BF<sub>4</sub>), and the precursor to the Me<sub>2</sub>acac‐Cl derivative [Ru(η<sup>6</sup>‐<i>p</i>‐cymene)(Me<sub>2</sub>acac‐Cl)Cl], have been prepared and characterised spectroscopically. Five of the compounds have also been characterised in the solid state by X‐ray crystallography. The tetrafluoroborate salts are water‐soluble, quite resistant to hydrolysis, and have been evaluated for cytotoxicity against A549 lung carcinoma and A2780 human ovarian cancer cells. The compounds are cytotoxic towards the latter cell line, and relative activities are discussed in terms of hydrolysis (less important) and lipophilicity, which appears to exert the dominating influence. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)</p></abstract><abstract type="graphical" xml:lang="en"><p>Some hydrolysis‐resistant organometallic complexes have been prepared and characterised and their cytotoxicity studied in twocancer cell lines. The results indicate that hydrolysis may not be a prerequisite (or the first step) in their mode of action. <blockFixed type="graphic"><mediaResourceGroup><mediaResource alt="image" eRights="yes" copyright="WILEY-VCH" href="urn:x-wiley:14341948:media:EJIC200701291:fig000"></mediaResource><mediaResource alt="thumbnail image" rendition="webLoRes" mimeType="image/gif" href=""></mediaResource><mediaResource alt="original image" rendition="webOriginal" mimeType="image/jpeg" href=""></mediaResource><mediaResource alt="magnified image" rendition="webHiRes" mimeType="image/jpeg" href=""></mediaResource></mediaResourceGroup></blockFixed></p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Influence of the Diketonato Ligand on the Cytotoxicities of [Ru(η6‐p‐cymene)(R2acac)(PTA)]+ Complexes (PTA = 1,3,5‐triaza‐7‐phosphaadamantane)</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Cytotoxicities of [Ru(η6‐p‐cymene)(R2acac)(PTA)]+ Complexes</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Influence of the Diketonato Ligand on the Cytotoxicities of [Ru(η6‐p‐cymene)(R2acac)(PTA)]+ Complexes (PTA = 1,3,5‐triaza‐7‐phosphaadamantane)</title></titleInfo><name type="personal"><namePart type="given">Carsten A.</namePart><namePart type="family">Vock</namePart><affiliation>Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland, Fax: +41‐21‐693 98 85</affiliation><affiliation>Current address: Laboratory of Pharmaceutical and Medicinal Chemistry, Department of Pharmacy, Saarland University, P. O. Box 151150, 66041 Saarbrücken, Germany</affiliation><affiliation>E-mail: c.vock@mx.uni‐saarland.de</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Anna K.</namePart><namePart type="family">Renfrew</namePart><affiliation>Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland, Fax: +41‐21‐693 98 85</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Rosario</namePart><namePart type="family">Scopelliti</namePart><affiliation>Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland, Fax: +41‐21‐693 98 85</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Lucienne</namePart><namePart type="family">Juillerat‐Jeanneret</namePart><affiliation>University Institute of Pathology, Centre Hospitalier Universitaire Vaudois (CHUV), 1011 Lausanne, Switzerland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Paul J.</namePart><namePart type="family">Dyson</namePart><affiliation>Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland, Fax: +41‐21‐693 98 85</affiliation><affiliation>E-mail: paul.dyson@epfl.ch</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="book-reviews" displayLabel="bookReview"></genre><originInfo><publisher>WILEY‐VCH Verlag</publisher><place><placeTerm type="text">Weinheim</placeTerm></place><dateIssued encoding="w3cdtf">2008-04</dateIssued><dateCaptured encoding="w3cdtf">2007-11-30</dateCaptured><copyrightDate encoding="w3cdtf">2008</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">5</extent><extent unit="tables">5</extent><extent unit="references">25</extent></physicalDescription><abstract lang="en">A series of compounds of general formula [Ru(η6‐p‐cymene)(R2acac)(PTA)][X] (R2acac = Me2acac, tBu2acac, Ph2acac, Me2acac‐Cl; PTA = 1,3,5‐triaza‐7‐phosphaadamantane; X = BPh4, BF4), and the precursor to the Me2acac‐Cl derivative [Ru(η6‐p‐cymene)(Me2acac‐Cl)Cl], have been prepared and characterised spectroscopically. Five of the compounds have also been characterised in the solid state by X‐ray crystallography. The tetrafluoroborate salts are water‐soluble, quite resistant to hydrolysis, and have been evaluated for cytotoxicity against A549 lung carcinoma and A2780 human ovarian cancer cells. The compounds are cytotoxic towards the latter cell line, and relative activities are discussed in terms of hydrolysis (less important) and lipophilicity, which appears to exert the dominating influence. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)</abstract><abstract type="graphical" lang="en">Some hydrolysis‐resistant organometallic complexes have been prepared and characterised and their cytotoxicity studied in twocancer cell lines. The results indicate that hydrolysis may not be a prerequisite (or the first step) in their mode of action.</abstract><note type="funding">Swiss Cancer League</note><note type="funding">EPFL</note><note type="funding">COST (Switzerland)</note><note type="funding">Swiss National Science Foundation (SNF)</note><subject lang="en"><genre>keywords</genre><topic>Bioorganometallics</topic><topic>Anticancer drugs</topic><topic>Metal‐based drugs</topic><topic>Ruthenium</topic><topic>X‐ray structure</topic></subject><relatedItem type="host"><titleInfo><title>European Journal of Inorganic Chemistry</title></titleInfo><titleInfo type="abbreviated"><title>Eur. J. Inorg. Chem.</title></titleInfo><genre type="journal">journal</genre><subject><genre>article-category</genre><topic>Full Paper</topic></subject><identifier type="ISSN">1434-1948</identifier><identifier type="eISSN">1099-0682</identifier><identifier type="DOI">10.1002/(ISSN)1099-0682c</identifier><identifier type="PublisherID">EJIC</identifier><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>2008</number></detail><detail type="issue"><caption>no.</caption><number>10</number></detail><extent unit="pages"><start>1661</start><end>1671</end><total>11</total></extent></part></relatedItem><identifier type="istex">0AAFB6BFA1498BF6AB0F73AB800226B58253AD30</identifier><identifier type="DOI">10.1002/ejic.200701291</identifier><identifier type="ArticleID">EJIC200701291</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2008 WILEY‐VCH Verlag GmbH & Co. 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