Long-term enhancement of maze learning in mice via a generalized Mozart effect.
Identifieur interne : 000172 ( PubMed/Corpus ); précédent : 000171; suivant : 000173Long-term enhancement of maze learning in mice via a generalized Mozart effect.
Auteurs : Peter Aoun ; Timothy Jones ; Gordon L. Shaw ; Mark BodnerSource :
- Neurological research [ 0161-6412 ] ; 2005.
English descriptors
- KwdEn :
- MESH :
- physiology : Cerebral Cortex, Higher Nervous Activity, Mammals, Maze Learning, Mice, Rats.
- Animals, Humans, Music, Species Specificity, Time Factors.
Abstract
An animal model of the 'generalized Mozart effect' (GME) - enhanced/normalized higher brain function in response to music exposure - has been established. We extend those results in two studies using another species (mice). Study 1: (1) maze testing after music exposure was extended to a minimum of 6 hours; (2) no exposure to music in utero. Study 2: (1) music exposure time further reduced; (2) maze testing extended to 24 hours.
DOI: 10.1179/016164105X63647
PubMed: 16354537
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Shaw</name></author><author><name sortKey="Bodner, Mark" sort="Bodner, Mark" uniqKey="Bodner M" first="Mark" last="Bodner">Mark Bodner</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2005">2005</date><idno type="doi">10.1179/016164105X63647</idno><idno type="RBID">pubmed:16354537</idno><idno type="pmid">16354537</idno><idno type="wicri:Area/PubMed/Corpus">000172</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Long-term enhancement of maze learning in mice via a generalized Mozart effect.</title><author><name sortKey="Aoun, Peter" sort="Aoun, Peter" uniqKey="Aoun P" first="Peter" last="Aoun">Peter Aoun</name><affiliation><nlm:affiliation>MIND Institute, 1503 South Coast Drive, Costa Mesa, CA 92626, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Jones, Timothy" sort="Jones, Timothy" uniqKey="Jones T" first="Timothy" last="Jones">Timothy Jones</name></author><author><name sortKey="Shaw, Gordon L" sort="Shaw, Gordon L" uniqKey="Shaw G" first="Gordon L" last="Shaw">Gordon L. Shaw</name></author><author><name sortKey="Bodner, Mark" sort="Bodner, Mark" uniqKey="Bodner M" first="Mark" last="Bodner">Mark Bodner</name></author></analytic><series><title level="j">Neurological research</title><idno type="ISSN">0161-6412</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Cerebral Cortex (physiology)</term><term>Higher Nervous Activity (physiology)</term><term>Humans</term><term>Mammals (physiology)</term><term>Maze Learning (physiology)</term><term>Mice (physiology)</term><term>Music</term><term>Rats (physiology)</term><term>Species Specificity</term><term>Time Factors</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Cerebral Cortex</term><term>Higher Nervous Activity</term><term>Mammals</term><term>Maze Learning</term><term>Mice</term><term>Rats</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term><term>Music</term><term>Species Specificity</term><term>Time Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">An animal model of the 'generalized Mozart effect' (GME) - enhanced/normalized higher brain function in response to music exposure - has been established. We extend those results in two studies using another species (mice). Study 1: (1) maze testing after music exposure was extended to a minimum of 6 hours; (2) no exposure to music in utero. Study 2: (1) music exposure time further reduced; (2) maze testing extended to 24 hours.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">16354537</PMID><DateCreated><Year>2005</Year><Month>12</Month><Day>15</Day></DateCreated><DateCompleted><Year>2006</Year><Month>03</Month><Day>29</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0161-6412</ISSN><JournalIssue CitedMedium="Print"><Volume>27</Volume><Issue>8</Issue><PubDate><Year>2005</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Neurological research</Title><ISOAbbreviation>Neurol. Res.</ISOAbbreviation></Journal><ArticleTitle>Long-term enhancement of maze learning in mice via a generalized Mozart effect.</ArticleTitle><Pagination><MedlinePgn>791-6</MedlinePgn></Pagination><Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">An animal model of the 'generalized Mozart effect' (GME) - enhanced/normalized higher brain function in response to music exposure - has been established. We extend those results in two studies using another species (mice). Study 1: (1) maze testing after music exposure was extended to a minimum of 6 hours; (2) no exposure to music in utero. Study 2: (1) music exposure time further reduced; (2) maze testing extended to 24 hours.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Study 1: two mouse groups were exposed to music continuously for 10 hours per day for 10 weeks (Group I: Mozart's Sonata K.448, Group II: Beethoven's Fur Elise). After 10 weeks, the ability to negotiate a T-maze was assessed (recording working time in maze, number of errors). Maze ability was tested 6 hours following the last music exposure. Study 2: two mouse groups were exposed periodically to music (58% silence) 10 hours per day for 10 weeks. Experiments after 10 weeks examined the groups' abilities to run the maze (recording working time/errors). Experiments were conducted 24 hours following the last music exposure.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The Mozart group exhibited significant enhancements compared with the control mice in both studies, i.e. significantly lower working time (p<0.05) and committed fewer errors.</AbstractText><AbstractText Label="DISCUSSION" NlmCategory="CONCLUSIONS">Observation of GME in another species supports its generality for the mammalian cortex. The absence of a GME in fMRI studies for the control music also indicates a neurophysiological basis. With extended exposure, GME is a long-term effect, indicating potential clinical importance. It has been demonstrated that GME reduces neuropathological spiking significantly in epileptics. We discuss the relevance of this study for epilepsy treatment.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Aoun</LastName><ForeName>Peter</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>MIND Institute, 1503 South Coast Drive, Costa Mesa, CA 92626, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jones</LastName><ForeName>Timothy</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Shaw</LastName><ForeName>Gordon L</ForeName><Initials>GL</Initials></Author><Author ValidYN="Y"><LastName>Bodner</LastName><ForeName>Mark</ForeName><Initials>M</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Neurol Res</MedlineTA><NlmUniqueID>7905298</NlmUniqueID><ISSNLinking>0161-6412</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000818">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D002540">Cerebral Cortex</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006613">Higher Nervous Activity</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008322">Mammals</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D018782">Maze Learning</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D051379">Mice</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D009146">Music</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D051381">Rats</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013045">Species Specificity</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013997">Time Factors</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2005</Year><Month>12</Month><Day>16</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2006</Year><Month>3</Month><Day>30</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2005</Year><Month>12</Month><Day>16</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1179/016164105X63647</ArticleId><ArticleId IdType="pubmed">16354537</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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