Mozart K.448 listening decreased seizure recurrence and epileptiform discharges in children with first unprovoked seizures: a randomized controlled study.
Identifieur interne : 000040 ( PubMed/Corpus ); précédent : 000039; suivant : 000041Mozart K.448 listening decreased seizure recurrence and epileptiform discharges in children with first unprovoked seizures: a randomized controlled study.
Auteurs : Lung-Chang Lin ; Mei-Wen Lee ; Ruey-Chang Wei ; Hin-Kiu Mok ; Rei-Cheng YangSource :
- BMC complementary and alternative medicine ; 2014.
English descriptors
- KwdEn :
- MESH :
- methods : Music Therapy, Secondary Prevention.
- prevention & control : Seizures.
- therapy : Seizures.
- Acoustic Stimulation, Child, Electroencephalography, Female, Humans, Male, Recurrence, Time Factors.
Abstract
Increasing numbers of reports show the beneficial effects of listening to Mozart music in decreasing epileptiform discharges as well as seizure frequency in epileptic children. There has been no effective method to reduce seizure recurrence after the first unprovoked seizure until now. In this study, we investigated the effect of listening to Mozart K.448 in reducing the seizure recurrence rate in children with first unprovoked seizures.
DOI: 10.1186/1472-6882-14-17
PubMed: 24410973
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pubmed:24410973Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Mozart K.448 listening decreased seizure recurrence and epileptiform discharges in children with first unprovoked seizures: a randomized controlled study.</title><author><name sortKey="Lin, Lung Chang" sort="Lin, Lung Chang" uniqKey="Lin L" first="Lung-Chang" last="Lin">Lung-Chang Lin</name></author><author><name sortKey="Lee, Mei Wen" sort="Lee, Mei Wen" uniqKey="Lee M" first="Mei-Wen" last="Lee">Mei-Wen Lee</name></author><author><name sortKey="Wei, Ruey Chang" sort="Wei, Ruey Chang" uniqKey="Wei R" first="Ruey-Chang" last="Wei">Ruey-Chang Wei</name></author><author><name sortKey="Mok, Hin Kiu" sort="Mok, Hin Kiu" uniqKey="Mok H" first="Hin-Kiu" last="Mok">Hin-Kiu Mok</name></author><author><name sortKey="Yang, Rei Cheng" sort="Yang, Rei Cheng" uniqKey="Yang R" first="Rei-Cheng" last="Yang">Rei-Cheng Yang</name><affiliation><nlm:affiliation>Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, #100, Tzu-you 1st Road, Kaohsiung City 80708, Taiwan. rechya@kmu.edu.tw.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="doi">10.1186/1472-6882-14-17</idno><idno type="RBID">pubmed:24410973</idno><idno type="pmid">24410973</idno><idno type="wicri:Area/PubMed/Corpus">000040</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Mozart K.448 listening decreased seizure recurrence and epileptiform discharges in children with first unprovoked seizures: a randomized controlled study.</title><author><name sortKey="Lin, Lung Chang" sort="Lin, Lung Chang" uniqKey="Lin L" first="Lung-Chang" last="Lin">Lung-Chang Lin</name></author><author><name sortKey="Lee, Mei Wen" sort="Lee, Mei Wen" uniqKey="Lee M" first="Mei-Wen" last="Lee">Mei-Wen Lee</name></author><author><name sortKey="Wei, Ruey Chang" sort="Wei, Ruey Chang" uniqKey="Wei R" first="Ruey-Chang" last="Wei">Ruey-Chang Wei</name></author><author><name sortKey="Mok, Hin Kiu" sort="Mok, Hin Kiu" uniqKey="Mok H" first="Hin-Kiu" last="Mok">Hin-Kiu Mok</name></author><author><name sortKey="Yang, Rei Cheng" sort="Yang, Rei Cheng" uniqKey="Yang R" first="Rei-Cheng" last="Yang">Rei-Cheng Yang</name><affiliation><nlm:affiliation>Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, #100, Tzu-you 1st Road, Kaohsiung City 80708, Taiwan. rechya@kmu.edu.tw.</nlm:affiliation></affiliation></author></analytic><series><title level="j">BMC complementary and alternative medicine</title><idno type="e-ISSN">1472-6882</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acoustic Stimulation</term><term>Child</term><term>Electroencephalography</term><term>Female</term><term>Humans</term><term>Male</term><term>Music Therapy (methods)</term><term>Recurrence</term><term>Secondary Prevention (methods)</term><term>Seizures (prevention & control)</term><term>Seizures (therapy)</term><term>Time Factors</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Music Therapy</term><term>Secondary Prevention</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Seizures</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Seizures</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Acoustic Stimulation</term><term>Child</term><term>Electroencephalography</term><term>Female</term><term>Humans</term><term>Male</term><term>Recurrence</term><term>Time Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Increasing numbers of reports show the beneficial effects of listening to Mozart music in decreasing epileptiform discharges as well as seizure frequency in epileptic children. There has been no effective method to reduce seizure recurrence after the first unprovoked seizure until now. In this study, we investigated the effect of listening to Mozart K.448 in reducing the seizure recurrence rate in children with first unprovoked seizures.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">24410973</PMID><DateCreated><Year>2014</Year><Month>01</Month><Day>17</Day></DateCreated><DateCompleted><Year>2015</Year><Month>05</Month><Day>21</Day></DateCompleted><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1472-6882</ISSN><JournalIssue CitedMedium="Internet"><Volume>14</Volume><PubDate><Year>2014</Year></PubDate></JournalIssue><Title>BMC complementary and alternative medicine</Title><ISOAbbreviation>BMC Complement Altern Med</ISOAbbreviation></Journal><ArticleTitle>Mozart K.448 listening decreased seizure recurrence and epileptiform discharges in children with first unprovoked seizures: a randomized controlled study.</ArticleTitle><Pagination><MedlinePgn>17</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1186/1472-6882-14-17</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Increasing numbers of reports show the beneficial effects of listening to Mozart music in decreasing epileptiform discharges as well as seizure frequency in epileptic children. There has been no effective method to reduce seizure recurrence after the first unprovoked seizure until now. In this study, we investigated the effect of listening to Mozart K.448 in reducing the seizure recurrence rate in children with first unprovoked seizures.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Forty-eight children who experienced their first unprovoked seizure with epileptiform discharges were included in the study. They were randomly placed into treatment (n = 24) and control (n = 24) groups. Children in the treatment group listened to Mozart K.448 daily before bedtime for at least six months. Two patients in the treatment group were excluded from analysis due to discontinuation intervention. Finally, forty-six patients were analyzed. Most of these patients (89.1%) were idiopathic in etiology. Seizure recurrence rates and reduction of epileptiform discharges were compared.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The average follow-up durations in the treatment and control groups were 18.6 ± 6.6 and 20.1 ± 5.1 months, respectively. The seizure recurrence rate was estimated to be significantly lower in the treatment group than the control group over 24 months (37.2% vs. 76.8%, p = 0.0109). Significant decreases in epileptiform discharges were also observed after 1, 2, and 6 months of listening to Mozart K.448 when compared with EEGs before listening to music. There were no significant differences in gender, mentality, seizure type, and etiology between the recurrence and non-recurrence groups.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Although the case number was limited and control music was not performed in this study, the study revealed that listening to Mozart K.448 reduced the seizure recurrence rate and epileptiform discharges in children with first unprovoked seizures, especially of idiopathic etiology. We believe that Mozart K.448 could be a promising alternative treatment in patients with first unprovoked seizures and abnormal EEGs. Further large-scaled study should be conducted to confirm the effect.</AbstractText><AbstractText Label="TRIAL REGISTRATION" NlmCategory="BACKGROUND">NCT01892605, date: June-19-2013.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lin</LastName><ForeName>Lung-Chang</ForeName><Initials>LC</Initials></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Mei-Wen</ForeName><Initials>MW</Initials></Author><Author ValidYN="Y"><LastName>Wei</LastName><ForeName>Ruey-Chang</ForeName><Initials>RC</Initials></Author><Author ValidYN="Y"><LastName>Mok</LastName><ForeName>Hin-Kiu</ForeName><Initials>HK</Initials></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Rei-Cheng</ForeName><Initials>RC</Initials><AffiliationInfo><Affiliation>Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, #100, Tzu-you 1st Road, Kaohsiung City 80708, Taiwan. rechya@kmu.edu.tw.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><DataBankList CompleteYN="Y"><DataBank><DataBankName>ClinicalTrials.gov</DataBankName><AccessionNumberList><AccessionNumber>NCT01892605</AccessionNumber></AccessionNumberList></DataBank></DataBankList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>01</Month><Day>13</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>BMC Complement Altern Med</MedlineTA><NlmUniqueID>101088661</NlmUniqueID><ISSNLinking>1472-6882</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Epilepsia. 2004 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UI="Q000379">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012008">Recurrence</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D055502">Secondary Prevention</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000379">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012640">Seizures</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000517">prevention & control</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000628">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013997">Time Factors</DescriptorName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC3893543</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2013</Year><Month>5</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>1</Month><Day>8</Day></PubMedPubDate><PubMedPubDate 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