Exposure to Mozart music reduces cognitive impairment in pilocarpine-induced status epilepticus rats.
Identifieur interne : 000001 ( PubMed/Corpus ); précédent : 000000; suivant : 000002Exposure to Mozart music reduces cognitive impairment in pilocarpine-induced status epilepticus rats.
Auteurs : Yingshou Xing ; Yi Qin ; Wei Jing ; Yunxiang Zhang ; Yanran Wang ; Daqing Guo ; Yang Xia ; Dezhong YaoSource :
- Cognitive neurodynamics [ 1871-4080 ] ; 2016.
Abstract
Patients with temporal lobe epilepsy (TLE) often display cognitive deficits. However, current epilepsy therapeutic interventions mainly aim at how to reduce the frequency and degree of epileptic seizures. Recovery of cognitive impairment is not attended enough, resulting in the lack of effective approaches in this respect. In the pilocarpine-induced temporal lobe epilepsy rat model, memory impairment has been classically reported. Here we evaluated spatial cognition changes at different epileptogenesis stages in rats of this model and explored the effects of long-term Mozart music exposure on the recovery of cognitive ability. Our results showed that pilocarpine rats suffered persisting cognitive impairment during epileptogenesis. Interestingly, we found that Mozart music exposure can significantly enhance cognitive ability in epileptic rats, and music intervention may be more effective for improving cognitive function during the early stages after Status epilepticus. These findings strongly suggest that Mozart music may help to promote the recovery of cognitive damage due to seizure activities, which provides a novel intervention strategy to diminish cognitive deficits in TLE patients.
DOI: 10.1007/s11571-015-9361-1
PubMed: 26834859
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Center for Information in Medicine, University of Electronic Science and Technology of China, Chengdu, 610054 People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Xia, Yang" sort="Xia, Yang" uniqKey="Xia Y" first="Yang" last="Xia">Yang Xia</name><affiliation><nlm:affiliation>Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, #4, Section 2, North Jian She Road, Chengdu, 610054 People's Republic of China ; Center for Information in Medicine, University of Electronic Science and Technology of China, Chengdu, 610054 People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Yao, Dezhong" sort="Yao, Dezhong" uniqKey="Yao D" first="Dezhong" last="Yao">Dezhong Yao</name><affiliation><nlm:affiliation>Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, #4, Section 2, North Jian She Road, Chengdu, 610054 People's Republic of China ; Center for Information in Medicine, University of Electronic Science and Technology of China, Chengdu, 610054 People's Republic of China.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="doi">10.1007/s11571-015-9361-1</idno><idno type="RBID">pubmed:26834859</idno><idno type="pmid">26834859</idno><idno type="wicri:Area/PubMed/Corpus">000001</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Exposure to Mozart music reduces cognitive impairment in pilocarpine-induced status epilepticus rats.</title><author><name sortKey="Xing, Yingshou" sort="Xing, Yingshou" uniqKey="Xing Y" first="Yingshou" last="Xing">Yingshou Xing</name><affiliation><nlm:affiliation>Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, #4, Section 2, North Jian She Road, Chengdu, 610054 People's Republic of China ; The School of Electronic Information Engineering, Yangtze Normal University, Chongqing, Fuling, 408100 People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Qin, Yi" sort="Qin, Yi" uniqKey="Qin Y" first="Yi" last="Qin">Yi Qin</name><affiliation><nlm:affiliation>Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, #4, Section 2, North Jian She Road, Chengdu, 610054 People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Jing, Wei" sort="Jing, Wei" uniqKey="Jing W" first="Wei" last="Jing">Wei Jing</name><affiliation><nlm:affiliation>Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, #4, Section 2, North Jian She Road, Chengdu, 610054 People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Yunxiang" sort="Zhang, Yunxiang" uniqKey="Zhang Y" first="Yunxiang" last="Zhang">Yunxiang Zhang</name><affiliation><nlm:affiliation>Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, #4, Section 2, North Jian She Road, Chengdu, 610054 People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Yanran" sort="Wang, Yanran" uniqKey="Wang Y" first="Yanran" last="Wang">Yanran Wang</name><affiliation><nlm:affiliation>Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, #4, Section 2, North Jian She Road, Chengdu, 610054 People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Guo, Daqing" sort="Guo, Daqing" uniqKey="Guo D" first="Daqing" last="Guo">Daqing Guo</name><affiliation><nlm:affiliation>Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, #4, Section 2, North Jian She Road, Chengdu, 610054 People's Republic of China ; Center for Information in Medicine, University of Electronic Science and Technology of China, Chengdu, 610054 People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Xia, Yang" sort="Xia, Yang" uniqKey="Xia Y" first="Yang" last="Xia">Yang Xia</name><affiliation><nlm:affiliation>Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, #4, Section 2, North Jian She Road, Chengdu, 610054 People's Republic of China ; Center for Information in Medicine, University of Electronic Science and Technology of China, Chengdu, 610054 People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Yao, Dezhong" sort="Yao, Dezhong" uniqKey="Yao D" first="Dezhong" last="Yao">Dezhong Yao</name><affiliation><nlm:affiliation>Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, #4, Section 2, North Jian She Road, Chengdu, 610054 People's Republic of China ; Center for Information in Medicine, University of Electronic Science and Technology of China, Chengdu, 610054 People's Republic of China.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Cognitive neurodynamics</title><idno type="ISSN">1871-4080</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Patients with temporal lobe epilepsy (TLE) often display cognitive deficits. However, current epilepsy therapeutic interventions mainly aim at how to reduce the frequency and degree of epileptic seizures. Recovery of cognitive impairment is not attended enough, resulting in the lack of effective approaches in this respect. In the pilocarpine-induced temporal lobe epilepsy rat model, memory impairment has been classically reported. Here we evaluated spatial cognition changes at different epileptogenesis stages in rats of this model and explored the effects of long-term Mozart music exposure on the recovery of cognitive ability. Our results showed that pilocarpine rats suffered persisting cognitive impairment during epileptogenesis. Interestingly, we found that Mozart music exposure can significantly enhance cognitive ability in epileptic rats, and music intervention may be more effective for improving cognitive function during the early stages after Status epilepticus. These findings strongly suggest that Mozart music may help to promote the recovery of cognitive damage due to seizure activities, which provides a novel intervention strategy to diminish cognitive deficits in TLE patients.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="PubMed-not-MEDLINE"><PMID Version="1">26834859</PMID><DateCreated><Year>2016</Year><Month>02</Month><Day>02</Day></DateCreated><DateCompleted><Year>2016</Year><Month>02</Month><Day>02</Day></DateCompleted><DateRevised><Year>2016</Year><Month>02</Month><Day>04</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">1871-4080</ISSN><JournalIssue CitedMedium="Print"><Volume>10</Volume><Issue>1</Issue><PubDate><Year>2016</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Cognitive neurodynamics</Title><ISOAbbreviation>Cogn Neurodyn</ISOAbbreviation></Journal><ArticleTitle>Exposure to Mozart music reduces cognitive impairment in pilocarpine-induced status epilepticus rats.</ArticleTitle><Pagination><MedlinePgn>23-30</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s11571-015-9361-1</ELocationID><Abstract><AbstractText>Patients with temporal lobe epilepsy (TLE) often display cognitive deficits. However, current epilepsy therapeutic interventions mainly aim at how to reduce the frequency and degree of epileptic seizures. Recovery of cognitive impairment is not attended enough, resulting in the lack of effective approaches in this respect. In the pilocarpine-induced temporal lobe epilepsy rat model, memory impairment has been classically reported. Here we evaluated spatial cognition changes at different epileptogenesis stages in rats of this model and explored the effects of long-term Mozart music exposure on the recovery of cognitive ability. Our results showed that pilocarpine rats suffered persisting cognitive impairment during epileptogenesis. Interestingly, we found that Mozart music exposure can significantly enhance cognitive ability in epileptic rats, and music intervention may be more effective for improving cognitive function during the early stages after Status epilepticus. These findings strongly suggest that Mozart music may help to promote the recovery of cognitive damage due to seizure activities, which provides a novel intervention strategy to diminish cognitive deficits in TLE patients.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Xing</LastName><ForeName>Yingshou</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, #4, Section 2, North Jian She Road, Chengdu, 610054 People's Republic of China ; The School of Electronic Information Engineering, Yangtze Normal University, Chongqing, Fuling, 408100 People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Qin</LastName><ForeName>Yi</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, #4, Section 2, North Jian She Road, Chengdu, 610054 People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jing</LastName><ForeName>Wei</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, #4, Section 2, North Jian She Road, Chengdu, 610054 People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Yunxiang</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, #4, Section 2, North Jian She Road, Chengdu, 610054 People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Yanran</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, #4, Section 2, North Jian She Road, Chengdu, 610054 People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guo</LastName><ForeName>Daqing</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, #4, Section 2, North Jian She Road, Chengdu, 610054 People's Republic of China ; Center for Information in Medicine, University of Electronic Science and Technology of China, Chengdu, 610054 People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xia</LastName><ForeName>Yang</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, #4, Section 2, North Jian She Road, Chengdu, 610054 People's Republic of China ; Center for Information in Medicine, University of Electronic Science and Technology of China, Chengdu, 610054 People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yao</LastName><ForeName>Dezhong</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, #4, Section 2, North Jian She Road, Chengdu, 610054 People's Republic of China ; Center for Information in Medicine, University of Electronic Science and Technology of China, Chengdu, 610054 People's Republic of China.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>11</Month><Day>04</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Cogn Neurodyn</MedlineTA><NlmUniqueID>101306907</NlmUniqueID></MedlineJournalInfo><OtherID Source="NLM">PMC4722134 [Available on 02/01/17]</OtherID><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Cognitive damage</Keyword><Keyword MajorTopicYN="N">Morris water maze</Keyword><Keyword MajorTopicYN="N">Mozart music</Keyword><Keyword MajorTopicYN="N">Status epilepticus</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>8</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2015</Year><Month>10</Month><Day>6</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>10</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="epublish"><Year>2015</Year><Month>11</Month><Day>4</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>2</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>2</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>2</Month><Day>3</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="pmc-release"><Year>2017</Year><Month>2</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1007/s11571-015-9361-1</ArticleId><ArticleId IdType="pii">9361</ArticleId><ArticleId IdType="pubmed">26834859</ArticleId><ArticleId IdType="pmc">PMC4722134</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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