Phosphoinositides and vesicular membrane traffic
Identifieur interne : 000638 ( Pmc/Curation ); précédent : 000637; suivant : 000639Phosphoinositides and vesicular membrane traffic
Auteurs : Peter MayingerSource :
- Biochimica et Biophysica Acta [ 0006-3002 ] ; 2012.
Abstract
Phosphoinositide lipids were initially discovered as precursors for specific second messengers involved in signal transduction, but have now taken the center stage in controlling many essential processes at virtually every cellular membrane. In particular, phosphoinositides play a critical role in regulating membrane dynamics and vesicular transport. The unique distribution of certain phosphoinositides at specific intracellular membranes makes these molecules uniquely suited to direct organelle-specific trafficking reactions. In this regulatory role, phosphoinositides cooperate specifically with small GTPases from the Arf and Rab families. This review will summarize recent progress in the study of phosphoinositides in membrane trafficking and organellar organization and highlight the particular relevance of these signaling pathways in disease.
Url:
DOI: 10.1016/j.bbalip.2012.01.002
PubMed: 22281700
PubMed Central: 3340507
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<front><div type="abstract" xml:lang="en"><p id="P1">Phosphoinositide lipids were initially discovered as precursors for specific second messengers involved in signal transduction, but have now taken the center stage in controlling many essential processes at virtually every cellular membrane. In particular, phosphoinositides play a critical role in regulating membrane dynamics and vesicular transport. The unique distribution of certain phosphoinositides at specific intracellular membranes makes these molecules uniquely suited to direct organelle-specific trafficking reactions. In this regulatory role, phosphoinositides cooperate specifically with small GTPases from the Arf and Rab families. This review will summarize recent progress in the study of phosphoinositides in membrane trafficking and organellar organization and highlight the particular relevance of these signaling pathways in disease.</p>
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<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0217513</journal-id>
<journal-id journal-id-type="pubmed-jr-id">1037</journal-id>
<journal-id journal-id-type="nlm-ta">Biochim Biophys Acta</journal-id>
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<article-id pub-id-type="doi">10.1016/j.bbalip.2012.01.002</article-id>
<article-id pub-id-type="manuscript">NIHMS349947</article-id>
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<title-group><article-title>Phosphoinositides and vesicular membrane traffic</article-title>
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<contrib-group><contrib contrib-type="author"><name><surname>Mayinger</surname>
<given-names>Peter</given-names>
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<aff id="A1">Division of Nephrology & Hypertension and Department of Cell & Developmental Biology, Oregon Health & Science University, Portland, OR 97239</aff>
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<author-notes><corresp id="cor1">Correspondence: <email>mayinger@ohsu.edu</email>
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<pub-date pub-type="nihms-submitted"><day>17</day>
<month>1</month>
<year>2012</year>
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<pub-date pub-type="epub"><day>14</day>
<month>1</month>
<year>2012</year>
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<pub-date pub-type="ppub"><month>8</month>
<year>2012</year>
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<pub-date pub-type="pmc-release"><day>01</day>
<month>8</month>
<year>2013</year>
</pub-date>
<volume>1821</volume>
<issue>8</issue>
<fpage>1104</fpage>
<lpage>1113</lpage>
<permissions><copyright-statement>© 2011 Elsevier B.V. All rights reserved.</copyright-statement>
<copyright-year>2011</copyright-year>
</permissions>
<abstract><p id="P1">Phosphoinositide lipids were initially discovered as precursors for specific second messengers involved in signal transduction, but have now taken the center stage in controlling many essential processes at virtually every cellular membrane. In particular, phosphoinositides play a critical role in regulating membrane dynamics and vesicular transport. The unique distribution of certain phosphoinositides at specific intracellular membranes makes these molecules uniquely suited to direct organelle-specific trafficking reactions. In this regulatory role, phosphoinositides cooperate specifically with small GTPases from the Arf and Rab families. This review will summarize recent progress in the study of phosphoinositides in membrane trafficking and organellar organization and highlight the particular relevance of these signaling pathways in disease.</p>
</abstract>
<funding-group><award-group><funding-source country="United States">National Institute of General Medical Sciences : NIGMS</funding-source>
<award-id>R01 GM071569-05 || GM</award-id>
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