Ezetimibe for the Treatment of Nonalcoholic Steatohepatitis: Assessment by Novel Magnetic Resonance Imaging and Magnetic Resonance Elastography in a Randomized Trial (MOZART Trial)
Identifieur interne : 000740 ( Pmc/Corpus ); précédent : 000739; suivant : 000741Ezetimibe for the Treatment of Nonalcoholic Steatohepatitis: Assessment by Novel Magnetic Resonance Imaging and Magnetic Resonance Elastography in a Randomized Trial (MOZART Trial)
Auteurs : Rohit Loomba ; Claude B. Sirlin ; Brandon Ang ; Ricki Bettencourt ; Rashmi Jain ; Joanie Salotti ; Linda Soaft ; Jonathan Hooker ; Yuko Kono ; Archana Bhatt ; Laura Hernandez ; Phirum Nguyen ; Mazen Noureddin ; William Haufe ; Catherine Hooker ; Meng Yin ; Richard Ehman ; Grace Y. Lin ; Mark A. Valasek ; David A. Brenner ; Lisa RichardsSource :
- Hepatology (Baltimore, Md.) [ 0270-9139 ] ; 2015.
Abstract
Ezetimibe inhibits intestinal cholesterol absorption and lowers low-density lipoprotein cholesterol. Uncontrolled studies have suggested that it reduces liver fat as estimated by ultrasound in nonalcoholic steatohepatitis (NASH). Therefore, we aimed to examine the efficacy of ezetimibe versus placebo in reducing liver fat by the magnetic resonance imaging-derived proton density-fat fraction (MRI-PDFF) and liver histology in patients with biopsy-proven NASH. In this randomized, double-blind, placebo-controlled trial, 50 patients with biopsy-proven NASH were randomized to either ezetimibe 10 mg orally daily or placebo for 24 weeks. The primary outcome was a change in liver fat as measured by MRI-PDFF in colocalized regions of interest within each of the nine liver segments. Novel assessment by two-dimensional and three-dimensional magnetic resonance elastography was also performed. Ezetimibe was not significantly better than placebo at reducing liver fat as measured by MRI-PDFF (mean difference between the ezetimibe and placebo arms -1.3%,
Url:
DOI: 10.1002/hep.27647
PubMed: 25482832
PubMed Central: 4407930
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