[Multicenter Ozurdex® assessment for diabetic macular edema: MOZART study].
Identifieur interne : 000715 ( Ncbi/Merge ); précédent : 000714; suivant : 000716[Multicenter Ozurdex® assessment for diabetic macular edema: MOZART study].
Auteurs : S. Guigou [France] ; C. Hajjar ; E. Parrat ; P Y Merite [France] ; S. Pommier [France] ; F. Matonti [France] ; O. Prost-Magnin [France] ; F. Meyer [France]Source :
- Journal français d'ophtalmologie ; 2014.
English descriptors
- KwdEn :
- Aged, Dexamethasone (therapeutic use), Diabetic Retinopathy (drug therapy), Follow-Up Studies, Glucocorticoids (therapeutic use), Humans, Intravitreal Injections, Macular Edema (drug therapy), Ocular Hypertension (epidemiology), Retina (pathology), Retrospective Studies, Tomography, Optical Coherence, Visual Acuity.
- MESH :
- chemical , therapeutic use : Dexamethasone, Glucocorticoids.
- drug therapy : Diabetic Retinopathy, Macular Edema.
- epidemiology : Ocular Hypertension.
- pathology : Retina.
- Aged, Follow-Up Studies, Humans, Intravitreal Injections, Retrospective Studies, Tomography, Optical Coherence, Visual Acuity.
Abstract
To evaluate the efficiency and safety of intravitreal implant of 0.7mg dexamathasone in visual impairment due to diabetic macular edema (DME).
DOI: 10.1016/j.jfo.2014.03.001
PubMed: 24813119
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000035
- to stream PubMed, to step Curation: 000035
- to stream PubMed, to step Checkpoint: 000025
Links to Exploration step
pubmed:24813119Le document en format XML
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Guigou</name><affiliation wicri:level="3"><nlm:affiliation>Service d'ophtalmologie, centre hospitalier Henri-Duffaut, 305, rue Raoul-Follereau, 84902 Avignon, France. Electronic address: s.guigou@wanadoo.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service d'ophtalmologie, centre hospitalier Henri-Duffaut, 305, rue Raoul-Follereau, 84902 Avignon</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Avignon</settlement></placeName></affiliation></author><author><name sortKey="Hajjar, C" sort="Hajjar, C" uniqKey="Hajjar C" first="C" last="Hajjar">C. Hajjar</name><affiliation><nlm:affiliation>Cabinet privé, 43, rue Dr-Joseph-Pilat, 97100 Basse Terre, Guadeloupe.</nlm:affiliation><wicri:noCountry code="subField">Guadeloupe</wicri:noCountry></affiliation></author><author><name sortKey="Parrat, E" sort="Parrat, E" uniqKey="Parrat E" first="E" last="Parrat">E. Parrat</name><affiliation><nlm:affiliation>Clinique des Eaux-Claires, Zac Moudong Sud, 97122 Baie Mahault, Guadeloupe.</nlm:affiliation><wicri:noCountry code="subField">Guadeloupe</wicri:noCountry></affiliation></author><author><name sortKey="Merite, P Y" sort="Merite, P Y" uniqKey="Merite P" first="P Y" last="Merite">P Y Merite</name><affiliation wicri:level="3"><nlm:affiliation>Centre d'ophtalmologie du pays d'Aix, 44, avenue Maréchal-de-Lattre-de-Tassigny, 13090 Aix-en-Provence, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre d'ophtalmologie du pays d'Aix, 44, avenue Maréchal-de-Lattre-de-Tassigny, 13090 Aix-en-Provence</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Aix-en-Provence</settlement></placeName></affiliation></author><author><name sortKey="Pommier, S" sort="Pommier, S" uniqKey="Pommier S" first="S" last="Pommier">S. Pommier</name><affiliation wicri:level="3"><nlm:affiliation>Cabinet privé, 1b- quai Lices-Berthelot, 84800 L'Isle-sur-Sorgue, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Cabinet privé, 1b- quai Lices-Berthelot, 84800 L'Isle-sur-Sorgue</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">L'Isle-sur-Sorgue</settlement></placeName></affiliation></author><author><name sortKey="Matonti, F" sort="Matonti, F" uniqKey="Matonti F" first="F" last="Matonti">F. Matonti</name><affiliation wicri:level="3"><nlm:affiliation>Service d'ophtalmologie, hôpital Nord, chemin des Bourrely, 13915 Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service d'ophtalmologie, hôpital Nord, chemin des Bourrely, 13915 Marseille</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Prost Magnin, O" sort="Prost Magnin, O" uniqKey="Prost Magnin O" first="O" last="Prost-Magnin">O. Prost-Magnin</name><affiliation wicri:level="3"><nlm:affiliation>Cabinet privé, 6 r, Docteur-Maret, 21000 Dijon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Cabinet privé, 6 r, Docteur-Maret, 21000 Dijon</wicri:regionArea><placeName><region type="region" nuts="2">Bourgogne-Franche-Comté</region><region type="old region" nuts="2">Bourgogne</region><settlement type="city">Dijon</settlement></placeName></affiliation></author><author><name sortKey="Meyer, F" sort="Meyer, F" uniqKey="Meyer F" first="F" last="Meyer">F. Meyer</name><affiliation wicri:level="3"><nlm:affiliation>Centre d'ophtalmologie du pays d'Aix, 44, avenue Maréchal-de-Lattre-de-Tassigny, 13090 Aix-en-Provence, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre d'ophtalmologie du pays d'Aix, 44, avenue Maréchal-de-Lattre-de-Tassigny, 13090 Aix-en-Provence</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Aix-en-Provence</settlement></placeName></affiliation></author></analytic><series><title level="j">Journal français d'ophtalmologie</title><idno type="e-ISSN">1773-0597</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Dexamethasone (therapeutic use)</term><term>Diabetic Retinopathy (drug therapy)</term><term>Follow-Up Studies</term><term>Glucocorticoids (therapeutic use)</term><term>Humans</term><term>Intravitreal Injections</term><term>Macular Edema (drug therapy)</term><term>Ocular Hypertension (epidemiology)</term><term>Retina (pathology)</term><term>Retrospective Studies</term><term>Tomography, Optical Coherence</term><term>Visual Acuity</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Dexamethasone</term><term>Glucocorticoids</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Diabetic Retinopathy</term><term>Macular Edema</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Ocular Hypertension</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Retina</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Follow-Up Studies</term><term>Humans</term><term>Intravitreal Injections</term><term>Retrospective Studies</term><term>Tomography, Optical Coherence</term><term>Visual Acuity</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To evaluate the efficiency and safety of intravitreal implant of 0.7mg dexamathasone in visual impairment due to diabetic macular edema (DME).</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">24813119</PMID><DateCreated><Year>2014</Year><Month>06</Month><Day>10</Day></DateCreated><DateCompleted><Year>2015</Year><Month>01</Month><Day>27</Day></DateCompleted><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1773-0597</ISSN><JournalIssue CitedMedium="Internet"><Volume>37</Volume><Issue>6</Issue><PubDate><Year>2014</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Journal français d'ophtalmologie</Title><ISOAbbreviation>J Fr Ophtalmol</ISOAbbreviation></Journal><ArticleTitle>[Multicenter Ozurdex® assessment for diabetic macular edema: MOZART study].</ArticleTitle><Pagination><MedlinePgn>480-5</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jfo.2014.03.001</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0181-5512(14)00152-1</ELocationID><Abstract><AbstractText Label="PURPOSE" NlmCategory="OBJECTIVE">To evaluate the efficiency and safety of intravitreal implant of 0.7mg dexamathasone in visual impairment due to diabetic macular edema (DME).</AbstractText><AbstractText Label="MATERIALS AND METHODS" NlmCategory="METHODS">This was a retrospective, multicenter, study. Seventy-four patients, with a mean age of 65 years, followed for at least 6 months (mean follow-up: 9.8 months) were included in 5 French eye clinics (P 1.5 collective). The mean systolic blood pressure was 138mmHg and the mean HbA1c was 7.2%. We monitored 2 systemic parameters: blood pressure and glycemic balance. Best-corrected visual acuity (BCVA), central retinal thickness (CRT, Spectralis OCT), intraocular pressure (IOP) and cataract progression are studied at baseline and then at 1, 2, 4 and 6 months.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The average CRT decrease was: 239μm at month 2 (M2) and 135μm at month 6 (M6). The mean improvement from baseline of BCVA is 8.5 letters at M2 and 7.6 letters at M6. A gain greater than 15 letters is found in 27% of patients at M6. For naive patients the BCVA is 71 letters versus 60 letters (P<0.05). Patients with a baseline CRT <500mmHg have a BCVA of 66 letters versus 57 letters (P<0.05). The mean rate injections was 1.2 at 6 months with an average of 5.4 months for reinjection. Ocular hypertension greater than 25mmHg, managed by topical treatment, is observed in 13.4% of patients. No glaucoma surgery was necessary.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Dexamethasone has an anatomical and functional effectiveness in the treatment of DME. Outcomes for naive patients and lower CRT suggest that the duration of diabetes mellitus and previous treatments are negative factors of recovery. Side effects are rare and manageable. Ozurdex(®) seems to be a treatment for visual impairment due to DME with a favorable safety profile. Patient follow-up must be adapted to half-life of the product with a control before M1 (intraocular pressure) and before M5 (DME recurrence, BCVA).</AbstractText><CopyrightInformation>Copyright © 2014 Elsevier Masson SAS. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Guigou</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Service d'ophtalmologie, centre hospitalier Henri-Duffaut, 305, rue Raoul-Follereau, 84902 Avignon, France. Electronic address: s.guigou@wanadoo.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hajjar</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Cabinet privé, 43, rue Dr-Joseph-Pilat, 97100 Basse Terre, Guadeloupe.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Parrat</LastName><ForeName>E</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Clinique des Eaux-Claires, Zac Moudong Sud, 97122 Baie Mahault, Guadeloupe.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Merite</LastName><ForeName>P Y</ForeName><Initials>PY</Initials><AffiliationInfo><Affiliation>Centre d'ophtalmologie du pays d'Aix, 44, avenue Maréchal-de-Lattre-de-Tassigny, 13090 Aix-en-Provence, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pommier</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Cabinet privé, 1b- quai Lices-Berthelot, 84800 L'Isle-sur-Sorgue, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Matonti</LastName><ForeName>F</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Service d'ophtalmologie, hôpital Nord, chemin des Bourrely, 13915 Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Prost-Magnin</LastName><ForeName>O</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Cabinet privé, 6 r, Docteur-Maret, 21000 Dijon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Meyer</LastName><ForeName>F</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Centre d'ophtalmologie du pays d'Aix, 44, avenue Maréchal-de-Lattre-de-Tassigny, 13090 Aix-en-Provence, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>fre</Language><PublicationTypeList><PublicationType UI="D004740">English Abstract</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016448">Multicenter Study</PublicationType></PublicationTypeList><VernacularTitle>Étude rétrospective du traitement par Ozurdex® dans l'œdème maculaire diabétique: MOZART study.</VernacularTitle><ArticleDate DateType="Electronic"><Year>2014</Year><Month>05</Month><Day>09</Day></ArticleDate></Article><MedlineJournalInfo><Country>France</Country><MedlineTA>J Fr Ophtalmol</MedlineTA><NlmUniqueID>7804128</NlmUniqueID><ISSNLinking>0181-5512</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005938">Glucocorticoids</NameOfSubstance></Chemical><Chemical><RegistryNumber>7S5I7G3JQL</RegistryNumber><NameOfSubstance UI="D003907">Dexamethasone</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D003907">Dexamethasone</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000627">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D003930">Diabetic Retinopathy</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000188">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005500">Follow-Up Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005938">Glucocorticoids</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000627">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D058449">Intravitreal Injections</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008269">Macular Edema</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000188">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009798">Ocular Hypertension</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000453">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012160">Retina</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000473">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012189">Retrospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D041623">Tomography, Optical Coherence</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D014792">Visual Acuity</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Dexamethasone</Keyword><Keyword MajorTopicYN="N">Dexaméthasone</Keyword><Keyword MajorTopicYN="N">Diabetes mellitus</Keyword><Keyword MajorTopicYN="N">Diabète</Keyword><Keyword MajorTopicYN="N">Macular edema</Keyword><Keyword MajorTopicYN="N">Optical coherence tomography</Keyword><Keyword MajorTopicYN="N">Tomographie par cohérence optique</Keyword><Keyword MajorTopicYN="N">Œdème maculaire</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>1</Month><Day>8</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2014</Year><Month>3</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>3</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="aheadofprint"><Year>2014</Year><Month>5</Month><Day>9</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>5</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>5</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>1</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24813119</ArticleId><ArticleId IdType="pii">S0181-5512(14)00152-1</ArticleId><ArticleId IdType="doi">10.1016/j.jfo.2014.03.001</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li></country><region><li>Bourgogne</li><li>Bourgogne-Franche-Comté</li><li>Provence-Alpes-Côte d'Azur</li></region><settlement><li>Aix-en-Provence</li><li>Avignon</li><li>Dijon</li><li>L'Isle-sur-Sorgue</li><li>Marseille</li></settlement></list><tree><noCountry><name sortKey="Hajjar, C" sort="Hajjar, C" uniqKey="Hajjar C" first="C" last="Hajjar">C. Hajjar</name><name sortKey="Parrat, E" sort="Parrat, E" uniqKey="Parrat E" first="E" last="Parrat">E. Parrat</name></noCountry><country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Guigou, S" sort="Guigou, S" uniqKey="Guigou S" first="S" last="Guigou">S. Guigou</name></region><name sortKey="Matonti, F" sort="Matonti, F" uniqKey="Matonti F" first="F" last="Matonti">F. Matonti</name><name sortKey="Merite, P Y" sort="Merite, P Y" uniqKey="Merite P" first="P Y" last="Merite">P Y Merite</name><name sortKey="Meyer, F" sort="Meyer, F" uniqKey="Meyer F" first="F" last="Meyer">F. Meyer</name><name sortKey="Pommier, S" sort="Pommier, S" uniqKey="Pommier S" first="S" last="Pommier">S. Pommier</name><name sortKey="Prost Magnin, O" sort="Prost Magnin, O" uniqKey="Prost Magnin O" first="O" last="Prost-Magnin">O. Prost-Magnin</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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