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Auto-aggressive metallic mercury injection around the knee joint: a case report

Identifieur interne : 000500 ( Ncbi/Merge ); précédent : 000499; suivant : 000501

Auto-aggressive metallic mercury injection around the knee joint: a case report

Auteurs : Joerg Friesenbichler [Autriche] ; Werner Maurer-Ertl [Autriche] ; Patrick Sadoghi [Autriche] ; Elisabeth Wolf [Autriche] ; Andreas Leithner [Autriche]

Source :

RBID : PMC:3226429

Abstract

Background

Accidental or intentional subcutaneous and/or intramuscular injection of metallic mercury is an uncommon form of poisoning. Although it does not carry the same risk as mercury vapour inhalation, it may cause destructive early and late reactions.

Case Presentation

Herein we present the case of a 29-year-old male patient who developed an obsessive-compulsive disorder causing auto-aggressive behaviour with injection of elemental mercury and several other foreign bodies into the soft tissues around the left knee about 15 years before initial presentation. For clinical examination X-rays and a CT-scan of the affected area were performed. Furthermore, blood was taken to determine the mercury concentration in the blood, which showed a concentration 17-fold higher than recommended. As a consequence, the mercury depots and several foreign bodies were resected marginally.

Conclusion

Blood levels of mercury will decrease rapidly following surgery, especially in combination with chelating therapy. In case of subcutaneous and intramuscular injection of metallic mercury we recommend marginal or wide excision of all contaminated tissue to prevent migration of mercury and chronic inflammation. Nevertheless, prolonged clinical and biochemical monitoring should be performed for several years to screen for chronic intoxication.


Url:
DOI: 10.1186/1471-2482-11-31
PubMed: 22093686
PubMed Central: 3226429

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PMC:3226429

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<div1 type="bibliography">
<listBibl>
<biblStruct>
<analytic>
<author>
<name sortKey="Franzen, C" uniqKey="Franzen C">C Franzen</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Heise, La" uniqKey="Heise L">LA Heise</name>
</author>
<author>
<name sortKey="Wagener, Bm" uniqKey="Wagener B">BM Wagener</name>
</author>
<author>
<name sortKey="Vigil, Jr" uniqKey="Vigil J">JR Vigil</name>
</author>
<author>
<name sortKey="Othman, M" uniqKey="Othman M">M Othman</name>
</author>
<author>
<name sortKey="Shahinpoor, P" uniqKey="Shahinpoor P">P Shahinpoor</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Lech, T" uniqKey="Lech T">T Lech</name>
</author>
<author>
<name sortKey="Goszcz, H" uniqKey="Goszcz H">H Goszcz</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Kayias, Eh" uniqKey="Kayias E">EH Kayias</name>
</author>
<author>
<name sortKey="Drosos, Gi" uniqKey="Drosos G">GI Drosos</name>
</author>
<author>
<name sortKey="Hapsas, D" uniqKey="Hapsas D">D Hapsas</name>
</author>
<author>
<name sortKey="Anagnostopoulou, Ga" uniqKey="Anagnostopoulou G">GA Anagnostopoulou</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Alhamad, T" uniqKey="Alhamad T">T Alhamad</name>
</author>
<author>
<name sortKey="Rooney, J" uniqKey="Rooney J">J Rooney</name>
</author>
<author>
<name sortKey="Nwosu, A" uniqKey="Nwosu A">A Nwosu</name>
</author>
<author>
<name sortKey="Maccombs, J" uniqKey="Maccombs J">J Maccombs</name>
</author>
<author>
<name sortKey="Kim, Ys" uniqKey="Kim Y">YS Kim</name>
</author>
<author>
<name sortKey="Shukla, V" uniqKey="Shukla V">V Shukla</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Lim, He" uniqKey="Lim H">HE Lim</name>
</author>
<author>
<name sortKey="Shim, Jj" uniqKey="Shim J">JJ Shim</name>
</author>
<author>
<name sortKey="Lee, Sy" uniqKey="Lee S">SY Lee</name>
</author>
<author>
<name sortKey="Lee, Sh" uniqKey="Lee S">SH Lee</name>
</author>
<author>
<name sortKey="Kang, Sy" uniqKey="Kang S">SY Kang</name>
</author>
<author>
<name sortKey="Jo, Jy" uniqKey="Jo J">JY Jo</name>
</author>
<author>
<name sortKey="In, Kh" uniqKey="In K">KH In</name>
</author>
<author>
<name sortKey="Kim, Hg" uniqKey="Kim H">HG Kim</name>
</author>
<author>
<name sortKey="Yoo, Sh" uniqKey="Yoo S">SH Yoo</name>
</author>
<author>
<name sortKey="Kang, Kh" uniqKey="Kang K">KH Kang</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Maynou, C" uniqKey="Maynou C">C Maynou</name>
</author>
<author>
<name sortKey="Mathieu Nolf, M" uniqKey="Mathieu Nolf M">M Mathieu-Nolf</name>
</author>
<author>
<name sortKey="Mestdagh, H" uniqKey="Mestdagh H">H Mestdagh</name>
</author>
<author>
<name sortKey="Gillas Buron, G" uniqKey="Gillas Buron G">G Gillas-Buron</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Lien, Dc" uniqKey="Lien D">DC Lien</name>
</author>
<author>
<name sortKey="Todoruk, Dn" uniqKey="Todoruk D">DN Todoruk</name>
</author>
<author>
<name sortKey="Rajani, Hr" uniqKey="Rajani H">HR Rajani</name>
</author>
<author>
<name sortKey="Cook, Da" uniqKey="Cook D">DA Cook</name>
</author>
<author>
<name sortKey="Herbert, Fa" uniqKey="Herbert F">FA Herbert</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Ellabban, Mg" uniqKey="Ellabban M">MG Ellabban</name>
</author>
<author>
<name sortKey="Ali, R" uniqKey="Ali R">R Ali</name>
</author>
<author>
<name sortKey="Hart, Nb" uniqKey="Hart N">NB Hart</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Prasad, Vl" uniqKey="Prasad V">VL Prasad</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Wong, F" uniqKey="Wong F">F Wong</name>
</author>
<author>
<name sortKey="Hung, Lk" uniqKey="Hung L">LK Hung</name>
</author>
<author>
<name sortKey="Wong, Ch" uniqKey="Wong C">CH Wong</name>
</author>
<author>
<name sortKey="Ho, Pc" uniqKey="Ho P">PC Ho</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Sarikaya, S" uniqKey="Sarikaya S">S Sarikaya</name>
</author>
<author>
<name sortKey="Karcioglu, O" uniqKey="Karcioglu O">O Karcioglu</name>
</author>
<author>
<name sortKey="Ay, D" uniqKey="Ay D">D Ay</name>
</author>
<author>
<name sortKey="Cetin, A" uniqKey="Cetin A">A Cetin</name>
</author>
<author>
<name sortKey="Aktas, C" uniqKey="Aktas C">C Aktas</name>
</author>
<author>
<name sortKey="Serinken, M" uniqKey="Serinken M">M Serinken</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Yoshida, M" uniqKey="Yoshida M">M Yoshida</name>
</author>
<author>
<name sortKey="Satoh, H" uniqKey="Satoh H">H Satoh</name>
</author>
<author>
<name sortKey="Igarashi, M" uniqKey="Igarashi M">M Igarashi</name>
</author>
<author>
<name sortKey="Akashi, K" uniqKey="Akashi K">K Akashi</name>
</author>
<author>
<name sortKey="Yamamura, Y" uniqKey="Yamamura Y">Y Yamamura</name>
</author>
<author>
<name sortKey="Yoshida, K" uniqKey="Yoshida K">K Yoshida</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Soo, Yo" uniqKey="Soo Y">YO Soo</name>
</author>
<author>
<name sortKey="Wong, Ch" uniqKey="Wong C">CH Wong</name>
</author>
<author>
<name sortKey="Griffith, Jf" uniqKey="Griffith J">JF Griffith</name>
</author>
<author>
<name sortKey="Chan, Ty" uniqKey="Chan T">TY Chan</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Davey, P" uniqKey="Davey P">P Davey</name>
</author>
<author>
<name sortKey="Benson, M" uniqKey="Benson M">M Benson</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Mcfee, Rb" uniqKey="Mcfee R">RB McFee</name>
</author>
<author>
<name sortKey="Caraccio, Tr" uniqKey="Caraccio T">TR Caraccio</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Zorrilla, P" uniqKey="Zorrilla P">P Zorrilla</name>
</author>
<author>
<name sortKey="Morales, C" uniqKey="Morales C">C Morales</name>
</author>
<author>
<name sortKey="Gomez, La" uniqKey="Gomez L">LA Gomez</name>
</author>
<author>
<name sortKey="Salido, Ja" uniqKey="Salido J">JA Salido</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Schwarz, S" uniqKey="Schwarz S">S Schwarz</name>
</author>
<author>
<name sortKey="Husstedt, I" uniqKey="Husstedt I">I Husstedt</name>
</author>
<author>
<name sortKey="Bertram, Hp" uniqKey="Bertram H">HP Bertram</name>
</author>
<author>
<name sortKey="Kuchelmeister, K" uniqKey="Kuchelmeister K">K Kuchelmeister</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Benz, Mr" uniqKey="Benz M">MR Benz</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Chodorowski, Z" uniqKey="Chodorowski Z">Z Chodorowski</name>
</author>
<author>
<name sortKey="Sein Anand, J" uniqKey="Sein Anand J">J Sein Anand</name>
</author>
<author>
<name sortKey="Nowicki, A" uniqKey="Nowicki A">A Nowicki</name>
</author>
<author>
<name sortKey="Galant, K" uniqKey="Galant K">K Galant</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Krohn, It" uniqKey="Krohn I">IT Krohn</name>
</author>
<author>
<name sortKey="Solof, A" uniqKey="Solof A">A Solof</name>
</author>
<author>
<name sortKey="Mobini, J" uniqKey="Mobini J">J Mobini</name>
</author>
<author>
<name sortKey="Wagner, Dk" uniqKey="Wagner D">DK Wagner</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
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<journal-title>BMC Surgery</journal-title>
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<article-title>Auto-aggressive metallic mercury injection around the knee joint: a case report</article-title>
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<contrib-group>
<contrib contrib-type="author" id="A1">
<name>
<surname>Friesenbichler</surname>
<given-names>Joerg</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<email>joerg.friesenbichler@medunigraz.at</email>
</contrib>
<contrib contrib-type="author" corresp="yes" id="A2">
<name>
<surname>Maurer-Ertl</surname>
<given-names>Werner</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<email>maeck2000@gmx.at</email>
</contrib>
<contrib contrib-type="author" id="A3">
<name>
<surname>Sadoghi</surname>
<given-names>Patrick</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<email>patrick.sadoghi@klinikum-graz.at</email>
</contrib>
<contrib contrib-type="author" id="A4">
<name>
<surname>Wolf</surname>
<given-names>Elisabeth</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<email>elisabeth.wolf@medunigraz.at</email>
</contrib>
<contrib contrib-type="author" id="A5">
<name>
<surname>Leithner</surname>
<given-names>Andreas</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<email>andreas.leithner@medunigraz.at</email>
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<aff id="I1">
<label>1</label>
Department of Orthopaedic Surgery, Medical University of Graz, Auenbruggerplatz 5, 8036 Graz, Austria</aff>
<pub-date pub-type="collection">
<year>2011</year>
</pub-date>
<pub-date pub-type="epub">
<day>17</day>
<month>11</month>
<year>2011</year>
</pub-date>
<volume>11</volume>
<fpage>31</fpage>
<lpage>31</lpage>
<history>
<date date-type="received">
<day>15</day>
<month>4</month>
<year>2011</year>
</date>
<date date-type="accepted">
<day>17</day>
<month>11</month>
<year>2011</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright ©2011 Friesenbichler et al; licensee BioMed Central Ltd.</copyright-statement>
<copyright-year>2011</copyright-year>
<copyright-holder>Friesenbichler et al; licensee BioMed Central Ltd.</copyright-holder>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.0">
<license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution License (
<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/2.0">http://creativecommons.org/licenses/by/2.0</ext-link>
), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
</license>
</permissions>
<self-uri xlink:href="http://www.biomedcentral.com/1471-2482/11/31"></self-uri>
<abstract>
<sec>
<title>Background</title>
<p>Accidental or intentional subcutaneous and/or intramuscular injection of metallic mercury is an uncommon form of poisoning. Although it does not carry the same risk as mercury vapour inhalation, it may cause destructive early and late reactions.</p>
</sec>
<sec>
<title>Case Presentation</title>
<p>Herein we present the case of a 29-year-old male patient who developed an obsessive-compulsive disorder causing auto-aggressive behaviour with injection of elemental mercury and several other foreign bodies into the soft tissues around the left knee about 15 years before initial presentation. For clinical examination X-rays and a CT-scan of the affected area were performed. Furthermore, blood was taken to determine the mercury concentration in the blood, which showed a concentration 17-fold higher than recommended. As a consequence, the mercury depots and several foreign bodies were resected marginally.</p>
</sec>
<sec>
<title>Conclusion</title>
<p>Blood levels of mercury will decrease rapidly following surgery, especially in combination with chelating therapy. In case of subcutaneous and intramuscular injection of metallic mercury we recommend marginal or wide excision of all contaminated tissue to prevent migration of mercury and chronic inflammation. Nevertheless, prolonged clinical and biochemical monitoring should be performed for several years to screen for chronic intoxication.</p>
</sec>
</abstract>
</article-meta>
</front>
<body>
<sec>
<title>Background</title>
<p>There are several reports in the literature concerning mercury intoxication with Wolfgang Amadeus Mozart as the most prominent possible victim [
<xref ref-type="bibr" rid="B1">1</xref>
]. In most cases, mercury is predominantly absorbed by the respiratory system, particularly by inhalation of the vapour, which is produced at room temperature [
<xref ref-type="bibr" rid="B2">2</xref>
-
<xref ref-type="bibr" rid="B6">6</xref>
]. Following inhalation, mercury damages the lung tissue. Furthermore, a large part of mercury is absorbed by the pulmonary vasculature and distributed to further organs. Mercury also passes the blood-brain barrier and remains in the nervous system before being oxidized [
<xref ref-type="bibr" rid="B6">6</xref>
-
<xref ref-type="bibr" rid="B8">8</xref>
].</p>
<p>Subcutaneous and intramuscular injection of elemental mercury is of rare occurrence, although in most cases it may be injected voluntarily in the setting of attempted suicide or in context of psychiatric diseases [
<xref ref-type="bibr" rid="B4">4</xref>
,
<xref ref-type="bibr" rid="B5">5</xref>
,
<xref ref-type="bibr" rid="B7">7</xref>
,
<xref ref-type="bibr" rid="B9">9</xref>
-
<xref ref-type="bibr" rid="B16">16</xref>
]. Prasad et al. [
<xref ref-type="bibr" rid="B10">10</xref>
] reported the subcutaneous injection of mercury for ethnic reasons and Lech and Goszcz [
<xref ref-type="bibr" rid="B3">3</xref>
] related a case of mercury intoxication due to ingestion with suicidal intent.</p>
<p>After entering the body following intravenous or even intra-arterial injection elemental mercury is transported to the liver, the spleen, the kidneys and the brain [
<xref ref-type="bibr" rid="B2">2</xref>
,
<xref ref-type="bibr" rid="B4">4</xref>
,
<xref ref-type="bibr" rid="B6">6</xref>
,
<xref ref-type="bibr" rid="B7">7</xref>
,
<xref ref-type="bibr" rid="B9">9</xref>
,
<xref ref-type="bibr" rid="B12">12</xref>
,
<xref ref-type="bibr" rid="B16">16</xref>
]. At these locations, mercury is oxidized into divalent mercury (mercurous and mercuric), which is able to cohere with thiol-groups of enzyme systems, causing tissue damages [
<xref ref-type="bibr" rid="B6">6</xref>
,
<xref ref-type="bibr" rid="B7">7</xref>
,
<xref ref-type="bibr" rid="B9">9</xref>
,
<xref ref-type="bibr" rid="B16">16</xref>
].</p>
<p>Herein we present the case of a 29-year-old male patient who developed an obsessive-compulsive disorder (OCD) causing auto-aggressive behaviour with injection of elemental mercury and other foreign bodies into the left upper and lower leg, 15 years before initial presentation.</p>
</sec>
<sec>
<title>Case Presentation</title>
<p>In October 2010, a 20-year-old patient was referred to our clinic complaining about stinging pain in the left thigh and the knee. One year before, he was treated due to an extra-skeletal osteosarcoma of the right thigh with a wide resection for local tumour control and poly-chemotherapy (EURAMOS scheme) and local radiation therapy.</p>
<p>Currently, the patient reported about the development of an obsessive-compulsive disorder (OCD) 15 years before, causing auto-aggressive behaviour. In the context of this disease, the patient injected elemental metallic mercury from a clinical thermometer into the soft tissues around the left knee and the upper and lower leg. Furthermore, he pricked 2 spikes and approximately 17 spicules into his thigh during a period of several months and left them in situ. Therefore, an infection of the soft tissues developed, which was treated surgically at an external hospital. Furthermore, a therapy with antidepressant agents was initiated.</p>
<p>Nevertheless, plain radiographs and computed tomography (CT) of the affected area showed significant volumes of radiopaque foreign material (depots of mercury) and several foreign bodies (2 spikes and 17 spicules; Figure
<xref ref-type="fig" rid="F1">1a-d</xref>
) in the soft tissues. The staging investigations performed for the osteosarcoma (local X-rays of the right thigh, CT scan of thorax, abdomen and pelvis) which are performed regularly never showed mercury depots elsewhere in the body.</p>
<fig id="F1" position="float">
<label>Figure 1</label>
<caption>
<p>
<bold>a-d. a&b) Preoperative anteroposterior and lateral radiographs of the left femur and tibia showing multiple radiopaque particles, spikes and spicules in the soft tissues around the knee</bold>
. c&d) Coronal and transversal CT scan of the left knee and the affected soft tissues showing several metallic foreign bodies (hollow arrow: 2 spikes) and mercury depots (white arrow).</p>
</caption>
<graphic xlink:href="1471-2482-11-31-1"></graphic>
</fig>
<p>Blood was taken to determine mercury concentration, the C-reactive protein (CRP) and renal function parameters preoperatively. While the renal parameters revealed no pathologic findings, the blood level of mercury (6,80 μg/dl) was 17-fold higher than recommended by the reference laboratory (standard: 0-0,40 μg/dl; Figure
<xref ref-type="fig" rid="F2">2</xref>
). The CRP was increased, additionally. Surprisingly, there were no neurological symptoms or other signs of systemic poisoning, which are known to occur following long time exposure to elemental mercury. Moreover, no context could be found between metallic mercury injection and the extra-skeletal osteosarcoma, neither in the current case, nor in the literature.</p>
<fig id="F2" position="float">
<label>Figure 2</label>
<caption>
<p>
<bold>Diagram showing the blood levels of mercury before and after excision of the mercury deposits, as well as under chelating therapy using DMPS</bold>
. Orange arrow: time of surgery.</p>
</caption>
<graphic xlink:href="1471-2482-11-31-2"></graphic>
</fig>
<p>As a consequence, foreign bodies (2 spikes and 4 spicules) and several mercury depots were resected marginally, except of 13 spicules, which had to be left in situ due to the diffuse distribution. Excision of these foreign bodies would have caused too much soft tissue damage of the extensor mechanism. Furthermore, a therapy with a chelating agent (2,3-dimercaptopropane-1-sulfonate, DMPS) was initiated for 2 months and the therapy with antidepressant agents was continued.</p>
<p>Haematoxylin and Eosin (H&E) stained sections of the specimen showed cicatricial tissue, granulomas caused by foreign bodies, multiple abscesses and black amorphous material (mercury depots) surrounded by the foreign-body reaction.</p>
<p>At 6-months follow-up, the patient reported less pain in the left upper leg, the blood concentrations of mercury and CRP had decreased significantly (0,49 μg/dl at 4 months of follow-up) (Figure
<xref ref-type="fig" rid="F2">2</xref>
). The patient did not report any adverse reactions to the chelation agent and he was able to ambulate without any facilities. Clinical and biochemical observation was continued.</p>
</sec>
<sec>
<title>Conclusions</title>
<p>Mercury intoxication presents many different symptoms, depending on the form and the route of entry to the organism. Inhalation of metallic or inorganic mercury vapour mainly induces pulmonary disease while chronic inhalation induces neurological or renal disorders [
<xref ref-type="bibr" rid="B5">5</xref>
,
<xref ref-type="bibr" rid="B6">6</xref>
,
<xref ref-type="bibr" rid="B12">12</xref>
]. There have been rare cases of acute renal failure, acute respiratory distress, hemorrhagic colitis secondary to inhalation, abdominal discomfort and acute chemical pneumonitis [
<xref ref-type="bibr" rid="B2">2</xref>
,
<xref ref-type="bibr" rid="B5">5</xref>
,
<xref ref-type="bibr" rid="B6">6</xref>
,
<xref ref-type="bibr" rid="B16">16</xref>
]. Nevertheless, ingestion of elemental mercury rarely causes symptoms of intoxication because it is not well absorbed in the gastrointestinal tract [
<xref ref-type="bibr" rid="B16">16</xref>
].</p>
<p>Pulmonic embolism, development of pulmonary empyema, and embolisation to the heart has been reported following intravenous injection [
<xref ref-type="bibr" rid="B4">4</xref>
,
<xref ref-type="bibr" rid="B15">15</xref>
-
<xref ref-type="bibr" rid="B17">17</xref>
]. Davey and Benson [
<xref ref-type="bibr" rid="B15">15</xref>
] and Alhamad et al. [
<xref ref-type="bibr" rid="B5">5</xref>
] reported metal dense deposits in the heart following intravenous injection of metallic mercury or inhalation of vaporized mercury. Intra-arterial injection can cause ischemia and/or gangrene secondary to embolisation [
<xref ref-type="bibr" rid="B10">10</xref>
].</p>
<p>In general, there are no clinical signs of acute systemic intoxication following subcutaneous and intramuscular injection of elemental mercury. An intense local inflammatory reaction with formation of granulomas or aseptic abscess formations may occur several weeks or months following injection [
<xref ref-type="bibr" rid="B4">4</xref>
,
<xref ref-type="bibr" rid="B5">5</xref>
,
<xref ref-type="bibr" rid="B7">7</xref>
,
<xref ref-type="bibr" rid="B9">9</xref>
,
<xref ref-type="bibr" rid="B10">10</xref>
,
<xref ref-type="bibr" rid="B14">14</xref>
-
<xref ref-type="bibr" rid="B17">17</xref>
]. Late reactions include foreign body giant cell reaction, fibrosis, granulomas and membranous fat necrosis [
<xref ref-type="bibr" rid="B4">4</xref>
,
<xref ref-type="bibr" rid="B10">10</xref>
,
<xref ref-type="bibr" rid="B16">16</xref>
]. Schwarz et al. [
<xref ref-type="bibr" rid="B18">18</xref>
] reported a case of amyotrophic lateral sclerosis 3 years after injuring the hand with a clinical thermometer and Benz et al. [
<xref ref-type="bibr" rid="B19">19</xref>
] described white matter lesions in a 4-year-old girl with chronic intoxication of inorganic mercury secondary to the accidental use of a skin whitening cream.</p>
<p>Nevertheless, following subcutaneous injection of metallic mercury it is essential to prevent systemic absorption and to treat local effects properly. Therefore, prompt marginal or wide excision of subcutaneous deposits has to be done according to Enneking et al. [
<xref ref-type="bibr" rid="B4">4</xref>
,
<xref ref-type="bibr" rid="B7">7</xref>
,
<xref ref-type="bibr" rid="B9">9</xref>
-
<xref ref-type="bibr" rid="B11">11</xref>
,
<xref ref-type="bibr" rid="B14">14</xref>
-
<xref ref-type="bibr" rid="B17">17</xref>
]. Furthermore, monitoring of the central nervous system and renal functions should be performed. Chelating therapy and psychiatric consultation should be applied when indicated [
<xref ref-type="bibr" rid="B4">4</xref>
,
<xref ref-type="bibr" rid="B9">9</xref>
-
<xref ref-type="bibr" rid="B11">11</xref>
,
<xref ref-type="bibr" rid="B14">14</xref>
,
<xref ref-type="bibr" rid="B16">16</xref>
].</p>
<p>Ellabban et al. [
<xref ref-type="bibr" rid="B9">9</xref>
] reported that subcutaneous deposition of mercury does not carry the systemic risk associated with mercury inhalation. Chodorowski et al. [
<xref ref-type="bibr" rid="B20">20</xref>
] reported two deaths secondary to renal failure and pulmonary empyema [
<xref ref-type="bibr" rid="B10">10</xref>
]. On the other hand, Davey and Benson [
<xref ref-type="bibr" rid="B15">15</xref>
] suggest that the chronic phase of metallic mercury intoxication following intravenous injection seems to be benign, with low risk of developing long term neurological or pulmonary sequel.</p>
<p>In the present case, there have been no symptoms of mercury intoxication during a period of nearly 15 years of exposure. However, prolonged clinical and biochemical follow-up have to be performed [
<xref ref-type="bibr" rid="B4">4</xref>
,
<xref ref-type="bibr" rid="B11">11</xref>
,
<xref ref-type="bibr" rid="B17">17</xref>
], although it is known that there is no correlation between mercury levels in the blood and urine and the severity of symptoms in case of chronic poisoning [
<xref ref-type="bibr" rid="B7">7</xref>
,
<xref ref-type="bibr" rid="B12">12</xref>
,
<xref ref-type="bibr" rid="B21">21</xref>
].</p>
<p>The usage of chelating agents (e.g. DMPS, dimercaprol (BAL), dimercaptosuccinic acid (DMSA), British Anti Lewisite (BAL), d-penicillamine) in the treatment of mercury intoxication is controversial [
<xref ref-type="bibr" rid="B4">4</xref>
-
<xref ref-type="bibr" rid="B6">6</xref>
,
<xref ref-type="bibr" rid="B8">8</xref>
,
<xref ref-type="bibr" rid="B15">15</xref>
,
<xref ref-type="bibr" rid="B16">16</xref>
]. Sarikaya et al. related the usage of N-acetyl cysteine (NAC) for chelating therapy, additionally. Several authors recommended the usage of chelation therapy if there are signs of systemic intoxication and following intravenous injection [
<xref ref-type="bibr" rid="B3">3</xref>
,
<xref ref-type="bibr" rid="B5">5</xref>
,
<xref ref-type="bibr" rid="B7">7</xref>
,
<xref ref-type="bibr" rid="B9">9</xref>
-
<xref ref-type="bibr" rid="B11">11</xref>
,
<xref ref-type="bibr" rid="B14">14</xref>
,
<xref ref-type="bibr" rid="B21">21</xref>
]. On the other hand, Davey and Benson [
<xref ref-type="bibr" rid="B15">15</xref>
] suggest that the long term benefit of chelation therapy is equally low in case of chronic mercury poisoning and therefore the usage should be restricted to acute intoxication, while Lim et al. [
<xref ref-type="bibr" rid="B6">6</xref>
] reported no effect on progression of acute lung injury.</p>
<p>In the present case, chelating therapy with DMPS was introduced due to the recommendation by the local centre for intoxications, although there were no signs of systemical poisoning. Furthermore, haemodialysis and plasma exchange are only indicated if renal failure occurs combined with anuria [
<xref ref-type="bibr" rid="B5">5</xref>
,
<xref ref-type="bibr" rid="B13">13</xref>
]. Nevertheless, Yoshida et al. [
<xref ref-type="bibr" rid="B13">13</xref>
] suggested that renal damages due to acute mercury poisoning may not be permanent.</p>
<p>Summarizing, blood levels of mercury will decrease rapidly following surgery combined with chelating therapy. Subcutaneous and intramuscular injection of metallic mercury requires marginal or wide excision of all contaminated tissue to prevent migration of mercury and chronic inflammation or intoxication. Nevertheless, prolonged clinical and biochemical monitoring should be performed for several years to screen for chronic intoxication.</p>
</sec>
<sec>
<title>Competing interests</title>
<p>The authors declare that they have no competing interests.</p>
</sec>
<sec>
<title>Authors' contributions</title>
<p>JF, WME, and PS acquired the data and wrote/revised the manuscript, ET performed the clinical follow-up of the patient, AL and WME performed the surgery. Furthermore, all authors have been involved in drafting the manuscript or revising it critically for important intellectual content read and approved the final manuscript.</p>
</sec>
<sec>
<title>Pre-publication history</title>
<p>The pre-publication history for this paper can be accessed here:</p>
<p>
<ext-link ext-link-type="uri" xlink:href="http://www.biomedcentral.com/1471-2482/11/31/prepub">http://www.biomedcentral.com/1471-2482/11/31/prepub</ext-link>
</p>
</sec>
</body>
<back>
<sec>
<title>Acknowledgements</title>
<p>We would like to thank Prof. Lorenz and his laboratory team from Lorenz & Petek GmbH for measuring mercury concentrations in the blood in their laboratory.</p>
<sec>
<title>Informed Consent</title>
<p>Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.</p>
</sec>
</sec>
<ref-list>
<ref id="B1">
<mixed-citation publication-type="journal">
<name>
<surname>Franzen</surname>
<given-names>C</given-names>
</name>
<article-title>Illness and death of Wolfgang Amadeus Mozart (1756-1791). A contribution to the Mozart Year 2006</article-title>
<source>Med Klin (Munich)</source>
<year>2006</year>
<volume>101</volume>
<fpage>761</fpage>
<lpage>772</lpage>
<pub-id pub-id-type="doi">10.1007/s00063-006-1105-x</pub-id>
</mixed-citation>
</ref>
<ref id="B2">
<mixed-citation publication-type="journal">
<name>
<surname>Heise</surname>
<given-names>LA</given-names>
</name>
<name>
<surname>Wagener</surname>
<given-names>BM</given-names>
</name>
<name>
<surname>Vigil</surname>
<given-names>JR</given-names>
</name>
<name>
<surname>Othman</surname>
<given-names>M</given-names>
</name>
<name>
<surname>Shahinpoor</surname>
<given-names>P</given-names>
</name>
<article-title>Hemorrhagic colitis secondary to acute elemental mercury vapor poisoning</article-title>
<source>Am J Gastroenterol</source>
<year>2009</year>
<volume>104</volume>
<fpage>530</fpage>
<lpage>531</lpage>
<pub-id pub-id-type="doi">10.1038/ajg.2008.54</pub-id>
<pub-id pub-id-type="pmid">19174799</pub-id>
</mixed-citation>
</ref>
<ref id="B3">
<mixed-citation publication-type="journal">
<name>
<surname>Lech</surname>
<given-names>T</given-names>
</name>
<name>
<surname>Goszcz</surname>
<given-names>H</given-names>
</name>
<article-title>Poisoning from aspiration of elemental mercury</article-title>
<source>Clin Toxicol (Phila)</source>
<year>2006</year>
<volume>44</volume>
<fpage>333</fpage>
<lpage>336</lpage>
<pub-id pub-id-type="doi">10.1080/15563650600584568</pub-id>
</mixed-citation>
</ref>
<ref id="B4">
<mixed-citation publication-type="journal">
<name>
<surname>Kayias</surname>
<given-names>EH</given-names>
</name>
<name>
<surname>Drosos</surname>
<given-names>GI</given-names>
</name>
<name>
<surname>Hapsas</surname>
<given-names>D</given-names>
</name>
<name>
<surname>Anagnostopoulou</surname>
<given-names>GA</given-names>
</name>
<article-title>Elemental mercury-induced subcutaneous granuloma. A case report and review of the literature</article-title>
<source>Acta Orthop Belg</source>
<year>2003</year>
<volume>69</volume>
<fpage>280</fpage>
<lpage>284</lpage>
<pub-id pub-id-type="pmid">12879712</pub-id>
</mixed-citation>
</ref>
<ref id="B5">
<mixed-citation publication-type="other">
<name>
<surname>Alhamad</surname>
<given-names>T</given-names>
</name>
<name>
<surname>Rooney</surname>
<given-names>J</given-names>
</name>
<name>
<surname>Nwosu</surname>
<given-names>A</given-names>
</name>
<name>
<surname>Maccombs</surname>
<given-names>J</given-names>
</name>
<name>
<surname>Kim</surname>
<given-names>YS</given-names>
</name>
<name>
<surname>Shukla</surname>
<given-names>V</given-names>
</name>
<article-title>Lessons learned from a fatal case of mercury intoxication</article-title>
<source>Int Urol Nephrol</source>
<year>2011</year>
<comment> in press </comment>
</mixed-citation>
</ref>
<ref id="B6">
<mixed-citation publication-type="journal">
<name>
<surname>Lim</surname>
<given-names>HE</given-names>
</name>
<name>
<surname>Shim</surname>
<given-names>JJ</given-names>
</name>
<name>
<surname>Lee</surname>
<given-names>SY</given-names>
</name>
<name>
<surname>Lee</surname>
<given-names>SH</given-names>
</name>
<name>
<surname>Kang</surname>
<given-names>SY</given-names>
</name>
<name>
<surname>Jo</surname>
<given-names>JY</given-names>
</name>
<name>
<surname>In</surname>
<given-names>KH</given-names>
</name>
<name>
<surname>Kim</surname>
<given-names>HG</given-names>
</name>
<name>
<surname>Yoo</surname>
<given-names>SH</given-names>
</name>
<name>
<surname>Kang</surname>
<given-names>KH</given-names>
</name>
<article-title>Mercury inhalation poisoning and acute lung injury</article-title>
<source>Korean J Intern Med</source>
<year>1998</year>
<volume>13</volume>
<fpage>127</fpage>
<lpage>130</lpage>
<pub-id pub-id-type="pmid">9735669</pub-id>
</mixed-citation>
</ref>
<ref id="B7">
<mixed-citation publication-type="journal">
<name>
<surname>Maynou</surname>
<given-names>C</given-names>
</name>
<name>
<surname>Mathieu-Nolf</surname>
<given-names>M</given-names>
</name>
<name>
<surname>Mestdagh</surname>
<given-names>H</given-names>
</name>
<name>
<surname>Gillas-Buron</surname>
<given-names>G</given-names>
</name>
<article-title>Accidental subcutaneous injection of elemental mercury. A case report</article-title>
<source>Acta Orthop Belg</source>
<year>2000</year>
<volume>66</volume>
<fpage>292</fpage>
<lpage>296</lpage>
<pub-id pub-id-type="pmid">11033922</pub-id>
</mixed-citation>
</ref>
<ref id="B8">
<mixed-citation publication-type="journal">
<name>
<surname>Lien</surname>
<given-names>DC</given-names>
</name>
<name>
<surname>Todoruk</surname>
<given-names>DN</given-names>
</name>
<name>
<surname>Rajani</surname>
<given-names>HR</given-names>
</name>
<name>
<surname>Cook</surname>
<given-names>DA</given-names>
</name>
<name>
<surname>Herbert</surname>
<given-names>FA</given-names>
</name>
<article-title>Accidental inhalation of mercury vapour: respiratory and toxicologic consequences</article-title>
<source>Can Med Assoc J</source>
<year>1983</year>
<volume>129</volume>
<fpage>591</fpage>
<lpage>595</lpage>
<pub-id pub-id-type="pmid">6883261</pub-id>
</mixed-citation>
</ref>
<ref id="B9">
<mixed-citation publication-type="journal">
<name>
<surname>Ellabban</surname>
<given-names>MG</given-names>
</name>
<name>
<surname>Ali</surname>
<given-names>R</given-names>
</name>
<name>
<surname>Hart</surname>
<given-names>NB</given-names>
</name>
<article-title>Subcutaneous metallic mercury injection of the hand</article-title>
<source>Br J Plast Surg</source>
<year>2003</year>
<volume>56</volume>
<fpage>47</fpage>
<lpage>49</lpage>
<pub-id pub-id-type="doi">10.1016/S0007-1226(03)00021-3</pub-id>
<pub-id pub-id-type="pmid">12706151</pub-id>
</mixed-citation>
</ref>
<ref id="B10">
<mixed-citation publication-type="journal">
<name>
<surname>Prasad</surname>
<given-names>VL</given-names>
</name>
<article-title>Subcutaneous injection of mercury: "warding off evil"</article-title>
<source>Environ Health Perspect</source>
<year>2004</year>
<volume>112</volume>
<fpage>1326</fpage>
<lpage>1328</lpage>
<pub-id pub-id-type="doi">10.1289/ehp.6891</pub-id>
<pub-id pub-id-type="pmid">15345347</pub-id>
</mixed-citation>
</ref>
<ref id="B11">
<mixed-citation publication-type="journal">
<name>
<surname>Wong</surname>
<given-names>F</given-names>
</name>
<name>
<surname>Hung</surname>
<given-names>LK</given-names>
</name>
<name>
<surname>Wong</surname>
<given-names>CH</given-names>
</name>
<name>
<surname>Ho</surname>
<given-names>PC</given-names>
</name>
<article-title>Suicidal mercury injection into the upper limb: a case study</article-title>
<source>Hand Surg</source>
<year>2004</year>
<volume>9</volume>
<fpage>225</fpage>
<lpage>228</lpage>
<pub-id pub-id-type="doi">10.1142/S0218810404002352</pub-id>
<pub-id pub-id-type="pmid">15810110</pub-id>
</mixed-citation>
</ref>
<ref id="B12">
<mixed-citation publication-type="journal">
<name>
<surname>Sarikaya</surname>
<given-names>S</given-names>
</name>
<name>
<surname>Karcioglu</surname>
<given-names>O</given-names>
</name>
<name>
<surname>Ay</surname>
<given-names>D</given-names>
</name>
<name>
<surname>Cetin</surname>
<given-names>A</given-names>
</name>
<name>
<surname>Aktas</surname>
<given-names>C</given-names>
</name>
<name>
<surname>Serinken</surname>
<given-names>M</given-names>
</name>
<article-title>Acute mercury poisoning: a case report</article-title>
<source>BMC Emerg Med</source>
<year>2010</year>
<volume>10</volume>
<fpage>7</fpage>
<pub-id pub-id-type="doi">10.1186/1471-227X-10-7</pub-id>
<pub-id pub-id-type="pmid">20302609</pub-id>
</mixed-citation>
</ref>
<ref id="B13">
<mixed-citation publication-type="journal">
<name>
<surname>Yoshida</surname>
<given-names>M</given-names>
</name>
<name>
<surname>Satoh</surname>
<given-names>H</given-names>
</name>
<name>
<surname>Igarashi</surname>
<given-names>M</given-names>
</name>
<name>
<surname>Akashi</surname>
<given-names>K</given-names>
</name>
<name>
<surname>Yamamura</surname>
<given-names>Y</given-names>
</name>
<name>
<surname>Yoshida</surname>
<given-names>K</given-names>
</name>
<article-title>Acute mercury poisoning by intentional ingestion of mercuric chloride</article-title>
<source>Tohoku J Exp Med</source>
<year>1997</year>
<volume>182</volume>
<fpage>347</fpage>
<lpage>352</lpage>
<pub-id pub-id-type="doi">10.1620/tjem.182.347</pub-id>
<pub-id pub-id-type="pmid">9352627</pub-id>
</mixed-citation>
</ref>
<ref id="B14">
<mixed-citation publication-type="journal">
<name>
<surname>Soo</surname>
<given-names>YO</given-names>
</name>
<name>
<surname>Wong</surname>
<given-names>CH</given-names>
</name>
<name>
<surname>Griffith</surname>
<given-names>JF</given-names>
</name>
<name>
<surname>Chan</surname>
<given-names>TY</given-names>
</name>
<article-title>Subcutaneous injection of metallic mercury</article-title>
<source>Hum Exp Toxicol</source>
<year>2003</year>
<volume>22</volume>
<fpage>345</fpage>
<lpage>348</lpage>
<pub-id pub-id-type="doi">10.1191/0960327103ht345cr</pub-id>
<pub-id pub-id-type="pmid">12856958</pub-id>
</mixed-citation>
</ref>
<ref id="B15">
<mixed-citation publication-type="journal">
<name>
<surname>Davey</surname>
<given-names>P</given-names>
</name>
<name>
<surname>Benson</surname>
<given-names>M</given-names>
</name>
<article-title>A young man with a heavy heart</article-title>
<source>Heart</source>
<year>1999</year>
<volume>82</volume>
<fpage>e11</fpage>
<pub-id pub-id-type="pmid">10573507</pub-id>
</mixed-citation>
</ref>
<ref id="B16">
<mixed-citation publication-type="journal">
<name>
<surname>McFee</surname>
<given-names>RB</given-names>
</name>
<name>
<surname>Caraccio</surname>
<given-names>TR</given-names>
</name>
<article-title>Intravenous mercury injection and ingestion: clinical manifestations and management</article-title>
<source>J Toxicol Clin Toxicol</source>
<year>2001</year>
<volume>39</volume>
<fpage>733</fpage>
<lpage>738</lpage>
<pub-id pub-id-type="doi">10.1081/CLT-100108515</pub-id>
<pub-id pub-id-type="pmid">11778672</pub-id>
</mixed-citation>
</ref>
<ref id="B17">
<mixed-citation publication-type="journal">
<name>
<surname>Zorrilla</surname>
<given-names>P</given-names>
</name>
<name>
<surname>Morales</surname>
<given-names>C</given-names>
</name>
<name>
<surname>Gomez</surname>
<given-names>LA</given-names>
</name>
<name>
<surname>Salido</surname>
<given-names>JA</given-names>
</name>
<article-title>Intravenous and subcutaneous injection of mercury: an unusual self-injury</article-title>
<source>J Trauma</source>
<year>2009</year>
<volume>66</volume>
<fpage>E32</fpage>
<lpage>33</lpage>
<pub-id pub-id-type="doi">10.1097/01.ta.0000219909.03256.64</pub-id>
<pub-id pub-id-type="pmid">18277286</pub-id>
</mixed-citation>
</ref>
<ref id="B18">
<mixed-citation publication-type="journal">
<name>
<surname>Schwarz</surname>
<given-names>S</given-names>
</name>
<name>
<surname>Husstedt</surname>
<given-names>I</given-names>
</name>
<name>
<surname>Bertram</surname>
<given-names>HP</given-names>
</name>
<name>
<surname>Kuchelmeister</surname>
<given-names>K</given-names>
</name>
<article-title>Amyotrophic lateral sclerosis after accidental injection of mercury</article-title>
<source>J Neurol Neurosurg Psychiatry</source>
<year>1996</year>
<volume>60</volume>
<fpage>698</fpage>
<pub-id pub-id-type="doi">10.1136/jnnp.60.6.698</pub-id>
<pub-id pub-id-type="pmid">8648348</pub-id>
</mixed-citation>
</ref>
<ref id="B19">
<mixed-citation publication-type="other">
<name>
<surname>Benz</surname>
<given-names>MR</given-names>
</name>
<article-title>Reply to correspondence letter by A. Costa et al.: pediatric mercury poisoning, brain MRI, and white matter hyperintensities</article-title>
<source>Eur J Pediatr</source>
<year>2011</year>
</mixed-citation>
</ref>
<ref id="B20">
<mixed-citation publication-type="journal">
<name>
<surname>Chodorowski</surname>
<given-names>Z</given-names>
</name>
<name>
<surname>Sein Anand</surname>
<given-names>J</given-names>
</name>
<name>
<surname>Nowicki</surname>
<given-names>A</given-names>
</name>
<name>
<surname>Galant</surname>
<given-names>K</given-names>
</name>
<article-title>Subcutaneous self-injection and oral self-administration of metallic mercury--case report</article-title>
<source>Przegl Lek</source>
<year>1997</year>
<volume>54</volume>
<fpage>759</fpage>
<lpage>762</lpage>
<pub-id pub-id-type="pmid">9478103</pub-id>
</mixed-citation>
</ref>
<ref id="B21">
<mixed-citation publication-type="journal">
<name>
<surname>Krohn</surname>
<given-names>IT</given-names>
</name>
<name>
<surname>Solof</surname>
<given-names>A</given-names>
</name>
<name>
<surname>Mobini</surname>
<given-names>J</given-names>
</name>
<name>
<surname>Wagner</surname>
<given-names>DK</given-names>
</name>
<article-title>Subcutaneous injection of metallic mercury</article-title>
<source>JAMA</source>
<year>1980</year>
<volume>243</volume>
<fpage>548</fpage>
<lpage>549</lpage>
<pub-id pub-id-type="doi">10.1001/jama.243.6.548</pub-id>
<pub-id pub-id-type="pmid">7351787</pub-id>
</mixed-citation>
</ref>
</ref-list>
</back>
</pmc>
<affiliations>
<list>
<country>
<li>Autriche</li>
</country>
</list>
<tree>
<country name="Autriche">
<noRegion>
<name sortKey="Friesenbichler, Joerg" sort="Friesenbichler, Joerg" uniqKey="Friesenbichler J" first="Joerg" last="Friesenbichler">Joerg Friesenbichler</name>
</noRegion>
<name sortKey="Leithner, Andreas" sort="Leithner, Andreas" uniqKey="Leithner A" first="Andreas" last="Leithner">Andreas Leithner</name>
<name sortKey="Maurer Ertl, Werner" sort="Maurer Ertl, Werner" uniqKey="Maurer Ertl W" first="Werner" last="Maurer-Ertl">Werner Maurer-Ertl</name>
<name sortKey="Sadoghi, Patrick" sort="Sadoghi, Patrick" uniqKey="Sadoghi P" first="Patrick" last="Sadoghi">Patrick Sadoghi</name>
<name sortKey="Wolf, Elisabeth" sort="Wolf, Elisabeth" uniqKey="Wolf E" first="Elisabeth" last="Wolf">Elisabeth Wolf</name>
</country>
</tree>
</affiliations>
</record>

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