Neural language networks at birth
Identifieur interne : 000482 ( Ncbi/Merge ); précédent : 000481; suivant : 000483Neural language networks at birth
Auteurs : Daniela Perani [Italie] ; Maria C. Saccuman [Italie] ; Paola Scifo ; Alfred Anwander ; Danilo Spada [Italie] ; Cristina Baldoli ; Antonella Poloniato [Italie] ; Gabriele Lohmann ; Angela D. Friederici [Allemagne]Source :
- Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2011.
Abstract
The ability to learn language is a human trait. In adults and children, brain imaging studies have shown that auditory language activates a bilateral frontotemporal network with a left hemispheric dominance. It is an open question whether these activations represent the complete neural basis for language present at birth. Here we demonstrate that in 2-d-old infants, the language-related neural substrate is fully active in both hemispheres with a preponderance in the right auditory cortex. Functional and structural connectivities within this neural network, however, are immature, with strong connectivities only between the two hemispheres, contrasting with the adult pattern of prevalent intrahemispheric connectivities. Thus, although the brain responds to spoken language already at birth, thereby providing a strong biological basis to acquire language, progressive maturation of intrahemispheric functional connectivity is yet to be established with language exposure as the brain develops.
Url:
DOI: 10.1073/pnas.1102991108
PubMed: 21896765
PubMed Central: 3179044
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000618
- to stream Pmc, to step Curation: 000618
- to stream Pmc, to step Checkpoint: 000322
Links to Exploration step
PMC:3179044Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Neural language networks at birth</title>
<author><name sortKey="Perani, Daniela" sort="Perani, Daniela" uniqKey="Perani D" first="Daniela" last="Perani">Daniela Perani</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Faculty of Psychology,<institution> Vita-Salute San Raffaele University</institution>
, 20132 Milan,<country>Italy</country>
;</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation><nlm:aff id="aff2">Center of Excellence for High-Field Magnetic Resonance Imaging (CERMAC),</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff3">Department of Nuclear Medicine, Division of Neuroscience, and Departments of</nlm:aff>
<wicri:noCountry code="subfield">and Departments of</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Saccuman, Maria C" sort="Saccuman, Maria C" uniqKey="Saccuman M" first="Maria C." last="Saccuman">Maria C. Saccuman</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Faculty of Psychology,<institution> Vita-Salute San Raffaele University</institution>
, 20132 Milan,<country>Italy</country>
;</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Scifo, Paola" sort="Scifo, Paola" uniqKey="Scifo P" first="Paola" last="Scifo">Paola Scifo</name>
<affiliation><nlm:aff id="aff2">Center of Excellence for High-Field Magnetic Resonance Imaging (CERMAC),</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff3">Department of Nuclear Medicine, Division of Neuroscience, and Departments of</nlm:aff>
<wicri:noCountry code="subfield">and Departments of</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Anwander, Alfred" sort="Anwander, Alfred" uniqKey="Anwander A" first="Alfred" last="Anwander">Alfred Anwander</name>
<affiliation><nlm:aff id="aff5">Cortical Network and Cognitive Function Group and Departments of</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Spada, Danilo" sort="Spada, Danilo" uniqKey="Spada D" first="Danilo" last="Spada">Danilo Spada</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Faculty of Psychology,<institution> Vita-Salute San Raffaele University</institution>
, 20132 Milan,<country>Italy</country>
;</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Baldoli, Cristina" sort="Baldoli, Cristina" uniqKey="Baldoli C" first="Cristina" last="Baldoli">Cristina Baldoli</name>
<affiliation><nlm:aff id="aff2">Center of Excellence for High-Field Magnetic Resonance Imaging (CERMAC),</nlm:aff>
</affiliation>
<affiliation><nlm:aff wicri:cut=" and" id="aff7">Neuroradiology</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Poloniato, Antonella" sort="Poloniato, Antonella" uniqKey="Poloniato A" first="Antonella" last="Poloniato">Antonella Poloniato</name>
<affiliation wicri:level="1"><nlm:aff wicri:cut="; and" id="aff4">Neonatology,<institution>San Raffaele Scientific Institute</institution>
, 20132 Milan,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lohmann, Gabriele" sort="Lohmann, Gabriele" uniqKey="Lohmann G" first="Gabriele" last="Lohmann">Gabriele Lohmann</name>
<affiliation><nlm:aff wicri:cut=" and" id="aff8">Neurophysics</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Friederici, Angela D" sort="Friederici, Angela D" uniqKey="Friederici A" first="Angela D." last="Friederici">Angela D. Friederici</name>
<affiliation wicri:level="1"><nlm:aff id="aff6">Neuropsychology,<institution>Max Planck Institute for Human Cognitive and Brain Sciences</institution>
, 04103 Leipzig,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">21896765</idno>
<idno type="pmc">3179044</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179044</idno>
<idno type="RBID">PMC:3179044</idno>
<idno type="doi">10.1073/pnas.1102991108</idno>
<date when="2011">2011</date>
<idno type="wicri:Area/Pmc/Corpus">000618</idno>
<idno type="wicri:Area/Pmc/Curation">000618</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000322</idno>
<idno type="wicri:Area/Ncbi/Merge">000482</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Neural language networks at birth</title>
<author><name sortKey="Perani, Daniela" sort="Perani, Daniela" uniqKey="Perani D" first="Daniela" last="Perani">Daniela Perani</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Faculty of Psychology,<institution> Vita-Salute San Raffaele University</institution>
, 20132 Milan,<country>Italy</country>
;</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation><nlm:aff id="aff2">Center of Excellence for High-Field Magnetic Resonance Imaging (CERMAC),</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff3">Department of Nuclear Medicine, Division of Neuroscience, and Departments of</nlm:aff>
<wicri:noCountry code="subfield">and Departments of</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Saccuman, Maria C" sort="Saccuman, Maria C" uniqKey="Saccuman M" first="Maria C." last="Saccuman">Maria C. Saccuman</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Faculty of Psychology,<institution> Vita-Salute San Raffaele University</institution>
, 20132 Milan,<country>Italy</country>
;</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Scifo, Paola" sort="Scifo, Paola" uniqKey="Scifo P" first="Paola" last="Scifo">Paola Scifo</name>
<affiliation><nlm:aff id="aff2">Center of Excellence for High-Field Magnetic Resonance Imaging (CERMAC),</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff3">Department of Nuclear Medicine, Division of Neuroscience, and Departments of</nlm:aff>
<wicri:noCountry code="subfield">and Departments of</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Anwander, Alfred" sort="Anwander, Alfred" uniqKey="Anwander A" first="Alfred" last="Anwander">Alfred Anwander</name>
<affiliation><nlm:aff id="aff5">Cortical Network and Cognitive Function Group and Departments of</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Spada, Danilo" sort="Spada, Danilo" uniqKey="Spada D" first="Danilo" last="Spada">Danilo Spada</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Faculty of Psychology,<institution> Vita-Salute San Raffaele University</institution>
, 20132 Milan,<country>Italy</country>
;</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Baldoli, Cristina" sort="Baldoli, Cristina" uniqKey="Baldoli C" first="Cristina" last="Baldoli">Cristina Baldoli</name>
<affiliation><nlm:aff id="aff2">Center of Excellence for High-Field Magnetic Resonance Imaging (CERMAC),</nlm:aff>
</affiliation>
<affiliation><nlm:aff wicri:cut=" and" id="aff7">Neuroradiology</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Poloniato, Antonella" sort="Poloniato, Antonella" uniqKey="Poloniato A" first="Antonella" last="Poloniato">Antonella Poloniato</name>
<affiliation wicri:level="1"><nlm:aff wicri:cut="; and" id="aff4">Neonatology,<institution>San Raffaele Scientific Institute</institution>
, 20132 Milan,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lohmann, Gabriele" sort="Lohmann, Gabriele" uniqKey="Lohmann G" first="Gabriele" last="Lohmann">Gabriele Lohmann</name>
<affiliation><nlm:aff wicri:cut=" and" id="aff8">Neurophysics</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Friederici, Angela D" sort="Friederici, Angela D" uniqKey="Friederici A" first="Angela D." last="Friederici">Angela D. Friederici</name>
<affiliation wicri:level="1"><nlm:aff id="aff6">Neuropsychology,<institution>Max Planck Institute for Human Cognitive and Brain Sciences</institution>
, 04103 Leipzig,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title>
<idno type="ISSN">0027-8424</idno>
<idno type="e-ISSN">1091-6490</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>The ability to learn language is a human trait. In adults and children, brain imaging studies have shown that auditory language activates a bilateral frontotemporal network with a left hemispheric dominance. It is an open question whether these activations represent the complete neural basis for language present at birth. Here we demonstrate that in 2-d-old infants, the language-related neural substrate is fully active in both hemispheres with a preponderance in the right auditory cortex. Functional and structural connectivities within this neural network, however, are immature, with strong connectivities only between the two hemispheres, contrasting with the adult pattern of prevalent intrahemispheric connectivities. Thus, although the brain responds to spoken language already at birth, thereby providing a strong biological basis to acquire language, progressive maturation of intrahemispheric functional connectivity is yet to be established with language exposure as the brain develops.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Proc Natl Acad Sci U S A</journal-id>
<journal-id journal-id-type="hwp">pnas</journal-id>
<journal-id journal-id-type="pmc">pnas</journal-id>
<journal-id journal-id-type="publisher-id">PNAS</journal-id>
<journal-title-group><journal-title>Proceedings of the National Academy of Sciences of the United States of America</journal-title>
</journal-title-group>
<issn pub-type="ppub">0027-8424</issn>
<issn pub-type="epub">1091-6490</issn>
<publisher><publisher-name>National Academy of Sciences</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">21896765</article-id>
<article-id pub-id-type="pmc">3179044</article-id>
<article-id pub-id-type="publisher-id">201102991</article-id>
<article-id pub-id-type="doi">10.1073/pnas.1102991108</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Biological Sciences</subject>
<subj-group><subject>Neuroscience</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group><article-title>Neural language networks at birth</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Perani</surname>
<given-names>Daniela</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>a</sup>
</xref>
<xref ref-type="aff" rid="aff2"><sup>b</sup>
</xref>
<xref ref-type="aff" rid="aff3"><sup>c</sup>
</xref>
<xref ref-type="corresp" rid="cor1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Saccuman</surname>
<given-names>Maria C.</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>a</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Scifo</surname>
<given-names>Paola</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>b</sup>
</xref>
<xref ref-type="aff" rid="aff3"><sup>c</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Anwander</surname>
<given-names>Alfred</given-names>
</name>
<xref ref-type="aff" rid="aff5"><sup>d</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Spada</surname>
<given-names>Danilo</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>a</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Baldoli</surname>
<given-names>Cristina</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>b</sup>
</xref>
<xref ref-type="aff" rid="aff7"><sup>e</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Poloniato</surname>
<given-names>Antonella</given-names>
</name>
<xref ref-type="aff" rid="aff4"><sup>f</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lohmann</surname>
<given-names>Gabriele</given-names>
</name>
<xref ref-type="aff" rid="aff8"><sup>g</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Friederici</surname>
<given-names>Angela D.</given-names>
</name>
<xref ref-type="aff" rid="aff6"><sup>h</sup>
</xref>
<xref ref-type="corresp" rid="cor1"><sup>1</sup>
</xref>
</contrib>
<aff id="aff1"><sup>a</sup>
Faculty of Psychology,<institution> Vita-Salute San Raffaele University</institution>
, 20132 Milan,<country>Italy</country>
;</aff>
<aff id="aff2"><sup>b</sup>
Center of Excellence for High-Field Magnetic Resonance Imaging (CERMAC),</aff>
<aff id="aff3"><sup>c</sup>
Department of Nuclear Medicine, Division of Neuroscience, and Departments of</aff>
<aff id="aff7"><sup>e</sup>
Neuroradiology and</aff>
<aff id="aff4"><sup>f</sup>
Neonatology,<institution>San Raffaele Scientific Institute</institution>
, 20132 Milan,<country>Italy</country>
; and</aff>
<aff id="aff5"><sup>d</sup>
Cortical Network and Cognitive Function Group and Departments of</aff>
<aff id="aff8"><sup>g</sup>
Neurophysics and</aff>
<aff id="aff6"><sup>h</sup>
Neuropsychology,<institution>Max Planck Institute for Human Cognitive and Brain Sciences</institution>
, 04103 Leipzig,<country>Germany</country>
</aff>
</contrib-group>
<author-notes><corresp id="cor1"><sup>1</sup>
To whom correspondence may be addressed. E-mail: <email>perani.daniela@hsr.it</email>
or <email>angelafr@cbs.mpg.de</email>
.</corresp>
<fn fn-type="edited-by"><p>Edited<xref ref-type="fn" rid="fn1">*</xref>
by Leslie G. Ungerleider, National Institute of Mental Health, Bethesda, MD, and approved August 5, 2011 (received for review March 1, 2011)</p>
</fn>
<fn fn-type="con"><p>Author contributions: D.P. and A.D.F. designed research; D.P., M.C.S., P.S., D.S., C.B., and A.P. performed research; M.C.S., P.S., A.A., D.S., and G.L. analyzed data; and D.P., M.C.S., and A.D.F. wrote the paper.</p>
</fn>
</author-notes>
<pub-date pub-type="ppub"><day>20</day>
<month>9</month>
<year>2011</year>
</pub-date>
<pub-date pub-type="epub"><day>6</day>
<month>9</month>
<year>2011</year>
</pub-date>
<volume>108</volume>
<issue>38</issue>
<fpage>16056</fpage>
<lpage>16061</lpage>
<self-uri xlink:title="pdf" xlink:type="simple" xlink:href="pnas.201102991.pdf"></self-uri>
<abstract><p>The ability to learn language is a human trait. In adults and children, brain imaging studies have shown that auditory language activates a bilateral frontotemporal network with a left hemispheric dominance. It is an open question whether these activations represent the complete neural basis for language present at birth. Here we demonstrate that in 2-d-old infants, the language-related neural substrate is fully active in both hemispheres with a preponderance in the right auditory cortex. Functional and structural connectivities within this neural network, however, are immature, with strong connectivities only between the two hemispheres, contrasting with the adult pattern of prevalent intrahemispheric connectivities. Thus, although the brain responds to spoken language already at birth, thereby providing a strong biological basis to acquire language, progressive maturation of intrahemispheric functional connectivity is yet to be established with language exposure as the brain develops.</p>
</abstract>
<kwd-group><kwd>brain activity</kwd>
<kwd>newborns</kwd>
<kwd>dorsal pathway</kwd>
<kwd>ventral pathway</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>Allemagne</li>
<li>Italie</li>
</country>
</list>
<tree><noCountry><name sortKey="Anwander, Alfred" sort="Anwander, Alfred" uniqKey="Anwander A" first="Alfred" last="Anwander">Alfred Anwander</name>
<name sortKey="Baldoli, Cristina" sort="Baldoli, Cristina" uniqKey="Baldoli C" first="Cristina" last="Baldoli">Cristina Baldoli</name>
<name sortKey="Lohmann, Gabriele" sort="Lohmann, Gabriele" uniqKey="Lohmann G" first="Gabriele" last="Lohmann">Gabriele Lohmann</name>
<name sortKey="Scifo, Paola" sort="Scifo, Paola" uniqKey="Scifo P" first="Paola" last="Scifo">Paola Scifo</name>
</noCountry>
<country name="Italie"><noRegion><name sortKey="Perani, Daniela" sort="Perani, Daniela" uniqKey="Perani D" first="Daniela" last="Perani">Daniela Perani</name>
</noRegion>
<name sortKey="Poloniato, Antonella" sort="Poloniato, Antonella" uniqKey="Poloniato A" first="Antonella" last="Poloniato">Antonella Poloniato</name>
<name sortKey="Saccuman, Maria C" sort="Saccuman, Maria C" uniqKey="Saccuman M" first="Maria C." last="Saccuman">Maria C. Saccuman</name>
<name sortKey="Spada, Danilo" sort="Spada, Danilo" uniqKey="Spada D" first="Danilo" last="Spada">Danilo Spada</name>
</country>
<country name="Allemagne"><noRegion><name sortKey="Friederici, Angela D" sort="Friederici, Angela D" uniqKey="Friederici A" first="Angela D." last="Friederici">Angela D. Friederici</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Musique/explor/MozartV1/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000482 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 000482 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Musique |area= MozartV1 |flux= Ncbi |étape= Merge |type= RBID |clé= PMC:3179044 |texte= Neural language networks at birth }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:21896765" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \ | NlmPubMed2Wicri -a MozartV1
This area was generated with Dilib version V0.6.20. |