Fodrin in Centrosomes: Implication of a Role of Fodrin in the Transport of Gamma-Tubulin Complex in Brain
Identifieur interne : 000263 ( Main/Merge ); précédent : 000262; suivant : 000264Fodrin in Centrosomes: Implication of a Role of Fodrin in the Transport of Gamma-Tubulin Complex in Brain
Auteurs : Sasidharan Shashikala [Inde] ; Rohith Kumar [Inde] ; Nisha E. Thomas [Inde] ; Dhanesh Sivadasan [Inde] ; Jackson James [Inde] ; Suparna Sengupta [Inde]Source :
- PLoS ONE ; 2013.
Abstract
Gamma-tubulin is the major protein involved in the nucleation of microtubules from centrosomes in eukaryotic cells. It is present in both cytoplasm and centrosome. However, before centrosome maturation prior to mitosis, gamma-tubulin concentration increases dramatically in the centrosome, the mechanism of which is not known. Earlier it was reported that cytoplasmic gamma-tubulin complex isolated from goat brain contains non-erythroid spectrin/fodrin. The major role of erythroid spectrin is to help in the membrane organisation and integrity. However, fodrin or non-erythroid spectrin has a distinct pattern of localisation in brain cells and evidently some special functions over its erythroid counterpart. In this study, we show that fodrin and γ-tubulin are present together in both the cytoplasm and centrosomes in all brain cells except differentiated neurons and astrocytes. Immunoprecipitation studies in purified centrosomes from brain tissue and brain cell lines confirm that fodrin and γ-tubulin interact with each other in centrosomes. Fodrin dissociates from centrosome just after the onset of mitosis, when the concentration of γ-tubulin attains a maximum at centrosomes. Further it is observed that the interaction between fodrin and γ-tubulin in the centrosome is dependent on actin as depolymerisation of microfilaments stops fodrin localization. Image analysis revealed that γ-tubulin concentration also decreased drastically in the centrosome under this condition. This indicates towards a role of fodrin as a regulatory transporter of γ-tubulin to the centrosomes for normal progression of mitosis.
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DOI: 10.1371/journal.pone.0076613
PubMed: 24098540
PubMed Central: 3788121
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Thomas</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Cancer Research Programme III, Rajiv Gandhi Centre for Biotechnology, Thiruvanantha-puram, Kerala, India</addr-line></nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Cancer Research Programme III, Rajiv Gandhi Centre for Biotechnology, Thiruvanantha-puram, Kerala</wicri:regionArea><wicri:noRegion>Kerala</wicri:noRegion></affiliation></author><author><name sortKey="Sivadasan, Dhanesh" sort="Sivadasan, Dhanesh" uniqKey="Sivadasan D" first="Dhanesh" last="Sivadasan">Dhanesh Sivadasan</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Neuro Stem Cell Biology, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala, India</addr-line></nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Neuro Stem Cell Biology, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala</wicri:regionArea><wicri:noRegion>Kerala</wicri:noRegion></affiliation></author><author><name sortKey="James, Jackson" sort="James, Jackson" uniqKey="James J" first="Jackson" last="James">Jackson James</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Neuro Stem Cell Biology, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala, India</addr-line></nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Neuro Stem Cell Biology, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala</wicri:regionArea><wicri:noRegion>Kerala</wicri:noRegion></affiliation></author><author><name sortKey="Sengupta, Suparna" sort="Sengupta, Suparna" uniqKey="Sengupta S" first="Suparna" last="Sengupta">Suparna Sengupta</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Cancer Research Programme III, Rajiv Gandhi Centre for Biotechnology, Thiruvanantha-puram, Kerala, India</addr-line></nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Cancer Research Programme III, Rajiv Gandhi Centre for Biotechnology, Thiruvanantha-puram, Kerala</wicri:regionArea><wicri:noRegion>Kerala</wicri:noRegion></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="e-ISSN">1932-6203</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Gamma-tubulin is the major protein involved in the nucleation of microtubules from centrosomes in eukaryotic cells. It is present in both cytoplasm and centrosome. However, before centrosome maturation prior to mitosis, gamma-tubulin concentration increases dramatically in the centrosome, the mechanism of which is not known. Earlier it was reported that cytoplasmic gamma-tubulin complex isolated from goat brain contains non-erythroid spectrin/fodrin. The major role of erythroid spectrin is to help in the membrane organisation and integrity. However, fodrin or non-erythroid spectrin has a distinct pattern of localisation in brain cells and evidently some special functions over its erythroid counterpart. In this study, we show that fodrin and γ-tubulin are present together in both the cytoplasm and centrosomes in all brain cells except differentiated neurons and astrocytes. Immunoprecipitation studies in purified centrosomes from brain tissue and brain cell lines confirm that fodrin and γ-tubulin interact with each other in centrosomes. Fodrin dissociates from centrosome just after the onset of mitosis, when the concentration of γ-tubulin attains a maximum at centrosomes. Further it is observed that the interaction between fodrin and γ-tubulin in the centrosome is dependent on actin as depolymerisation of microfilaments stops fodrin localization. Image analysis revealed that γ-tubulin concentration also decreased drastically in the centrosome under this condition. This indicates towards a role of fodrin as a regulatory transporter of γ-tubulin to the centrosomes for normal progression of mitosis.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Doxsey, S" uniqKey="Doxsey S">S Doxsey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Khodjakov, A" uniqKey="Khodjakov A">A Khodjakov</name></author><author><name sortKey="Rieder, Cl" uniqKey="Rieder C">CL Rieder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sunkel, Ce" uniqKey="Sunkel C">CE Sunkel</name></author><author><name sortKey="Gomes, R" uniqKey="Gomes R">R Gomes</name></author><author><name sortKey="Sampaio, P" uniqKey="Sampaio P">P Sampaio</name></author><author><name sortKey="Perdigao, J" uniqKey="Perdigao J">J Perdigao</name></author><author><name sortKey="Gonzalez, C" uniqKey="Gonzalez C">C 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