Mozart's music in children with drug-refractory epileptic encephalopathies.
Identifieur interne : 000045 ( Main/Exploration ); précédent : 000044; suivant : 000046Mozart's music in children with drug-refractory epileptic encephalopathies.
Auteurs : Giangennaro Coppola [Italie] ; Annacarmela Toro [Italie] ; Francesca Felicia Operto [Italie] ; Giuseppe Ferrarioli [Italie] ; Simone Pisano [Italie] ; Andrea Viggiano [Italie] ; Alberto Verrotti [Italie]Source :
- Epilepsy & behavior : E&B ; 2015.
Abstract
Mozart's sonata for two pianos in D major, K448, has been shown to decrease interictal EEG discharges and recurrence of clinical seizures in both adults and young patients. In this prospective, open-label study, we evaluated the effect of listening to a set of Mozart's compositions, according to the Tomatis method, on sleep quality and behavioral disorders, including auto-/hetero-aggression, irritability, and hyperactivity, in a group of children and adolescents with drug-resistant epilepsy. The study group was composed of 11 outpatients (7 males and 4 females), between 1.5years and 21years of age (mean age: 11.9years), all suffering from drug-resistant epileptic encephalopathy (n=11). All of them had a severe/profound intellectual disability associated with cerebral palsy. During the study period, each patient had to listen to a set of Mozart's compositions 2h per day for fifteen days for a total of 30h, which could be distributed over the day depending on the habits and compliance of each patient. The music was filtered by a device preferably delivering higher sound frequencies (>3000Hz) according to the Tomatis principles. The antiepileptic drug therapy remained unchanged throughout the study period. During the 15-day music therapy, 2 out of 11 patients had a reduction of 50-75% in seizure recurrence, and 3 out of 12 patients had a reduction of 75-89%. Overall, 5 (45.4%) out of 11 patients had a ≥50% reduction in the total number of seizures, while the percentage decrease of the total seizure number (11/11) compared with baseline was -51.5% during the 15-day music therapy and -20.7% in the two weeks after the end of treatment. All responders also had an improvement in nighttime sleep and daytime behavior.
DOI: 10.1016/j.yebeh.2015.05.038
PubMed: 26093514
Affiliations:
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<front><div type="abstract" xml:lang="en">Mozart's sonata for two pianos in D major, K448, has been shown to decrease interictal EEG discharges and recurrence of clinical seizures in both adults and young patients. In this prospective, open-label study, we evaluated the effect of listening to a set of Mozart's compositions, according to the Tomatis method, on sleep quality and behavioral disorders, including auto-/hetero-aggression, irritability, and hyperactivity, in a group of children and adolescents with drug-resistant epilepsy. The study group was composed of 11 outpatients (7 males and 4 females), between 1.5years and 21years of age (mean age: 11.9years), all suffering from drug-resistant epileptic encephalopathy (n=11). All of them had a severe/profound intellectual disability associated with cerebral palsy. During the study period, each patient had to listen to a set of Mozart's compositions 2h per day for fifteen days for a total of 30h, which could be distributed over the day depending on the habits and compliance of each patient. The music was filtered by a device preferably delivering higher sound frequencies (>3000Hz) according to the Tomatis principles. The antiepileptic drug therapy remained unchanged throughout the study period. During the 15-day music therapy, 2 out of 11 patients had a reduction of 50-75% in seizure recurrence, and 3 out of 12 patients had a reduction of 75-89%. Overall, 5 (45.4%) out of 11 patients had a ≥50% reduction in the total number of seizures, while the percentage decrease of the total seizure number (11/11) compared with baseline was -51.5% during the 15-day music therapy and -20.7% in the two weeks after the end of treatment. All responders also had an improvement in nighttime sleep and daytime behavior.</div>
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<tree><country name="Italie"><noRegion><name sortKey="Coppola, Giangennaro" sort="Coppola, Giangennaro" uniqKey="Coppola G" first="Giangennaro" last="Coppola">Giangennaro Coppola</name>
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<name sortKey="Ferrarioli, Giuseppe" sort="Ferrarioli, Giuseppe" uniqKey="Ferrarioli G" first="Giuseppe" last="Ferrarioli">Giuseppe Ferrarioli</name>
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<name sortKey="Pisano, Simone" sort="Pisano, Simone" uniqKey="Pisano S" first="Simone" last="Pisano">Simone Pisano</name>
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