The long-term effect of listening to Mozart K.448 decreases epileptiform discharges in children with epilepsy.
Identifieur interne : 000519 ( Main/Exploration ); précédent : 000518; suivant : 000520The long-term effect of listening to Mozart K.448 decreases epileptiform discharges in children with epilepsy.
Auteurs : Lung-Chang Lin [Taïwan] ; Wei-Te Lee ; Hui-Chuan Wu ; Chin-Lin Tsai ; Ruey-Chang Wei ; Hin-Kiu Mok ; Chia-Fen Weng ; Mei-Wen Lee ; Rei-Cheng YangSource :
- Epilepsy & behavior : E&B ; 2011.
English descriptors
- KwdEn :
- Acoustic Stimulation, Adolescent, Auditory Perception (physiology), Brain (physiopathology), Brain Waves (physiology), Child, Child, Preschool, Electroencephalography, Epilepsy (physiopathology), Epilepsy (therapy), Female, Follow-Up Studies, Humans, Infant, Male, Music, Music Therapy, Time, Treatment Outcome.
- MESH :
- physiology : Auditory Perception, Brain Waves.
- physiopathology : Brain, Epilepsy.
- therapy : Epilepsy.
- Acoustic Stimulation, Adolescent, Child, Child, Preschool, Electroencephalography, Female, Follow-Up Studies, Humans, Infant, Male, Music, Music Therapy, Time, Treatment Outcome.
Abstract
Mozart's Sonata for Two Pianos in D major, K.448 (Mozart K.448), has been shown to improve mental function, leading to what is known as the Mozart Effect. Our previous work revealed that epileptiform discharges in children with epilepsy decrease during and right after listening to Mozart K.448. However, the duration of the effect was not studied. In the study described here, we evaluated the long-term effect of Mozart K.448 on epileptiform discharges in children with epilepsy. Eighteen children with epilepsy whose seizures were clinically well controlled with antiepileptic drugs were included. For each child, EEGs had revealed persistent epileptiform discharges for at least 6 months. These patients listened to Mozart K.448 for 8 minutes once a day before bedtime for 6 months. Epileptiform discharges were recorded and compared before and after 1, 2, and 6 months of listening to Mozart K.448. All of the children remained on the same antiepileptic drug over the 6 months. Relationships between number of epileptiform discharges and foci of discharges, intelligence, epilepsy etiology, age, and gender were analyzed. Epileptiform discharges significantly decreased by 53.2±47.4, 64.4±47.1, and 71.6±45.8%, respectively, after listening to Mozart K.448 for 1, 2, and 6 months. All patients except those with occipital discharges showed a significant decrease in epileptiform discharges. Patients with normal intelligence and idiopathic epilepsy had greater decreases than those with mental retardation and symptomatic epilepsy. Age and gender did not affect the results. We conclude that long-term listening to Mozart K.448 may be effective in decreasing epileptiform discharges in children with epilepsy in a chronologically progressive manner.
DOI: 10.1016/j.yebeh.2011.05.015
PubMed: 21689988
Affiliations:
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sortKey="Tsai, Chin Lin" sort="Tsai, Chin Lin" uniqKey="Tsai C" first="Chin-Lin" last="Tsai">Chin-Lin Tsai</name></author><author><name sortKey="Wei, Ruey Chang" sort="Wei, Ruey Chang" uniqKey="Wei R" first="Ruey-Chang" last="Wei">Ruey-Chang Wei</name></author><author><name sortKey="Mok, Hin Kiu" sort="Mok, Hin Kiu" uniqKey="Mok H" first="Hin-Kiu" last="Mok">Hin-Kiu Mok</name></author><author><name sortKey="Weng, Chia Fen" sort="Weng, Chia Fen" uniqKey="Weng C" first="Chia-Fen" last="Weng">Chia-Fen Weng</name></author><author><name sortKey="Lee, Mei Wen" sort="Lee, Mei Wen" uniqKey="Lee M" first="Mei-Wen" last="Lee">Mei-Wen Lee</name></author><author><name sortKey="Yang, Rei Cheng" sort="Yang, Rei Cheng" uniqKey="Yang R" first="Rei-Cheng" last="Yang">Rei-Cheng Yang</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2011">2011</date><idno type="doi">10.1016/j.yebeh.2011.05.015</idno><idno type="RBID">pubmed:21689988</idno><idno 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xml:lang="fr">Taïwan</country><wicri:regionArea>Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung City</wicri:regionArea><wicri:noRegion>Kaohsiung City</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Wei Te" sort="Lee, Wei Te" uniqKey="Lee W" first="Wei-Te" last="Lee">Wei-Te Lee</name></author><author><name sortKey="Wu, Hui Chuan" sort="Wu, Hui Chuan" uniqKey="Wu H" first="Hui-Chuan" last="Wu">Hui-Chuan Wu</name></author><author><name sortKey="Tsai, Chin Lin" sort="Tsai, Chin Lin" uniqKey="Tsai C" first="Chin-Lin" last="Tsai">Chin-Lin Tsai</name></author><author><name sortKey="Wei, Ruey Chang" sort="Wei, Ruey Chang" uniqKey="Wei R" first="Ruey-Chang" last="Wei">Ruey-Chang Wei</name></author><author><name sortKey="Mok, Hin Kiu" sort="Mok, Hin Kiu" uniqKey="Mok H" first="Hin-Kiu" last="Mok">Hin-Kiu Mok</name></author><author><name sortKey="Weng, Chia Fen" sort="Weng, Chia Fen" uniqKey="Weng C" first="Chia-Fen" last="Weng">Chia-Fen Weng</name></author><author><name sortKey="Lee, Mei Wen" sort="Lee, Mei Wen" uniqKey="Lee M" first="Mei-Wen" last="Lee">Mei-Wen Lee</name></author><author><name sortKey="Yang, Rei Cheng" sort="Yang, Rei Cheng" uniqKey="Yang R" first="Rei-Cheng" last="Yang">Rei-Cheng Yang</name></author></analytic><series><title level="j">Epilepsy & behavior : E&B</title><idno type="e-ISSN">1525-5069</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acoustic Stimulation</term><term>Adolescent</term><term>Auditory Perception (physiology)</term><term>Brain (physiopathology)</term><term>Brain Waves (physiology)</term><term>Child</term><term>Child, Preschool</term><term>Electroencephalography</term><term>Epilepsy (physiopathology)</term><term>Epilepsy (therapy)</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Infant</term><term>Male</term><term>Music</term><term>Music Therapy</term><term>Time</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Auditory Perception</term><term>Brain Waves</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Brain</term><term>Epilepsy</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Epilepsy</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Acoustic Stimulation</term><term>Adolescent</term><term>Child</term><term>Child, Preschool</term><term>Electroencephalography</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Infant</term><term>Male</term><term>Music</term><term>Music Therapy</term><term>Time</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Mozart's Sonata for Two Pianos in D major, K.448 (Mozart K.448), has been shown to improve mental function, leading to what is known as the Mozart Effect. Our previous work revealed that epileptiform discharges in children with epilepsy decrease during and right after listening to Mozart K.448. However, the duration of the effect was not studied. In the study described here, we evaluated the long-term effect of Mozart K.448 on epileptiform discharges in children with epilepsy. Eighteen children with epilepsy whose seizures were clinically well controlled with antiepileptic drugs were included. For each child, EEGs had revealed persistent epileptiform discharges for at least 6 months. These patients listened to Mozart K.448 for 8 minutes once a day before bedtime for 6 months. Epileptiform discharges were recorded and compared before and after 1, 2, and 6 months of listening to Mozart K.448. All of the children remained on the same antiepileptic drug over the 6 months. Relationships between number of epileptiform discharges and foci of discharges, intelligence, epilepsy etiology, age, and gender were analyzed. Epileptiform discharges significantly decreased by 53.2±47.4, 64.4±47.1, and 71.6±45.8%, respectively, after listening to Mozart K.448 for 1, 2, and 6 months. All patients except those with occipital discharges showed a significant decrease in epileptiform discharges. Patients with normal intelligence and idiopathic epilepsy had greater decreases than those with mental retardation and symptomatic epilepsy. Age and gender did not affect the results. We conclude that long-term listening to Mozart K.448 may be effective in decreasing epileptiform discharges in children with epilepsy in a chronologically progressive manner.</div></front></TEI><affiliations><list><country><li>Taïwan</li></country></list><tree><noCountry><name sortKey="Lee, Mei Wen" sort="Lee, Mei Wen" uniqKey="Lee M" first="Mei-Wen" last="Lee">Mei-Wen Lee</name><name sortKey="Lee, Wei Te" sort="Lee, Wei Te" uniqKey="Lee W" first="Wei-Te" last="Lee">Wei-Te Lee</name><name sortKey="Mok, Hin Kiu" sort="Mok, Hin Kiu" uniqKey="Mok H" first="Hin-Kiu" last="Mok">Hin-Kiu Mok</name><name sortKey="Tsai, Chin Lin" sort="Tsai, Chin Lin" uniqKey="Tsai C" first="Chin-Lin" last="Tsai">Chin-Lin Tsai</name><name sortKey="Wei, Ruey Chang" sort="Wei, Ruey Chang" uniqKey="Wei R" first="Ruey-Chang" last="Wei">Ruey-Chang Wei</name><name sortKey="Weng, Chia Fen" sort="Weng, Chia Fen" uniqKey="Weng C" first="Chia-Fen" last="Weng">Chia-Fen Weng</name><name sortKey="Wu, Hui Chuan" sort="Wu, Hui Chuan" uniqKey="Wu H" first="Hui-Chuan" last="Wu">Hui-Chuan Wu</name><name sortKey="Yang, Rei Cheng" sort="Yang, Rei Cheng" uniqKey="Yang R" first="Rei-Cheng" last="Yang">Rei-Cheng Yang</name></noCountry><country name="Taïwan"><noRegion><name sortKey="Lin, Lung Chang" sort="Lin, Lung Chang" uniqKey="Lin L" first="Lung-Chang" last="Lin">Lung-Chang Lin</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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