MozartV1, Main, Exploration, bibRecordById, pubmed:21292560

Mozart K.448 acts as a potential add-on therapy in children with refractory epilepsy.

Identifieur interne : 000541 ( Main/Exploration ); précédent : 000540; suivant : 000542

Mozart K.448 acts as a potential add-on therapy in children with refractory epilepsy.

Auteurs : Lung-Chang Lin [Taïwan] ; Wei-Te Lee ; Chien-Hua Wang ; Hsiu-Lin Chen ; Hui-Chuan Wu ; Chin-Lin Tsai ; Ruey-Chang Wei ; Hin-Kiu Mok ; Chia-Fen Weng ; Mei-Wen Lee ; Rei-Cheng Yang

Source :

Epilepsy & behavior : E&B ; 2011.

RBID : pubmed:21292560

English descriptors

KwdEn :
- Acoustic Stimulation (methods), Analysis of Variance, Anticonvulsants (therapeutic use), Auditory Perception (physiology), Child, Child, Preschool, Epilepsy (therapy), Female, Humans, Infant, Intelligence Tests, Male, Music Therapy (methods), Treatment Outcome.
MESH :
- chemical , therapeutic use : Anticonvulsants.
- methods : Acoustic Stimulation, Music Therapy.
- physiology : Auditory Perception.
- therapy : Epilepsy.
- Analysis of Variance, Child, Child, Preschool, Female, Humans, Infant, Intelligence Tests, Male, Treatment Outcome.

Abstract

Mozart's Sonata for two pianos in D major, K.448 (Mozart K.448), has been shown to improve mental function, leading to what is known as the Mozart effect. Our previous work revealed that epileptiform discharges in children with epilepsy decreased during and immediately after listening to Mozart K.448. In this study, we evaluated the long-term effects of Mozart K.448 on children with refractory epilepsy. Eleven children with refractory epilepsy were enrolled. All of the patients were diagnosed as having had refractory epilepsy for more than 1 year (range =1 year to 6 years 4 months, mean =3 years 11 months) and had been receiving at least two antiepileptic drugs (AED). During the study period, they listened to Mozart K.448 once a day before bedtime for 6 months. Seizure frequencies were recorded 6 months before they started listening to this music and monthly during the study period. All of the patients remained on the same AEDs during the 6-month study period. Frequencies of seizures were compared before and after listening to Mozart K.448. Eight of eleven patients were seizure free (N=2) or had very good responses (N=6) after 6 months of listening to Mozart K.448. The remaining three (27.3%) showed minimal or no effect (effectiveness <50%; unmodified or worsened seizure frequency). The average seizure reduction was 53.6 ± 62.0%. There were no significant differences in seizure reduction with IQ, etiology, or gender. We conclude that Mozart K.448 should be further studied as a potential add-on therapy in the treatment of children with refractory epilepsy.

DOI: 10.1016/j.yebeh.2010.12.044
PubMed: 21292560

Affiliations:

Taïwan

Le document en format XML

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<front><div type="abstract" xml:lang="en">Mozart's Sonata for two pianos in D major, K.448 (Mozart K.448), has been shown to improve mental function, leading to what is known as the Mozart effect. Our previous work revealed that epileptiform discharges in children with epilepsy decreased during and immediately after listening to Mozart K.448. In this study, we evaluated the long-term effects of Mozart K.448 on children with refractory epilepsy. Eleven children with refractory epilepsy were enrolled. All of the patients were diagnosed as having had refractory epilepsy for more than 1 year (range =1 year to 6 years 4 months, mean =3 years 11 months) and had been receiving at least two antiepileptic drugs (AED). During the study period, they listened to Mozart K.448 once a day before bedtime for 6 months. Seizure frequencies were recorded 6 months before they started listening to this music and monthly during the study period. All of the patients remained on the same AEDs during the 6-month study period. Frequencies of seizures were compared before and after listening to Mozart K.448. Eight of eleven patients were seizure free (N=2) or had very good responses (N=6) after 6 months of listening to Mozart K.448. The remaining three (27.3%) showed minimal or no effect (effectiveness <50%; unmodified or worsened seizure frequency). The average seizure reduction was 53.6 ± 62.0%. There were no significant differences in seizure reduction with IQ, etiology, or gender. We conclude that Mozart K.448 should be further studied as a potential add-on therapy in the treatment of children with refractory epilepsy.</div>
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Mozart K.448 acts as a potential add-on therapy in children with refractory epilepsy.

Mozart K.448 acts as a potential add-on therapy in children with refractory epilepsy.

Source :

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Abstract

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