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Mozart K.448 attenuates spontaneous absence seizure and related high-voltage rhythmic spike discharges in Long Evans rats

Identifieur interne : 000364 ( Main/Exploration ); précédent : 000363; suivant : 000365

Mozart K.448 attenuates spontaneous absence seizure and related high-voltage rhythmic spike discharges in Long Evans rats

Auteurs : Lung-Chang Lin [Taïwan] ; Chun-Ting Juan [Taïwan] ; Hsueh-Wen Chang [Taïwan] ; Ching-Tai Chiang [Taïwan] ; Ruey-Chang Wei [Taïwan] ; Mei-Wen Lee [Taïwan] ; Hin-Kiu Mok [Taïwan] ; Rei-Cheng Yang [Taïwan]

Source :

Epilepsy research [ 0920-1211 ] ; 2013.

RBID : Pascal:13-0202475

Descripteurs français

Pascal (Inist)
- Epilepsie, Convulsion, Tension électrique, Décharge rythmique, Pointe positive, Rat, Animal.

English descriptors

KwdEn :
- Animal, Convulsion, Epilepsy, Rat, Rhythmic discharge, Spike, Voltage.

Abstract

Purpose: Recent research has revealed more evidence supporting the positive effects of music on humans and animals. However, evidence of music's effects on improving epilepsy in animals is sparse. This study aimed to clarify the influence of Mozart's music in Long Evans rats, which are characterized by spontaneous absence epilepsy (SAE) and high-voltage rhythmic spike (HVRS) discharges. Methods: Continuous electroencephalograms comprised of HVRS discharges, and behavioral performance were recorded in Long Evans rats (n = 5) before, during, and after exposure to the Mozart's Sonata for Two Pianos in D Major, K.448 (Mozart K.448). The same evaluation was repeated after they had been subjected to daily exposure of the music for 20 days. Results: Seizure frequencies and spontaneous HVRS discharges were reduced in all of the SAE rats during and after music exposure compared with the pre-music stage. The average seizure frequencies were 79.8±24.6, 48±15.2, and 33±2.1/h before, during, and after music exposure, respectively. The average run of spike episodes were 84.6±18.4, 52±17.8, and 36.8±16.9/h before, during, and after music exposure, respectively. The seizure frequencies and related run of spike episodes decreased by 39.8% and 38.5% during, and 58.6% and 56.6% post music exposure, respectively. The average run of spike durations and spike numbers also showed significant decreases (reduction by 47.1%, 47.8% during music and 60.8%, 61.3% post music). After daily music exposure for 20 days, the number of HVRS discharges and seizure frequencies during and after music exposure, however, showed no further accumulative reduction or adaptation effect. These results suggest that Mozart K.448 had a positive short-term effect in attenuating the spontaneous HVRS discharges in Long Evans rats. However, the mechanism needs further investigation.

Affiliations:

Taïwan

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Le document en format XML

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<author><name sortKey="Lin, Lung Chang" sort="Lin, Lung Chang" uniqKey="Lin L" first="Lung-Chang" last="Lin">Lung-Chang Lin</name>
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<country>Taïwan</country>
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<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University</s1>
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<author><name sortKey="Chang, Hsueh Wen" sort="Chang, Hsueh Wen" uniqKey="Chang H" first="Hsueh-Wen" last="Chang">Hsueh-Wen Chang</name>
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<author><name sortKey="Chiang, Ching Tai" sort="Chiang, Ching Tai" uniqKey="Chiang C" first="Ching-Tai" last="Chiang">Ching-Tai Chiang</name>
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<author><name sortKey="Wei, Ruey Chang" sort="Wei, Ruey Chang" uniqKey="Wei R" first="Ruey-Chang" last="Wei">Ruey-Chang Wei</name>
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<author><name sortKey="Yang, Rei Cheng" sort="Yang, Rei Cheng" uniqKey="Yang R" first="Rei-Cheng" last="Yang">Rei-Cheng Yang</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University</s1>
<s2>Kaohsiung City 80708</s2>
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<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Pediatrics, Changhua Christian Hospital</s1>
<s2>Changhua</s2>
<s3>TWN</s3>
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<country>Taïwan</country>
<wicri:noRegion>Changhua</wicri:noRegion>
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<author><name sortKey="Juan, Chun Ting" sort="Juan, Chun Ting" uniqKey="Juan C" first="Chun-Ting" last="Juan">Chun-Ting Juan</name>
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<author><name sortKey="Chiang, Ching Tai" sort="Chiang, Ching Tai" uniqKey="Chiang C" first="Ching-Tai" last="Chiang">Ching-Tai Chiang</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Computer and Communication, National Pingtung Institute of Commerce</s1>
<s2>Pingtung</s2>
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<author><name sortKey="Wei, Ruey Chang" sort="Wei, Ruey Chang" uniqKey="Wei R" first="Ruey-Chang" last="Wei">Ruey-Chang Wei</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Institute of Undersea Technology and Applied Marine Physics, National Sun Yat-Sen University</s1>
<s2>Kaohsiung City 80424</s2>
<s3>TWN</s3>
<sZ>5 aut.</sZ>
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<country>Taïwan</country>
<wicri:noRegion>Kaohsiung City 80424</wicri:noRegion>
</affiliation>
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<author><name sortKey="Lee, Mei Wen" sort="Lee, Mei Wen" uniqKey="Lee M" first="Mei-Wen" last="Lee">Mei-Wen Lee</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Music, National Sun Yat-Sen University</s1>
<s2>Kaohsiung City 80424</s2>
<s3>TWN</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Taïwan</country>
<wicri:noRegion>Kaohsiung City 80424</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mok, Hin Kiu" sort="Mok, Hin Kiu" uniqKey="Mok H" first="Hin-Kiu" last="Mok">Hin-Kiu Mok</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Institute of Marine Biology, National Sun Yat-Sen University</s1>
<s2>Kaohsiung City 80424</s2>
<s3>TWN</s3>
<sZ>2 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Taïwan</country>
<wicri:noRegion>Kaohsiung City 80424</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yang, Rei Cheng" sort="Yang, Rei Cheng" uniqKey="Yang R" first="Rei-Cheng" last="Yang">Rei-Cheng Yang</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University</s1>
<s2>Kaohsiung City 80708</s2>
<s3>TWN</s3>
<sZ>1 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Taïwan</country>
<wicri:noRegion>Kaohsiung City 80708</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Pediatrics, Changhua Christian Hospital</s1>
<s2>Changhua</s2>
<s3>TWN</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Taïwan</country>
<wicri:noRegion>Changhua</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Epilepsy research</title>
<title level="j" type="abbreviated">Epilepsy res.</title>
<idno type="ISSN">0920-1211</idno>
<imprint><date when="2013">2013</date>
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<seriesStmt><title level="j" type="main">Epilepsy research</title>
<title level="j" type="abbreviated">Epilepsy res.</title>
<idno type="ISSN">0920-1211</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal</term>
<term>Convulsion</term>
<term>Epilepsy</term>
<term>Rat</term>
<term>Rhythmic discharge</term>
<term>Spike</term>
<term>Voltage</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Epilepsie</term>
<term>Convulsion</term>
<term>Tension électrique</term>
<term>Décharge rythmique</term>
<term>Pointe positive</term>
<term>Rat</term>
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<front><div type="abstract" xml:lang="en">Purpose: Recent research has revealed more evidence supporting the positive effects of music on humans and animals. However, evidence of music's effects on improving epilepsy in animals is sparse. This study aimed to clarify the influence of Mozart's music in Long Evans rats, which are characterized by spontaneous absence epilepsy (SAE) and high-voltage rhythmic spike (HVRS) discharges. Methods: Continuous electroencephalograms comprised of HVRS discharges, and behavioral performance were recorded in Long Evans rats (n = 5) before, during, and after exposure to the Mozart's Sonata for Two Pianos in D Major, K.448 (Mozart K.448). The same evaluation was repeated after they had been subjected to daily exposure of the music for 20 days. Results: Seizure frequencies and spontaneous HVRS discharges were reduced in all of the SAE rats during and after music exposure compared with the pre-music stage. The average seizure frequencies were 79.8±24.6, 48±15.2, and 33±2.1/h before, during, and after music exposure, respectively. The average run of spike episodes were 84.6±18.4, 52±17.8, and 36.8±16.9/h before, during, and after music exposure, respectively. The seizure frequencies and related run of spike episodes decreased by 39.8% and 38.5% during, and 58.6% and 56.6% post music exposure, respectively. The average run of spike durations and spike numbers also showed significant decreases (reduction by 47.1%, 47.8% during music and 60.8%, 61.3% post music). After daily music exposure for 20 days, the number of HVRS discharges and seizure frequencies during and after music exposure, however, showed no further accumulative reduction or adaptation effect. These results suggest that Mozart K.448 had a positive short-term effect in attenuating the spontaneous HVRS discharges in Long Evans rats. However, the mechanism needs further investigation.</div>
</front>
</TEI>
<affiliations><list><country><li>Taïwan</li>
</country>
</list>
<tree><country name="Taïwan"><noRegion><name sortKey="Lin, Lung Chang" sort="Lin, Lung Chang" uniqKey="Lin L" first="Lung-Chang" last="Lin">Lung-Chang Lin</name>
</noRegion>
<name sortKey="Chang, Hsueh Wen" sort="Chang, Hsueh Wen" uniqKey="Chang H" first="Hsueh-Wen" last="Chang">Hsueh-Wen Chang</name>
<name sortKey="Chiang, Ching Tai" sort="Chiang, Ching Tai" uniqKey="Chiang C" first="Ching-Tai" last="Chiang">Ching-Tai Chiang</name>
<name sortKey="Juan, Chun Ting" sort="Juan, Chun Ting" uniqKey="Juan C" first="Chun-Ting" last="Juan">Chun-Ting Juan</name>
<name sortKey="Lee, Mei Wen" sort="Lee, Mei Wen" uniqKey="Lee M" first="Mei-Wen" last="Lee">Mei-Wen Lee</name>
<name sortKey="Lin, Lung Chang" sort="Lin, Lung Chang" uniqKey="Lin L" first="Lung-Chang" last="Lin">Lung-Chang Lin</name>
<name sortKey="Mok, Hin Kiu" sort="Mok, Hin Kiu" uniqKey="Mok H" first="Hin-Kiu" last="Mok">Hin-Kiu Mok</name>
<name sortKey="Wei, Ruey Chang" sort="Wei, Ruey Chang" uniqKey="Wei R" first="Ruey-Chang" last="Wei">Ruey-Chang Wei</name>
<name sortKey="Yang, Rei Cheng" sort="Yang, Rei Cheng" uniqKey="Yang R" first="Rei-Cheng" last="Yang">Rei-Cheng Yang</name>
<name sortKey="Yang, Rei Cheng" sort="Yang, Rei Cheng" uniqKey="Yang R" first="Rei-Cheng" last="Yang">Rei-Cheng Yang</name>
</country>
</tree>
</affiliations>
</record>

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Mozart K.448 attenuates spontaneous absence seizure and related high-voltage rhythmic spike discharges in Long Evans rats

Mozart K.448 attenuates spontaneous absence seizure and related high-voltage rhythmic spike discharges in Long Evans rats

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri