Is silence golden? Effects of auditory stimuli and their absence on adult hippocampal neurogenesis
Identifieur interne : 000253 ( Main/Exploration ); précédent : 000252; suivant : 000254Is silence golden? Effects of auditory stimuli and their absence on adult hippocampal neurogenesis
Auteurs : Imke Kirste [Allemagne, États-Unis] ; Zeina Nicola [Allemagne] ; Golo Kronenberg [Allemagne] ; Tara L. Walker [Allemagne] ; Robert C. Liu [États-Unis] ; Gerd Kempermann [Allemagne]Source :
- Brain Structure & Function [ 1863-2653 ] ; 2013.
English descriptors
- KwdEn :
- Acoustic Stimulation (methods), Animals, Cell Proliferation, Evoked Potentials, Auditory, Brain Stem, Female, Hippocampus (cytology), Hippocampus (metabolism), Hippocampus (physiology), Mice, Inbred C57BL, Models, Animal, Music, Neural Stem Cells (metabolism), Neural Stem Cells (physiology), Neurogenesis, Neuronal Plasticity, Noise, SOXB1 Transcription Factors (metabolism), Time Factors, Vocalization, Animal.
- MESH :
- chemical , metabolism : SOXB1 Transcription Factors.
- cytology : Hippocampus.
- metabolism : Hippocampus, Neural Stem Cells.
- methods : Acoustic Stimulation.
- physiology : Hippocampus, Neural Stem Cells.
- Animals, Cell Proliferation, Evoked Potentials, Auditory, Brain Stem, Female, Mice, Inbred C57BL, Models, Animal, Music, Neurogenesis, Neuronal Plasticity, Noise, Time Factors, Vocalization, Animal.
Abstract
We have previously hypothesized that the reason why physical activity increases precursor cell proliferation in adult neurogenesis is that movement serves as non-specific signal to evoke the alertness required to meet cognitive demands. Thereby a pool of immature neurons is generated that are potentially recruitable by subsequent cognitive stimuli. Along these lines, we here tested whether auditory stimuli might exert a similar non-specific effect on adult neurogenesis in mice. We used the standard noise level in the animal facility as baseline and compared this condition to white noise, pup calls, and silence. In addition, as patterned auditory stimulus without ethological relevance to mice we used piano music by Mozart (KV 448). All stimuli were transposed to the frequency range of C57BL/6 and hearing was objectified with acoustic evoked potentials. We found that except for white noise all stimuli, including silence, increased precursor cell proliferation (assessed 24 h after labeling with bromodeoxyuridine, BrdU). This could be explained by significant increases in BrdU-labeled Sox2-positive cells (type-1/2a). But after 7 days, only silence remained associated with increased numbers of BrdU-labeled cells. Compared to controls at this stage, exposure to silence had generated significantly increased numbers of BrdU/NeuN-labeled neurons. Our results indicate that the unnatural absence of auditory input as well as spectrotemporally rich albeit ethological irrelevant stimuli activate precursor cells—in the case of silence also leading to greater numbers of newborn immature neurons—whereas ambient and unstructured background auditory stimuli do not.
Url:
DOI: 10.1007/s00429-013-0679-3
PubMed: 24292324
PubMed Central: 4087081
Affiliations:
- Allemagne, États-Unis
- Berlin, Caroline du Nord, District de Dresde, Géorgie (États-Unis), Saxe (Land)
- Berlin, Dresde
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Le document en format XML
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Effects of auditory stimuli and their absence on adult hippocampal neurogenesis</title><author><name sortKey="Kirste, Imke" sort="Kirste, Imke" uniqKey="Kirste I" first="Imke" last="Kirste">Imke Kirste</name><affiliation wicri:level="3"><nlm:aff id="Aff1">CRTD, DFG Research Center for Regenerative Therapies Dresden, Fetscherstraße 105, 01307 Dresden, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>CRTD, DFG Research Center for Regenerative Therapies Dresden, Fetscherstraße 105, 01307 Dresden</wicri:regionArea><placeName><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Dresde</region><settlement type="city">Dresde</settlement></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="Aff2">Brain Imaging and Analysis Center (BIAC), Duke University Medical Center, Durham, NC 27710 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Brain Imaging and Analysis Center (BIAC), Duke University Medical Center, Durham</wicri:cityArea></affiliation></author><author><name sortKey="Nicola, Zeina" sort="Nicola, Zeina" uniqKey="Nicola Z" first="Zeina" last="Nicola">Zeina Nicola</name><affiliation wicri:level="3"><nlm:aff id="Aff1">CRTD, DFG Research Center for Regenerative Therapies Dresden, Fetscherstraße 105, 01307 Dresden, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>CRTD, DFG Research Center for Regenerative Therapies Dresden, Fetscherstraße 105, 01307 Dresden</wicri:regionArea><placeName><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Dresde</region><settlement type="city">Dresde</settlement></placeName></affiliation></author><author><name sortKey="Kronenberg, Golo" sort="Kronenberg, Golo" uniqKey="Kronenberg G" first="Golo" last="Kronenberg">Golo Kronenberg</name><affiliation wicri:level="3"><nlm:aff id="Aff3">Klinik und Poliklinik für Psychiatrie und Psychotherapie, Charité- Universitätsmedizin Berlin, Charité Campus Mitte, 10117 Berlin, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Klinik und Poliklinik für Psychiatrie und Psychotherapie, Charité- Universitätsmedizin Berlin, Charité Campus Mitte, 10117 Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Walker, Tara L" sort="Walker, Tara L" uniqKey="Walker T" first="Tara L." last="Walker">Tara L. Walker</name><affiliation wicri:level="3"><nlm:aff id="Aff1">CRTD, DFG Research Center for Regenerative Therapies Dresden, Fetscherstraße 105, 01307 Dresden, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>CRTD, DFG Research Center for Regenerative Therapies Dresden, Fetscherstraße 105, 01307 Dresden</wicri:regionArea><placeName><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Dresde</region><settlement type="city">Dresde</settlement></placeName></affiliation></author><author><name sortKey="Liu, Robert C" sort="Liu, Robert C" uniqKey="Liu R" first="Robert C." last="Liu">Robert C. Liu</name><affiliation wicri:level="2"><nlm:aff id="Aff4">Department of Biology, Emory University, Atlanta, GA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName><wicri:cityArea>Department of Biology, Emory University, Atlanta</wicri:cityArea></affiliation></author><author><name sortKey="Kempermann, Gerd" sort="Kempermann, Gerd" uniqKey="Kempermann G" first="Gerd" last="Kempermann">Gerd Kempermann</name><affiliation wicri:level="3"><nlm:aff id="Aff1">CRTD, DFG Research Center for Regenerative Therapies Dresden, Fetscherstraße 105, 01307 Dresden, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>CRTD, DFG Research Center for Regenerative Therapies Dresden, Fetscherstraße 105, 01307 Dresden</wicri:regionArea><placeName><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Dresde</region><settlement type="city">Dresde</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff5">German Center for Neurodegenerative Diseases (DZNE) Dresden, Arnoldstraße 18b, 01307 Dresden, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Center for Neurodegenerative Diseases (DZNE) Dresden, Arnoldstraße 18b, 01307 Dresden</wicri:regionArea><placeName><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Dresde</region><settlement type="city">Dresde</settlement></placeName></affiliation></author></analytic><series><title level="j">Brain Structure & Function</title><idno type="ISSN">1863-2653</idno><idno type="e-ISSN">1863-2661</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acoustic Stimulation (methods)</term><term>Animals</term><term>Cell Proliferation</term><term>Evoked Potentials, Auditory, Brain Stem</term><term>Female</term><term>Hippocampus (cytology)</term><term>Hippocampus (metabolism)</term><term>Hippocampus (physiology)</term><term>Mice, Inbred C57BL</term><term>Models, Animal</term><term>Music</term><term>Neural Stem Cells (metabolism)</term><term>Neural Stem Cells (physiology)</term><term>Neurogenesis</term><term>Neuronal Plasticity</term><term>Noise</term><term>SOXB1 Transcription Factors (metabolism)</term><term>Time Factors</term><term>Vocalization, Animal</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>SOXB1 Transcription Factors</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Hippocampus</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Hippocampus</term><term>Neural Stem Cells</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Acoustic Stimulation</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Hippocampus</term><term>Neural Stem Cells</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Proliferation</term><term>Evoked Potentials, Auditory, Brain Stem</term><term>Female</term><term>Mice, Inbred C57BL</term><term>Models, Animal</term><term>Music</term><term>Neurogenesis</term><term>Neuronal Plasticity</term><term>Noise</term><term>Time Factors</term><term>Vocalization, Animal</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>We have previously hypothesized that the reason why physical activity increases precursor cell proliferation in adult neurogenesis is that movement serves as non-specific signal to evoke the alertness required to meet cognitive demands. Thereby a pool of immature neurons is generated that are potentially recruitable by subsequent cognitive stimuli. Along these lines, we here tested whether auditory stimuli might exert a similar non-specific effect on adult neurogenesis in mice. We used the standard noise level in the animal facility as baseline and compared this condition to white noise, pup calls, and silence. In addition, as patterned auditory stimulus without ethological relevance to mice we used piano music by Mozart (KV 448). All stimuli were transposed to the frequency range of C57BL/6 and hearing was objectified with acoustic evoked potentials. We found that except for white noise all stimuli, including silence, increased precursor cell proliferation (assessed 24 h after labeling with bromodeoxyuridine, BrdU). This could be explained by significant increases in BrdU-labeled Sox2-positive cells (type-1/2a). But after 7 days, only silence remained associated with increased numbers of BrdU-labeled cells. Compared to controls at this stage, exposure to silence had generated significantly increased numbers of BrdU/NeuN-labeled neurons. Our results indicate that the unnatural absence of auditory input as well as spectrotemporally rich albeit ethological irrelevant stimuli activate precursor cells—in the case of silence also leading to greater numbers of newborn immature neurons—whereas ambient and unstructured background auditory stimuli do not.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Aimone, Jb" uniqKey="Aimone J">JB Aimone</name></author><author><name sortKey="Deng, W" uniqKey="Deng W">W Deng</name></author><author><name sortKey="Gage, Fh" uniqKey="Gage F">FH Gage</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aoun, P" uniqKey="Aoun P">P Aoun</name></author><author><name sortKey="Jones, T" uniqKey="Jones T">T Jones</name></author><author><name sortKey="Shaw, Gl" uniqKey="Shaw G">GL Shaw</name></author><author><name sortKey="Bodner, M" uniqKey="Bodner M">M 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Makino</name></author><author><name sortKey="Gage, Fh" uniqKey="Gage F">FH Gage</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Praag, H" uniqKey="Van Praag H">H Van Praag</name></author><author><name sortKey="Kempermann, G" uniqKey="Kempermann G">G Kempermann</name></author><author><name sortKey="Gage, Fh" uniqKey="Gage F">FH Gage</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Voisin, J" uniqKey="Voisin J">J Voisin</name></author><author><name sortKey="Bidet Caulet, A" uniqKey="Bidet Caulet A">A Bidet-Caulet</name></author><author><name sortKey="Bertrand, O" uniqKey="Bertrand O">O Bertrand</name></author><author><name sortKey="Fonlupt, P" uniqKey="Fonlupt P">P Fonlupt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wiskott, L" uniqKey="Wiskott L">L Wiskott</name></author><author><name sortKey="Rasch, Mj" uniqKey="Rasch M">MJ Rasch</name></author><author><name sortKey="Kempermann, G" uniqKey="Kempermann G">G Kempermann</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li><li>États-Unis</li></country><region><li>Berlin</li><li>Caroline du Nord</li><li>District de Dresde</li><li>Géorgie (États-Unis)</li><li>Saxe (Land)</li></region><settlement><li>Berlin</li><li>Dresde</li></settlement></list><tree><country name="Allemagne"><region name="Saxe (Land)"><name sortKey="Kirste, Imke" sort="Kirste, Imke" uniqKey="Kirste I" first="Imke" last="Kirste">Imke Kirste</name></region><name sortKey="Kempermann, Gerd" sort="Kempermann, Gerd" uniqKey="Kempermann G" first="Gerd" last="Kempermann">Gerd Kempermann</name><name sortKey="Kempermann, Gerd" sort="Kempermann, Gerd" uniqKey="Kempermann G" first="Gerd" last="Kempermann">Gerd Kempermann</name><name sortKey="Kronenberg, Golo" sort="Kronenberg, Golo" uniqKey="Kronenberg G" first="Golo" last="Kronenberg">Golo Kronenberg</name><name sortKey="Nicola, Zeina" sort="Nicola, Zeina" uniqKey="Nicola Z" first="Zeina" last="Nicola">Zeina Nicola</name><name sortKey="Walker, Tara L" sort="Walker, Tara L" uniqKey="Walker T" first="Tara L." last="Walker">Tara L. Walker</name></country><country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Kirste, Imke" sort="Kirste, Imke" uniqKey="Kirste I" first="Imke" last="Kirste">Imke Kirste</name></region><name sortKey="Liu, Robert C" sort="Liu, Robert C" uniqKey="Liu R" first="Robert C." last="Liu">Robert C. Liu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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