The consequences of microneurography electrode-induced injury of peripheral nerves observed in the rat and man
Identifieur interne : 003869 ( Main/Exploration ); précédent : 003868; suivant : 003870The consequences of microneurography electrode-induced injury of peripheral nerves observed in the rat and man
Auteurs : Andrew S. C. Rice ; Nicholai Y. Andreev ; Stephen B. McmahonSource :
- Pain [ 0304-3959 ] ; 1994.
Abstract
The consequences of microneurography were assessed, using tungsten and coaxial electrodes in rat and man. Firstly, the sequelae of microneurography were examined for up to 1 month in a rat sciatic nerve model, using 3 techniques. Expression of the injury-associated protein GAP-43 was measured by immunofluorescence in sciatic nerve and dorsal root ganglia 3 and 28 days following sciatic nerve injury by microneurography electrodes. No increase in GAP-43 was observed in sciatic nerve 3 days following injury, but 28 days after injury the coaxial electrode was associated with an increase in GAP-43 expression. All electrodes were associated with an increase in GAP-43 in dorsal root ganglia 28 days after injury. The capacity of unmyelinated afferent fibres to induce neurogenic oedema was examined up to the 28th post-experimental day, as measured by Evan's Blue extravasation. The tungsten electrode induced a decrease in extravasation, which persisted for 28 days. In contrast, the decrease in plasma extravasation associated with lesions induced by the coaxial electrode returned to baseline within 7 days. The hind-limb withdrawal time from a noxious stimulus was also measured up to 28 days following injury. Both types of electrode induced a significant change in the immediate post-experimental period, but this returned to normal within 1 week. The direction of change differed between the tungsten and coaxial electrodes. In humans, symptomatology questionnaires were collected after microneurography experiments with the coaxial electrode. Thirty-two volunteers were studied. Two subjects reported mild paraesthesiae, which fully resolved within 24 h. This compares favourably with similar studies of the tungsten electrode.
Url:
DOI: 10.1016/0304-3959(94)90025-6
Affiliations:
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>The consequences of microneurography electrode-induced injury of peripheral nerves observed in the rat and man</title><author><name sortKey="Rice, Andrew S C" sort="Rice, Andrew S C" uniqKey="Rice A" first="Andrew S. C." last="Rice">Andrew S. C. Rice</name></author><author><name sortKey="Andreev, Nicholai Y" sort="Andreev, Nicholai Y" uniqKey="Andreev N" first="Nicholai Y." last="Andreev">Nicholai Y. Andreev</name></author><author><name sortKey="Mcmahon, Stephen B" sort="Mcmahon, Stephen B" uniqKey="Mcmahon S" first="Stephen B." last="Mcmahon">Stephen B. Mcmahon</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:BAD0B5AE8433E86840AC704303C765E66BAD9218</idno><date when="1994" year="1994">1994</date><idno type="doi">10.1016/0304-3959(94)90025-6</idno><idno type="url">https://api.istex.fr/document/BAD0B5AE8433E86840AC704303C765E66BAD9218/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000815</idno><idno type="wicri:Area/Istex/Curation">000656</idno><idno type="wicri:Area/Istex/Checkpoint">002F89</idno><idno type="wicri:doubleKey">0304-3959:1994:Rice A:the:consequences:of</idno><idno type="wicri:Area/Main/Merge">003974</idno><idno type="wicri:Area/Main/Curation">003869</idno><idno type="wicri:Area/Main/Exploration">003869</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">The consequences of microneurography electrode-induced injury of peripheral nerves observed in the rat and man</title><author><name sortKey="Rice, Andrew S C" sort="Rice, Andrew S C" uniqKey="Rice A" first="Andrew S. C." last="Rice">Andrew S. C. Rice</name><affiliation><wicri:noCountry code="subField">London SE1 7EH UK</wicri:noCountry></affiliation></author><author><name sortKey="Andreev, Nicholai Y" sort="Andreev, Nicholai Y" uniqKey="Andreev N" first="Nicholai Y." last="Andreev">Nicholai Y. Andreev</name><affiliation><wicri:noCountry code="subField">London SE1 7EH UK</wicri:noCountry></affiliation></author><author><name sortKey="Mcmahon, Stephen B" sort="Mcmahon, Stephen B" uniqKey="Mcmahon S" first="Stephen B." last="Mcmahon">Stephen B. Mcmahon</name><affiliation><wicri:noCountry code="subField">London SE1 7EH UK</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j">Pain</title><title level="j" type="abbrev">PAIN</title><idno type="ISSN">0304-3959</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1994">1994</date><biblScope unit="volume">59</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="385">385</biblScope><biblScope unit="page" to="393">393</biblScope></imprint><idno type="ISSN">0304-3959</idno></series><idno type="istex">BAD0B5AE8433E86840AC704303C765E66BAD9218</idno><idno type="DOI">10.1016/0304-3959(94)90025-6</idno><idno type="PII">0304-3959(94)90025-6</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0304-3959</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The consequences of microneurography were assessed, using tungsten and coaxial electrodes in rat and man. Firstly, the sequelae of microneurography were examined for up to 1 month in a rat sciatic nerve model, using 3 techniques. Expression of the injury-associated protein GAP-43 was measured by immunofluorescence in sciatic nerve and dorsal root ganglia 3 and 28 days following sciatic nerve injury by microneurography electrodes. No increase in GAP-43 was observed in sciatic nerve 3 days following injury, but 28 days after injury the coaxial electrode was associated with an increase in GAP-43 expression. All electrodes were associated with an increase in GAP-43 in dorsal root ganglia 28 days after injury. The capacity of unmyelinated afferent fibres to induce neurogenic oedema was examined up to the 28th post-experimental day, as measured by Evan's Blue extravasation. The tungsten electrode induced a decrease in extravasation, which persisted for 28 days. In contrast, the decrease in plasma extravasation associated with lesions induced by the coaxial electrode returned to baseline within 7 days. The hind-limb withdrawal time from a noxious stimulus was also measured up to 28 days following injury. Both types of electrode induced a significant change in the immediate post-experimental period, but this returned to normal within 1 week. The direction of change differed between the tungsten and coaxial electrodes. In humans, symptomatology questionnaires were collected after microneurography experiments with the coaxial electrode. Thirty-two volunteers were studied. Two subjects reported mild paraesthesiae, which fully resolved within 24 h. This compares favourably with similar studies of the tungsten electrode.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Andreev, Nicholai Y" sort="Andreev, Nicholai Y" uniqKey="Andreev N" first="Nicholai Y." last="Andreev">Nicholai Y. Andreev</name><name sortKey="Mcmahon, Stephen B" sort="Mcmahon, Stephen B" uniqKey="Mcmahon S" first="Stephen B." last="Mcmahon">Stephen B. Mcmahon</name><name sortKey="Rice, Andrew S C" sort="Rice, Andrew S C" uniqKey="Rice A" first="Andrew S. C." last="Rice">Andrew S. C. Rice</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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