Melatonin stimulates the growth of new bone around implants in the tibia of rabbits
Identifieur interne : 002092 ( Istex/Corpus ); précédent : 002091; suivant : 002093Melatonin stimulates the growth of new bone around implants in the tibia of rabbits
Auteurs : José L. Calvo Uirado ; María P. Ramírez Ernández ; Gerardo G Mez Oreno ; José E. Maté Nchez ; Rafael Delgado Uiz ; Javier Guardia ; Laura L Pez Arí ; Antonio Barone ; Antonio J. Ortiz Uiz ; José M. Martínez Onzález ; Luis A. BravoSource :
- Journal of Pineal Research [ 0742-3098 ] ; 2010-11.
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Abstract
Abstract: This study evaluated the effect of the topical application of melatonin in accelerating bone formation associated with implants 2 months after their application to the tibiae of rabbits. Twenty New Zealand rabbits were used. Twenty implants treated with melatonin and 20 control implants without melatonin were placed in the proximal metaphyseal area of each tibia. Studies of new bone formation were subsequently made at 15, 30, 45 and 60 days. Cortical width and cortical length of new bone formation were measured. Following implantation, an anteroposterior and lateral radiologic study was carried out. Collected samples were sectioned at 5 μm and stained using hematoxylin–eosin, Masson’s trichromic and Gordon‐Switt reticulin stains. After a 60 day treatment period, melatonin increased the length of cortical bone (95.13 ± 0.42%) versus that around control implants (62.91 ± 1.45%). Related to the perimeter of cortical bone of the tibiae, melatonin induced new bone 88.35 ± 1.56% versus 60.20 ± 1.67% in the control implants. Melatonin regenerated the width and length of cortical bone around implants in tibiae of rabbits more quickly than around control implants without the addition of melatonin.
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DOI: 10.1111/j.1600-079X.2010.00801.x
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Ortiz Uiz</name><affiliation><mods:affiliation>Department of General Dentistry, Faculty of Medicine and Dentistry, University of Murcia, Murcia, Spain</mods:affiliation></affiliation></author><author><name sortKey="Martinez Onzalez, Jose M" sort="Martinez Onzalez, Jose M" uniqKey="Martinez Onzalez J" first="José M." last="Martínez Onzález">José M. Martínez Onzález</name><affiliation><mods:affiliation>Department of Oral Surgery, Faculty of Dentistry, University Complutense of Madrid, Madrid, Spain</mods:affiliation></affiliation></author><author><name sortKey="Bravo, Luis A" sort="Bravo, Luis A" uniqKey="Bravo L" first="Luis A." last="Bravo">Luis A. 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Twenty New Zealand rabbits were used. Twenty implants treated with melatonin and 20 control implants without melatonin were placed in the proximal metaphyseal area of each tibia. Studies of new bone formation were subsequently made at 15, 30, 45 and 60 days. Cortical width and cortical length of new bone formation were measured. Following implantation, an anteroposterior and lateral radiologic study was carried out. Collected samples were sectioned at 5 μm and stained using hematoxylin–eosin, Masson’s trichromic and Gordon‐Switt reticulin stains. After a 60 day treatment period, melatonin increased the length of cortical bone (95.13 ± 0.42%) versus that around control implants (62.91 ± 1.45%). Related to the perimeter of cortical bone of the tibiae, melatonin induced new bone 88.35 ± 1.56% versus 60.20 ± 1.67% in the control implants. Melatonin regenerated the width and length of cortical bone around implants in tibiae of rabbits more quickly than around control implants without the addition of melatonin.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>José L. Calvo‐Guirado</name><affiliations><json:string>Department of General Dentistry, Faculty of Medicine and Dentistry, University of Murcia, Murcia, Spain</json:string></affiliations></json:item><json:item><name>María P. Ramírez‐Fernández</name><affiliations><json:string>Department of Estomatology, University of Murcia, Murcia, Spain</json:string></affiliations></json:item><json:item><name>Gerardo Gómez‐Moreno</name><affiliations><json:string>Department of Pharmacological Interactions in Dentistry, Dental School, University of Granada, Granada, Spain</json:string></affiliations></json:item><json:item><name>José E. 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Bravo</name><affiliations><json:string>Department of Orthodontics, University of Murcia, Murcia, Spain</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>bone grafts</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>melatonin</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>porcine bone implant</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Abstract: This study evaluated the effect of the topical application of melatonin in accelerating bone formation associated with implants 2 months after their application to the tibiae of rabbits. Twenty New Zealand rabbits were used. Twenty implants treated with melatonin and 20 control implants without melatonin were placed in the proximal metaphyseal area of each tibia. Studies of new bone formation were subsequently made at 15, 30, 45 and 60 days. Cortical width and cortical length of new bone formation were measured. Following implantation, an anteroposterior and lateral radiologic study was carried out. Collected samples were sectioned at 5 μm and stained using hematoxylin–eosin, Masson’s trichromic and Gordon‐Switt reticulin stains. After a 60 day treatment period, melatonin increased the length of cortical bone (95.13 ± 0.42%) versus that around control implants (62.91 ± 1.45%). Related to the perimeter of cortical bone of the tibiae, melatonin induced new bone 88.35 ± 1.56% versus 60.20 ± 1.67% in the control implants. 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type="first">Antonio</forename><surname>Barone</surname></persName><affiliation>Department of Oral Surgery, Faculty of Medicine, University of Genova, Genova, Italy</affiliation></author><author><persName><forename type="first">Antonio J.</forename><surname>Ortiz‐Ruiz</surname></persName><affiliation>Department of General Dentistry, Faculty of Medicine and Dentistry, University of Murcia, Murcia, Spain</affiliation></author><author><persName><forename type="first">José M.</forename><surname>Martínez‐González</surname></persName><affiliation>Department of Oral Surgery, Faculty of Dentistry, University Complutense of Madrid, Madrid, Spain</affiliation></author><author><persName><forename type="first">Luis A.</forename><surname>Bravo</surname></persName><affiliation>Department of Orthodontics, University of Murcia, Murcia, Spain</affiliation></author></analytic><monogr><title level="j">Journal of Pineal Research</title><idno type="pISSN">0742-3098</idno><idno 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Twenty New Zealand rabbits were used. Twenty implants treated with melatonin and 20 control implants without melatonin were placed in the proximal metaphyseal area of each tibia. Studies of new bone formation were subsequently made at 15, 30, 45 and 60 days. Cortical width and cortical length of new bone formation were measured. Following implantation, an anteroposterior and lateral radiologic study was carried out. Collected samples were sectioned at 5 μm and stained using hematoxylin–eosin, Masson’s trichromic and Gordon‐Switt reticulin stains. After a 60 day treatment period, melatonin increased the length of cortical bone (95.13 ± 0.42%) versus that around control implants (62.91 ± 1.45%). Related to the perimeter of cortical bone of the tibiae, melatonin induced new bone 88.35 ± 1.56% versus 60.20 ± 1.67% in the control implants. Melatonin regenerated the width and length of cortical bone around implants in tibiae of rabbits more quickly than around control implants without the addition of melatonin.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>bone grafts</term></item><item><term>melatonin</term></item><item><term>porcine bone implant</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2010-11">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/808D2861B9BAB1A3B1E0126EC67E0CB1E4BA2E7E/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1600-079X</doi><issn type="print">0742-3098</issn><issn type="electronic">1600-079X</issn><idGroup><id type="product" value="JPI"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="JOURNAL OF PINEAL RESEARCH">Journal of Pineal Research</title></titleGroup></publicationMeta><publicationMeta level="part" position="11104"><doi origin="wiley">10.1111/jpi.2010.49.issue-4</doi><numberingGroup><numbering type="journalVolume" number="49">49</numbering><numbering type="journalIssue" number="4">4</numbering></numberingGroup><coverDate startDate="2010-11">November 2010</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="5" status="forIssue"><doi origin="wiley">10.1111/j.1600-079X.2010.00801.x</doi><idGroup><id type="unit" value="JPI801"></id></idGroup><countGroup><count type="pageTotal" number="8"></count></countGroup><titleGroup><title type="tocHeading1">Original Articles</title></titleGroup><copyright>© 2010 The Authors. Journal of Pineal Research © 2010 John Wiley & Sons A/S</copyright><eventGroup><event type="firstOnline" date="2010-07-28"></event><event type="publishedOnlineFinalForm" date="2010-07-28"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.23 mode:FullText" date="2010-10-18"></event><event type="publishedOnlineEarlyUnpaginated" date="2010-07-28"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-01"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-30"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="356">356</numbering><numbering type="pageLast" number="363">363</numbering></numberingGroup><correspondenceTo>Address reprint requests to José L. Calvo Guirado, Department of General Dentistry, Faculty of Medicine and Dentistry, University of Murcia, Mozart 1, 1ºG, 30002. Murcia, Spain.
Email: <email>joseluis.calvo@um.es</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:JPI.JPI801.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Received April 8, 2010; accepted June 23, 2010.</unparsedEditorialHistory><countGroup><count type="figureTotal" number="5"></count><count type="tableTotal" number="1"></count></countGroup><titleGroup><title type="main">Melatonin stimulates the growth of new bone around implants in the tibia of rabbits</title><title type="shortAuthors"><i>Calvo‐Guirado et al.</i></title><title type="short"><i>Melatonin in tibia rabbits</i></title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1"><personName><givenNames>José L.</givenNames><familyName>Calvo‐Guirado</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a2"><personName><givenNames>María P.</givenNames><familyName>Ramírez‐Fernández</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a3"><personName><givenNames>Gerardo</givenNames><familyName>Gómez‐Moreno</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a2"><personName><givenNames>José E.</givenNames><familyName>Maté‐Sánchez</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a2"><personName><givenNames>Rafael</givenNames><familyName>Delgado‐Ruiz</familyName></personName></creator><creator creatorRole="author" xml:id="cr6" affiliationRef="#a3"><personName><givenNames>Javier</givenNames><familyName>Guardia</familyName></personName></creator><creator creatorRole="author" xml:id="cr7" affiliationRef="#a4"><personName><givenNames>Laura</givenNames><familyName>López‐Marí</familyName></personName></creator><creator creatorRole="author" xml:id="cr8" affiliationRef="#a5"><personName><givenNames>Antonio</givenNames><familyName>Barone</familyName></personName></creator><creator creatorRole="author" xml:id="cr9" affiliationRef="#a6"><personName><givenNames>Antonio J.</givenNames><familyName>Ortiz‐Ruiz</familyName></personName></creator><creator creatorRole="author" xml:id="cr10" affiliationRef="#a7"><personName><givenNames>José M.</givenNames><familyName>Martínez‐González</familyName></personName></creator><creator creatorRole="author" xml:id="cr11" affiliationRef="#a8"><personName><givenNames>Luis A.</givenNames><familyName>Bravo</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="ES"><unparsedAffiliation>Department of General Dentistry, Faculty of Medicine and Dentistry, University of Murcia, Murcia, Spain</unparsedAffiliation></affiliation><affiliation xml:id="a2" countryCode="ES"><unparsedAffiliation>Department of Estomatology, University of Murcia, Murcia, Spain</unparsedAffiliation></affiliation><affiliation xml:id="a3" countryCode="ES"><unparsedAffiliation>Department of Pharmacological Interactions in Dentistry, Dental School, University of Granada, Granada, Spain</unparsedAffiliation></affiliation><affiliation xml:id="a4" countryCode="ES"><unparsedAffiliation>Master in Implant Dentistry, University of Murcia, Murcia, Spain</unparsedAffiliation></affiliation><affiliation xml:id="a5" countryCode="IT"><unparsedAffiliation>Department of Oral Surgery, Faculty of Medicine, University of Genova, Genova, Italy</unparsedAffiliation></affiliation><affiliation xml:id="a6" countryCode="ES"><unparsedAffiliation>Department of General Dentistry, Faculty of Medicine and Dentistry, University of Murcia, Murcia, Spain</unparsedAffiliation></affiliation><affiliation xml:id="a7" countryCode="ES"><unparsedAffiliation>Department of Oral Surgery, Faculty of Dentistry, University Complutense of Madrid, Madrid, Spain</unparsedAffiliation></affiliation><affiliation xml:id="a8" countryCode="ES"><unparsedAffiliation>Department of Orthodontics, University of Murcia, Murcia, Spain</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">bone grafts</keyword><keyword xml:id="k2">melatonin</keyword><keyword xml:id="k3">porcine bone implant</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><p><b>Abstract: </b> This study evaluated the effect of the topical application of melatonin in accelerating bone formation associated with implants 2 months after their application to the tibiae of rabbits. Twenty New Zealand rabbits were used. Twenty implants treated with melatonin and 20 control implants without melatonin were placed in the proximal metaphyseal area of each tibia. Studies of new bone formation were subsequently made at 15, 30, 45 and 60 days. Cortical width and cortical length of new bone formation were measured. Following implantation, an anteroposterior and lateral radiologic study was carried out. Collected samples were sectioned at 5 μm and stained using hematoxylin–eosin, Masson’s trichromic and Gordon‐Switt reticulin stains. After a 60 day treatment period, melatonin increased the length of cortical bone (95.13 ± 0.42%) versus that around control implants (62.91 ± 1.45%). Related to the perimeter of cortical bone of the tibiae, melatonin induced new bone 88.35 ± 1.56% versus 60.20 ± 1.67% in the control implants. Melatonin regenerated the width and length of cortical bone around implants in tibiae of rabbits more quickly than around control implants without the addition of melatonin.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Melatonin stimulates the growth of new bone around implants in the tibia of rabbits</title></titleInfo><titleInfo type="abbreviated"><title>Melatonin in tibia rabbits</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Melatonin stimulates the growth of new bone around implants in the tibia of rabbits</title></titleInfo><name type="personal"><namePart type="given">José L.</namePart><namePart type="family">Calvo‐Guirado</namePart><affiliation>Department of General Dentistry, Faculty of Medicine and Dentistry, University of Murcia, Murcia, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">María P.</namePart><namePart type="family">Ramírez‐Fernández</namePart><affiliation>Department of Estomatology, University of Murcia, Murcia, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Gerardo</namePart><namePart type="family">Gómez‐Moreno</namePart><affiliation>Department of Pharmacological Interactions in Dentistry, Dental School, University of Granada, Granada, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">José E.</namePart><namePart type="family">Maté‐Sánchez</namePart><affiliation>Department of Estomatology, University of Murcia, Murcia, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Rafael</namePart><namePart type="family">Delgado‐Ruiz</namePart><affiliation>Department of Estomatology, University of Murcia, Murcia, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Javier</namePart><namePart type="family">Guardia</namePart><affiliation>Department of Pharmacological Interactions in Dentistry, Dental School, University of Granada, Granada, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Laura</namePart><namePart type="family">López‐Marí</namePart><affiliation>Master in Implant Dentistry, University of Murcia, Murcia, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Antonio</namePart><namePart type="family">Barone</namePart><affiliation>Department of Oral Surgery, Faculty of Medicine, University of Genova, Genova, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Antonio J.</namePart><namePart type="family">Ortiz‐Ruiz</namePart><affiliation>Department of General Dentistry, Faculty of Medicine and Dentistry, University of Murcia, Murcia, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">José M.</namePart><namePart type="family">Martínez‐González</namePart><affiliation>Department of Oral Surgery, Faculty of Dentistry, University Complutense of Madrid, Madrid, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Luis A.</namePart><namePart type="family">Bravo</namePart><affiliation>Department of Orthodontics, University of Murcia, Murcia, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2010-11</dateIssued><edition>Received April 8, 2010; accepted June 23, 2010.</edition><copyrightDate encoding="w3cdtf">2010</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">5</extent><extent unit="tables">1</extent></physicalDescription><abstract lang="en">Abstract: This study evaluated the effect of the topical application of melatonin in accelerating bone formation associated with implants 2 months after their application to the tibiae of rabbits. Twenty New Zealand rabbits were used. Twenty implants treated with melatonin and 20 control implants without melatonin were placed in the proximal metaphyseal area of each tibia. Studies of new bone formation were subsequently made at 15, 30, 45 and 60 days. Cortical width and cortical length of new bone formation were measured. Following implantation, an anteroposterior and lateral radiologic study was carried out. Collected samples were sectioned at 5 μm and stained using hematoxylin–eosin, Masson’s trichromic and Gordon‐Switt reticulin stains. After a 60 day treatment period, melatonin increased the length of cortical bone (95.13 ± 0.42%) versus that around control implants (62.91 ± 1.45%). Related to the perimeter of cortical bone of the tibiae, melatonin induced new bone 88.35 ± 1.56% versus 60.20 ± 1.67% in the control implants. Melatonin regenerated the width and length of cortical bone around implants in tibiae of rabbits more quickly than around control implants without the addition of melatonin.</abstract><subject lang="en"><genre>Keywords</genre><topic>bone grafts</topic><topic>melatonin</topic><topic>porcine bone implant</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Pineal Research</title></titleInfo><identifier type="ISSN">0742-3098</identifier><identifier type="eISSN">1600-079X</identifier><identifier type="DOI">10.1111/(ISSN)1600-079X</identifier><identifier type="PublisherID">JPI</identifier><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>49</number></detail><detail type="issue"><caption>no.</caption><number>4</number></detail><extent unit="pages"><start>356</start><end>363</end><total>8</total></extent></part></relatedItem><identifier type="istex">808D2861B9BAB1A3B1E0126EC67E0CB1E4BA2E7E</identifier><identifier type="DOI">10.1111/j.1600-079X.2010.00801.x</identifier><identifier type="ArticleID">JPI801</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2010 The Authors. 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