Quantitative analysis of apoptosis and bcl-2 in Sjögren's syndrome.
Identifieur interne : 000069 ( PubMed/Corpus ); précédent : 000068; suivant : 000070Quantitative analysis of apoptosis and bcl-2 in Sjögren's syndrome.
Auteurs : P. Manganelli ; F. Quaini ; A M Andreoli ; C. Lagrasta ; F P Pilato ; A. Zuccarelli ; R. Monteverdi ; C. D'Aversa ; G. OlivettiSource :
- The Journal of rheumatology [ 0315-162X ] ; 1997.
English descriptors
- KwdEn :
- Aged, Apoptosis, CD4-Positive T-Lymphocytes (metabolism), DNA Damage, Down-Regulation, Epithelium (metabolism), Epithelium (pathology), Female, Humans, Immunohistochemistry, Middle Aged, Proto-Oncogene Proteins c-bcl-2 (metabolism), Salivary Glands (metabolism), Salivary Glands (pathology), Sjogren's Syndrome (metabolism), Sjogren's Syndrome (pathology).
- MESH :
- chemical , metabolism : Proto-Oncogene Proteins c-bcl-2.
- metabolism : CD4-Positive T-Lymphocytes, Epithelium, Salivary Glands, Sjogren's Syndrome.
- pathology : Epithelium, Salivary Glands, Sjogren's Syndrome.
- Aged, Apoptosis, DNA Damage, Down-Regulation, Female, Humans, Immunohistochemistry, Middle Aged.
Abstract
To determine whether apoptosis plays a significant role in tissue damage of Sjögren's syndrome (SS).
PubMed: 9263150
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Quantitative analysis of apoptosis and bcl-2 in Sjögren's syndrome.</title><author><name sortKey="Manganelli, P" sort="Manganelli, P" uniqKey="Manganelli P" first="P" last="Manganelli">P. Manganelli</name><affiliation><nlm:affiliation>Rheumatic Disease Unit, Hospital of Parma, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Quaini, F" sort="Quaini, F" uniqKey="Quaini F" first="F" last="Quaini">F. Quaini</name></author><author><name sortKey="Andreoli, A M" sort="Andreoli, A M" uniqKey="Andreoli A" first="A M" last="Andreoli">A M Andreoli</name></author><author><name sortKey="Lagrasta, C" sort="Lagrasta, C" uniqKey="Lagrasta C" first="C" last="Lagrasta">C. Lagrasta</name></author><author><name sortKey="Pilato, F P" sort="Pilato, F P" uniqKey="Pilato F" first="F P" last="Pilato">F P Pilato</name></author><author><name sortKey="Zuccarelli, A" sort="Zuccarelli, A" uniqKey="Zuccarelli A" first="A" last="Zuccarelli">A. Zuccarelli</name></author><author><name sortKey="Monteverdi, R" sort="Monteverdi, R" uniqKey="Monteverdi R" first="R" last="Monteverdi">R. Monteverdi</name></author><author><name sortKey="D Aversa, C" sort="D Aversa, C" uniqKey="D Aversa C" first="C" last="D'Aversa">C. D'Aversa</name></author><author><name sortKey="Olivetti, G" sort="Olivetti, G" uniqKey="Olivetti G" first="G" last="Olivetti">G. Olivetti</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1997">1997</date><idno type="RBID">pubmed:9263150</idno><idno type="pmid">9263150</idno><idno type="wicri:Area/PubMed/Corpus">000069</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Quantitative analysis of apoptosis and bcl-2 in Sjögren's syndrome.</title><author><name sortKey="Manganelli, P" sort="Manganelli, P" uniqKey="Manganelli P" first="P" last="Manganelli">P. Manganelli</name><affiliation><nlm:affiliation>Rheumatic Disease Unit, Hospital of Parma, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Quaini, F" sort="Quaini, F" uniqKey="Quaini F" first="F" last="Quaini">F. Quaini</name></author><author><name sortKey="Andreoli, A M" sort="Andreoli, A M" uniqKey="Andreoli A" first="A M" last="Andreoli">A M Andreoli</name></author><author><name sortKey="Lagrasta, C" sort="Lagrasta, C" uniqKey="Lagrasta C" first="C" last="Lagrasta">C. Lagrasta</name></author><author><name sortKey="Pilato, F P" sort="Pilato, F P" uniqKey="Pilato F" first="F P" last="Pilato">F P Pilato</name></author><author><name sortKey="Zuccarelli, A" sort="Zuccarelli, A" uniqKey="Zuccarelli A" first="A" last="Zuccarelli">A. Zuccarelli</name></author><author><name sortKey="Monteverdi, R" sort="Monteverdi, R" uniqKey="Monteverdi R" first="R" last="Monteverdi">R. Monteverdi</name></author><author><name sortKey="D Aversa, C" sort="D Aversa, C" uniqKey="D Aversa C" first="C" last="D'Aversa">C. D'Aversa</name></author><author><name sortKey="Olivetti, G" sort="Olivetti, G" uniqKey="Olivetti G" first="G" last="Olivetti">G. Olivetti</name></author></analytic><series><title level="j">The Journal of rheumatology</title><idno type="ISSN">0315-162X</idno><imprint><date when="1997" type="published">1997</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Apoptosis</term><term>CD4-Positive T-Lymphocytes (metabolism)</term><term>DNA Damage</term><term>Down-Regulation</term><term>Epithelium (metabolism)</term><term>Epithelium (pathology)</term><term>Female</term><term>Humans</term><term>Immunohistochemistry</term><term>Middle Aged</term><term>Proto-Oncogene Proteins c-bcl-2 (metabolism)</term><term>Salivary Glands (metabolism)</term><term>Salivary Glands (pathology)</term><term>Sjogren's Syndrome (metabolism)</term><term>Sjogren's Syndrome (pathology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Proto-Oncogene Proteins c-bcl-2</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>CD4-Positive T-Lymphocytes</term><term>Epithelium</term><term>Salivary Glands</term><term>Sjogren's Syndrome</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Epithelium</term><term>Salivary Glands</term><term>Sjogren's Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Apoptosis</term><term>DNA Damage</term><term>Down-Regulation</term><term>Female</term><term>Humans</term><term>Immunohistochemistry</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To determine whether apoptosis plays a significant role in tissue damage of Sjögren's syndrome (SS).</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">9263150</PMID><DateCreated><Year>1997</Year><Month>09</Month><Day>25</Day></DateCreated><DateCompleted><Year>1997</Year><Month>09</Month><Day>25</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0315-162X</ISSN><JournalIssue CitedMedium="Print"><Volume>24</Volume><Issue>8</Issue><PubDate><Year>1997</Year><Month>Aug</Month></PubDate></JournalIssue><Title>The Journal of rheumatology</Title><ISOAbbreviation>J. Rheumatol.</ISOAbbreviation></Journal><ArticleTitle>Quantitative analysis of apoptosis and bcl-2 in Sjögren's syndrome.</ArticleTitle><Pagination><MedlinePgn>1552-7</MedlinePgn></Pagination><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To determine whether apoptosis plays a significant role in tissue damage of Sjögren's syndrome (SS).</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We performed a quantitative analysis of programmed cell death on salivary glands of 11 patients. Ten age matched women with sicca syndrome served as controls. Morphometric measurement of the fractional volume of acini and ducts showing DNA strand breaks was performed in sections stained by deoxynucleotidyl transferase assay. The extent of bcl-2 expression was determined in sections labeled with monoclonal antibody. The different cell populations infiltrating the glands were examined in tissues stained with anti-leukocyte common antigen and OPD4 monoclonal antibodies.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">In patients with SS, 68% of the ductal epithelium was occupied by apoptotic structures, whereas only 12% of acini showed DNA strand breaks. Corresponding values in control salivary glands were 3 and 0.13%. bcl-2 labeling was higher in ducts than in acini of both control and pathologic glands. However, in SS a 43% (p < 0.001) and 75% (p < 0.001) reduction in bcl-2 expression was observed in ductal and acinar epithelium, respectively. In comparison with controls, the numerical density of CD4+ cells and plasma cells scattered throughout the interstitium was 323% and 203% higher (p < 0.001) in SS. Moreover, T helper/inducer lymphocytes represented 52% of the inflammatory foci.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Apoptosis occurs in minor salivary glands of patients with SS with a prevailing localization on the ductal epithelium in association with downregulation of bcl-2 and a large number of infiltrating CD4+ lymphocytes. Thus, the destruction of glandular tissue and the loss of secretory function in SS is dependent on the activation of the suicide program of epithelial cells.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Manganelli</LastName><ForeName>P</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Rheumatic Disease Unit, Hospital of Parma, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Quaini</LastName><ForeName>F</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Andreoli</LastName><ForeName>A M</ForeName><Initials>AM</Initials></Author><Author ValidYN="Y"><LastName>Lagrasta</LastName><ForeName>C</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Pilato</LastName><ForeName>F P</ForeName><Initials>FP</Initials></Author><Author ValidYN="Y"><LastName>Zuccarelli</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Monteverdi</LastName><ForeName>R</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>D'Aversa</LastName><ForeName>C</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Olivetti</LastName><ForeName>G</ForeName><Initials>G</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>CANADA</Country><MedlineTA>J Rheumatol</MedlineTA><NlmUniqueID>7501984</NlmUniqueID><ISSNLinking>0315-162X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019253">Proto-Oncogene Proteins c-bcl-2</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D017209">Apoptosis</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D015496">CD4-Positive T-Lymphocytes</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004249">DNA Damage</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D015536">Down-Regulation</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004848">Epithelium</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000378">metabolism</QualifierName><QualifierName MajorTopicYN="N" UI="Q000473">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007150">Immunohistochemistry</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D019253">Proto-Oncogene Proteins c-bcl-2</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012469">Salivary Glands</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000378">metabolism</QualifierName><QualifierName MajorTopicYN="N" UI="Q000473">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012859">Sjogren's Syndrome</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000378">metabolism</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000473">pathology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1997</Year><Month>8</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1997</Year><Month>8</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1997</Year><Month>8</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">9263150</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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