BENZO(A)PYRENE DECREASES BRAIN AND OVARIAN AROMATASE mRNA EXPRESSION IN FUNDULUS HETEROCLITUS
Identifieur interne : 000027 ( Pmc/Corpus ); précédent : 000026; suivant : 000028BENZO(A)PYRENE DECREASES BRAIN AND OVARIAN AROMATASE mRNA EXPRESSION IN FUNDULUS HETEROCLITUS
Auteurs : Wu Dong ; Lu Wang ; Cammi Thornton ; Brian E. Scheffler ; Kristine L. WillettSource :
- Aquatic toxicology (Amsterdam, Netherlands) [ 0166-445X ] ; 2008.
Abstract
The higher molecular weight polycyclic aromatic hydrocarbons (PAHs) such as benzo(a)pyrene (BaP) are typically associated with genotoxicity, however, newer evidence suggests that these compounds may also act as endocrine system disruptors. We hypothesized that altered expression of the P450 enzyme aromatase genes could be a target for reproductive or developmental dysfunction caused by BaP exposure. Aromatase is at least partially responsible for estrogen homeostasis by converting androgens into estrogens. In fish, there are two isoforms of aromatase, a predominantly ovarian form, CYP19A1, and a brain form, CYP19A2. CYP19 mRNA expression was measured following BaP exposure (0, 10, 100 µg/L waterborne for 10 or 15 days) in
Url:
DOI: 10.1016/j.aquatox.2008.05.006
PubMed: 18571745
PubMed Central: 2530897
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