Endocrine disrupting compounds: effect of octylphenol on reproduction over three generations
Identifieur interne : 000288 ( Istex/Corpus ); précédent : 000287; suivant : 000289Endocrine disrupting compounds: effect of octylphenol on reproduction over three generations
Auteurs : I. B. B Gh ; P. Christensen ; V. Dantzer ; M. Groot ; I. C. N. Th Fner ; R. K. Rasmussen ; M. Schmidt ; T. GreveSource :
- Theriogenology [ 0093-691X ] ; 2000.
Abstract
With the growing concern that environmental chemicals might impair human and animal fertility, it is important to investigate the possible influence of these substances on sexual differentiation and genital development of mammals. Many of these substances are suspected to interfere with endocrine processes, and exposure during critical periods of prenatal development might affect reproductive performance over several generations. Alkylphenols and their metabolites are lipophilic substances exerting apparent estrogenic action in in vitro and in vivo testing systems. With the widespread industrial use of alkylphenols, these are disseminated in the environment with sewage sludge, and domestic animals and humans are likely to be exposed via the food chain. Using the pig as an in vivo model, we studied the effect of intrauterine exposure to tertiary octylphenol (OP) on essential reproductive parameters over 3 generations. Sows were treated daily from D 23 to 85 of pregnancy with either 0, 10 or 1000 μg OP/kg body weight. Treatment with OP extended pregnancy length and induced basal cell proliferation in the cervical epithelium of the parental generation. In F1 offspring of sows treated with the low dosage of OP, onset of puberty was accelerated. Furthermore, when F1 gilts and F1 boars originating from sows treated with high dosages of OP were bred, the litter size was reduced. The results of the present study are compared with previous reports on estrogenicity of OP, and the usefulness of in vivo animal or embryo models for the evaluation of possible consequences of human exposure to endocrine disrupting compounds is discussed. Furthermore, possible consequences of exposure to endocrine disrupting compounds for the embryo transfer industry are addressed.
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DOI: 10.1016/S0093-691X(00)00451-9
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Th Fner</name><affiliation><mods:affiliation>Department of Clinical Studies, Section for Reproduction, Royal Veterinary and Agricultural University, 68 Dyrlægevej, 1870 Frederiksberg C, Denmark</mods:affiliation></affiliation></author><author><name sortKey="Rasmussen, R K" sort="Rasmussen, R K" uniqKey="Rasmussen R" first="R. K." last="Rasmussen">R. K. Rasmussen</name><affiliation><mods:affiliation>Department of Pharmacology and Pathobiology, Royal Veterinary and Agricultural University, 13 Bülowsvej, 1870 Frederiksberg C, Denmark</mods:affiliation></affiliation></author><author><name sortKey="Schmidt, M" sort="Schmidt, M" uniqKey="Schmidt M" first="M." last="Schmidt">M. 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B Gh</name><affiliation><mods:affiliation>E-mail: ibb@kvl.dk</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Clinical Studies, Section for Reproduction, Royal Veterinary and Agricultural University, 68 Dyrlægevej, 1870 Frederiksberg C, Denmark</mods:affiliation></affiliation></author><author><name sortKey="Christensen, P" sort="Christensen, P" uniqKey="Christensen P" first="P." last="Christensen">P. Christensen</name><affiliation><mods:affiliation>Department of Clinical Studies, Section for Reproduction, Royal Veterinary and Agricultural University, 68 Dyrlægevej, 1870 Frederiksberg C, Denmark</mods:affiliation></affiliation></author><author><name sortKey="Dantzer, V" sort="Dantzer, V" uniqKey="Dantzer V" first="V." last="Dantzer">V. Dantzer</name><affiliation><mods:affiliation>Department of Anatomy and Physiology, Royal Veterinary and Agricultural University 7 Grønnegårdsvej, 1870 Frederiksberg C, Denmark</mods:affiliation></affiliation></author><author><name sortKey="Groot, M" sort="Groot, M" uniqKey="Groot M" first="M." last="Groot">M. Groot</name><affiliation><mods:affiliation>State Institute for Quality Control of Agricultural Products, PO Box 230, 6700 AE Wageningen, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Th Fner, I C N" sort="Th Fner, I C N" uniqKey="Th Fner I" first="I. C. N." last="Th Fner">I. C. N. Th Fner</name><affiliation><mods:affiliation>Department of Clinical Studies, Section for Reproduction, Royal Veterinary and Agricultural University, 68 Dyrlægevej, 1870 Frederiksberg C, Denmark</mods:affiliation></affiliation></author><author><name sortKey="Rasmussen, R K" sort="Rasmussen, R K" uniqKey="Rasmussen R" first="R. K." last="Rasmussen">R. K. Rasmussen</name><affiliation><mods:affiliation>Department of Pharmacology and Pathobiology, Royal Veterinary and Agricultural University, 13 Bülowsvej, 1870 Frederiksberg C, Denmark</mods:affiliation></affiliation></author><author><name sortKey="Schmidt, M" sort="Schmidt, M" uniqKey="Schmidt M" first="M." last="Schmidt">M. Schmidt</name><affiliation><mods:affiliation>Department of Clinical Studies, Section for Reproduction, Royal Veterinary and Agricultural University, 68 Dyrlægevej, 1870 Frederiksberg C, Denmark</mods:affiliation></affiliation></author><author><name sortKey="Greve, T" sort="Greve, T" uniqKey="Greve T" first="T." last="Greve">T. Greve</name><affiliation><mods:affiliation>Department of Clinical Studies, Section for Reproduction, Royal Veterinary and Agricultural University, 68 Dyrlægevej, 1870 Frederiksberg C, Denmark</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Theriogenology</title><title level="j" type="abbrev">THE</title><idno type="ISSN">0093-691X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="2000">2000</date><biblScope unit="volume">55</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="131">131</biblScope><biblScope unit="page" to="150">150</biblScope></imprint><idno type="ISSN">0093-691X</idno></series><idno type="istex">9F8D829B6A37F3BF403EB46A0F72CC10B06D228C</idno><idno type="DOI">10.1016/S0093-691X(00)00451-9</idno><idno type="PII">S0093-691X(00)00451-9</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0093-691X</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">With the growing concern that environmental chemicals might impair human and animal fertility, it is important to investigate the possible influence of these substances on sexual differentiation and genital development of mammals. Many of these substances are suspected to interfere with endocrine processes, and exposure during critical periods of prenatal development might affect reproductive performance over several generations. Alkylphenols and their metabolites are lipophilic substances exerting apparent estrogenic action in in vitro and in vivo testing systems. With the widespread industrial use of alkylphenols, these are disseminated in the environment with sewage sludge, and domestic animals and humans are likely to be exposed via the food chain. Using the pig as an in vivo model, we studied the effect of intrauterine exposure to tertiary octylphenol (OP) on essential reproductive parameters over 3 generations. Sows were treated daily from D 23 to 85 of pregnancy with either 0, 10 or 1000 μg OP/kg body weight. Treatment with OP extended pregnancy length and induced basal cell proliferation in the cervical epithelium of the parental generation. In F1 offspring of sows treated with the low dosage of OP, onset of puberty was accelerated. Furthermore, when F1 gilts and F1 boars originating from sows treated with high dosages of OP were bred, the litter size was reduced. The results of the present study are compared with previous reports on estrogenicity of OP, and the usefulness of in vivo animal or embryo models for the evaluation of possible consequences of human exposure to endocrine disrupting compounds is discussed. Furthermore, possible consequences of exposure to endocrine disrupting compounds for the embryo transfer industry are addressed.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>I.B. Bøgh</name><affiliations><json:string>E-mail: ibb@kvl.dk</json:string><json:string>Department of Clinical Studies, Section for Reproduction, Royal Veterinary and Agricultural University, 68 Dyrlægevej, 1870 Frederiksberg C, Denmark</json:string></affiliations></json:item><json:item><name>P. Christensen</name><affiliations><json:string>Department of Clinical Studies, Section for Reproduction, Royal Veterinary and Agricultural University, 68 Dyrlægevej, 1870 Frederiksberg C, Denmark</json:string></affiliations></json:item><json:item><name>V. Dantzer</name><affiliations><json:string>Department of Anatomy and Physiology, Royal Veterinary and Agricultural University 7 Grønnegårdsvej, 1870 Frederiksberg C, Denmark</json:string></affiliations></json:item><json:item><name>M. Groot</name><affiliations><json:string>State Institute for Quality Control of Agricultural Products, PO Box 230, 6700 AE Wageningen, The Netherlands</json:string></affiliations></json:item><json:item><name>I.C.N. Thøfner</name><affiliations><json:string>Department of Clinical Studies, Section for Reproduction, Royal Veterinary and Agricultural University, 68 Dyrlægevej, 1870 Frederiksberg C, Denmark</json:string></affiliations></json:item><json:item><name>R.K. Rasmussen</name><affiliations><json:string>Department of Pharmacology and Pathobiology, Royal Veterinary and Agricultural University, 13 Bülowsvej, 1870 Frederiksberg C, Denmark</json:string></affiliations></json:item><json:item><name>M. Schmidt</name><affiliations><json:string>Department of Clinical Studies, Section for Reproduction, Royal Veterinary and Agricultural University, 68 Dyrlægevej, 1870 Frederiksberg C, Denmark</json:string></affiliations></json:item><json:item><name>T. Greve</name><affiliations><json:string>Department of Clinical Studies, Section for Reproduction, Royal Veterinary and Agricultural University, 68 Dyrlægevej, 1870 Frederiksberg C, Denmark</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>estrogenic</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>xenobiotics</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>environment</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>alkylphenol</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>porcine</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>fertility</value></json:item></subject><language><json:string>eng</json:string></language><abstract>With the growing concern that environmental chemicals might impair human and animal fertility, it is important to investigate the possible influence of these substances on sexual differentiation and genital development of mammals. Many of these substances are suspected to interfere with endocrine processes, and exposure during critical periods of prenatal development might affect reproductive performance over several generations. Alkylphenols and their metabolites are lipophilic substances exerting apparent estrogenic action in in vitro and in vivo testing systems. With the widespread industrial use of alkylphenols, these are disseminated in the environment with sewage sludge, and domestic animals and humans are likely to be exposed via the food chain. Using the pig as an in vivo model, we studied the effect of intrauterine exposure to tertiary octylphenol (OP) on essential reproductive parameters over 3 generations. Sows were treated daily from D 23 to 85 of pregnancy with either 0, 10 or 1000 μg OP/kg body weight. Treatment with OP extended pregnancy length and induced basal cell proliferation in the cervical epithelium of the parental generation. In F1 offspring of sows treated with the low dosage of OP, onset of puberty was accelerated. Furthermore, when F1 gilts and F1 boars originating from sows treated with high dosages of OP were bred, the litter size was reduced. The results of the present study are compared with previous reports on estrogenicity of OP, and the usefulness of in vivo animal or embryo models for the evaluation of possible consequences of human exposure to endocrine disrupting compounds is discussed. 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Denmark</affiliation></author><author><persName><forename type="first">V.</forename><surname>Dantzer</surname></persName><affiliation>Department of Anatomy and Physiology, Royal Veterinary and Agricultural University 7 Grønnegårdsvej, 1870 Frederiksberg C, Denmark</affiliation></author><author><persName><forename type="first">M.</forename><surname>Groot</surname></persName><affiliation>State Institute for Quality Control of Agricultural Products, PO Box 230, 6700 AE Wageningen, The Netherlands</affiliation></author><author><persName><forename type="first">I.C.N.</forename><surname>Thøfner</surname></persName><affiliation>Department of Clinical Studies, Section for Reproduction, Royal Veterinary and Agricultural University, 68 Dyrlægevej, 1870 Frederiksberg C, Denmark</affiliation></author><author><persName><forename type="first">R.K.</forename><surname>Rasmussen</surname></persName><affiliation>Department of Pharmacology and Pathobiology, Royal Veterinary and Agricultural University, 13 Bülowsvej, 1870 Frederiksberg C, Denmark</affiliation></author><author><persName><forename type="first">M.</forename><surname>Schmidt</surname></persName><affiliation>Department of Clinical Studies, Section for Reproduction, Royal Veterinary and Agricultural University, 68 Dyrlægevej, 1870 Frederiksberg C, Denmark</affiliation></author><author><persName><forename type="first">T.</forename><surname>Greve</surname></persName><affiliation>Department of Clinical Studies, Section for Reproduction, Royal Veterinary and Agricultural University, 68 Dyrlægevej, 1870 Frederiksberg C, Denmark</affiliation></author></analytic><monogr><title level="j">Theriogenology</title><title level="j" type="abbrev">THE</title><idno type="pISSN">0093-691X</idno><idno type="PII">S0093-691X(00)X0072-6</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="2000"></date><biblScope unit="volume">55</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="131">131</biblScope><biblScope unit="page" to="150">150</biblScope></imprint></monogr><idno type="istex">9F8D829B6A37F3BF403EB46A0F72CC10B06D228C</idno><idno type="DOI">10.1016/S0093-691X(00)00451-9</idno><idno type="PII">S0093-691X(00)00451-9</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2000</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>With the growing concern that environmental chemicals might impair human and animal fertility, it is important to investigate the possible influence of these substances on sexual differentiation and genital development of mammals. Many of these substances are suspected to interfere with endocrine processes, and exposure during critical periods of prenatal development might affect reproductive performance over several generations. Alkylphenols and their metabolites are lipophilic substances exerting apparent estrogenic action in in vitro and in vivo testing systems. With the widespread industrial use of alkylphenols, these are disseminated in the environment with sewage sludge, and domestic animals and humans are likely to be exposed via the food chain. Using the pig as an in vivo model, we studied the effect of intrauterine exposure to tertiary octylphenol (OP) on essential reproductive parameters over 3 generations. Sows were treated daily from D 23 to 85 of pregnancy with either 0, 10 or 1000 μg OP/kg body weight. Treatment with OP extended pregnancy length and induced basal cell proliferation in the cervical epithelium of the parental generation. In F1 offspring of sows treated with the low dosage of OP, onset of puberty was accelerated. Furthermore, when F1 gilts and F1 boars originating from sows treated with high dosages of OP were bred, the litter size was reduced. The results of the present study are compared with previous reports on estrogenicity of OP, and the usefulness of in vivo animal or embryo models for the evaluation of possible consequences of human exposure to endocrine disrupting compounds is discussed. Furthermore, possible consequences of exposure to endocrine disrupting compounds for the embryo transfer industry are addressed.</p></abstract><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>estrogenic</term></item><item><term>xenobiotics</term></item><item><term>environment</term></item><item><term>alkylphenol</term></item><item><term>porcine</term></item><item><term>fertility</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2000">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/9F8D829B6A37F3BF403EB46A0F72CC10B06D228C/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>THE</jid><aid>00004519</aid><ce:pii>S0093-691X(00)00451-9</ce:pii><ce:doi>10.1016/S0093-691X(00)00451-9</ce:doi><ce:copyright type="unknown" year="2000"></ce:copyright></item-info><head><ce:title>Endocrine disrupting compounds: effect of octylphenol on reproduction over three generations</ce:title><ce:author-group><ce:author><ce:given-name>I.B.</ce:given-name><ce:surname>Bøgh</ce:surname><ce:cross-ref refid="COR1"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref><ce:e-address>ibb@kvl.dk</ce:e-address></ce:author><ce:author><ce:given-name>P.</ce:given-name><ce:surname>Christensen</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>V.</ce:given-name><ce:surname>Dantzer</ce:surname><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>M.</ce:given-name><ce:surname>Groot</ce:surname><ce:cross-ref refid="AFF3"><ce:sup>c</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>I.C.N.</ce:given-name><ce:surname>Thøfner</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>R.K.</ce:given-name><ce:surname>Rasmussen</ce:surname><ce:cross-ref refid="AFF4"><ce:sup>d</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>M.</ce:given-name><ce:surname>Schmidt</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>T.</ce:given-name><ce:surname>Greve</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="AFF1"><ce:label>a</ce:label><ce:textfn>Department of Clinical Studies, Section for Reproduction, Royal Veterinary and Agricultural University, 68 Dyrlægevej, 1870 Frederiksberg C, Denmark</ce:textfn></ce:affiliation><ce:affiliation id="AFF2"><ce:label>b</ce:label><ce:textfn>Department of Anatomy and Physiology, Royal Veterinary and Agricultural University 7 Grønnegårdsvej, 1870 Frederiksberg C, Denmark</ce:textfn></ce:affiliation><ce:affiliation id="AFF3"><ce:label>c</ce:label><ce:textfn>State Institute for Quality Control of Agricultural Products, PO Box 230, 6700 AE Wageningen, The Netherlands</ce:textfn></ce:affiliation><ce:affiliation id="AFF4"><ce:label>d</ce:label><ce:textfn>Department of Pharmacology and Pathobiology, Royal Veterinary and Agricultural University, 13 Bülowsvej, 1870 Frederiksberg C, Denmark</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>a</ce:label><ce:text>Correspondence and reprint requests</ce:text></ce:correspondence></ce:author-group><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>With the growing concern that environmental chemicals might impair human and animal fertility, it is important to investigate the possible influence of these substances on sexual differentiation and genital development of mammals. Many of these substances are suspected to interfere with endocrine processes, and exposure during critical periods of prenatal development might affect reproductive performance over several generations. Alkylphenols and their metabolites are lipophilic substances exerting apparent estrogenic action in in vitro and in vivo testing systems. With the widespread industrial use of alkylphenols, these are disseminated in the environment with sewage sludge, and domestic animals and humans are likely to be exposed via the food chain. Using the pig as an in vivo model, we studied the effect of intrauterine exposure to tertiary octylphenol (OP) on essential reproductive parameters over 3 generations. Sows were treated daily from D 23 to 85 of pregnancy with either 0, 10 or 1000 μg OP/kg body weight. Treatment with OP extended pregnancy length and induced basal cell proliferation in the cervical epithelium of the parental generation. In F<ce:inf>1</ce:inf> offspring of sows treated with the low dosage of OP, onset of puberty was accelerated. Furthermore, when F<ce:inf>1</ce:inf> gilts and F<ce:inf>1</ce:inf> boars originating from sows treated with high dosages of OP were bred, the litter size was reduced. The results of the present study are compared with previous reports on estrogenicity of OP, and the usefulness of in vivo animal or embryo models for the evaluation of possible consequences of human exposure to endocrine disrupting compounds is discussed. Furthermore, possible consequences of exposure to endocrine disrupting compounds for the embryo transfer industry are addressed.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>estrogenic</ce:text></ce:keyword><ce:keyword><ce:text>xenobiotics</ce:text></ce:keyword><ce:keyword><ce:text>environment</ce:text></ce:keyword><ce:keyword><ce:text>alkylphenol</ce:text></ce:keyword><ce:keyword><ce:text>porcine</ce:text></ce:keyword><ce:keyword><ce:text>fertility</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Endocrine disrupting compounds: effect of octylphenol on reproduction over three generations</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Endocrine disrupting compounds: effect of octylphenol on reproduction over three generations</title></titleInfo><name type="personal"><namePart type="given">I.B.</namePart><namePart type="family">Bøgh</namePart><affiliation>E-mail: ibb@kvl.dk</affiliation><affiliation>Department of Clinical Studies, Section for Reproduction, Royal Veterinary and Agricultural University, 68 Dyrlægevej, 1870 Frederiksberg C, Denmark</affiliation><description>Correspondence and reprint requests</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Christensen</namePart><affiliation>Department of Clinical Studies, Section for Reproduction, Royal Veterinary and Agricultural University, 68 Dyrlægevej, 1870 Frederiksberg C, Denmark</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V.</namePart><namePart type="family">Dantzer</namePart><affiliation>Department of Anatomy and Physiology, Royal Veterinary and Agricultural University 7 Grønnegårdsvej, 1870 Frederiksberg C, Denmark</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Groot</namePart><affiliation>State Institute for Quality Control of Agricultural Products, PO Box 230, 6700 AE Wageningen, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I.C.N.</namePart><namePart type="family">Thøfner</namePart><affiliation>Department of Clinical Studies, Section for Reproduction, Royal Veterinary and Agricultural University, 68 Dyrlægevej, 1870 Frederiksberg C, Denmark</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.K.</namePart><namePart type="family">Rasmussen</namePart><affiliation>Department of Pharmacology and Pathobiology, Royal Veterinary and Agricultural University, 13 Bülowsvej, 1870 Frederiksberg C, Denmark</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Schmidt</namePart><affiliation>Department of Clinical Studies, Section for Reproduction, Royal Veterinary and Agricultural University, 68 Dyrlægevej, 1870 Frederiksberg C, Denmark</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Greve</namePart><affiliation>Department of Clinical Studies, Section for Reproduction, Royal Veterinary and Agricultural University, 68 Dyrlægevej, 1870 Frederiksberg C, Denmark</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">2000</dateIssued><copyrightDate encoding="w3cdtf">2000</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">With the growing concern that environmental chemicals might impair human and animal fertility, it is important to investigate the possible influence of these substances on sexual differentiation and genital development of mammals. Many of these substances are suspected to interfere with endocrine processes, and exposure during critical periods of prenatal development might affect reproductive performance over several generations. Alkylphenols and their metabolites are lipophilic substances exerting apparent estrogenic action in in vitro and in vivo testing systems. With the widespread industrial use of alkylphenols, these are disseminated in the environment with sewage sludge, and domestic animals and humans are likely to be exposed via the food chain. Using the pig as an in vivo model, we studied the effect of intrauterine exposure to tertiary octylphenol (OP) on essential reproductive parameters over 3 generations. Sows were treated daily from D 23 to 85 of pregnancy with either 0, 10 or 1000 μg OP/kg body weight. Treatment with OP extended pregnancy length and induced basal cell proliferation in the cervical epithelium of the parental generation. In F1 offspring of sows treated with the low dosage of OP, onset of puberty was accelerated. Furthermore, when F1 gilts and F1 boars originating from sows treated with high dosages of OP were bred, the litter size was reduced. The results of the present study are compared with previous reports on estrogenicity of OP, and the usefulness of in vivo animal or embryo models for the evaluation of possible consequences of human exposure to endocrine disrupting compounds is discussed. Furthermore, possible consequences of exposure to endocrine disrupting compounds for the embryo transfer industry are addressed.</abstract><subject><genre>Keywords</genre><topic>estrogenic</topic><topic>xenobiotics</topic><topic>environment</topic><topic>alkylphenol</topic><topic>porcine</topic><topic>fertility</topic></subject><relatedItem type="host"><titleInfo><title>Theriogenology</title></titleInfo><titleInfo type="abbreviated"><title>THE</title></titleInfo><genre type="Journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">20010101</dateIssued></originInfo><identifier type="ISSN">0093-691X</identifier><identifier type="PII">S0093-691X(00)X0072-6</identifier><part><date>20010101</date><detail type="volume"><number>55</number><caption>vol.</caption></detail><detail type="issue"><number>1</number><caption>no.</caption></detail><extent unit="issue pages"><start>1</start><end>549</end></extent><extent unit="pages"><start>131</start><end>150</end></extent></part></relatedItem><identifier type="istex">9F8D829B6A37F3BF403EB46A0F72CC10B06D228C</identifier><identifier type="DOI">10.1016/S0093-691X(00)00451-9</identifier><identifier type="PII">S0093-691X(00)00451-9</identifier><recordInfo><recordContentSource>ELSEVIER</recordContentSource></recordInfo></mods></metadata><enrichments><istex:catWosTEI uri="https://api.istex.fr/document/9F8D829B6A37F3BF403EB46A0F72CC10B06D228C/enrichments/catWos"><teiHeader><profileDesc><textClass><classCode scheme="WOS">VETERINARY SCIENCES</classCode><classCode scheme="WOS">REPRODUCTIVE BIOLOGY</classCode></textClass></profileDesc></teiHeader></istex:catWosTEI></enrichments></istex></record>Pour manipuler ce document sous Unix (Dilib)
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