Local immunity in the respiratory tract of the chicken. II. The secretory immune response to newcastle disease virus and the role of IgA
Identifieur interne : 000D22 ( Main/Exploration ); précédent : 000D21; suivant : 000D23Local immunity in the respiratory tract of the chicken. II. The secretory immune response to newcastle disease virus and the role of IgA
Auteurs : S. H. Parry [Royaume-Uni] ; I. D. Aitken [Royaume-Uni]Source :
- Veterinary Microbiology [ 0378-1135 ] ; 1977.
Abstract
The nature, specificity and characteristics of the secretory immune response in the respiratory tract of the chicken were investigated in young specific-pathogen-free chickens after vaccination with live lentogenic and inactivated Newcastle disease virus (NDV). Virus-neutralizing (VN) activity considerably exceeding transudation levels from serum were detected in lachrymal fluid, saliva and tracheal washes following infection by both ocular and oral routes. Heat inactivated virus inoculated into the trachea evoked neither serum nor secretory VN activity, whereas a commercial inactivated virus vaccine in mineral oil adjuvant stimulated high titres of serum antibody and some VN activity in tracheal fluids. Antibody in secretions limited, but did not prevent, reinfection of the trachea when birds were challenged 2 weeks later. In contrast to an elevation of circulating antibody titre, challenge induced only a repeated primary response of secreted antibody. All secretions contained IgA which, at least in saliva, accounted for 85% of its activity, the remainder being due to IgG. Fluorescent localization of immunoglobulin producing cells (IPC) demonstrated large numbers containing IgA in association with the upper respiratory tract, particularly in the Harderian gland which contained dense aggregations of plasma cells, many of which were producing IgA. It is concluded that the respiratory tract of the chicken possesses an antibody mediated secretory immune system analogous to that of mammalian species.
Url:
DOI: 10.1016/0378-1135(77)90005-0
Affiliations:
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II. The secretory immune response to newcastle disease virus and the role of IgA</title><author><name sortKey="Parry, S H" sort="Parry, S H" uniqKey="Parry S" first="S. H." last="Parry">S. H. Parry</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sub-department of Avian Medicine, University of Liverpool, Veterinary Field Station, Neston</wicri:regionArea><wicri:noRegion>Neston</wicri:noRegion></affiliation></author><author><name sortKey="Aitken, I D" sort="Aitken, I D" uniqKey="Aitken I" first="I. D." last="Aitken">I. D. 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Virus-neutralizing (VN) activity considerably exceeding transudation levels from serum were detected in lachrymal fluid, saliva and tracheal washes following infection by both ocular and oral routes. Heat inactivated virus inoculated into the trachea evoked neither serum nor secretory VN activity, whereas a commercial inactivated virus vaccine in mineral oil adjuvant stimulated high titres of serum antibody and some VN activity in tracheal fluids. Antibody in secretions limited, but did not prevent, reinfection of the trachea when birds were challenged 2 weeks later. In contrast to an elevation of circulating antibody titre, challenge induced only a repeated primary response of secreted antibody. All secretions contained IgA which, at least in saliva, accounted for 85% of its activity, the remainder being due to IgG. Fluorescent localization of immunoglobulin producing cells (IPC) demonstrated large numbers containing IgA in association with the upper respiratory tract, particularly in the Harderian gland which contained dense aggregations of plasma cells, many of which were producing IgA. It is concluded that the respiratory tract of the chicken possesses an antibody mediated secretory immune system analogous to that of mammalian species.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Parry, S H" sort="Parry, S H" uniqKey="Parry S" first="S. H." last="Parry">S. H. Parry</name></noRegion><name sortKey="Aitken, I D" sort="Aitken, I D" uniqKey="Aitken I" first="I. D." last="Aitken">I. D. Aitken</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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