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Ibuprofen in Experimental Vascular Surgery

Identifieur interne : 000B07 ( Main/Exploration ); précédent : 000B06; suivant : 000B08

Ibuprofen in Experimental Vascular Surgery

Auteurs : Michael P. Kaye [États-Unis] ; Peter Gloviczki [États-Unis] ; Mrinal K. Dewanjee [États-Unis] ; Paul L. Claus [États-Unis] ; Mark E. Lovaas [États-Unis]

Source :

RBID : ISTEX:2B3599CFCEAB48A3B985360B16CC43AE19D4C82F

Abstract

Animal studies have been conducted to determine the effectiveness of ibuprofen in reducing early platelet deposition on small diameter (4 mm) Gore-Tex (polytetrafluoroethylene) arterial grafts and larger (10 mm) Gore-Tex grafts placed in the inferior vena cava. These studies demonstrated a significant reduction ln platelet deposition at one and three hours. Additional studies of animals undergoing treatment with ibuprofen and subjected to arterial replacement with 1 or 4 mm Gore-Tex grafts demonstrated enhanced patency at 30 days. Cautious evaluation of Ibuprofen as an adjunct in vascular surgery appears warranted.

Url:
DOI: 10.1016/S0002-9343(84)80026-1


Affiliations:


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