Immunocytochemical localization of growth-associated protein GAP-43 in early human development
Identifieur interne : 000577 ( Istex/Curation ); précédent : 000576; suivant : 000578Immunocytochemical localization of growth-associated protein GAP-43 in early human development
Auteurs : Ana Milosevic [Yougoslavie] ; Selma Kanazir [Yougoslavie] ; Nada Zecevic [États-Unis]Source :
- Developmental Brain Research [ 0165-3806 ] ; 1994.
Abstract
Fibers labelled with antibody to the growth associated protein (GAP-43) were observed as early as 4 gestational weeks (g.w.) in the nervous system of human embryos. At 6 g.w. these fibers could be traced throughout the brainstem and the diencephalon. None of the immunolabelled fibers entered the telencephalic wall at that point, but 2 weeks later at 8 g.w., GAP-43 positive fibers were observed below the newly formed cortical plate of the cerebral cortex. GAP-43 positive fiber bundles had the same distribution as those previously labeled with tyrosine hydroxylase antibodies at the same age. These results strongly suggest that this growth associated protein is localized in the early growing dopaminergic fibers.
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DOI: 10.1016/0165-3806(94)00187-5
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Selemon for helpful comments on the paper.</wicri:noCountry></affiliation></author><author><name sortKey="Kanazir, Selma" sort="Kanazir, Selma" uniqKey="Kanazir S" first="Selma" last="Kanazir">Selma Kanazir</name><affiliation wicri:level="1"><mods:affiliation>Institute for Biological Research, Belgrade, Yugoslavia</mods:affiliation><country xml:lang="fr">Yougoslavie</country><wicri:regionArea>Institute for Biological Research, Belgrade</wicri:regionArea></affiliation><affiliation><mods:affiliation>∗ The authors thank Drs. A. Vigny and L. Benowitz for TH and GAP-43 antisera and Dr. L. Selemon for helpful comments on the paper.</mods:affiliation><wicri:noCountry code="no comma">∗ The authors thank Drs. A. Vigny and L. Benowitz for TH and GAP-43 antisera and Dr. L. Selemon for helpful comments on the paper.</wicri:noCountry></affiliation></author><author><name sortKey="Zecevic, Nada" sort="Zecevic, Nada" uniqKey="Zecevic N" first="Nada" last="Zecevic">Nada Zecevic</name><affiliation><mods:affiliation>Corresponding author. Dept. Medicine, MC-1305, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA. Fax: (1) (203) 679-3346.</mods:affiliation><wicri:noCountry code="subField">679-3346.</wicri:noCountry></affiliation><affiliation wicri:level="1"><mods:affiliation>University of Connecticut, Medical School, Department of Medicine, MC-1305, Farmington, CT 06030, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Connecticut, Medical School, Department of Medicine, MC-1305, Farmington, CT 06030</wicri:regionArea></affiliation><affiliation><mods:affiliation>∗ The authors thank Drs. A. Vigny and L. Benowitz for TH and GAP-43 antisera and Dr. L. 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A. Vigny and L. Benowitz for TH and GAP-43 antisera and Dr. L. Selemon for helpful comments on the paper.</mods:affiliation></affiliation></author><author><name sortKey="Kanazir, Selma" sort="Kanazir, Selma" uniqKey="Kanazir S" first="Selma" last="Kanazir">Selma Kanazir</name><affiliation wicri:level="1"><mods:affiliation>Institute for Biological Research, Belgrade, Yugoslavia</mods:affiliation><country xml:lang="fr">Yougoslavie</country><wicri:regionArea>Institute for Biological Research, Belgrade</wicri:regionArea></affiliation><affiliation><mods:affiliation>∗ The authors thank Drs. A. Vigny and L. Benowitz for TH and GAP-43 antisera and Dr. L. Selemon for helpful comments on the paper.</mods:affiliation></affiliation></author><author><name sortKey="Zecevic, Nada" sort="Zecevic, Nada" uniqKey="Zecevic N" first="Nada" last="Zecevic">Nada Zecevic</name><affiliation><mods:affiliation>Corresponding author. Dept. Medicine, MC-1305, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA. Fax: (1) (203) 679-3346.</mods:affiliation></affiliation><affiliation wicri:level="1"><mods:affiliation>University of Connecticut, Medical School, Department of Medicine, MC-1305, Farmington, CT 06030, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Connecticut, Medical School, Department of Medicine, MC-1305, Farmington, CT 06030</wicri:regionArea></affiliation><affiliation><mods:affiliation>∗ The authors thank Drs. A. Vigny and L. Benowitz for TH and GAP-43 antisera and Dr. L. Selemon for helpful comments on the paper.</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Developmental Brain Research</title><title level="j" type="abbrev">BRESD</title><idno type="ISSN">0165-3806</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1994">1994</date><biblScope unit="volume">84</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="282">282</biblScope><biblScope unit="page" to="286">286</biblScope></imprint><idno type="ISSN">0165-3806</idno></series><idno type="istex">0DA6798340296A5556CB7166F0C67E8FE507ADE2</idno><idno type="DOI">10.1016/0165-3806(94)00187-5</idno><idno type="PII">0165-3806(94)00187-5</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0165-3806</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Fibers labelled with antibody to the growth associated protein (GAP-43) were observed as early as 4 gestational weeks (g.w.) in the nervous system of human embryos. At 6 g.w. these fibers could be traced throughout the brainstem and the diencephalon. None of the immunolabelled fibers entered the telencephalic wall at that point, but 2 weeks later at 8 g.w., GAP-43 positive fibers were observed below the newly formed cortical plate of the cerebral cortex. GAP-43 positive fiber bundles had the same distribution as those previously labeled with tyrosine hydroxylase antibodies at the same age. These results strongly suggest that this growth associated protein is localized in the early growing dopaminergic fibers.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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