Dispersal of junctional particles, not internalization, during the in vivo disappearance of gap junctions
Identifieur interne : 000180 ( Istex/Curation ); précédent : 000179; suivant : 000181Dispersal of junctional particles, not internalization, during the in vivo disappearance of gap junctions
Auteurs : Nancy J. Lane [Royaume-Uni] ; Lesley S. Swales [Royaume-Uni]Source :
- Cell [ 0092-8674 ] ; 1979.
Abstract
Gap junctions composed of intramembranous particles are frequently found to couple adjacent cells and are the sites of cell-to-cell exchange of physiologically important ions and molecules. In many vertebrate systems, the disappearance of gap junctions during development is thought to be due to a process of interiorization involving endocytosis. Intramembranous particle dispersal, however, is an alternative, more economical mode of gap junction removal. Studies on a metamorphosing insect, the moth Manduca sexta, show that mature larval gap junctions are maintained only briefly during early pupal stages as macular plaques of EF particles. After this stage, ecdysone initiates pupal cellular rearrangements, and the maculae break down by a “streaming out” of junctional particles in linear arrays away from the plaque periphery. A particle-free aisle, running along an intramembranous groove, lies in the center of these aligned arrays, and this groove is observed before particle streaming commences. As development proceeds, the particle-free aisles widen and the gap junctional particles are dispersed over the intramembranous E face, rather than being disposed of by “internalization”. Diapausing controls suggest that the intramembranous groove along which the junctional particles become aligned may be a cellular response to hormonal stimulation. Fracturing differences render comparable junctional particle redistribution more difficult to follow in vertebrate cells, making arthropod systems preferable for the analysis of gap junction breakdown in vivo. Particle dispersal rather than interiorization may thus be more widespread than currently suspected.
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DOI: 10.1016/S0092-8674(80)80034-1
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Unit of Invertebrate Chemistry and Physiology Department of Zoology University of Cambridge Downing Street Cambridge CB2 3EJ</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Cell</title><title level="j" type="abbrev">CELL</title><idno type="ISSN">0092-8674</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1979">1979</date><biblScope unit="volume">19</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="579">579</biblScope><biblScope unit="page" to="586">586</biblScope></imprint><idno type="ISSN">0092-8674</idno></series><idno type="istex">16CCC96397C29BC60321BEB03F1A21B7DA60400A</idno><idno type="DOI">10.1016/S0092-8674(80)80034-1</idno><idno type="PII">S0092-8674(80)80034-1</idno><idno type="ArticleID">80800341</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0092-8674</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Gap junctions composed of intramembranous particles are frequently found to couple adjacent cells and are the sites of cell-to-cell exchange of physiologically important ions and molecules. In many vertebrate systems, the disappearance of gap junctions during development is thought to be due to a process of interiorization involving endocytosis. Intramembranous particle dispersal, however, is an alternative, more economical mode of gap junction removal. Studies on a metamorphosing insect, the moth Manduca sexta, show that mature larval gap junctions are maintained only briefly during early pupal stages as macular plaques of EF particles. After this stage, ecdysone initiates pupal cellular rearrangements, and the maculae break down by a “streaming out” of junctional particles in linear arrays away from the plaque periphery. A particle-free aisle, running along an intramembranous groove, lies in the center of these aligned arrays, and this groove is observed before particle streaming commences. As development proceeds, the particle-free aisles widen and the gap junctional particles are dispersed over the intramembranous E face, rather than being disposed of by “internalization”. Diapausing controls suggest that the intramembranous groove along which the junctional particles become aligned may be a cellular response to hormonal stimulation. Fracturing differences render comparable junctional particle redistribution more difficult to follow in vertebrate cells, making arthropod systems preferable for the analysis of gap junction breakdown in vivo. Particle dispersal rather than interiorization may thus be more widespread than currently suspected.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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