On the ultrastructure of primary cultures of normal and dystrophic hamster tongue muscle
Identifieur interne : 000515 ( Istex/Corpus ); précédent : 000514; suivant : 000516On the ultrastructure of primary cultures of normal and dystrophic hamster tongue muscle
Auteurs : J. H. Thakar ; A. Thede ; A. StricklandSource :
- Muscle & Nerve [ 0148-639X ] ; 1980-07.
Abstract
Primary cultures, prepared from the tongue muscle of 1‐day‐old normal and dystrophic (UM‐X7.1 strain) hamsters, were examined under the electron microscope after 6 to 8 days in vitro when myotube development was in progress. Myotubes from normal tongue showed development similar to that of muscle of other tissues and species grown in culture. Compared to myotubes of normal cultures, those of dystrophic cultures showed a number of differences. The sarcoplasmic reticulum and mitochondria showed areas of dilation or swelling and poor development. The density of ribosomes and polyribosomes was less, Z‐band formation was primitive or absent, myofibrillar formation was less, and its organization was poor. Also, spontaneous contractions in dystrophic myotubes were few and irregular. These differences agree well with those reported for heart cells from the dystrophic (cardiomyopathic) hamster grown in culture.
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DOI: 10.1002/mus.880030411
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Myotubes from normal tongue showed development similar to that of muscle of other tissues and species grown in culture. Compared to myotubes of normal cultures, those of dystrophic cultures showed a number of differences. The sarcoplasmic reticulum and mitochondria showed areas of dilation or swelling and poor development. The density of ribosomes and polyribosomes was less, Z‐band formation was primitive or absent, myofibrillar formation was less, and its organization was poor. Also, spontaneous contractions in dystrophic myotubes were few and irregular. These differences agree well with those reported for heart cells from the dystrophic (cardiomyopathic) hamster grown in culture.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>J. H. Thakar PhD</name><affiliations><json:string>Department of Biochemistry, Health Sciences Center, University of Western Ontario, London, Ontario, Canada</json:string></affiliations></json:item><json:item><name>A. 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The sarcoplasmic reticulum and mitochondria showed areas of dilation or swelling and poor development. The density of ribosomes and polyribosomes was less, Z‐band formation was primitive or absent, myofibrillar formation was less, and its organization was poor. Also, spontaneous contractions in dystrophic myotubes were few and irregular. 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H.</namePart><namePart type="family">Thakar</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Biochemistry, Health Sciences Center, University of Western Ontario, London, Ontario, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Thede</namePart><affiliation>Department of Biochemistry, Health Sciences Center, University of Western Ontario, London, Ontario, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="termsOfAddress">Dr.</namePart><namePart type="family">Strickland</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Biochemistry, Health Sciences Center, University of Western Ontario, London, Ontario, Canada</affiliation><description>Correspondence: Department of Biochemistry, Health Sciences Center, University of Western Ontario, London, Ontario, Canada N6A 5C1</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">1980-07</dateIssued><dateCaptured encoding="w3cdtf">1979-09-24</dateCaptured><copyrightDate encoding="w3cdtf">1980</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">5</extent><extent unit="references">22</extent></physicalDescription><abstract lang="en">Primary cultures, prepared from the tongue muscle of 1‐day‐old normal and dystrophic (UM‐X7.1 strain) hamsters, were examined under the electron microscope after 6 to 8 days in vitro when myotube development was in progress. Myotubes from normal tongue showed development similar to that of muscle of other tissues and species grown in culture. Compared to myotubes of normal cultures, those of dystrophic cultures showed a number of differences. The sarcoplasmic reticulum and mitochondria showed areas of dilation or swelling and poor development. The density of ribosomes and polyribosomes was less, Z‐band formation was primitive or absent, myofibrillar formation was less, and its organization was poor. Also, spontaneous contractions in dystrophic myotubes were few and irregular. 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