Applying a calcium phosphate layer on PEO/PBT copolymers affects bone formation in vivo
Identifieur interne : 000257 ( Istex/Corpus ); précédent : 000256; suivant : 000258Applying a calcium phosphate layer on PEO/PBT copolymers affects bone formation in vivo
Auteurs : M. L. Gaillard ; J. Van Den Brink ; C. A. Van Blitterswijk ; Z. B. LuklinskaSource :
- Journal of Materials Science: Materials in Medicine [ 0957-4530 ] ; 1994-06-01.
Abstract
: Recently a copolymer (PolyactiveR) has been introduced that combines elastomeric and bone-bonding properties. Since calcification of the copolymer is a prerequisite for bone bonding. Polyactive was precalcified in vitro in order to increase the bone-bonding rate. Precalcification was performed by subsequent incubation in Ca and P solutions and resulted in formation of a hydroxyapatite layer on the surface of the implant. Within one week after implantation this layer had disappeared from the surface and a new calcification zone was formed under the surface of the copolymer. Longer implantation periods showed that in precalcified implants bone was apposited along the walls of the pores, while in control implants new bone was first formed in the centre of the pores. Consequently, the percentage of bone contact was increased in precalcified implants, however, the amount of bone ingrowth was equal in both control and precalcified implants. Transmission electron microscopy showed the presence of an electron-dense layer at the bone implant interface, which was indicative for bone-bonding. It is concluded from these experiments that precalcification of PEO/PBT copolymers affected the direction of bone apposition and increased the bone-bonding rate.
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DOI: 10.1007/BF00058977
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Gaillard</name><affiliation><mods:affiliation>Laboratory for Otobiology and Biocompatibility, Biomaterials Research Group, University of Leiden, Rijnsburgerweg 10, 2333 AA, Leiden, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Van Den Brink, J" sort="Van Den Brink, J" uniqKey="Van Den Brink J" first="J." last="Van Den Brink">J. Van Den Brink</name><affiliation><mods:affiliation>Laboratory for Otobiology and Biocompatibility, Biomaterials Research Group, University of Leiden, Rijnsburgerweg 10, 2333 AA, Leiden, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Van Blitterswijk, C A" sort="Van Blitterswijk, C A" uniqKey="Van Blitterswijk C" first="C. A." last="Van Blitterswijk">C. A. 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Luklinska</name><affiliation><mods:affiliation>University of London, Department of Materials, Oueen Mary and Westfield College, Mile End Road, E1 4NS, London, UK</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Materials Science: Materials in Medicine</title><title level="j" type="sub">Official Journal of the European Society for Biomaterials</title><title level="j" type="abbrev">J Mater Sci: Mater Med</title><idno type="ISSN">0957-4530</idno><idno type="eISSN">1573-4838</idno><imprint><publisher>Kluwer Academic Publishers</publisher><pubPlace>Dordrecht</pubPlace><date type="published" when="1994-06-01">1994-06-01</date><biblScope unit="volume">5</biblScope><biblScope unit="issue">6-7</biblScope><biblScope unit="page" from="424">424</biblScope><biblScope unit="page" to="428">428</biblScope></imprint><idno type="ISSN">0957-4530</idno></series><idno type="istex">28173E7EA7D41201173BCE080DE482EDFD12F9AE</idno><idno type="DOI">10.1007/BF00058977</idno><idno type="ArticleID">Art26</idno><idno type="ArticleID">BF00058977</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0957-4530</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">: Recently a copolymer (PolyactiveR) has been introduced that combines elastomeric and bone-bonding properties. Since calcification of the copolymer is a prerequisite for bone bonding. Polyactive was precalcified in vitro in order to increase the bone-bonding rate. Precalcification was performed by subsequent incubation in Ca and P solutions and resulted in formation of a hydroxyapatite layer on the surface of the implant. Within one week after implantation this layer had disappeared from the surface and a new calcification zone was formed under the surface of the copolymer. Longer implantation periods showed that in precalcified implants bone was apposited along the walls of the pores, while in control implants new bone was first formed in the centre of the pores. Consequently, the percentage of bone contact was increased in precalcified implants, however, the amount of bone ingrowth was equal in both control and precalcified implants. Transmission electron microscopy showed the presence of an electron-dense layer at the bone implant interface, which was indicative for bone-bonding. It is concluded from these experiments that precalcification of PEO/PBT copolymers affected the direction of bone apposition and increased the bone-bonding rate.</div></front></TEI><istex><corpusName>springer</corpusName><author><json:item><name>M. L. Gaillard</name><affiliations><json:string>Laboratory for Otobiology and Biocompatibility, Biomaterials Research Group, University of Leiden, Rijnsburgerweg 10, 2333 AA, Leiden, The Netherlands</json:string></affiliations></json:item><json:item><name>J. Van Den Brink</name><affiliations><json:string>Laboratory for Otobiology and Biocompatibility, Biomaterials Research Group, University of Leiden, Rijnsburgerweg 10, 2333 AA, Leiden, The Netherlands</json:string></affiliations></json:item><json:item><name>C. A. Van Blitterswijk</name><affiliations><json:string>Laboratory for Otobiology and Biocompatibility, Biomaterials Research Group, University of Leiden, Rijnsburgerweg 10, 2333 AA, Leiden, The Netherlands</json:string></affiliations></json:item><json:item><name>Z. B. Luklinska</name><affiliations><json:string>University of London, Department of Materials, Oueen Mary and Westfield College, Mile End Road, E1 4NS, London, UK</json:string></affiliations></json:item></author><articleId><json:string>Art26</json:string><json:string>BF00058977</json:string></articleId><language><json:string>eng</json:string></language><abstract>: Recently a copolymer (PolyactiveR) has been introduced that combines elastomeric and bone-bonding properties. Since calcification of the copolymer is a prerequisite for bone bonding. Polyactive was precalcified in vitro in order to increase the bone-bonding rate. Precalcification was performed by subsequent incubation in Ca and P solutions and resulted in formation of a hydroxyapatite layer on the surface of the implant. Within one week after implantation this layer had disappeared from the surface and a new calcification zone was formed under the surface of the copolymer. Longer implantation periods showed that in precalcified implants bone was apposited along the walls of the pores, while in control implants new bone was first formed in the centre of the pores. Consequently, the percentage of bone contact was increased in precalcified implants, however, the amount of bone ingrowth was equal in both control and precalcified implants. Transmission electron microscopy showed the presence of an electron-dense layer at the bone implant interface, which was indicative for bone-bonding. 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ContainsESM="No"><ArticleID>BF00058977</ArticleID><ArticleDOI>10.1007/BF00058977</ArticleDOI><ArticleSequenceNumber>26</ArticleSequenceNumber><ArticleTitle Language="En">Applying a calcium phosphate layer on PEO/PBT copolymers affects bone formation <Emphasis Type="Italic">in vivo</Emphasis></ArticleTitle><ArticleCategory>Papers</ArticleCategory><ArticleFirstPage>424</ArticleFirstPage><ArticleLastPage>428</ArticleLastPage><ArticleHistory><RegistrationDate><Year>2004</Year><Month>5</Month><Day>12</Day></RegistrationDate><Received><Year>1993</Year><Month>9</Month><Day>9</Day></Received><Accepted><Year>1993</Year><Month>10</Month><Day>7</Day></Accepted></ArticleHistory><ArticleCopyright><CopyrightHolderName>Chapman & Hall</CopyrightHolderName><CopyrightYear>1994</CopyrightYear></ArticleCopyright><ArticleGrants Type="Regular"><MetadataGrant Grant="OpenAccess"></MetadataGrant><AbstractGrant Grant="OpenAccess"></AbstractGrant><BodyPDFGrant Grant="Restricted"></BodyPDFGrant><BodyHTMLGrant 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DisplayOrder="Western"><GivenName>Z.</GivenName><GivenName>B.</GivenName><FamilyName>Luklinska</FamilyName></AuthorName></Author><Affiliation ID="Aff1"><OrgDivision>Laboratory for Otobiology and Biocompatibility, Biomaterials Research Group</OrgDivision><OrgName>University of Leiden</OrgName><OrgAddress><Street>Rijnsburgerweg 10</Street><Postcode>2333 AA</Postcode><City>Leiden</City><Country>The Netherlands</Country></OrgAddress></Affiliation><Affiliation ID="Aff2"><OrgDivision>University of London, Department of Materials</OrgDivision><OrgName>Oueen Mary and Westfield College</OrgName><OrgAddress><Street>Mile End Road</Street><Postcode>E1 4NS</Postcode><City>London</City><Country>UK</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En"><Heading></Heading><Para>Recently a copolymer (Polyactive<Superscript>R</Superscript>) has been introduced that combines elastomeric and bone-bonding properties. Since calcification of the copolymer is a prerequisite for bone bonding. Polyactive was precalcified <Emphasis Type="Italic">in vitro</Emphasis> in order to increase the bone-bonding rate. Precalcification was performed by subsequent incubation in Ca and P solutions and resulted in formation of a hydroxyapatite layer on the surface of the implant. Within one week after implantation this layer had disappeared from the surface and a new calcification zone was formed under the surface of the copolymer. Longer implantation periods showed that in precalcified implants bone was apposited along the walls of the pores, while in control implants new bone was first formed in the centre of the pores. Consequently, the percentage of bone contact was increased in precalcified implants, however, the amount of bone ingrowth was equal in both control and precalcified implants. Transmission electron microscopy showed the presence of an electron-dense layer at the bone implant interface, which was indicative for bone-bonding. It is concluded from these experiments that precalcification of PEO/PBT copolymers affected the direction of bone apposition and increased the bone-bonding rate.</Para></Abstract></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Applying a calcium phosphate layer on PEO/PBT copolymers affects bone formation in vivo</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Applying a calcium phosphate layer on PEO/PBT copolymers affects bone formation in vivo</title></titleInfo><name type="personal"><namePart type="given">M.</namePart><namePart type="given">L.</namePart><namePart type="family">Gaillard</namePart><affiliation>Laboratory for Otobiology and Biocompatibility, Biomaterials Research Group, University of Leiden, Rijnsburgerweg 10, 2333 AA, Leiden, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Van Den Brink</namePart><affiliation>Laboratory for Otobiology and Biocompatibility, Biomaterials Research Group, University of Leiden, Rijnsburgerweg 10, 2333 AA, Leiden, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="given">A.</namePart><namePart type="family">Van Blitterswijk</namePart><affiliation>Laboratory for Otobiology and Biocompatibility, Biomaterials Research Group, University of Leiden, Rijnsburgerweg 10, 2333 AA, Leiden, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Z.</namePart><namePart type="given">B.</namePart><namePart type="family">Luklinska</namePart><affiliation>University of London, Department of Materials, Oueen Mary and Westfield College, Mile End Road, E1 4NS, London, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="OriginalPaper"></genre><originInfo><publisher>Kluwer Academic Publishers</publisher><place><placeTerm type="text">Dordrecht</placeTerm></place><dateCreated encoding="w3cdtf">1993-09-09</dateCreated><dateIssued encoding="w3cdtf">1994-06-01</dateIssued><copyrightDate encoding="w3cdtf">1994</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">: Recently a copolymer (PolyactiveR) has been introduced that combines elastomeric and bone-bonding properties. Since calcification of the copolymer is a prerequisite for bone bonding. Polyactive was precalcified in vitro in order to increase the bone-bonding rate. Precalcification was performed by subsequent incubation in Ca and P solutions and resulted in formation of a hydroxyapatite layer on the surface of the implant. Within one week after implantation this layer had disappeared from the surface and a new calcification zone was formed under the surface of the copolymer. Longer implantation periods showed that in precalcified implants bone was apposited along the walls of the pores, while in control implants new bone was first formed in the centre of the pores. Consequently, the percentage of bone contact was increased in precalcified implants, however, the amount of bone ingrowth was equal in both control and precalcified implants. Transmission electron microscopy showed the presence of an electron-dense layer at the bone implant interface, which was indicative for bone-bonding. It is concluded from these experiments that precalcification of PEO/PBT copolymers affected the direction of bone apposition and increased the bone-bonding rate.</abstract><note>Papers</note><relatedItem type="host"><titleInfo><title>Journal of Materials Science: Materials in Medicine</title><subTitle>Official Journal of the European Society for Biomaterials</subTitle></titleInfo><titleInfo type="abbreviated"><title>J Mater Sci: Mater Med</title></titleInfo><genre type="Journal" displayLabel="Archive Journal"></genre><originInfo><dateIssued encoding="w3cdtf">1994-06-01</dateIssued><copyrightDate encoding="w3cdtf">1994</copyrightDate></originInfo><subject><genre>Chemistry</genre><topic>Biotechnology</topic><topic>Polymer Sciences</topic><topic>Characterization and Evaluation Materials</topic></subject><identifier type="ISSN">0957-4530</identifier><identifier type="eISSN">1573-4838</identifier><identifier type="JournalID">10856</identifier><identifier type="IssueArticleCount">41</identifier><identifier type="VolumeIssueCount">12</identifier><part><date>1994</date><detail type="volume"><number>5</number><caption>vol.</caption></detail><detail type="issue"><number>6-7</number><caption>no.</caption></detail><extent unit="pages"><start>424</start><end>428</end></extent></part><recordInfo><recordOrigin>Chapman & Hall, 1994</recordOrigin></recordInfo></relatedItem><identifier type="istex">28173E7EA7D41201173BCE080DE482EDFD12F9AE</identifier><identifier type="DOI">10.1007/BF00058977</identifier><identifier type="ArticleID">Art26</identifier><identifier type="ArticleID">BF00058977</identifier><accessCondition type="use and reproduction" contentType="copyright">Chapman & Hall</accessCondition><recordInfo><recordContentSource>SPRINGER</recordContentSource><recordOrigin>Chapman & Hall, 1994</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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