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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Children with obsessive-compulsive disorder: are they just
“little adults”?</title><author><name sortKey="Kalra, Simran K" sort="Kalra, Simran K" uniqKey="Kalra S" first="Simran K." last="Kalra">Simran K. Kalra</name></author><author><name sortKey="Swedo, Susan E" sort="Swedo, Susan E" uniqKey="Swedo S" first="Susan E." last="Swedo">Susan E. Swedo</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">19339765</idno><idno type="pmc">2662563</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662563</idno><idno type="RBID">PMC:2662563</idno><idno type="doi">10.1172/JCI37563</idno><date when="2009">2009</date><idno type="wicri:Area/Pmc/Corpus">000319</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000319</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Children with obsessive-compulsive disorder: are they just
“little adults”?</title><author><name sortKey="Kalra, Simran K" sort="Kalra, Simran K" uniqKey="Kalra S" first="Simran K." last="Kalra">Simran K. Kalra</name></author><author><name sortKey="Swedo, Susan E" sort="Swedo, Susan E" uniqKey="Swedo S" first="Susan E." last="Swedo">Susan E. Swedo</name></author></analytic><series><title level="j">The Journal of Clinical Investigation</title><idno type="ISSN">0021-9738</idno><idno type="eISSN">1558-8238</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Childhood-onset obsessive-compulsive disorder (OCD) affects 1%–2% of
children and adolescents. It is characterized by recurrent obsessions and
compulsions that create distress and interfere with daily life. The symptoms
reported by children are similar to those seen among individuals who develop OCD
in adulthood, and the two groups of patients are treated with similar
symptom-relieving behavior therapies and medications. However, there are
differences in sex ratios, patterns of comorbidity, and the results of
neuroimaging studies that might be important. Here we review the diagnosis and
treatment of childhood-onset OCD in light of pediatric and adult studies. We
also discuss current knowledge of the pathophysiology of the disorder. Despite
advances in this area, further research is needed to understand better the
etiopathogenesis of the disorder and to develop new, more effective therapeutic
options.</p></div></front></TEI><pmc article-type="review-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Clin Invest</journal-id><journal-id journal-id-type="publisher-id">J CLIN INVEST</journal-id><journal-title-group><journal-title>The Journal of Clinical Investigation</journal-title></journal-title-group><issn pub-type="ppub">0021-9738</issn><issn pub-type="epub">1558-8238</issn><publisher><publisher-name>American Society for Clinical Investigation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">19339765</article-id><article-id pub-id-type="pmc">2662563</article-id><article-id pub-id-type="publisher-id">37563</article-id><article-id pub-id-type="doi">10.1172/JCI37563</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review Series</subject></subj-group></article-categories><title-group><article-title>Children with obsessive-compulsive disorder: are they just
“little adults”?</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Kalra</surname><given-names>Simran K.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Swedo</surname><given-names>Susan E.</given-names></name></contrib></contrib-group><aff id="JCI37563">National Institute of Mental Health, NIH, Bethesda, Maryland, USA.</aff><author-notes><corresp>Address correspondence to: Simran K. Kalra or Susan E. Swedo, National
Institutes of Health, Pediatric Neuropsychiatry Branch, 10 Center Drive, Rm
4N208, Bethesda, Maryland 20892, USA. Phone: (301) 435-6640; Fax: (301)
402-8497; E-mail: <email>kalras@mail.nih.gov</email> (S.K. Kalra). Phone: (301)
496-5323; Fax: (301) 402-8497; E-mail: <email>swedos@mail.nih.gov</email> (S.E.
Swedo). </corresp></author-notes><pub-date pub-type="epub"><day>1</day><month>4</month><year>2009</year></pub-date><pub-date pub-type="ppub"><day>1</day><month>4</month><year>2009</year></pub-date><pub-date pub-type="pmc-release"><day>31</day><month>12</month><year>2009</year></pub-date><pmc-comment> PMC Release delay is 8 months and 30 days and was based on the
<volume>119</volume><issue>4</issue><fpage>737</fpage><lpage>746</lpage><permissions><copyright-statement>Copyright © 2009, American Society for Clinical
Investigation</copyright-statement></permissions><abstract><p>Childhood-onset obsessive-compulsive disorder (OCD) affects 1%–2% of
children and adolescents. It is characterized by recurrent obsessions and
compulsions that create distress and interfere with daily life. The symptoms
reported by children are similar to those seen among individuals who develop OCD
in adulthood, and the two groups of patients are treated with similar
symptom-relieving behavior therapies and medications. However, there are
differences in sex ratios, patterns of comorbidity, and the results of
neuroimaging studies that might be important. Here we review the diagnosis and
treatment of childhood-onset OCD in light of pediatric and adult studies. We
also discuss current knowledge of the pathophysiology of the disorder. Despite
advances in this area, further research is needed to understand better the
etiopathogenesis of the disorder and to develop new, more effective therapeutic
options.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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