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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Closed-loop Brain-Machine-Body Interfaces for Noninvasive Rehabilitation of Movement Disorders</title><author><name sortKey="Broccard, Frederic D" sort="Broccard, Frederic D" uniqKey="Broccard F" first="Frédéric D." last="Broccard">Frédéric D. Broccard</name><affiliation><nlm:aff id="A1"> Institute for Neural Computation at University of California San Diego, La Jolla, CA, 92093, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2"> Department of Bioengineering at University of California San Diego, La Jolla, CA, 92093, USA</nlm:aff></affiliation></author><author><name sortKey="Mullen, Tim" sort="Mullen, Tim" uniqKey="Mullen T" first="Tim" last="Mullen">Tim Mullen</name><affiliation><nlm:aff id="A3"> Swartz Center for Computational Neuroscience at University of California San Diego, La Jolla, CA, 92093, USA</nlm:aff></affiliation></author><author><name sortKey="Chi, Yu Mike" sort="Chi, Yu Mike" uniqKey="Chi Y" first="Yu Mike" last="Chi">Yu Mike Chi</name><affiliation><nlm:aff id="A4"> Cognionics, Inc.,San Diego, CA, 92121, USA</nlm:aff></affiliation></author><author><name sortKey="Peterson, David" sort="Peterson, David" uniqKey="Peterson D" first="David" last="Peterson">David Peterson</name><affiliation><nlm:aff id="A1"> Institute for Neural Computation at University of California San Diego, La Jolla, CA, 92093, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A5"> Computational Neuroscience Laboratory at the Salk Institute for Biological Studies, La Jolla, CA, 92037, USA</nlm:aff></affiliation></author><author><name sortKey="Iversen, John R" sort="Iversen, John R" uniqKey="Iversen J" first="John R." last="Iversen">John R. Iversen</name><affiliation><nlm:aff id="A3"> Swartz Center for Computational Neuroscience at University of California San Diego, La Jolla, CA, 92093, USA</nlm:aff></affiliation></author><author><name sortKey="Arnold, Mike" sort="Arnold, Mike" uniqKey="Arnold M" first="Mike" last="Arnold">Mike Arnold</name><affiliation><nlm:aff id="A6"> Isoloader, 2452 New South Wales, Australia</nlm:aff></affiliation></author><author><name sortKey="Kreutz Delgado, Kenneth" sort="Kreutz Delgado, Kenneth" uniqKey="Kreutz Delgado K" first="Kenneth" last="Kreutz-Delgado">Kenneth Kreutz-Delgado</name><affiliation><nlm:aff id="A3"> Swartz Center for Computational Neuroscience at University of California San Diego, La Jolla, CA, 92093, USA</nlm:aff></affiliation></author><author><name sortKey="Jung, Tzyy Ping" sort="Jung, Tzyy Ping" uniqKey="Jung T" first="Tzyy-Ping" last="Jung">Tzyy-Ping Jung</name><affiliation><nlm:aff id="A3"> Swartz Center for Computational Neuroscience at University of California San Diego, La Jolla, CA, 92093, USA</nlm:aff></affiliation></author><author><name sortKey="Makeig, Scott" sort="Makeig, Scott" uniqKey="Makeig S" first="Scott" last="Makeig">Scott Makeig</name><affiliation><nlm:aff id="A3"> Swartz Center for Computational Neuroscience at University of California San Diego, La Jolla, CA, 92093, USA</nlm:aff></affiliation></author><author><name sortKey="Poizner, Howard" sort="Poizner, Howard" uniqKey="Poizner H" first="Howard" last="Poizner">Howard Poizner</name><affiliation><nlm:aff id="A1"> Institute for Neural Computation at University of California San Diego, La Jolla, CA, 92093, USA</nlm:aff></affiliation></author><author><name sortKey="Sejnowski, Terrence" sort="Sejnowski, Terrence" uniqKey="Sejnowski T" first="Terrence" last="Sejnowski">Terrence Sejnowski</name><affiliation><nlm:aff id="A1"> Institute for Neural Computation at University of California San Diego, La Jolla, CA, 92093, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A5"> Computational Neuroscience Laboratory at the Salk Institute for Biological Studies, La Jolla, CA, 92037, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A7"> Howard Hughes Medical Institute, 2452 New South Wales, Australia</nlm:aff></affiliation></author><author><name sortKey="Cauwenberghs, Gert" sort="Cauwenberghs, Gert" uniqKey="Cauwenberghs G" first="Gert" last="Cauwenberghs">Gert Cauwenberghs</name><affiliation><nlm:aff id="A1"> Institute for Neural Computation at University of California San Diego, La Jolla, CA, 92093, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2"> Department of Bioengineering at University of California San Diego, La Jolla, CA, 92093, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24833254</idno><idno type="pmc">4099421</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4099421</idno><idno type="RBID">PMC:4099421</idno><idno type="doi">10.1007/s10439-014-1032-6</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000242</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000242</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Closed-loop Brain-Machine-Body Interfaces for Noninvasive Rehabilitation of Movement Disorders</title><author><name sortKey="Broccard, Frederic D" sort="Broccard, Frederic D" uniqKey="Broccard F" first="Frédéric D." last="Broccard">Frédéric D. Broccard</name><affiliation><nlm:aff id="A1"> Institute for Neural Computation at University of California San Diego, La Jolla, CA, 92093, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2"> Department of Bioengineering at University of California San Diego, La Jolla, CA, 92093, USA</nlm:aff></affiliation></author><author><name sortKey="Mullen, Tim" sort="Mullen, Tim" uniqKey="Mullen T" first="Tim" last="Mullen">Tim Mullen</name><affiliation><nlm:aff id="A3"> Swartz Center for Computational Neuroscience at University of California San Diego, La Jolla, CA, 92093, USA</nlm:aff></affiliation></author><author><name sortKey="Chi, Yu Mike" sort="Chi, Yu Mike" uniqKey="Chi Y" first="Yu Mike" last="Chi">Yu Mike Chi</name><affiliation><nlm:aff id="A4"> Cognionics, Inc.,San Diego, CA, 92121, USA</nlm:aff></affiliation></author><author><name sortKey="Peterson, David" sort="Peterson, David" uniqKey="Peterson D" first="David" last="Peterson">David Peterson</name><affiliation><nlm:aff id="A1"> Institute for Neural Computation at University of California San Diego, La Jolla, CA, 92093, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A5"> Computational Neuroscience Laboratory at the Salk Institute for Biological Studies, La Jolla, CA, 92037, USA</nlm:aff></affiliation></author><author><name sortKey="Iversen, John R" sort="Iversen, John R" uniqKey="Iversen J" first="John R." last="Iversen">John R. Iversen</name><affiliation><nlm:aff id="A3"> Swartz Center for Computational Neuroscience at University of California San Diego, La Jolla, CA, 92093, USA</nlm:aff></affiliation></author><author><name sortKey="Arnold, Mike" sort="Arnold, Mike" uniqKey="Arnold M" first="Mike" last="Arnold">Mike Arnold</name><affiliation><nlm:aff id="A6"> Isoloader, 2452 New South Wales, Australia</nlm:aff></affiliation></author><author><name sortKey="Kreutz Delgado, Kenneth" sort="Kreutz Delgado, Kenneth" uniqKey="Kreutz Delgado K" first="Kenneth" last="Kreutz-Delgado">Kenneth Kreutz-Delgado</name><affiliation><nlm:aff id="A3"> Swartz Center for Computational Neuroscience at University of California San Diego, La Jolla, CA, 92093, USA</nlm:aff></affiliation></author><author><name sortKey="Jung, Tzyy Ping" sort="Jung, Tzyy Ping" uniqKey="Jung T" first="Tzyy-Ping" last="Jung">Tzyy-Ping Jung</name><affiliation><nlm:aff id="A3"> Swartz Center for Computational Neuroscience at University of California San Diego, La Jolla, CA, 92093, USA</nlm:aff></affiliation></author><author><name sortKey="Makeig, Scott" sort="Makeig, Scott" uniqKey="Makeig S" first="Scott" last="Makeig">Scott Makeig</name><affiliation><nlm:aff id="A3"> Swartz Center for Computational Neuroscience at University of California San Diego, La Jolla, CA, 92093, USA</nlm:aff></affiliation></author><author><name sortKey="Poizner, Howard" sort="Poizner, Howard" uniqKey="Poizner H" first="Howard" last="Poizner">Howard Poizner</name><affiliation><nlm:aff id="A1"> Institute for Neural Computation at University of California San Diego, La Jolla, CA, 92093, USA</nlm:aff></affiliation></author><author><name sortKey="Sejnowski, Terrence" sort="Sejnowski, Terrence" uniqKey="Sejnowski T" first="Terrence" last="Sejnowski">Terrence Sejnowski</name><affiliation><nlm:aff id="A1"> Institute for Neural Computation at University of California San Diego, La Jolla, CA, 92093, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A5"> Computational Neuroscience Laboratory at the Salk Institute for Biological Studies, La Jolla, CA, 92037, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A7"> Howard Hughes Medical Institute, 2452 New South Wales, Australia</nlm:aff></affiliation></author><author><name sortKey="Cauwenberghs, Gert" sort="Cauwenberghs, Gert" uniqKey="Cauwenberghs G" first="Gert" last="Cauwenberghs">Gert Cauwenberghs</name><affiliation><nlm:aff id="A1"> Institute for Neural Computation at University of California San Diego, La Jolla, CA, 92093, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2"> Department of Bioengineering at University of California San Diego, La Jolla, CA, 92093, USA</nlm:aff></affiliation></author></analytic><series><title level="j">Annals of biomedical engineering</title><idno type="ISSN">0090-6964</idno><idno type="eISSN">1573-9686</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Traditional approaches for neurological rehabilitation of patients affected with movement disorders, such as Parkinson's disease (PD), dystonia, and essential tremor (ET) consist mainly of oral medication, physical therapy, and botulinum toxin injections. Recently, the more invasive method of deep brain stimulation (DBS) showed significant improvement of the physical symptoms associated with these disorders. In the past several years, the adoption of feedback control theory helped DBS protocols to take into account the progressive and dynamic nature of these neurological movement disorders that had largely been ignored so far. As a result, a more efficient and effective management of PD cardinal symptoms has emerged.</p><p id="P2">In this paper, we review closed-loop systems for rehabilitation of movement disorders, focusing on PD, for which several invasive and noninvasive methods have been developed during the last decade, reducing the complications and side effects associated with traditional rehabilitation approaches and paving the way for tailored individual therapeutics. We then present a novel, transformative, noninvasive closed-loop framework based on force neurofeedback and discuss several future developments of closed-loop systems that might bring us closer to individualized solutions for neurological rehabilitation of movement disorders.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0361512</journal-id><journal-id journal-id-type="pubmed-jr-id">561</journal-id><journal-id journal-id-type="nlm-ta">Ann Biomed Eng</journal-id><journal-id journal-id-type="iso-abbrev">Ann Biomed Eng</journal-id><journal-title-group><journal-title>Annals of biomedical engineering</journal-title></journal-title-group><issn pub-type="ppub">0090-6964</issn><issn pub-type="epub">1573-9686</issn></journal-meta><article-meta><article-id pub-id-type="pmid">24833254</article-id><article-id pub-id-type="pmc">4099421</article-id><article-id pub-id-type="doi">10.1007/s10439-014-1032-6</article-id><article-id pub-id-type="manuscript">NIHMS596215</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Closed-loop Brain-Machine-Body Interfaces for Noninvasive Rehabilitation of Movement Disorders</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Broccard</surname><given-names>Frédéric D.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Mullen</surname><given-names>Tim</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Chi</surname><given-names>Yu Mike</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Peterson</surname><given-names>David</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Iversen</surname><given-names>John R.</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Arnold</surname><given-names>Mike</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Kreutz-Delgado</surname><given-names>Kenneth</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Jung</surname><given-names>Tzyy-Ping</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Makeig</surname><given-names>Scott</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Poizner</surname><given-names>Howard</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Sejnowski</surname><given-names>Terrence</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A5">5</xref><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Cauwenberghs</surname><given-names>Gert</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib></contrib-group><aff id="A1"><label>1</label> Institute for Neural Computation at University of California San Diego, La Jolla, CA, 92093, USA</aff><aff id="A2"><label>2</label> Department of Bioengineering at University of California San Diego, La Jolla, CA, 92093, USA</aff><aff id="A3"><label>3</label> Swartz Center for Computational Neuroscience at University of California San Diego, La Jolla, CA, 92093, USA</aff><aff id="A4"><label>4</label> Cognionics, Inc.,San Diego, CA, 92121, USA</aff><aff id="A5"><label>5</label> Computational Neuroscience Laboratory at the Salk Institute for Biological Studies, La Jolla, CA, 92037, USA</aff><aff id="A6"><label>6</label> Isoloader, 2452 New South Wales, Australia</aff><aff id="A7"><label>7</label> Howard Hughes Medical Institute, 2452 New South Wales, Australia</aff><pub-date pub-type="nihms-submitted"><day>4</day><month>6</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>15</day><month>5</month><year>2014</year></pub-date><pub-date pub-type="ppub"><month>8</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>8</month><year>2015</year></pub-date><volume>42</volume><issue>8</issue><fpage>1573</fpage><lpage>1593</lpage><pmc-comment>elocation-id from pubmed: 10.1007/s10439-014-1032-6</pmc-comment>
<abstract><p id="P1">Traditional approaches for neurological rehabilitation of patients affected with movement disorders, such as Parkinson's disease (PD), dystonia, and essential tremor (ET) consist mainly of oral medication, physical therapy, and botulinum toxin injections. Recently, the more invasive method of deep brain stimulation (DBS) showed significant improvement of the physical symptoms associated with these disorders. In the past several years, the adoption of feedback control theory helped DBS protocols to take into account the progressive and dynamic nature of these neurological movement disorders that had largely been ignored so far. As a result, a more efficient and effective management of PD cardinal symptoms has emerged.</p><p id="P2">In this paper, we review closed-loop systems for rehabilitation of movement disorders, focusing on PD, for which several invasive and noninvasive methods have been developed during the last decade, reducing the complications and side effects associated with traditional rehabilitation approaches and paving the way for tailored individual therapeutics. We then present a novel, transformative, noninvasive closed-loop framework based on force neurofeedback and discuss several future developments of closed-loop systems that might bring us closer to individualized solutions for neurological rehabilitation of movement disorders.</p></abstract><kwd-group><kwd>brain-machine-body interface</kwd><kwd>closed-loop systems</kwd><kwd>movement disorders</kwd><kwd>noninvasive</kwd><kwd>rehabilitation</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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