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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">How often does music and rhythm improve patients’ perception of motor symptoms in Parkinson’s disease?</title><author><name sortKey="Nombela, C" sort="Nombela, C" uniqKey="Nombela C" first="C." last="Nombela">C. Nombela</name><affiliation><nlm:aff id="Aff1">Department of Clinical Neurosciences, Cambridge University, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Rae, C L" sort="Rae, C L" uniqKey="Rae C" first="C. L." last="Rae">C. L. Rae</name><affiliation><nlm:aff id="Aff2">MRC-Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Grahn, J A" sort="Grahn, J A" uniqKey="Grahn J" first="J. A." last="Grahn">J. A. Grahn</name><affiliation><nlm:aff id="Aff3">Brain and Mind Institute, University of Western Ontario, London, ON Canada</nlm:aff></affiliation><affiliation><nlm:aff id="Aff4">Department of Psychology, University of Western Ontario, London, ON Canada</nlm:aff></affiliation></author><author><name sortKey="Barker, R A" sort="Barker, R A" uniqKey="Barker R" first="R. A." last="Barker">R. A. Barker</name><affiliation><nlm:aff id="Aff1">Department of Clinical Neurosciences, Cambridge University, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Owen, A M" sort="Owen, A M" uniqKey="Owen A" first="A. M." last="Owen">A. M. Owen</name><affiliation><nlm:aff id="Aff3">Brain and Mind Institute, University of Western Ontario, London, ON Canada</nlm:aff></affiliation><affiliation><nlm:aff id="Aff4">Department of Psychology, University of Western Ontario, London, ON Canada</nlm:aff></affiliation></author><author><name sortKey="Rowe, J B" sort="Rowe, J B" uniqKey="Rowe J" first="J. B." last="Rowe">J. B. Rowe</name><affiliation><nlm:aff id="Aff1">Department of Clinical Neurosciences, Cambridge University, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="Aff2">MRC-Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge, UK</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23400501</idno><idno type="pmc">3642358</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642358</idno><idno type="RBID">PMC:3642358</idno><idno type="doi">10.1007/s00415-013-6860-z</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000028</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000028</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">How often does music and rhythm improve patients’ perception of motor symptoms in Parkinson’s disease?</title><author><name sortKey="Nombela, C" sort="Nombela, C" uniqKey="Nombela C" first="C." last="Nombela">C. Nombela</name><affiliation><nlm:aff id="Aff1">Department of Clinical Neurosciences, Cambridge University, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Rae, C L" sort="Rae, C L" uniqKey="Rae C" first="C. L." last="Rae">C. L. Rae</name><affiliation><nlm:aff id="Aff2">MRC-Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Grahn, J A" sort="Grahn, J A" uniqKey="Grahn J" first="J. A." last="Grahn">J. A. Grahn</name><affiliation><nlm:aff id="Aff3">Brain and Mind Institute, University of Western Ontario, London, ON Canada</nlm:aff></affiliation><affiliation><nlm:aff id="Aff4">Department of Psychology, University of Western Ontario, London, ON Canada</nlm:aff></affiliation></author><author><name sortKey="Barker, R A" sort="Barker, R A" uniqKey="Barker R" first="R. A." last="Barker">R. A. Barker</name><affiliation><nlm:aff id="Aff1">Department of Clinical Neurosciences, Cambridge University, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Owen, A M" sort="Owen, A M" uniqKey="Owen A" first="A. M." last="Owen">A. M. Owen</name><affiliation><nlm:aff id="Aff3">Brain and Mind Institute, University of Western Ontario, London, ON Canada</nlm:aff></affiliation><affiliation><nlm:aff id="Aff4">Department of Psychology, University of Western Ontario, London, ON Canada</nlm:aff></affiliation></author><author><name sortKey="Rowe, J B" sort="Rowe, J B" uniqKey="Rowe J" first="J. B." last="Rowe">J. B. Rowe</name><affiliation><nlm:aff id="Aff1">Department of Clinical Neurosciences, Cambridge University, Cambridge, UK</nlm:aff></affiliation><affiliation><nlm:aff id="Aff2">MRC-Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge, UK</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Neurology</title><idno type="ISSN">0340-5354</idno><idno type="eISSN">1432-1459</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="De Dreu, Mj" uniqKey="De Dreu M">MJ de Dreu</name></author><author><name sortKey="Van Der Wilk, As" uniqKey="Van Der Wilk A">AS van der Wilk</name></author><author><name sortKey="Poppe, E" uniqKey="Poppe E">E Poppe</name></author><author><name sortKey="Kwakkel, G" uniqKey="Kwakkel G">G Kwakkel</name></author><author><name sortKey="Van Wegen, Ee" uniqKey="Van Wegen E">EE van Wegen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rochester, L" uniqKey="Rochester L">L Rochester</name></author><author><name sortKey="Baker, K" uniqKey="Baker K">K Baker</name></author><author><name sortKey="Hetherington, V" uniqKey="Hetherington V">V Hetherington</name></author><author><name sortKey="Jones, D" uniqKey="Jones D">D Jones</name></author><author><name sortKey="Willems, A M" uniqKey="Willems A">A-M Willems</name></author><author><name sortKey="Kwakkel, G" uniqKey="Kwakkel G">G Kwakkel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thaut, Mh" uniqKey="Thaut M">MH Thaut</name></author><author><name sortKey="Mcintosh, C" uniqKey="Mcintosh C">C McIntosh</name></author><author><name sortKey="Rice, R" uniqKey="Rice R">R Rice</name></author><author><name sortKey="Miller, Ra" uniqKey="Miller R">RA Miller</name></author><author><name sortKey="Rathbun, J" uniqKey="Rathbun J">J Rathbun</name></author><author><name sortKey="Brault, Jm" uniqKey="Brault J">JM Brault</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grahn, Ja" uniqKey="Grahn J">JA Grahn</name></author><author><name sortKey="Rowe, Jb" uniqKey="Rowe J">JB Rowe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lewis, Sj" uniqKey="Lewis S">SJ Lewis</name></author><author><name sortKey="Dove, A" uniqKey="Dove A">A Dove</name></author><author><name sortKey="Robbins, Tw" uniqKey="Robbins T">TW Robbins</name></author><author><name sortKey="Barker, Ra" uniqKey="Barker R">RA Barker</name></author><author><name sortKey="Owen, Am" uniqKey="Owen A">AM Owen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Martens, Ka" uniqKey="Martens K">KA Martens</name></author><author><name sortKey="Almeida, Qj" uniqKey="Almeida Q">QJ Almeida</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="letter"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Neurol</journal-id><journal-id journal-id-type="iso-abbrev">J. Neurol</journal-id><journal-title-group><journal-title>Journal of Neurology</journal-title></journal-title-group><issn pub-type="ppub">0340-5354</issn><issn pub-type="epub">1432-1459</issn><publisher><publisher-name>Springer-Verlag</publisher-name><publisher-loc>Berlin/Heidelberg</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">23400501</article-id><article-id pub-id-type="pmc">3642358</article-id><article-id pub-id-type="publisher-id">6860</article-id><article-id pub-id-type="doi">10.1007/s00415-013-6860-z</article-id><article-categories><subj-group subj-group-type="heading"><subject>Letter to the Editors</subject></subj-group></article-categories><title-group><article-title>How often does music and rhythm improve patients’ perception of motor symptoms in Parkinson’s disease?</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Nombela</surname><given-names>C.</given-names></name><address><email>cn331@cam.ac.uk</email></address><xref ref-type="aff" rid="Aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Rae</surname><given-names>C. L.</given-names></name><xref ref-type="aff" rid="Aff2"></xref></contrib><contrib contrib-type="author"><name><surname>Grahn</surname><given-names>J. A.</given-names></name><xref ref-type="aff" rid="Aff3"></xref><xref ref-type="aff" rid="Aff4"></xref></contrib><contrib contrib-type="author"><name><surname>Barker</surname><given-names>R. A.</given-names></name><xref ref-type="aff" rid="Aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Owen</surname><given-names>A. M.</given-names></name><xref ref-type="aff" rid="Aff3"></xref><xref ref-type="aff" rid="Aff4"></xref></contrib><contrib contrib-type="author"><name><surname>Rowe</surname><given-names>J. B.</given-names></name><xref ref-type="aff" rid="Aff1"></xref><xref ref-type="aff" rid="Aff2"></xref></contrib><aff id="Aff1"><label></label>Department of Clinical Neurosciences, Cambridge University, Cambridge, UK</aff><aff id="Aff2"><label></label>MRC-Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge, UK</aff><aff id="Aff3"><label></label>Brain and Mind Institute, University of Western Ontario, London, ON Canada</aff><aff id="Aff4"><label></label>Department of Psychology, University of Western Ontario, London, ON Canada</aff></contrib-group><pub-date pub-type="epub"><day>12</day><month>2</month><year>2013</year></pub-date><pub-date pub-type="pmc-release"><day>12</day><month>2</month><year>2013</year></pub-date><pub-date pub-type="ppub"><month>5</month><year>2013</year></pub-date><volume>260</volume><issue>5</issue><fpage>1404</fpage><lpage>1405</lpage><history><date date-type="received"><day>12</day><month>12</month><year>2012</year></date><date date-type="rev-recd"><day>28</day><month>1</month><year>2013</year></date><date date-type="accepted"><day>29</day><month>1</month><year>2013</year></date></history><permissions><copyright-statement>© The Author(s) 2013</copyright-statement><license license-type="OpenAccess"><license-p><bold>Open Access</bold>This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.</license-p></license></permissions><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© Springer-Verlag Berlin Heidelberg 2013</meta-value></custom-meta></custom-meta-group></article-meta></front><body><p>Dear Sirs,</p><p>There is a strong interest in combining pharmacological treatments with non-drug therapies for Parkinson’s disease (PD). One such non-pharmacological therapy is music and rhythm stimulation, with anecdotal benefits and favorable preliminary clinical studies. It is suggested that the rhythmic properties of music reduce certain motor features of PD [<xref ref-type="bibr" rid="CR1">1</xref>], perhaps by entraining the brain mechanisms that control timing, sequencing and coordination of movements [<xref ref-type="bibr" rid="CR2">2</xref>]. Early investigations into the effect of auditory rhythms on movement and PD were promising [<xref ref-type="bibr" rid="CR3">3</xref>], and their benefits and possible modes of action confirmed by recent neuroimaging studies [<xref ref-type="bibr" rid="CR4">4</xref>]. However, we noticed an apparent discrepancy between the evolving literature on music, rhythm and PD, and the frequency of spontaneously reported benefits of music from patients in the clinic. We therefore asked: how commonly do patients themselves perceive an improvement in their motor symptoms with music and rhythm?</p><p>We designed and administered a written structured music questionnaire (Supplementary Material) to 50 patients with idiopathic PD (age 65.47 ± 7.8, stage I–III H&Y) during their routine visit to the Cambridge University PD Research Clinic. In addition, eight members of a PD choir (age 68.84 ± 6.9, II–III H&Y) completed the questionnaire, providing a highly motivated and musically experienced patient group. Participants completed the questionnaire (with multiple choice and open-ended questions) sitting in a quiet room. They were asked about (1) handedness, (2) symptomatic hearing problems (Y/N/details), (3) enjoyment of music (Y/N), (4) hours spent weekly listening to music, (5) styles of music listened to (free text), (6) formal musical training (instrument, type and years of training) and dance training (style, type and years of training), (7) current weekly time playing/performing music (Y/N/hours), and (8) whether they had ever noticed a beneficial effect of music on their PD symptoms (Y/N/free text details). Statistical analysis used IBM SPSS Statistics Version 19.</p><p>Of the clinic patients, 46 (92 %) reported normal hearing and 47/50 (94 %) enjoyed listening to music. Sixteen out of 50 (32 %) had formal musical training (average 5 years). Previous dance training was less frequent (10/50, 20 %) and of a shorter duration (average 3.2 years).</p><p>The entire clinic sample (100 %) reported no change in their PD symptoms when listening to music, although 32/50 (64 %) reported pleasant calm feelings. Therefore, despite the common benefit of experience relaxation while listening to music, there were surprisingly no perceived improvements in PD symptoms in this randomly selected cohort of patients.</p><p>Of the choir sample, four patients (50 %) had received musical training (average 5.2 years) and none had previous dance training. Apart from pleasure and a rewarding effect (in 7/8 patients), six patients reported no subjective beneficial effects from listening to music on their Parkinsonian symptoms. Two patients reported a general amelioration of their symptoms with a reduction of tremor.</p><p>This study provides preliminary evidence that a subjective beneficial effect of music on PD symptoms is uncommon. Although there is evidence for music stimulation as a potential therapy from clinical [<xref ref-type="bibr" rid="CR2">2</xref>, <xref ref-type="bibr" rid="CR3">3</xref>] and neuroimaging [<xref ref-type="bibr" rid="CR4">4</xref>] studies, it appears that patients with mild to moderate PD are often not aware of any significant effects on their motor function from listening to music. This largely negative result could be due to the insensitivity of our questionnaire, or it may be that the lack of such a subjective benefit is due to poor memory or awareness of actual benefits. Contributing factors may be the cognitive deficits that can arise even in early stages of PD [<xref ref-type="bibr" rid="CR5">5</xref>], or inaccurate perception of movement [<xref ref-type="bibr" rid="CR6">6</xref>].</p><p>Our data do not of course indicate a lack of objective benefit of music on motor signs. However, the low rate of positive responses (2/58 patients) poses a challenge for therapeutic studies. Music and rhythm therapies may need to train subjects to be more aware of their own state, or to target therapies at the subgroup of patients who have experienced musical benefit.</p><sec sec-type="supplementary-material" id="AppESM1"><title>Electronic supplementary material</title><sec id="SecESM1"><supplementary-material content-type="local-data" id="MOESM1"><media xlink:href="415_2013_6860_MOESM1_ESM.doc" mimetype="application" mime-subtype="msword"><caption><p>Supplementary material 1 (DOC 27 kb)</p></caption></media></supplementary-material></sec></sec></body><back><ack><p>This study was funded by Parkinson’s UK (RES/0211-7258: CN, AMO), Medical Research Council (CLR), the Wellcome Trust (088324: JBR) and the NIHR Biomedical Research Centre, Cambridge.</p><sec id="d30e302"><title>Conflicts of interest</title><p>The authors declare that they have no conflict of interest.</p></sec><sec id="d30e307"><title>Ethical standard</title><p>The study was approved by the local ethics committee, and performed in accordance with the 1964 Declaration of Helsinki. 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between sensory and perceptual deficits in PD: more than simply a motor deficit</article-title><source>Mov Disord</source><year>2012</year><volume>27</volume><fpage>387</fpage><lpage>392</lpage><pub-id pub-id-type="doi">10.1002/mds.24042</pub-id><pub-id pub-id-type="pmid">22173884</pub-id></element-citation></ref></ref-list></back></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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